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medium_divergent_branch_01590 | KLF6 interacts with multiple proteins. One specific interaction was identified via a yeast two-hybrid screen, revealing binding between the C-terminal domain of the interacting partner and KLF6, a putative tumor suppressor in prostate cancer. Which protein is encoded by the gene corresponding to this interacting partne... | Ligand-dependent corepressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01590","source_qa_id":"medium_divergent_branch_05720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KLF6 interacts with multiple proteins. One specific interaction was identified via a yeast two-hy... | |
medium_divergent_branch_01592 | ARMC8 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The association was confirmed by a yeast two-hybrid assay and a co-immunoprecipitation assay.' Which protein corresponds to this specific interaction evidence? | Hepatocyte growth factor-regulated tyrosine kinase substrate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01592","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARMC8 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The association was confirmed by a yeast two-hyb... | |
medium_divergent_branch_01593 | SIAH2 interacts with multiple genes. One of these interaction partners is reported to interact with SIAH2 in vitro and in vivo, and to colocalize with it in the cytoplasm of hematopoietic cells. Which cell type is the gene satisfying this description enriched in? | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH2 interacts with multiple genes. One of these interaction partners is reported to interact with SIAH2 in vitro and in vivo, and to colocalize wit... | |
medium_divergent_branch_01594 | CCR2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Surface expressions of both CCR2 and CCR1 were also increased by LZIP. LZIP also enhanced the chemotactic activities of monocyte chemoattractant protein-1/CCL2 and Lkn-1.... | monocyte chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01594","source_qa_id":"medium_divergent_branch_03576","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CCR2 is associated with multiple biological processes via the 'involved in' relationship. One spe... | |
medium_divergent_branch_01595 | The pleura consists of multiple anatomical components. One component is described as the invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). Which anatomical structure is adjacent to the component identified by this description? | lung | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01595","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pleura consists of multiple anatomical components. One component is described as the invaginated serous membrane that surrounds the lungs (the vi... | |
medium_divergent_branch_01596 | FOXP1 interacts with multiple genes. One specific interaction is supported by evidence from double luciferase reporter, RNA immunoprecipitation (RIP), and biotin-labeled RNA pull-down assays, which demonstrated that circFOXP1 interacts with a partner protein that binds to the 3'UTR and coding region (CDS) of pyruvate k... | hypercholesterolemia, familial, 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP1 interacts with multiple genes. One specific interaction is supported by evidence from double luciferase reporter, RNA immunoprecipitation (RIP)... | |
medium_divergent_branch_01598 | mmu-miR-24-3p regulates more than one type of cell. Evidence for one of these regulatory connections notes that, unlike other family members, miR-24 promotes Th1 and Th17 responses. Which cell type is the target of this specific regulation, and what is its immediate parent class in the cell hierarchy (connected via 'is... | CD4-positive helper T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01598","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-24-3p regulates more than one type of cell. Evidence for one of these regulatory connections notes that, unlike other family members, miR-24 ... | |
medium_divergent_branch_01599 | PRKCZ interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Using affinity chromatography and Western blot analysis, we found interaction with all PKC isotypes and casein kinase I isoforms, CKIalpha and CKI.' Which disease is associated with this specific interacting gene v... | mesothelioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01599","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCZ interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Using affinity chromatography and Western b... | |
medium_divergent_branch_01600 | The gene DEK is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In searching for novel [transcription factor]-interacting factors, using an affinity chromatography approach, we have observed that oncoprotein DEK interacts with [transcription factor] in vitro.' Which... | Transcription factor AP-2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DEK is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In searching for novel [transcr... | |
medium_divergent_branch_01601 | The biological process 'negative regulation of catecholamine secretion' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of a catecholamine. This process is a subtype of two broader biological processes. One of these broader processes is defined by its r... | amine transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01601","source_qa_id":"medium_divergent_branch_01274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of catecholamine secretion' is defined as any process... | |
medium_divergent_branch_01602 | GRIN2A interacts with multiple genes. One interaction is supported by evidence stating: 'By co-immunoprecipitation with subunit-specific antibodies, we present here direct evidence that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and the other ... | fetal growth restriction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01602","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRIN2A interacts with multiple genes. One interaction is supported by evidence stating: 'By co-immunoprecipitation with subunit-specific antibodies, ... | |
medium_divergent_branch_01603 | ZFP36L1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In addition, we demonstrate that both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner.' Identify the biological process linked to this specific a... | regulation of epidermal cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01603","source_qa_id":"medium_divergent_branch_06030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZFP36L1 is associated with multiple biological processes. One specific association is supported b... | |
medium_divergent_branch_01604 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.306 and an adjusted p-value of 0.0388. Which protein does that selected gene encode? | Interferon gamma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01604","source_qa_id":"medium_divergent_branch_03425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_01605 | AKAP8 interacts with multiple genes. One of these interactions is supported by evidence showing that endogenous AKAP95 interacts with a specific cyclin D family member or cyclin D1 in canine thyrocytes, human fibroblasts, and NIH-3T3 cells. Which cellular component is the gene implicated by this specific evidence locat... | cyclin-dependent protein kinase holoenzyme complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP8 interacts with multiple genes. One of these interactions is supported by evidence showing that endogenous AKAP95 interacts with a specific cycl... | |
medium_divergent_branch_01606 | MCM10 interacts with multiple proteins. One specific interaction is supported by evidence stating that HsMcm10 associates with the target protein when both are overexpressed in COS-1 cells. Which protein, encoded by the gene connected to MCM10 via this interaction, is the subject of this evidence? | Origin recognition complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01606","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM10 interacts with multiple proteins. One specific interaction is supported by evidence stating that HsMcm10 associates with the target protein whe... | |
medium_divergent_branch_01607 | The innate immune response is enabled by multiple cell types. One such cell is described as a mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands, playing activation and regulatory roles particularly early in an immune response. Wh... | immature NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The innate immune response is enabled by multiple cell types. One such cell is described as a mature alpha-beta T cell of a distinct lineage that bea... | |
medium_divergent_branch_01608 | The protein FREM2 is associated with multiple biological processes. One association is supported by evidence stating: 'our work highlights the importance of the FREM2 protein during the development of eyelids and the anterior segment of the eyeballs.' Identify the biological process described by this evidence, and then... | sensory organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01608","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein FREM2 is associated with multiple biological processes. One association is supported by evidence stating: 'our work highlights the import... | |
medium_divergent_branch_01609 | MIR30C2 is associated with multiple biological processes. One association is supported by evidence stating: 'In a previous genome-wide miRNA screen, we had identified miR-30c-2-3p as one of the strongest negative regulators of NF-κB signaling.' Which biological process, connected to the process supported by this eviden... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR30C2 is associated with multiple biological processes. One association is supported by evidence stating: 'In a previous genome-wide miRNA screen, ... | |
medium_divergent_branch_01610 | MAFG interacts with multiple genes. One of these interaction partners is described as follows: In BRAF-positive human colorectal cancer (CRC) cell lines and tumors, this entity binds to the promoters of MLH1 and other CIMP genes. It recruits a corepressor complex that includes its heterodimeric partner, the chromatin r... | neuroblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01610","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAFG interacts with multiple genes. One of these interaction partners is described as follows: In BRAF-positive human colorectal cancer (CRC) cell li... | |
medium_divergent_branch_01612 | SPRED2 interacts with multiple genes. One of these interaction partners is described as a highly conserved multidomain protein that interacts and colocalizes with SPRED2 in vivo. Which biological process is this specific interaction partner involved in? | macroautophagy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPRED2 interacts with multiple genes. One of these interaction partners is described as a highly conserved multidomain protein that interacts and col... | |
medium_divergent_branch_01613 | TLCD2 is associated with multiple biological processes. One association is supported by evidence stating that Human TLCD1/2 regulate membrane fluidity by limiting the levels of polyunsaturated fatty acid-containing membrane phospholipids. Which biological process, connected to the process supported by this evidence via... | endomembrane system organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01613","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TLCD2 is associated with multiple biological processes. One association is supported by evidence stating that Human TLCD1/2 regulate membrane fluidit... | |
medium_divergent_branch_01614 | PAK1 interacts with multiple genes. One interaction is supported by evidence stating: 'The dissociation constants of the p21-binding domains of PAK1, PAK2, and the RasGAP-related domain of IQGAP1, which all cause significant reduction of the intrinsic rate of GTP hydrolysis upon binding to the target GTPase-GTP, are fo... | cutaneous melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01614","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAK1 interacts with multiple genes. One interaction is supported by evidence stating: 'The dissociation constants of the p21-binding domains of PAK1,... | |
medium_divergent_branch_01615 | GFM2 is associated with multiple biological processes. One association is supported by evidence that EF-G2mt mediates ribosome recycling with human mitochondrial RRF but lacks translocation activity. Which biological process is a component of the process linked to this specific evidence? | mitochondrial gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFM2 is associated with multiple biological processes. One association is supported by evidence that EF-G2mt mediates ribosome recycling with human m... | |
medium_divergent_branch_01617 | ZFP36 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a specific interactor in a yeast two-hybrid screen as a TTP interactor using the C-terminal mRNA decay domain of TTP as bait.' Which protein is encoded by the gene corresponding to this specific interactor? | Proline-rich protein 5-like | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZFP36 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a specific interactor in a yeast two-hybrid ... | |
medium_divergent_branch_01618 | The pontine raphe nucleus is classified as a type of specific brain structure. Evidence indicates that this nucleus is located in the pontine tegmentum. Which broader anatomical region is this specific brain structure a part of? | brainstem | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01618","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pontine raphe nucleus is classified as a type of specific brain structure. Evidence indicates that this nucleus is located in the pontine tegment... | |
medium_divergent_branch_01620 | MYO6 interacts with multiple proteins. One interaction is supported by evidence that recombinant proteins bearing the cargo-binding domain of Myosin VI (Myo VI-CBD) or the cytoplasmic tail of E-cadherin can interact directly with one another. Which protein, connected to MYO6 via this specific interaction evidence, is e... | Cadherin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01620","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYO6 interacts with multiple proteins. One interaction is supported by evidence that recombinant proteins bearing the cargo-binding domain of Myosin ... | |
medium_divergent_branch_01621 | ADAR interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that these proteins interact with each ADAR and modulate RNA editing levels.' Identify the disease associated with this specific interacting partner via a biomarker relationship. | nasopharyngeal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01621","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAR interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that these proteins interact with each ADA... | |
medium_divergent_branch_01622 | Juxtacanalicular tissue cells are a specific subtype of cell found in the eye's drainage system. Evidence indicates that these cells are characterized by a spindle-shaped, fibroblast-like morphology within a loose extracellular matrix immediately adjacent to Schlemm's canal. They express CHI3L1 and ANGPTL7, as well as ... | connective tissue cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01622","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Juxtacanalicular tissue cells are a specific subtype of cell found in the eye's drainage system. Evidence indicates that these cells are characterize... | |
medium_divergent_branch_01623 | CD274 (PD-L1) interacts with multiple genes. One of these interacting partners is an E3 ligase that binds, ubiquitinates, and downregulates tumor-surface PD-L1/L2 in MAPKi-treated human melanoma cells, thereby promoting T-cell activation. Which disease is associated with this specific interacting gene? | syndromic multisystem autoimmune disease due to ITCH deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01623","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD274 (PD-L1) interacts with multiple genes. One of these interacting partners is an E3 ligase that binds, ubiquitinates, and downregulates tumor-sur... | |
medium_divergent_branch_01624 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.085 and an adjusted p-value of 0.000188. For which disease is that selected gene recorded as a biomarker? | hypercholesterolemia, familial, 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01624","source_qa_id":"medium_divergent_branch_00067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_01625 | TRIM39 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we report the identification of TRIM39 as a MOAP-1-binding protein.' Which protein, connected to TRIM39 via an interaction, is the subject of this specific evidence? | Modulator of apoptosis 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01625","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM39 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we report the identification of TRIM39 as ... | |
medium_divergent_branch_01626 | The gene ITCH interacts with multiple partners. One specific interaction is characterized by the finding that the partner protein's association with the second WW domain (WW2) of ITCH interferes with ITCH's binding to its substrates. Which protein is encoded by the gene corresponding to this specific interacting partne... | NEDD4-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITCH interacts with multiple partners. One specific interaction is characterized by the finding that the partner protein's association with ... | |
medium_divergent_branch_01627 | PCBP1 interacts with multiple genes. One of these interacting partners is an E3 ubiquitin ligase that targets PCBP1 for ubiquitination and subsequent degradation. Which gene is this interacting partner? | IP6K1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01627","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCBP1 interacts with multiple genes. One of these interacting partners is an E3 ubiquitin ligase that targets PCBP1 for ubiquitination and subsequent... | |
medium_divergent_branch_01628 | GOLGA2 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we report for the first time that the [protein] interacts specifically with GM130 in a GTP-dependent manner and therefore needs the hypervariable regions of the N- and C-termini.' Which protein, encoded by ... | Ras-related protein Rab-1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GOLGA2 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we report for the first time that t... | |
medium_divergent_branch_01629 | EIF4E interacts with multiple proteins. One specific interaction partner is characterized by the following mechanism: it acts as an E3 ubiquitin ligase that ubiquitinates EIF4E, and it also functions as a mediator to present EIF4E to another E3 ligase, CHIP. Which protein is encoded by the gene corresponding to this sp... | Baculoviral IAP repeat-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01629","source_qa_id":"medium_divergent_branch_05448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EIF4E interacts with multiple proteins. One specific interaction partner is characterized by the ... | |
medium_divergent_branch_01630 | The gene AHSG interacts with multiple other genes. One of these interacting partners is described by the following mechanism: it directly binds to the hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, a process important for maintaining glucose homeostasis. Which protein is encode... | F-box/WD repeat-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01630","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AHSG interacts with multiple other genes. One of these interacting partners is described by the following mechanism: it directly binds to th... | |
medium_divergent_branch_01631 | TDP1 interacts with multiple proteins. One of these interaction partners is supported by evidence showing that the TDP1-R586 variant promotes binding between TDP1 and this partner, as well as the formation of foci for this partner at Top1cc-damage sites. Which protein is encoded by the gene corresponding to this intera... | DNA repair protein XRCC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01631","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TDP1 interacts with multiple proteins. One of these interaction partners is supported by evidence showing that the TDP1-R586 variant promotes binding... | |
medium_divergent_branch_01633 | SPACA9 is associated with multiple cellular components via a 'located in' relationship. One specific association is supported by evidence that SPACA9 forms intralumenal striations in the B tubule of respiratory doublet microtubules and noncontinuous spirals in sperm singlet microtubules. Which cellular component, conne... | axoneme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01633","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPACA9 is associated with multiple cellular components via a 'located in' relationship. One specific association is supported by evidence that SPACA9... | |
medium_divergent_branch_01634 | The conjunctival vein is classified as a type of anatomy via the 'is a' relationship. One such classification is supported by the description: 'A vein that is part of a conjunctiva.' Which anatomical structure is the parent of this specific classification via the 'part of' relationship? | cranial blood vasculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01634","source_qa_id":"medium_divergent_branch_04337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The conjunctival vein is classified as a type of anatomy via the 'is a' relationship. One such cl... | |
medium_divergent_branch_01635 | IL10 is associated with multiple biological processes. One association is supported by evidence stating: 'The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota.' Which biological process is negatively regulated by the process linke... | inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01635","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL10 is associated with multiple biological processes. One association is supported by evidence stating: 'The cytokine IL-10 is a key anti-inflammato... | |
medium_divergent_branch_01636 | MAVS interacts with multiple genes. One of these interaction partners is characterized by evidence showing it binds to MAVS in the mitochondrial compartment following viral infection and negatively regulates RIG-I-like receptor (RLR)-mediated antiviral immunity. Which disease is therapeutically linked to this specific ... | malignant colon neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01636","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAVS interacts with multiple genes. One of these interaction partners is characterized by evidence showing it binds to MAVS in the mitochondrial comp... | |
medium_divergent_branch_01637 | PIK3CB interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A glutathione S-transferase fusion protein containing the N-terminal 171 amino-acids of p110 beta bound to free [regulatory subunit of PI3K] in cell lysates.' Which protein, encoded by the gene involved in this specific... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01637","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3CB interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A glutathione S-transferase fusion protein conta... | |
medium_divergent_branch_01638 | CEP63 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it colocalizes with CEP63 to satellites, binds to CEP63, and identifies other satellite proteins via BioID. Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein moonraker | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01638","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEP63 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it colocalizes with CEP63 to sate... | |
medium_divergent_branch_01639 | RPL29 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast two-hybrid system, we found hBH bound to human homologues of rat ribosomal proteins L11 and L29.' Which disease is associated with the gene identified by this specific evidence? | amyloidosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPL29 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast two-hybrid system, we found hBH bound to human ... | |
medium_divergent_branch_01641 | MYO6 interacts with multiple proteins. One specific interaction is characterized by the binding of the MYO6 cargo domain, via its RRL motif, to the C-terminal M2 and DHR2 domains of the interacting partner. This interaction has been observed in various cell lines. Which disease is associated with genomic alterations in... | hyperlipidemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01641","source_qa_id":"medium_divergent_branch_01962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYO6 interacts with multiple proteins. One specific interaction is characterized by the binding o... | |
medium_divergent_branch_01642 | HEATR5B interacts with multiple proteins. One specific interaction is supported by evidence showing that antibodies against any one of three proteins immunoprecipitate the other two, and siRNA-mediated knockdown of any of the three reduces the levels of the others, indicating they form a stable complex. Which protein, ... | Aftiphilin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01642","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HEATR5B interacts with multiple proteins. One specific interaction is supported by evidence showing that antibodies against any one of three proteins... | |
medium_divergent_branch_01643 | The hindlimb is a type of anatomy that connects to a broader anatomical category via an 'is a' relationship. One such category is defined as a free structure connected to the pelvic girdle region, encompassing the autopod, stylopod, and zeugopod regions when present, while explicitly excluding the pelvic girdle and its... | limb bud | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01643","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The hindlimb is a type of anatomy that connects to a broader anatomical category via an 'is a' relationship. One such category is defined as a free s... | |
medium_divergent_branch_01644 | TSG101 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins.' W... | HGS | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01644","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSG101 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The ability of HCRP1 (which we assign the ... | |
medium_divergent_branch_01645 | SHANK3 interacts with multiple proteins. One specific interaction is described as being mediated by the PDZ domain of Shank and the C-terminal leucine zipper domain and the PDZ domain-binding motif at the extreme C terminus of the protein encoded by ARHGEF7. Which protein, encoded by the gene involved in this specific ... | Rho guanine nucleotide exchange factor 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01645","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHANK3 interacts with multiple proteins. One specific interaction is described as being mediated by the PDZ domain of Shank and the C-terminal leucin... | |
medium_divergent_branch_01647 | WNT5B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT5B, WNT2B, WNT10B, FZD6, and FZD7, exhibited altered expression in human dermal fibroblasts (hDFs) after 3 days of exposure to DBP. Given this context, which biological process, connected to WNT5B via a... | cartilage development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01647","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT5B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT5B, WNT2B, WNT10B, FZD6, and FZ... | |
medium_divergent_branch_01648 | The gene PRELID1P6 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 6.41 TPM, a z-score of 1.65, and a fold enrichment of 2.34. Identify the cell type that corresponds to this expression profile and then determine the cell type from which it develops. | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01648","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRELID1P6 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 6.41 TPM, a z-score o... | |
medium_divergent_branch_01649 | RNF31 interacts with multiple proteins. One of these interaction partners is characterized by binding to CYLD through its PUB domain and engaging the PUB domain of the LUBAC component HOIP via a PUB interaction motif (PIM). Which disease is associated with this specific interaction partner as a biomarker? | thymic carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01649","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF31 interacts with multiple proteins. One of these interaction partners is characterized by binding to CYLD through its PUB domain and engaging the... | |
medium_divergent_branch_01652 | ZAP70 interacts with multiple gene products. One interaction is supported by evidence stating: 'Two molecules involved in signal transduction via the T cell antigen receptor, namely the protein-tyrosine kinase ZAP-70 and the proto-oncoprotein Vav, were found to be constitutively associated with tubulin in Jurkat T cell... | Tubulin alpha-1A chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01652","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZAP70 interacts with multiple gene products. One interaction is supported by evidence stating: 'Two molecules involved in signal transduction via the... | |
medium_divergent_branch_01653 | The gene NF1 interacts with multiple partners. One interaction is supported by evidence stating: 'In the present study, we identified a novel cellular neurofibromin-associating protein, 14-3-3, which belongs to a highly conserved family of proteins that regulate intracellular signal transduction events in all eukaryoti... | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01653","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NF1 interacts with multiple partners. One interaction is supported by evidence stating: 'In the present study, we identified a novel cellula... | |
medium_divergent_branch_01654 | BAX interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrated in the yeast two-hybrid system that BFL-1 interacts strongly with human BAX but is not able to form homodimers nor to interact with human BCL-2 or BCL-xL.' Which protein, encoded by the gene connected to BAX via thi... | Bcl-2-related protein A1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01654","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAX interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrated in the yeast two-hybrid system that BFL-1 in... | |
medium_divergent_branch_01655 | ERCC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated with hRad52, a recombinational repair protein, in human cell-free extracts and that these factors interact directly via the N-terminal domain of hRad52 and the XPF protein.' Which ... | DNA repair protein RAD52 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01655","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated with hRad... | |
medium_divergent_branch_01656 | The gene EIF4EBP1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Here, we show that a functional TOS motif is required for 4E-BP1 to bind to raptor (a recently identified [interacting protein]), for 4E-BP1 to be efficiently phosphorylated in vitro by the [complex], and ... | Serine/threonine-protein kinase mTOR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01656","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF4EBP1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Here, we show that a functional TO... | |
medium_divergent_branch_01657 | RNF31 interacts with multiple proteins. One specific interaction is described as an unexpected binding between the E2 ubiquitin-conjugating enzyme and RNF31 (also known as HOIP), which serves as the catalytic subunit of the LUBAC complex. Which protein, connected to RNF31 via this interaction, is the subject of the 'en... | Ubiquitin-conjugating enzyme E2 L3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01657","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF31 interacts with multiple proteins. One specific interaction is described as an unexpected binding between the E2 ubiquitin-conjugating enzyme an... | |
medium_divergent_branch_01658 | MAST2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of... | Cadherin-related family member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01658","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAST2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, we identified a protein, hMAST205 (microtubul... | |
medium_divergent_branch_01659 | EIF1AX is associated with multiple biological processes. One association is supported by evidence stating that the proteins remodel the initiation complex to orient the initiator aminoacyl-tRNA in a conformation compatible with ribosomal subunit joining. Which biological process is a part of the process linked to EIF1A... | ribosome biogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF1AX is associated with multiple biological processes. One association is supported by evidence stating that the proteins remodel the initiation co... | |
medium_divergent_branch_01660 | VPS35 interacts with multiple genes. One of these interacting partners was experimentally shown to be co-immunoprecipitated with VPS35 and lysosome-associated membrane protein-2a (Lamp2a). Which disease is associated with this specific interacting gene? | leukodystrophy, hypomyelinating, 17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01660","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS35 interacts with multiple genes. One of these interacting partners was experimentally shown to be co-immunoprecipitated with VPS35 and lysosome-a... | |
medium_divergent_branch_01661 | WWC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally we found that KIBRA interacts with histone H3 via its glutamic acid-rich region and that such interaction might play a mechanistic role in conferring an optimal ER transactivation function as well as the proliferation of l... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01661","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally we found that KIBRA interacts with histone H3 via i... | |
medium_divergent_branch_01664 | The term 'extra-ocular muscle' is a subtype of two distinct anatomical categories. One category is defined by the evidence: 'Skeletal muscle derived from cranial mesoderm and controls eye movements.' Which anatomical structure is the 'part of' target for the category supported by this specific evidence? | craniocervical region musculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01664","source_qa_id":"medium_divergent_branch_02983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The term 'extra-ocular muscle' is a subtype of two distinct anatomical categories. One category i... | |
medium_divergent_branch_01665 | TRAF5 interacts with multiple genes. One of these interaction partners is described in experimental evidence as being capable of binding in vitro via its TRAF domain (TD) to all previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6). In contrast, the TD of SPOP interacts weakly with o... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01665","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF5 interacts with multiple genes. One of these interaction partners is described in experimental evidence as being capable of binding in vitro via... | |
medium_divergent_branch_01666 | CUL5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that this protein is an active substrate recruitment module for a Cullin5-based E3 ligase and have defined the core protein components required for ubiquitination.' Which protein, connected to CUL5 via this interaction, is... | Suppressor of cytokine signaling 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01666","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that this protein is an active substrate recruitmen... | |
medium_divergent_branch_01667 | Secretagogin (SCGN) interacts with multiple proteins. One study expanded the cellular interaction network of secretagogin to include nine proteins: SNAP-23, DOC2alpha, ARFGAP2, rootletin, KIF5B, β-tubulin, DDAH-2, ATP-synthase, and myeloid leukemia factor 2, based on high-content protein array screening and validation ... | Double C2-like domain-containing protein alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01667","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Secretagogin (SCGN) interacts with multiple proteins. One study expanded the cellular interaction network of secretagogin to include nine proteins: S... | |
medium_divergent_branch_01669 | PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.' Which protein, connected to PPARG via th... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01669","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'To elucidate the mechanism of attenuation, we found that P... | |
medium_divergent_branch_01670 | The gene OBI1 (RNF219) has multiple interacting partners. One interaction is supported by evidence stating: 'We demonstrate that RNF219 is an active RING-type E3 ligase which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity region of RNF219.' Whi... | CCR4-NOT transcription complex subunit 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01670","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OBI1 (RNF219) has multiple interacting partners. One interaction is supported by evidence stating: 'We demonstrate that RNF219 is an active ... | |
medium_divergent_branch_01671 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.303 and an adjusted p-value of 0.0381. Which protein does that selected gene encode? | Chromobox protein homolog 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01671","source_qa_id":"medium_divergent_branch_03131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_01672 | GNAS interacts with multiple proteins. One interaction is supported by evidence describing the direct association of the G protein alpha subunit with the regulator of G protein signaling (RGS) domain of axin. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Axin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01672","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAS interacts with multiple proteins. One interaction is supported by evidence describing the direct association of the G protein alpha subunit with... | |
medium_divergent_branch_01673 | FBXO4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We provide evidence that phosphorylation of Ser12 generates a docking site for 14-3-3ɛ.' Which protein, encoded by the gene connected to FBXO4 via this specific interaction, is the subject of this evidence? | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01673","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We provide evidence that phosphorylation of Ser12 generate... | |
medium_divergent_branch_01674 | MAGI2 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that MAGI-2 contains eight potential protein-protein interaction domains and is localized to tight junctions in the membrane of epithelial cells. Which cellular component is a parent... | tight junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01674","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGI2 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that MAGI-2... | |
medium_divergent_branch_01675 | NCF2 interacts with multiple proteins. One of these interaction partners is known to bind to amino acid residues 170-199 of p67(phox), and the N terminus of p67(phox) (amino acids 1-192) serves as a specific inhibitor of its signaling. Which protein, encoded by the gene connected to NCF2 via this binding interaction, i... | Ras-related C3 botulinum toxin substrate 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01675","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCF2 interacts with multiple proteins. One of these interaction partners is known to bind to amino acid residues 170-199 of p67(phox), and the N term... | |
medium_divergent_branch_01676 | CDX2 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'pax-6 and cdx-2 also directly interacted with one another at the protein level.' Which protein corresponds to this specific interaction partner? | Paired box protein Pax-6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01676","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDX2 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'pax-6 and cdx-2 also directly interacted with ... | |
medium_divergent_branch_01677 | PRMT3 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that Protein arginine methyltransferase 3 comprises a region not required for catalytic activity in its amino-terminus and a core domain catalyzing protein arginine methylation. Which protein, connected to PRM... | Small ribosomal subunit protein uS5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01677","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRMT3 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that Protein arginine methyltransferas... | |
medium_divergent_branch_01678 | The gene CATSPER1 is enriched in multiple cell types. One specific cell type shows a mean expression of 29.32 TPM, a z-score of 1.55, and a fold enrichment of 3.21. Which cell type corresponds to these expression statistics, and what is its immediate parent category in the cell type hierarchy (i.e., what is it a type o... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01678","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CATSPER1 is enriched in multiple cell types. One specific cell type shows a mean expression of 29.32 TPM, a z-score of 1.55, and a fold enri... | |
medium_divergent_branch_01680 | FANCE interacts with multiple proteins. One interaction is supported by evidence stating: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and the interacting protein but not with FANCD2.' Which protein, connected to FANCE via a binding interaction, is encoded by the gene in question? | Fanconi anemia group G protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01680","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCE interacts with multiple proteins. One interaction is supported by evidence stating: 'In normal cells, HA-tagged FANCE protein coimmunoprecipita... | |
medium_divergent_branch_01681 | THAP12 interacts with multiple genes. One of these interactions is supported by evidence stating that DAP4 binds a specific kinase through its carboxyl-terminal segment. Which protein is encoded by the gene connected to THAP12 via this specific interaction? | Serine/threonine-protein kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01681","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"THAP12 interacts with multiple genes. One of these interactions is supported by evidence stating that DAP4 binds a specific kinase through its carbox... | |
medium_divergent_branch_01682 | SUMO1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'we show for the first time that this protein is SUMOylated both in vitro and in cellulo and that Lysine 10 is the main SUMOylation site.' Which protein is encoded by the gene corresponding to this interaction par... | Tripartite motif-containing protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01682","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUMO1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'we show for the first time that this prot... | |
medium_divergent_branch_01684 | NR1H2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a nuclear receptor can interact with the liver X receptors LXRalpha (NR1H3) and LXRbeta (NR1H2), as demonstrated by glutathione-S-transferase pull-down assays, mammalian two-hybrid, and coimmunoprecipitation exp... | Nuclear receptor subfamily 0 group B member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01684","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR1H2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a nuclear receptor can interact with the... | |
medium_divergent_branch_01685 | TUT4 is associated with multiple interacting partners. One specific interaction was identified in a study where a novel zinc finger protein, ZCCHC11, was found to interact with a target protein isolated from phosphoproteins of the macrophage cell line RAW 264.7. This identification was achieved using affinity purificat... | TRAF-interacting protein with FHA domain-containing protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01685","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TUT4 is associated with multiple interacting partners. One specific interaction was identified in a study where a novel zinc finger protein, ZCCHC11,... | |
medium_divergent_branch_01686 | GAS6 is associated with multiple biological processes. One of these processes is supported by evidence stating that the phagocytic clearance of apoptotic cells involves bridging by GAS6. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | phagocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01686","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAS6 is associated with multiple biological processes. One of these processes is supported by evidence stating that the phagocytic clearance of apopt... | |
medium_divergent_branch_01687 | CLASP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that CLASP1, a microtubule-associated protein, localizes preferentially near the plus ends of growing spindle microtubules. Which molecular function, connected to this specifi... | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01687","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLASP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that... | |
medium_divergent_branch_01688 | The gene SLC39A10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 35.48 TPM, a z-score of 1.87, and a fold enrichment of 4.00. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell t... | granulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01688","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC39A10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 35.48 TPM,... | |
medium_divergent_branch_01689 | MCM7 interacts with multiple genes. One of these interacting partners has a physical interaction with MCM7 that was confirmed in vivo in yeast cells and verified with in vitro protein binding assays. Which disease is associated with this specific interacting gene through genomic alterations? | Crohn disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01689","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM7 interacts with multiple genes. One of these interacting partners has a physical interaction with MCM7 that was confirmed in vivo in yeast cells ... | |
medium_divergent_branch_01690 | The cervical vertebra cartilage element is a type of two distinct anatomical structures. One of these structures is described in evidence as being composed primarily of cartilage tissue. Which anatomical structure is the cervical vertebra cartilage element a part of? | cervical region of vertebral column | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01690","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The cervical vertebra cartilage element is a type of two distinct anatomical structures. One of these structures is described in evidence as being co... | |
medium_divergent_branch_01691 | MCL1 interacts with multiple proteins. One specific interaction partner binds Mcl-1 at its constitutively phosphorylated site, Thr163Pro, and stabilizes the protein by inhibiting its ubiquitination. Which disease is associated with genomic alterations in this specific interacting protein? | hypogonadotropic hypogonadism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01691","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCL1 interacts with multiple proteins. One specific interaction partner binds Mcl-1 at its constitutively phosphorylated site, Thr163Pro, and stabili... | |
medium_divergent_branch_01693 | USP33 interacts with multiple genes. One of these interaction partners is a receptor that binds to the deubiquitinating enzyme USP33. Which disease is associated with this specific interacting gene through genomic alterations? | pituitary stalk interruption syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01693","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP33 interacts with multiple genes. One of these interaction partners is a receptor that binds to the deubiquitinating enzyme USP33. Which disease i... | |
medium_divergent_branch_01694 | SORL1 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that sorLA acts as a retention factor for APP in trans-Golgi compartments/trans-Golgi network.' Identify the parent biological process (via an 'is a' relationship) of the specific process linked to ... | protein localization to organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01694","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SORL1 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that sorLA acts as a retent... | |
medium_divergent_branch_01695 | TERT is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that 'A fraction of TERT localizes to the [component]'. Identify the cellular component that satisfies this evidence and is connected to another component via a 'part of' relati... | nuclear lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01695","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TERT is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that '... | |
medium_divergent_branch_01696 | The gene BRS3 is associated with multiple biological processes. One association is supported by evidence that mice lacking functional BRS-3 develop mild obesity, hypertension, and impaired glucose metabolism. Which biological process, connected to the process implicated by this evidence via an 'is a' relationship, repr... | hexose metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01696","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BRS3 is associated with multiple biological processes. One association is supported by evidence that mice lacking functional BRS-3 develop m... | |
medium_divergent_branch_01697 | The gene RGCC is associated with multiple biological processes. One association is supported by evidence stating: 'We provide the first direct evidence for RGC-32 as a hypoxia-inducible gene and antiangiogenic factor in endothelial cells.' Identify the biological process that is negatively regulated by the specific pro... | angiogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01697","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RGCC is associated with multiple biological processes. One association is supported by evidence stating: 'We provide the first direct eviden... | |
medium_divergent_branch_01698 | SIN3B interacts with multiple proteins. One interaction is characterized by the following mechanism: In the repression complex involving the interacting partner, the N-terminal repressor domain of that partner recruits SIN3B via its paired amphipathic helix 1 (PAH1) domain, which serves as a scaffold for histone deacet... | RE1-silencing transcription factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01698","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIN3B interacts with multiple proteins. One interaction is characterized by the following mechanism: In the repression complex involving the interact... | |
medium_divergent_branch_01699 | The gene GRIN2A interacts with multiple proteins. One interaction is supported by evidence stating: 'We also showed that a protein tyrosine phosphatase interacted with GluRdelta2 as well as with N-methyl-d-aspartate receptor GluRepsilon1 in cultured cells and in brain.' Which protein, encoded by the gene connected to G... | Tyrosine-protein phosphatase non-receptor type 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01699","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRIN2A interacts with multiple proteins. One interaction is supported by evidence stating: 'We also showed that a protein tyrosine phosphata... | |
medium_divergent_branch_01700 | CRY1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified that USP2a, a circadian-controlled deubiquitinating enzyme, interacts with CRY1 and enhances its protein stability via deubiquitination upon serum shock.' What is the protein encoded by the gene corresponding t... | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01700","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRY1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified that USP2a, a circadian-controlled deub... | |
medium_divergent_branch_01701 | The gene SLC3A2 is known to interact with multiple other genes. One specific interaction partner is supported by evidence showing that a protein encoded by the gene TLCD3A can interact with SLC3A2 (member 2 of solute carrier family 3) and GGTL3B (isoform of gamma-glutamyltranspeptidase-like 3) in eukaryotic cells, as d... | TLC domain-containing protein 3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01701","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC3A2 is known to interact with multiple other genes. One specific interaction partner is supported by evidence showing that a protein enco... | |
medium_divergent_branch_01702 | EIF4E interacts with multiple proteins. One of these interaction partners is reported to be associated with EIF4E in both cell compartments. Which protein, connected to EIF4E via an interaction, is encoded by the gene in question? | Eukaryotic translation initiation factor 4E-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01702","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4E interacts with multiple proteins. One of these interaction partners is reported to be associated with EIF4E in both cell compartments. Which pr... | |
medium_divergent_branch_01703 | Lymphatic endothelial cells are structurally associated with multiple anatomical entities via 'part of' relationships. One such association is supported by evidence describing the specific morphology of these cells: the borders of oak leaf-shaped endothelial cells in initial lymphatics are joined by specialized 'button... | immune system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01703","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Lymphatic endothelial cells are structurally associated with multiple anatomical entities via 'part of' relationships. One such association is suppor... | |
medium_divergent_branch_01704 | FASLG interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that a TNF receptor superfamily member specifically binds two cellular ligands, LIGHT (herpes virus entry mediator (HVEM)-L) and Fas ligand (FasL/CD95L).' Which cell type is the interacting partner enriched i... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01704","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FASLG interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that a TNF receptor superfamily membe... | |
medium_divergent_branch_01705 | ABL1 is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, we show that loss of Abl kinase activity was accompanied by activation of the barrier-stabilizing GTPases Rac1 and Rap1, as well as inhibition of agonist-induced Ca(2+) mobilization and generation ... | regulation of biological quality | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01705","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABL1 is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, we show that loss of Abl k... |
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