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medium_divergent_branch_01706 | Heterochromatin is a component of multiple cell types. One of these cell types is a leukocyte commonly found in the blood and lymph, characterized by a large nucleus, neutral staining cytoplasm, and prominent heterochromatin. Which cellular component is part of this specific leukocyte? | neutrophillic cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01706","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Heterochromatin is a component of multiple cell types. One of these cell types is a leukocyte commonly found in the blood and lymph, characterized by... | |
medium_divergent_branch_01707 | PRKAR2A interacts with multiple genes. One interaction is supported by evidence stating: 'Mutational analysis identified the RII binding domain in MTG16b as residues 399-420, and coimmunoprecipitation assays provide strong evidence that MTG16b is an AKAP in vivo.' Which gene, connected to PRKAR2A via this specific evid... | ERBB4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01707","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAR2A interacts with multiple genes. One interaction is supported by evidence stating: 'Mutational analysis identified the RII binding domain in MT... | |
medium_divergent_branch_01708 | ACTN1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'The missense mutation occurred within actin-binding domain of alpha-actinin 1, a functionally critical domain that crosslinks actin filaments into bundles.' Which cellular componen... | polymeric cytoskeletal fiber | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01708","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTN1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'The misse... | |
medium_divergent_branch_01709 | EMP2 is associated with multiple biological processes. One association is supported by evidence that EMP2 positively modulates collagen gel contraction by ARPE-19 cells through increased FAK activation. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | glomerular mesangial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01709","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EMP2 is associated with multiple biological processes. One association is supported by evidence that EMP2 positively modulates collagen gel contracti... | |
medium_divergent_branch_01710 | NOS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that NOS-3 binds to the globular, but not the filamentous, form of beta-actin, and the affinity of NOS-3 for globular beta-actin is, in turn, increased by Hsp90.' Which protein, encoded by the gene connected to NOS3 via t... | Actin, cytoplasmic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01710","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that NOS-3 binds to the globular, but not the fila... | |
medium_divergent_branch_01711 | FBLN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A distinct interaction was also observed with nidogen but this was only partially blocked by EDTA.' Which protein, encoded by the gene connected to FBLN2 via this specific interaction, is the subject of this evidence? | Nidogen-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01711","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBLN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A distinct interaction was also observed with nidogen but ... | |
medium_divergent_branch_01712 | NEK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrated that Nek2A binds specifically to a specific mitogen-activated protein kinase.' Which protein, connected to NEK2 via this specific interaction, is encoded by the gene in question? | Mitogen-activated protein kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01712","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrated that Nek2A binds specifically to a spe... | |
medium_divergent_branch_01713 | RAD21 interacts with multiple genes. One interaction is supported by evidence stating that a 14S complex (x-cohesin) contains SMC1, SMC3, RAD21, and a newly identified subunit. Which disease is associated with the gene identified in this complex context? | intellectual disability, autosomal dominant 47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01713","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD21 interacts with multiple genes. One interaction is supported by evidence stating that a 14S complex (x-cohesin) contains SMC1, SMC3, RAD21, and ... | |
medium_divergent_branch_01714 | EPHA4 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we found that EphA4 formed a heteroreceptor complex with a fibroblast growth factor receptor family member in the cells and that the EphA4-fibroblast growth factor receptor family member complex potentiated FGF... | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01714","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHA4 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we found that EphA4 formed a heterorece... | |
medium_divergent_branch_01715 | KDM4B interacts with multiple genes. One specific interaction involves a complex where Skp1, Cullin1, and an F-box-containing protein ubiquitylate KDM4B when it is complexed with tamoxifen-bound estrogen receptor (ER); the subsequent degradation of this complex releases steroid receptor coactivator (SRC) from ER. Which... | Tayoun-Maawali syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01715","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KDM4B interacts with multiple genes. One specific interaction involves a complex where Skp1, Cullin1, and an F-box-containing protein ubiquitylate KD... | |
medium_divergent_branch_01716 | CD9 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'The association is also disrupted in the presence of digitonin, suggesting that CD9 associates with CD19 only through this protein.' Which protein corresponds to this description, and what is the name of the anti... | CD81 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01716","source_qa_id":"medium_divergent_branch_06535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CD9 interacts with multiple proteins. One specific interaction is characterized by the following ... | |
medium_divergent_branch_01717 | BCL11A interacts with multiple genes. One interaction is supported by evidence stating: 'Two novel and related C(2)H(2) zinc finger proteins that are highly expressed in the brain, CTIP1 and CTIP2 (COUP TF-interacting proteins 1 and 2, respectively), were isolated and shown to interact with all members of the chicken o... | FOXP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01717","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL11A interacts with multiple genes. One interaction is supported by evidence stating: 'Two novel and related C(2)H(2) zinc finger proteins that are... | |
medium_divergent_branch_01718 | CDK4 interacts with multiple proteins. One of these interaction partners is described in the literature as a protein that interacts with CDK4 and inhibits the CDK4/cyclin D1 enzyme complex. Which protein, encoded by the gene connected to CDK4 via this specific interaction, is the subject of this description? | Y-box-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01718","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK4 interacts with multiple proteins. One of these interaction partners is described in the literature as a protein that interacts with CDK4 and inh... | |
medium_divergent_branch_01719 | RNF219 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate that RNF219 is an active RING-type E3 ligase which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity region of RNF219.' Which gene, connected t... | KIAA0232 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01719","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF219 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate that RNF219 is an active RING-type E3 ligase ... | |
medium_divergent_branch_01720 | CREB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that Luman, its homolog in Drosophila, dCREB-A (also known as BBF-2), and VP16 bind to HCF by a motif, (D/E)HXY(S/A), present in all three proteins.' Which protein, connected to CREB3 via this interaction, is encoded by ... | Host cell factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CREB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that Luman, its homolog in Drosophila, dCREB-A (a... | |
medium_divergent_branch_01721 | CDK4 interacts with multiple genes. One of these interaction partners is described in the following context: 'Mechanistically, the interacting partner directly bound to HIF-1α, CDK4 and C-myc through its Sec7 domain and led to the ubiquitin degradation of these proteins, thereby inhibiting cell cycle progression, proli... | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01721","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK4 interacts with multiple genes. One of these interaction partners is described in the following context: 'Mechanistically, the interacting partne... | |
medium_divergent_branch_01722 | GATA2 is known to interact with multiple proteins. One specific interaction partner is identified by evidence stating: 'Ex vivo binding studies demonstrated that a zinc finger protein interacts with both GATA1 and GATA2.' Which disease is associated with this specific interaction partner? | neuroblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01722","source_qa_id":"medium_divergent_branch_01424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GATA2 is known to interact with multiple proteins. One specific interaction partner is identified... | |
medium_divergent_branch_01723 | Gemfibrozil interacts with multiple drugs. One of these interacting drugs is contraindicated when used with strong organic anion transporter polypeptide B1 (OATP1B1) inhibitors, such as cyclosporine and gemfibrozil itself. Which disease is this specific interacting drug indicated for? | endometriosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01723","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Gemfibrozil interacts with multiple drugs. One of these interacting drugs is contraindicated when used with strong organic anion transporter polypept... | |
medium_divergent_branch_01724 | POLH interacts with multiple proteins. One interaction partner was identified in a study where polypeptides associated with Poleta, including Rad6 and Rev1, were detected via mass spectrometry and Western blot analysis. Which protein, connected to POLH through this interaction, is the entity encoded by the gene in ques... | E3 ubiquitin-protein ligase RAD18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01724","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLH interacts with multiple proteins. One interaction partner was identified in a study where polypeptides associated with Poleta, including Rad6 an... | |
medium_divergent_branch_01725 | VAMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'our observations indicate for the first time a critical role for VAMP-7 in both eosinophil and neutrophil mediator release.' Identify the biological process linked to this specific association via an 'is a' relati... | leukocyte degranulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01725","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'our observations indicate for the first ti... | |
medium_divergent_branch_01726 | HIST2H3C interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We herein provide biochemical and structural evidence showing that WDR5 binds the Win motifs of MLL2-4, SET1A and SET1B.' Which protein, among the interactors of HIST2H3C, is encoded by the gene corresponding... | Histone-lysine N-methyltransferase 2C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01726","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST2H3C interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We herein provide biochemical and str... | |
medium_divergent_branch_01728 | PEX14 interacts with multiple proteins. One specific interaction partner associates with the peroxisomal translocation pore via PEX14, and a splice variant of this partner (specifically lacking exon 5) of unknown function has been reported. Which disease is associated with this specific interaction partner as a biomark... | adrenoleukodystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01728","source_qa_id":"medium_divergent_branch_01209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PEX14 interacts with multiple proteins. One specific interaction partner associates with the pero... | |
medium_divergent_branch_01729 | The pre-B cell receptor complex is absent from the plasma membrane of two distinct cell types. One of these cell types is characterized by being pre-BCR-negative, negative for kappa and lambda light chains, CD43-low, BP-1-positive, CD45R-positive, CD25-positive, AA4-positive, IgM-negative, CD19-positive, and HSA-positi... | fraction B/C precursor B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01729","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pre-B cell receptor complex is absent from the plasma membrane of two distinct cell types. One of these cell types is characterized by being pre-... | |
medium_divergent_branch_01730 | MAGEA11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Screening for targets of MAGE-A11 revealed that it ubiquitinates this protein, resulting in loss of CFIm25 from the mRNA 3' end processing complex.' Which protein is encoded by the gene corresponding to this interaction partner... | Pre-mRNA cleavage complex 2 protein Pcf11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01730","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGEA11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Screening for targets of MAGE-A11 revealed that it ubiqu... | |
medium_divergent_branch_01731 | The gene NEFH interacts with multiple other genes. One interaction is supported by evidence stating: 'Combining this method with Western blot analysis, disulfide cross-linking, and SDS-polyacrylamide gel electrophoresis in the second dimension showed that the protein encoded by the interacting gene readily forms signif... | Neurofilament light polypeptide | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01731","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NEFH interacts with multiple other genes. One interaction is supported by evidence stating: 'Combining this method with Western blot analysi... | |
medium_divergent_branch_01732 | Tranexamic acid interacts with multiple drugs. One of these interacting drugs is associated with clinical guidance stating that Desmopressin, the drug itself, or platelet infusions may be used to decrease antiplatelet drug effects in case of bleeding. Which disease is this specific interacting drug indicated for? | myocardial infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01732","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Tranexamic acid interacts with multiple drugs. One of these interacting drugs is associated with clinical guidance stating that Desmopressin, the dru... | |
medium_divergent_branch_01733 | The RET gene interacts with multiple partners. One interaction is characterized by the statement: 'We showed that RET interacts specifically with this partner both in mammalian cell lines and in vivo in the pituitary gland, regardless of the presence of pituitary adenoma-specific mutations.' Which protein is encoded by... | AH receptor-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01733","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RET gene interacts with multiple partners. One interaction is characterized by the statement: 'We showed that RET interacts specifically with thi... | |
medium_divergent_branch_01734 | GAS6 is involved in multiple biological processes. One specific process is supported by evidence showing that blocking the Axl-GAS6 interaction (using Axl-Fc or warfarin) significantly reduces the number and percentage of CD3(-)CD56(+) NK cells derived from human CD34(+) hematopoietic progenitor cells cultured with IL-... | natural killer cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01734","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAS6 is involved in multiple biological processes. One specific process is supported by evidence showing that blocking the Axl-GAS6 interaction (usin... | |
medium_divergent_branch_01735 | MAP3K1 interacts with multiple proteins. One interaction partner is supported by evidence stating that hUBC9, an E2 ubiquitin conjugating enzyme, was identified via yeast two-hybrid screening and coprecipitation studies to interact with MEKK1 (an alias for MAP3K1). Which protein is encoded by the gene corresponding to ... | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01735","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K1 interacts with multiple proteins. One interaction partner is supported by evidence stating that hUBC9, an E2 ubiquitin conjugating enzyme, was... | |
medium_divergent_branch_01736 | DYRK2 interacts with multiple proteins. One specific interaction is supported by evidence stating that hPXR is a substrate for the interacting partner, and that phosphorylation of hPXR by this partner facilitates its subsequent ubiquitination by UBR5. Which protein is encoded by the gene corresponding to this specific ... | Nuclear receptor subfamily 1 group I member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01736","source_qa_id":"medium_divergent_branch_03107","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DYRK2 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_01739 | THRA interacts with multiple genes. One such interacting partner is described by the following evidence: 'The protein uses two distinct regions to bind Rb and thyroid hormone receptor (TR), respectively, and thus was named a specific interacting protein.' Which cellular component is the location of this specific intera... | endoplasmic reticulum-Golgi intermediate compartment | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01739","source_qa_id":"medium_divergent_branch_05336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"THRA interacts with multiple genes. One such interacting partner is described by the following ev... | |
medium_divergent_branch_01740 | RALGDS interacts with multiple genes. One of these interaction partners is described by the following evidence: 'These proteins, which also interact with activated Ras and Rap1, are effectors of Ras and mediate the activation of Ral in response to the activation of Ras.' Which disease is associated with this specific g... | choroidal neovascularization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01740","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RALGDS interacts with multiple genes. One of these interaction partners is described by the following evidence: 'These proteins, which also interact ... | |
medium_divergent_branch_01741 | The protein FAM9B is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that the entity localized to chromosomal region Xp22.3 is expressed in testes. Which cellular component, connected to the component indicated by this evidence th... | intracellular membraneless organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01741","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein FAM9B is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidenc... | |
medium_divergent_branch_01742 | RAB38 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'In addition, we show that BLOC-3 can promote specific membrane recruitment of Rab32/38.' Based on this clue, which cellular component is the correct target of the 'located in' relationship for RAB38, ... | pigment granule membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01742","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB38 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'In addition, we show that BLO... | |
medium_divergent_branch_01743 | Interleukin-3 (IL3) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that human IL-3 induces heterodimerization of IL-3R alpha and beta c and that disulfide linkage of these chains is involved in receptor activation but not high-affinity binding.' Which protein,... | Interleukin-3 receptor subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-3 (IL3) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that human IL-3 induce... | |
medium_divergent_branch_01744 | ADD1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I.' ... | DNA-binding transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01744","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADD1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'The ... | |
medium_divergent_branch_01745 | SALL1 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid screen we identified an isoform of telomere-repeat-binding factor 1, as an interaction partner of SALL1, and showed that the N-terminus of SALL1 is not necessary for the interaction with this isoform.' Which pr... | Telomeric repeat-binding factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01745","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SALL1 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid screen we identified an isoform of telo... | |
medium_divergent_branch_01746 | PDGFRB interacts with multiple proteins. One interaction is supported by evidence stating that PDGF stimulation promotes the association of PDGFR-beta with p85, ras GTPase-activating protein, and PLC gamma. Which protein, encoded by the gene involved in this specific interaction, is the target of the 'encodes' relation... | Ras GTPase-activating protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01746","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDGFRB interacts with multiple proteins. One interaction is supported by evidence stating that PDGF stimulation promotes the association of PDGFR-bet... | |
medium_divergent_branch_01747 | The hypodermis is composed primarily of a specific anatomical entity. Evidence for this entity describes it as the lowermost layer of the integumentary system in vertebrates, containing fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm but not the dermatome region, and is used mainly for fat ... | irregular connective tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01747","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The hypodermis is composed primarily of a specific anatomical entity. Evidence for this entity describes it as the lowermost layer of the integumenta... | |
medium_divergent_branch_01749 | EHD3 is implicated in multiple biological processes. One specific process is supported by evidence showing that Cathepsin D, a hydrolase typically transported to lysosomes via an M6PR-dependent pathway, remained trapped at the Golgi apparatus. Which cellular component serves as the target end location for this specific... | lysosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01749","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHD3 is implicated in multiple biological processes. One specific process is supported by evidence showing that Cathepsin D, a hydrolase typically tr... | |
medium_divergent_branch_01750 | ARMC8 interacts with multiple proteins. One interaction partner is characterized by the fact that its substrate binding and ligase activity are regulated by the ARMC8α isoform, whereas the shorter ARMC8β isoform forms a stable hGID complex that fails to recruit this partner. Which protein, connected to ARMC8 via a bind... | Glucose-induced degradation protein 4 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01750","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARMC8 interacts with multiple proteins. One interaction partner is characterized by the fact that its substrate binding and ligase activity are regul... | |
medium_divergent_branch_01751 | USP40 interacts with multiple proteins. One interaction partner is supported by evidence showing that Apoc1 interacts with this partner, which in turn interacts with USP40. Which protein, connected to USP40 via an interaction, is encoded by the gene in question? | Medium-chain acyl-CoA ligase ACSF2, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01751","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP40 interacts with multiple proteins. One interaction partner is supported by evidence showing that Apoc1 interacts with this partner, which in tur... | |
medium_divergent_branch_01752 | SLIT2 is associated with multiple biological processes. One association is supported by evidence that recombinant Slit2-N prevented platelet-derived growth factor (PDGF)-stimulated migration of vascular smooth muscle cells (VSMCs). Which biological process, connected to the process supported by this evidence, is linked... | smooth muscle cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01752","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLIT2 is associated with multiple biological processes. One association is supported by evidence that recombinant Slit2-N prevented platelet-derived ... | |
medium_divergent_branch_01753 | hsa-miR-146b-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that miR-146b-5p expression was determined by qRT-PCR in the specific cells of obese subjects. Which cell type, connected to hsa-miR-146b-5p via 'regulates', is the one described by this evidence, and what cell... | promonocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01753","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-146b-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that miR-146b-5p expression was determi... | |
medium_divergent_branch_01754 | Cholesteryl ester transfer protein (CETP) is associated with multiple biological processes. One association is supported by evidence stating that CETP binds to plasma lipoproteins and promotes the transfer of cholesteryl esters between them. Which broader biological process, defined by an 'is a' relationship, is connec... | transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cholesteryl ester transfer protein (CETP) is associated with multiple biological processes. One association is supported by evidence stating that CET... | |
medium_divergent_branch_01755 | GLIS3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated that GLIS3 interacts with Suppressor of Fused, which involves a VYGHF motif located within this conserved region.' Which protein, encoded by the gene connected to GLIS3 via this specific interaction, is t... | Suppressor of fused homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01755","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLIS3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated that GLIS3 interacts with Suppres... | |
medium_divergent_branch_01756 | The gene HGSNAT shows significant enrichment in multiple immune cell types. One specific cell type exhibits a mean expression of 15.36 TPM, a z-score of 1.72, and a fold enrichment of 2.75 for this gene. Which broader cell lineage does this specific cell type belong to? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01756","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HGSNAT shows significant enrichment in multiple immune cell types. One specific cell type exhibits a mean expression of 15.36 TPM, a z-score... | |
medium_divergent_branch_01757 | CBX2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By crosslinking mass spectrometry, we identified novel interactions between the protein encoded by RNF2 and the three non-catalytic subunits.' Which protein, connected to CBX2 via this interaction, is encoded by the gene in questi... | E3 ubiquitin-protein ligase RING2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CBX2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By crosslinking mass spectrometry, we identified novel inte... | |
medium_divergent_branch_01758 | HIST1H4A interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'In this study, we characterized the chromatin association of this protein and found that it preferentially binds histone H3/H4 via its C-terminal NAP-like domain both in vitro and ex vivo.' What is the na... | Testis-specific Y-encoded-like protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST1H4A interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'In this study, we characterized t... | |
medium_divergent_branch_01759 | PSEN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Subcellular fractionation of membrane vesicles and subsequent coimmunoprecipitation of individual gamma-secretase components revealed that interactions among all proteins occurred in the Golgi/trans-Golgi network (TGN) c... | Dowling-Degos disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01759","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSEN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Subcellular fractionation of membrane vesicles an... | |
medium_divergent_branch_01760 | The ethmoid bone is anatomically connected to two distinct higher-level structures via a 'part of' relationship. One of these connections is supported by evidence describing the ethmoid bone as a lightweight, spongy bone located at the roof of the nose between the orbits, separating the nasal cavity from the brain, and... | subdivision of skeletal system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01760","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ethmoid bone is anatomically connected to two distinct higher-level structures via a 'part of' relationship. One of these connections is supporte... | |
medium_divergent_branch_01761 | RAP2A is associated with multiple biological processes. One association is supported by evidence that Rap2 promoted the translocation of TNIK to the detergent-insoluble cytoskeletal fraction, rather than enhancing JNK activation. Which broader biological category, defined by an 'is a' relationship, encompasses this spe... | macromolecule localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01761","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAP2A is associated with multiple biological processes. One association is supported by evidence that Rap2 promoted the translocation of TNIK to the ... | |
medium_divergent_branch_01762 | AP1G1 interacts with multiple genes. One interaction is supported by evidence stating: 'Analysis using a yeast two-hybrid system has revealed that, similarly to gamma1-adaptin, gamma2-adaptin is capable of interacting not only with the sigma1 chain (called as [the first sigma1 variant] in this paper), the small chain o... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01762","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP1G1 interacts with multiple genes. One interaction is supported by evidence stating: 'Analysis using a yeast two-hybrid system has revealed that, s... | |
medium_divergent_branch_01763 | CASP3 is associated with multiple biological processes. One association is supported by evidence showing that Caspase-3-deficient parental MCF7 cells failed to undergo morphological nuclear and DNA fragmentation, whereas MCF7 cells expressing the relevant entity displayed intact nuclear dismantling and DNA fragmentatio... | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP3 is associated with multiple biological processes. One association is supported by evidence showing that Caspase-3-deficient parental MCF7 cells... | |
medium_divergent_branch_01764 | CEBPB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we show that C/EBPbeta and a histone acetyltransferase interact with each other and demonstrate that the sequences responsible for interaction map to the E1A binding region of the histone acetyltransferase and ... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEBPB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we show that C/EBPbeta and a histone ac... | |
medium_divergent_branch_01765 | MAPK8IP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrated that c-Jun N-terminal kinase (JNK)/stress activated protein kinase-associated protein 1 (JSAP1), a scaffold factor in the mitogen-activated protein kinase (MAPK) cascades, forms a complex with the N-termin... | Focal adhesion kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8IP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrated that c-Jun N-terminal kinase (JNK)... | |
medium_divergent_branch_01766 | SIAH1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this report, we describe the identification of an E3 ubiquitin ligase, Seven in Absentia homologue-1 (SIAH1), as a transcription factor-interacting protein.' Which cellular component is the gene identified in this specific eviden... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this report, we describe the identification of an E3 ubiqu... | |
medium_divergent_branch_01767 | NCF2 interacts with multiple proteins. One interaction is supported by evidence describing the identification of a novel PB1 domain in the budding yeast protein Bem1p and mammalian p67(phox), noting that maximal activation of NADPH oxidase requires the formation of a complex between p40(phox) and p67(phox) via their PB... | Neutrophil cytosol factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01767","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCF2 interacts with multiple proteins. One interaction is supported by evidence describing the identification of a novel PB1 domain in the budding ye... | |
medium_divergent_branch_01768 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 2.536 and an adjusted p-value of 0.0291. Which protein does that selected gene encode? | Rho-related GTP-binding protein Rho6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01768","source_qa_id":"medium_divergent_branch_07227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_01769 | GABARAPL2 interacts with multiple proteins. One interaction is supported by biochemical evidence stating that purified mutant Atg8 homologs with an exposed C-terminal Glycine formed an E1-substrate intermediate with hAtg7 and an E2-substrate intermediate with the interacting partner via ATP-dependent thioester bonds. W... | Ubiquitin-like-conjugating enzyme ATG3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL2 interacts with multiple proteins. One interaction is supported by biochemical evidence stating that purified mutant Atg8 homologs with an e... | |
medium_divergent_branch_01770 | UBE2L3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that UBE2L3 (E2) and the corresponding E3 ligase form a functional pair that generates Ub chains linked via lysine 48 (K48) and also via lysine 63 (K63) in vitro.' What is the protein product encoded by the gene for thi... | Ubiquitin-protein ligase E3C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2L3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that UBE2L3 (E2) and the corresponding E3 ligase... | |
medium_divergent_branch_01771 | Paxillin (PXN) interacts with multiple proteins. One specific interaction is supported by evidence from a cell-free interaction assay using immobilized paxillin, which demonstrates that TG-2 binds directly to paxillin. Which protein is encoded by the gene corresponding to this interacting partner? | Protein-glutamine gamma-glutamyltransferase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01771","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Paxillin (PXN) interacts with multiple proteins. One specific interaction is supported by evidence from a cell-free interaction assay using immobiliz... | |
medium_divergent_branch_01772 | TAF7 (formerly known as TAFII55) is associated with multiple molecular functions. One specific function is supported by evidence that human TAF7 physically interacts with c-Jun through two independent interaction domains. What is the parent molecular function (connected via an 'is a' relationship) of this specific func... | transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01772","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF7 (formerly known as TAFII55) is associated with multiple molecular functions. One specific function is supported by evidence that human TAF7 phys... | |
medium_divergent_branch_01773 | MUC16 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'The epithelial mucins MUC1, MUC4, and MUC16 also contributed to the vesicles' structure.' Based on this evidence, which cellular component is connected to MUC16 through the 'located in' relationship, ... | membrane-bounded organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MUC16 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'The epithelial mucins MUC1, M... | |
medium_divergent_branch_01774 | The gene COQ2 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 29.09 TPM, a z-score of 1.90, and a fold enrichment of 3.79. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01774","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene COQ2 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 29.09 TPM, a z-score of 1.90, and a fold enri... | |
medium_divergent_branch_01775 | BIRC2 interacts with multiple proteins. One specific interaction involves a kinase binding to the second baculovirus IAP repeat (BIR2) domain of c-IAP1 via the IBM, a mechanism that facilitates c-IAP1-mediated ubiquitylation and degradation of this kinase. Which disease is associated with the gene encoding this interac... | Pick disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple proteins. One specific interaction involves a kinase binding to the second baculovirus IAP repeat (BIR2) domain of c-IA... | |
medium_divergent_branch_01776 | RCOR1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here we report that this protein interacts with transcription corepressor complexes NCoR/SMRT, SIN3A, NuRD, and REST/CoREST to repress a cohort of genes including HIF1β and EZH2 and to regulate several sig... | Forkhead box protein K2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RCOR1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here we report that this protein i... | |
medium_divergent_branch_01777 | The gene GTF2F1 interacts with multiple proteins. One of these interacting partners is described by the following evidence: 'Using a yeast interaction assay, we find that this protein binds the RAP74 subunit of TFIIF and that its transcriptional activation domain is the region involved in this binding.' Which protein i... | Serum response factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01777","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GTF2F1 interacts with multiple proteins. One of these interacting partners is described by the following evidence: 'Using a yeast interactio... | |
medium_divergent_branch_01779 | CAMK2A interacts with multiple proteins. One interaction is supported by evidence stating that the binding of CaMKII to the NR2B subunit of the NMDAR in the postsynaptic density is essential for the induction of long-term potentiation. Which protein, encoded by the gene corresponding to this specific interaction partne... | Glutamate receptor ionotropic, NMDA 2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAMK2A interacts with multiple proteins. One interaction is supported by evidence stating that the binding of CaMKII to the NR2B subunit of the NMDAR... | |
medium_divergent_branch_01780 | AP1G1 interacts with multiple genes. One of these interaction partners is characterized by bipartite binding mechanisms: GGA-GAE domains recognize an FGPLV sequence (residues 439-443) in a predicted random coil of this partner, while GGA-GAT domains bind to the C-terminal coiled-coils of this partner. Which disease is ... | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP1G1 interacts with multiple genes. One of these interaction partners is characterized by bipartite binding mechanisms: GGA-GAE domains recognize an... | |
medium_divergent_branch_01781 | CD33 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Here we show that treatment of human monocytes with anti-CD33 mAb induces the production of the proinflammatory cytokines IL-1 beta, TNF-alpha, and IL-8.' Identify the bi... | interleukin-8 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01781","source_qa_id":"medium_divergent_branch_00421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CD33 is associated with multiple biological processes via the 'involved in' relationship. One spe... | |
medium_divergent_branch_01782 | HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results establish HMGA2 as a regulator of human genes linked to mesenchymal cell differentiation, adipogenesis, and hES cell growth.' Which cell type is the final product of the biological process connected to... | adipocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01782","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results establish HMGA2 as a regulator... | |
medium_divergent_branch_01783 | Sperm travels through multiple anatomical structures. One such structure is described as an anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia. Which anatomical structure, connected to this specific n... | testis sex cord | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Sperm travels through multiple anatomical structures. One such structure is described as an anastomosing network of delicate tubules located in the h... | |
medium_divergent_branch_01784 | IL27 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system.' Which biological process, connected to the proc... | T-helper 1 cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01784","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL27 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, during the initiation of Th1 differen... | |
medium_divergent_branch_01785 | The protein LECT2 is associated with multiple biological processes. One association is supported by evidence stating that LECT2 is a multifunctional protein identical to chondromodulin-II, a growth stimulator of chondrocyte cells. Which biological process, connected to the process supported by this evidence via an 'is ... | system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01785","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein LECT2 is associated with multiple biological processes. One association is supported by evidence stating that LECT2 is a multifunctional ... | |
medium_divergent_branch_01786 | MAP3K4 interacts with multiple downstream kinases. One specific interaction is supported by evidence stating: 'The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAPKKKs), including MTK1 (MEKK4), ASK1, TAK1, TAO2, MEKK1, and Raf-1.' Identify the protein encoded by the gene that interacts with MAP3... | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01786","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K4 interacts with multiple downstream kinases. One specific interaction is supported by evidence stating: 'The DVD sites bind to their specific u... | |
medium_divergent_branch_01787 | KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that this gene, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL degradation through interaction with the PHD/Bromodomain region of MLL.' Which disease is associated with this gene? | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that this gene, a component of the ECS(ASB) E3 u... | |
medium_divergent_branch_01788 | CRY1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that a mutant form of this partner, which fails to bind CRY1, is unable to form an SCF complex. This suggests that the interaction between CRY1 and this partner is essential for the formation of the SCF complex ... | intellectual disability, short stature, facial anomalies, and joint dislocations | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRY1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that a mutant form of this partner, whic... | |
medium_divergent_branch_01789 | STX12 interacts with multiple proteins. One interaction is supported by evidence stating: 'A soluble recombinant form of the polypeptide without the hydrophobic region binds to alpha-SNAP (soluble N-ethylmaleimide-sensitive factor attachment protein) and syndet/SNAP-23 in vitro.' Which protein, encoded by the gene conn... | Alpha-soluble NSF attachment protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01789","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX12 interacts with multiple proteins. One interaction is supported by evidence stating: 'A soluble recombinant form of the polypeptide without the ... | |
medium_divergent_branch_01790 | The protein ABL1 is involved in multiple biological processes. One specific process is supported by evidence stating that 'Activation of the c-Abl kinase in response to oxidative damage is not observed in CSB null cells.' What is the parent biological process (via an 'is a' relationship) of the process described by thi... | response to stress | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ABL1 is involved in multiple biological processes. One specific process is supported by evidence stating that 'Activation of the c-Abl ki... | |
medium_divergent_branch_01791 | EHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have now identified [interaction partner] as an interaction partner for the recycling regulatory protein, Eps15 homology domain 1 (EHD1).' Which protein is encoded by the gene corresponding to this interaction partner? | Ankyrin repeat and FYVE domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01791","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have now identified [interaction partner] as an... | |
medium_divergent_branch_01792 | HNRNPM interacts with multiple proteins. One of these interaction partners is described in experimental evidence as interacting with several heterogeneous nuclear ribonucleoprotein family proteins, including HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPM, HNRNPR, and HNRNPU, as well as other ribonucleoproteins, DNA... | Transcription factor SOX-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNRNPM interacts with multiple proteins. One of these interaction partners is described in experimental evidence as interacting with several heteroge... | |
medium_divergent_branch_01793 | CDK6 interacts with multiple gene products. One interaction is supported by evidence stating: 'The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the protein encoded by the gene connected to CDK6 through this specific binding interaction has been determined at 1.9 A resolution.' Which protein is encod... | Cyclin-dependent kinase 4 inhibitor D | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01793","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK6 interacts with multiple gene products. One interaction is supported by evidence stating: 'The crystal structure of the cyclin D-dependent kinase... | |
medium_divergent_branch_01794 | HIPK2 interacts with multiple proteins. One specific interaction is described by the statement: 'Here, we identify the homeodomain-interacting protein kinase 2 (HIPK2) as a kinase that binds the target protein and phosphorylates it at Ser 80 in vitro and in vivo.' What is the name of the protein encoded by the gene cor... | Methyl-CpG-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIPK2 interacts with multiple proteins. One specific interaction is described by the statement: 'Here, we identify the homeodomain-interacting protei... | |
medium_divergent_branch_01795 | PAWR interacts with multiple proteins. One specific interaction is characterized by the statement: 'The leucine repeat domain of par-4 was shown to interact with the zinc finger DNA binding domain of this protein.' Which protein corresponds to this description, and what is the name of the protein product encoded by the... | Wilms tumor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAWR interacts with multiple proteins. One specific interaction is characterized by the statement: 'The leucine repeat domain of par-4 was shown to i... | |
medium_divergent_branch_01796 | ETV4 interacts with multiple genes. One interaction is supported by evidence stating: 'We showed that the PEA3 transcriptional factor interacted with a serine/threonine kinase, which is somatically mutated in lung cancer.' Which protein is encoded by the gene connected to ETV4 via this specific interaction? | Serine/threonine-protein kinase STK11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETV4 interacts with multiple genes. One interaction is supported by evidence stating: 'We showed that the PEA3 transcriptional factor interacted with... | |
medium_divergent_branch_01797 | PCBP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we selected several prey proteins from the interactome data and confirmed that the protein interacting with PCBP2 interacted with ancient ubiquitous protein 1 (AUP1), Fas-associated factor family member 2 (FAF2), tri... | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01797","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCBP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we selected several prey proteins from the in... | |
medium_divergent_branch_01798 | The gene PRKN interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to the amino terminus and the ring finger domains of parkin. Which protein corresponds to this specific binding partner? | Septin-5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRKN interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to the amino terminus and ... | |
medium_divergent_branch_01800 | Ameloblasts are a type of cell involved in enamel formation. Evidence indicates that this cell type is a skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast. Based on this description, which broader cell category is the ameloblast classified a... | epithelial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01800","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ameloblasts are a type of cell involved in enamel formation. Evidence indicates that this cell type is a skeletogenic cell that produces enamel, over... | |
medium_divergent_branch_01801 | Ciclesonide interacts with multiple drugs. One of these interacting drugs, when combined with diethyldithiocarbamate, was reported to inhibit M2 and M3 formation by 85% and 45%, respectively. Which disease is this specific interacting drug indicated for? | bacterial infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01801","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ciclesonide interacts with multiple drugs. One of these interacting drugs, when combined with diethyldithiocarbamate, was reported to inhibit M2 and ... | |
medium_divergent_branch_01802 | TREM2 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Our data demonstrate TREM2 as a microglial Aβ receptor transducing physiological and AD-related pathological effects associated with Aβ.' Which broader molecular function category is this specific function a ... | signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TREM2 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Our data demonstrate TREM2 as a micro... | |
medium_divergent_branch_01803 | BCOR interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fusion protein pull-down assays, and co-immunoprecipitation assays showed that the zinc finger DNA-binding domain and the interaction domain of this protein are able to inter... | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01803","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCOR interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fus... | |
medium_divergent_branch_01804 | ACTN4 is localized to multiple cellular components. One of these localizations is supported by evidence that IκBα blocks the association of ACTN4 and p65 in the cytosol. Which cellular component, connected to this specific localization site via a 'part of' relationship, is the correct answer? | intracellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01804","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTN4 is localized to multiple cellular components. One of these localizations is supported by evidence that IκBα blocks the association of ACTN4 and... | |
medium_divergent_branch_01805 | The HTT gene interacts with multiple partners. One specific interaction is supported by evidence showing that the huntingtin exon 1 protein (httex1p) co-aggregates with a tumor suppressor protein in inclusions generated in cell culture and interacts with this protein in vitro and in cell culture. Which disease is causa... | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The HTT gene interacts with multiple partners. One specific interaction is supported by evidence showing that the huntingtin exon 1 protein (httex1p)... | |
medium_divergent_branch_01806 | The gene CCDC78 is associated with multiple biological processes. One association is supported by evidence that modeling CCDC78 mutations in zebrafish recapitulated human disease phenotypes, specifically altered motor function and abnormal muscle ultrastructure. Which biological process, connected to the process implic... | musculoskeletal movement | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CCDC78 is associated with multiple biological processes. One association is supported by evidence that modeling CCDC78 mutations in zebrafis... | |
medium_divergent_branch_01808 | VPS13A is associated with multiple cellular components. One line of evidence states: 'We demonstrate that VPS13A is a peripheral membrane protein, associated with mitochondria, the endoplasmic reticulum and lipid droplets.' Based on this evidence, which cellular component is the bounding layer of the organelle mentione... | mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS13A is associated with multiple cellular components. One line of evidence states: 'We demonstrate that VPS13A is a peripheral membrane protein, as... | |
medium_divergent_branch_01809 | ACVRL1 interacts with multiple genes. One interaction is supported by evidence stating: 'Although both forms of the ligand were capable of binding to the prodomain and ALK1, the M-form demonstrated less sustained induction of Smad1/5/8 phosphorylation.' Which disease is associated with the gene identified by this evide... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01809","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACVRL1 interacts with multiple genes. One interaction is supported by evidence stating: 'Although both forms of the ligand were capable of binding to... | |
medium_divergent_branch_01810 | DACH1 interacts with multiple proteins. One interaction is supported by evidence showing the partner protein bound to endogenous NCoR and DACH1 in cultured cells, as well as co-localization with NCoR in nuclear dotlike structures. Which protein is this interaction partner? | SMAD family member 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01810","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DACH1 interacts with multiple proteins. One interaction is supported by evidence showing the partner protein bound to endogenous NCoR and DACH1 in cu... | |
medium_divergent_branch_01811 | GATA4 interacts with multiple proteins. One specific interaction is characterized by the binding of a protein (or its variants) to GATA4 and Nkx2.5, which inhibits the binding of these transcription factors to each other and to DNA, as well as their synergistic transactivation of genes such as atrial natriuretic factor... | DNA-binding protein inhibitor ID-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01811","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple proteins. One specific interaction is characterized by the binding of a protein (or its variants) to GATA4 and Nkx2.5, ... | |
medium_divergent_branch_01813 | CTNND1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We report that delta-catenin interacts with a specific protein in a tyrosine phosphorylation-dependent manner.' Which protein, encoded by the gene involved in this specific interaction, is the target of the 'encodes' re... | Src substrate cortactin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNND1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We report that delta-catenin interacts with a sp... |
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