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medium_divergent_branch_01814 | FANCD2 interacts with multiple proteins. One specific interaction involves a partner that is a member of the PARP family, specifically a protein encoded by the TNKS gene, and functions as a telomere component. Which protein, encoded by the gene connected to FANCD2 via this specific interaction, is the subject of this d... | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCD2 interacts with multiple proteins. One specific interaction involves a partner that is a member of the PARP family, specifically a protein enco... | |
medium_divergent_branch_01815 | MLH1 interacts with multiple proteins. One of these interactions is supported by evidence stating that 'Coimmunoprecipitation and colocalization experiments validated the interaction of MLH1 with these proteins.' Which protein, connected to MLH1 via this specific interaction evidence, is the gene that encodes the prote... | Actin, cytoplasmic 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01815","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLH1 interacts with multiple proteins. One of these interactions is supported by evidence stating that 'Coimmunoprecipitation and colocalization expe... | |
medium_divergent_branch_01816 | PSMC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identified gankyrin, a liver oncoprotein, as an interacting protein.' Which disease is associated with the protein identified in this evid... | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01816","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'A yeast two-hybrid screen with the human S6 (TBP7, RPT3) A... | |
medium_divergent_branch_01817 | IL17RA is involved in multiple biological processes. One of these processes is characterized by the evidence: 'Like IL-25, this activity is dependent on the IL-17RA and IL-17RB receptor subunits.' Which biological process is positively regulated by the process identified by this evidence? | interleukin-13 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL17RA is involved in multiple biological processes. One of these processes is characterized by the evidence: 'Like IL-25, this activity is dependent... | |
medium_divergent_branch_01818 | The gene TSPAN3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 440.60 TPM, a z-score of 1.65, and a fold enrichment of 4.96. Identify the broader cell lineage category (parent class) to which this specific enriched cell type belongs. | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01818","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TSPAN3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 440.60 TPM, a z-score o... | |
medium_divergent_branch_01819 | The gene IL27RA is known to bind to multiple partner genes. One specific interaction partner is characterized by evidence stating that it interacts with tyrosine-phosphorylated WSX-1, and that the conserved tyrosine residue within the cytoplasmic domain of WSX-1 is essential for the transcriptional activation of this p... | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL27RA is known to bind to multiple partner genes. One specific interaction partner is characterized by evidence stating that it interacts w... | |
medium_divergent_branch_01820 | The gene CSF3 is associated with multiple biological processes. One association is supported by evidence stating that Granulocyte colony-stimulating factor (G-CSF) promotes granulopoiesis and granulocytic differentiation. Identify the biological process linked to this specific process via an 'is a' relationship. | myeloid leukocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01820","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CSF3 is associated with multiple biological processes. One association is supported by evidence stating that Granulocyte colony-stimulating ... | |
medium_divergent_branch_01821 | COPS6 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The immunoprecipitation assay verified that COP9 signalosome subunit 6 (CSN6) interacted with CULA4.' Which protein is encoded by the gene corresponding to the interacting partner mentioned in this evidence? | Cullin-4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01821","source_qa_id":"medium_divergent_branch_05052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"COPS6 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_01822 | E2F6 interacts with multiple genes. One specific interaction partner is characterized by evidence showing that it interacts with and stabilizes E2F6, leading to the transcriptional repression of the phosphatase DUSP1. Which disease is associated with this specific interacting gene through genomic alterations? | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01822","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F6 interacts with multiple genes. One specific interaction partner is characterized by evidence showing that it interacts with and stabilizes E2F6,... | |
medium_divergent_branch_01823 | CEBPD interacts with multiple proteins. One specific interaction involves C/EBPδ binding to a target protein and importin 4 (also known as Imp4 and RanBP4) via separate domains. This binding mediates the association between the target protein and importin 4, thereby augmenting the nuclear import of the target protein, ... | Fanconi anemia group D2 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEBPD interacts with multiple proteins. One specific interaction involves C/EBPδ binding to a target protein and importin 4 (also known as Imp4 and R... | |
medium_divergent_branch_01824 | XBP1 is associated with multiple biological processes. One association is supported by evidence stating: 'When introduced into B-lineage cells, XBP-1 initiated plasma-cell differentiation.' Identify the biological process that is positively regulated by the process linked to XBP1 via this specific evidence. | B cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XBP1 is associated with multiple biological processes. One association is supported by evidence stating: 'When introduced into B-lineage cells, XBP-1... | |
medium_divergent_branch_01825 | A specific cell type is defined as an epithelial cell of the proximal tubule that is part of the proximal straight tubule. This cell type is a subclass of a broader cell category found in the kidney. Which anatomical structure is this broader cell category part of? | outer medulla of kidney | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A specific cell type is defined as an epithelial cell of the proximal tubule that is part of the proximal straight tubule. This cell type is a subcla... | |
medium_divergent_branch_01826 | RNPS1 interacts with multiple genes. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradation by the E3 ubiquitin ligase ZSWIM6 through direct protein interaction, thereby promoting high expression of this partner in head and neck squamous cell carcinoma (HNSCC). ... | atherosclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01826","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNPS1 interacts with multiple genes. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradation... | |
medium_divergent_branch_01827 | The protein SNAP29 is enriched in multiple immune cell types. One specific cell type exhibits a mean expression of 80.25 TPM, a z-score of 1.73, and a fold enrichment of 2.08 for SNAP29. Which cell type is the developmental precursor to this specific cell? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01827","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein SNAP29 is enriched in multiple immune cell types. One specific cell type exhibits a mean expression of 80.25 TPM, a z-score of 1.73, and ... | |
medium_divergent_branch_01829 | PNPLA2 interacts with multiple proteins. One of these interaction partners has been shown to interact directly with ATGL in cells, as demonstrated by yeast two-hybrid assays, co-immunoprecipitation in mammalian cells, and direct protein binding approaches, involving multiple contact sites on each protein. Which protein... | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01829","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PNPLA2 interacts with multiple proteins. One of these interaction partners has been shown to interact directly with ATGL in cells, as demonstrated by... | |
medium_divergent_branch_01830 | The gene TUBB3 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The TAPE domain binds α/β-tubulin via its conserved, concave surface, including part of the atypical blade.' Which protein is encoded by the gene that interacts with TUBB3 in this specific context? | Echinoderm microtubule-associated protein-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01830","source_qa_id":"medium_divergent_branch_06429","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene TUBB3 interacts with multiple other genes. One specific interaction is supported by evid... | |
medium_divergent_branch_01831 | DAPK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In these studies, we identified two holoenzyme forms of protein phosphatase 2A (PP2A), ABalphaC and ABdeltaC, as DAPK-interacting proteins.' Which biological process is the gene identified in this evidence involved in? | negative regulation of protein localization to plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAPK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In these studies, we identified two holoenzyme forms of prote... | |
medium_divergent_branch_01833 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fold change of approximately 1.057 and an adjusted p-value of 0.04727. Which protein is encoded by this upregulated gene? | Translation initiation factor eIF2B subunit gamma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fol... | |
medium_divergent_branch_01834 | LRRC45 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The association of LRRC45 with the basal body of primary and motile cilia in both differentiated and stem cells reveals a broad function in ciliogenesis.' Which cellular ... | cilium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01834","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRRC45 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: ... | |
medium_divergent_branch_01835 | TREX1 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that it binds to TREX1 and colocalizes and translocates with the TREX1 complex. Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein SET | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01835","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TREX1 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that it binds to TREX1 and colocalizes... | |
medium_divergent_branch_01836 | CHD8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression.' What is the name of the protein encoded by the gene corresponding... | Zinc finger protein Gfi-1b | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHD8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein forms complexes with β-caten... | |
medium_divergent_branch_01837 | The gene EFNB1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-terminal motif.' Which protein is encoded by the gene that binds to EFNB1 in this specif... | Syntenin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EFNB1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'In vitro studies demonstrated that the f... | |
medium_divergent_branch_01838 | SNX19 interacts with multiple proteins. One interaction is supported by evidence stating: 'Six new interacting proteins were identified by this approach: mitogen-activated protein kinase-activating death domain (MADD), the MADD isoform IG20, PTPrho, PTPsigma, sorting nexin 19 (SNX19) and cyclophilin A.' Which of the in... | Receptor-type tyrosine-protein phosphatase-like N | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNX19 interacts with multiple proteins. One interaction is supported by evidence stating: 'Six new interacting proteins were identified by this appro... | |
medium_divergent_branch_01839 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.675 and an adjusted p-value of 0.0381. Which protein does that selected gene encode? | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01839","source_qa_id":"medium_divergent_branch_06988","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_01840 | Bone morphogenetic protein 2 (BMP2) interacts with multiple proteins. One interaction is supported by evidence describing the crystal structure of the signaling complex formed between BMP-2 and the extracellular domains of its type I receptor (BMPR-Ia) and its type II receptor (a specific activin receptor type II). Whi... | Activin receptor type-2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Bone morphogenetic protein 2 (BMP2) interacts with multiple proteins. One interaction is supported by evidence describing the crystal structure of th... | |
medium_divergent_branch_01843 | RASA3 interacts with multiple G-protein alpha subunits. One specific interaction is supported by evidence from GH4ZR7 cells, where co-immunoprecipitation of endogenous proteins revealed a complex between RASA3 and Galphai3 induced by TRH/D2S receptor co-activation. Which protein is encoded by the gene corresponding to ... | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASA3 interacts with multiple G-protein alpha subunits. One specific interaction is supported by evidence from GH4ZR7 cells, where co-immunoprecipita... | |
medium_divergent_branch_01844 | Spermatozoa traverse multiple anatomical structures. One such structure is described as an elongated organ attached to the posterior surface of the testis, responsible for transporting, storing, and maturing sperm between the testis and the vas deferens. Which anatomical structure, connected to this specific organ, is ... | mesonephric duct | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Spermatozoa traverse multiple anatomical structures. One such structure is described as an elongated organ attached to the posterior surface of the t... | |
medium_divergent_branch_01845 | mmu-miR-185-5p regulates more than one type of immune cell. Evidence for one of these regulatory connections states: 'Our findings indicate that miR-185 regulates the development of this cell type through its targeting of several mRNAs including Mzb1.' Which anatomical domain is this cell type a part of? | T cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-185-5p regulates more than one type of immune cell. Evidence for one of these regulatory connections states: 'Our findings indicate that miR-... | |
medium_divergent_branch_01846 | RGS2 interacts with multiple proteins. One interaction partner is identified in literature as the substrate recognition component of an E3 ligase complex (containing CUL4B and DDB1) that mediates RGS2 degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | F-box only protein 44 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RGS2 interacts with multiple proteins. One interaction partner is identified in literature as the substrate recognition component of an E3 ligase com... | |
medium_divergent_branch_01847 | SH3BP2 interacts with multiple proteins. One interaction partner is characterized by evidence stating that 3BP2 (the protein encoded by SH3BP2) was selectively expressed in hematopoietic/lymphoid tissues and, via its SH2 domain, activated kinases belonging to this partner's family in mammalian cells, including in antig... | Tyrosine-protein kinase SYK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01847","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3BP2 interacts with multiple proteins. One interaction partner is characterized by evidence stating that 3BP2 (the protein encoded by SH3BP2) was s... | |
medium_divergent_branch_01848 | The gene CHUK interacts with multiple partners. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments indicated that a specific protein interacted with IKKepsilon and TRAF family-associated NF-kappaB activator-binding kinase-1 as well as the two canonical IKK family members, IKKbeta and I... | Zinc finger protein RFP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01848","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHUK interacts with multiple partners. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments indicated that a... | |
medium_divergent_branch_01850 | STX12 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a yeast two-hybrid screen, we discovered that pallidin interacts with syntaxin 13, a t-SNARE protein that mediates vesicle-docking and fusion.' Which protein, connected to STX12 via an interaction, is encoded by the gene corre... | Biogenesis of lysosome-related organelles complex 1 subunit 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01850","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX12 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a yeast two-hybrid screen, we discovered that pallidin ... | |
medium_divergent_branch_01851 | The gene ARHGEF12 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We found that LARG could complex with the target protein, but not Rac or Cdc42, in vitro, and that expression of LARG caused an increase in the levels of the activated GTP-bound form of the target protein, bu... | Transforming protein RhoA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01851","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ARHGEF12 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We found that LARG could complex with... | |
medium_divergent_branch_01852 | The protein C1QBP is associated with multiple biological processes. One specific association is supported by evidence stating: 'We observed that gC1qR enhanced binding of free C1q to adherent neutrophils and promoted C1q-mediated chemotaxis of neutrophils by nearly seven-fold.' Identify the cell type that is linked to ... | epidermal keratinocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein C1QBP is associated with multiple biological processes. One specific association is supported by evidence stating: 'We observed that gC1q... | |
medium_divergent_branch_01853 | DEAF1 interacts with multiple proteins. One specific interaction is described by the statement: 'In particular, we identified the deformed epidermal autoregulatory factor-1 (DEAF1) transcription factor as an interactor and in vitro substrate of [Protein X] and [Protein Y].' Based on this evidence, which protein is the ... | Glycogen synthase kinase-3 beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DEAF1 interacts with multiple proteins. One specific interaction is described by the statement: 'In particular, we identified the deformed epidermal ... | |
medium_divergent_branch_01854 | The gene ALDOA is associated with multiple biological processes. One specific association is supported by clinical evidence describing transfusion-dependent anemia, increasing muscle weakness, and death at age 4 due to rhabdomyolysis and hyperkalemia. Which cellular component is the site of the biological process linke... | muscle cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ALDOA is associated with multiple biological processes. One specific association is supported by clinical evidence describing transfusion-de... | |
medium_divergent_branch_01855 | ERN1 interacts with multiple proteins. One interaction partner is characterized by evidence stating that a specific E3 ubiquitin ligase promotes K63-linked chain ubiquitination of IRE1α at lysine 481 (K481), thereby preventing hyper-oligomerization of IRE1α and regulated IRE1α-dependent decay (RIDD). Which protein is e... | E3 ubiquitin-protein ligase MARCHF5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01855","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERN1 interacts with multiple proteins. One interaction partner is characterized by evidence stating that a specific E3 ubiquitin ligase promotes K63-... | |
medium_divergent_branch_01856 | CXCL12 (also known as SDF-1alpha) is involved in multiple biological processes. One specific process is supported by evidence stating: 'We demonstrate here that SDF-1alpha stimulates migration of monocytes through its receptor, CXCR4.' Which biological process is positively regulated by the process linked to CXCL12 via... | monocyte chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01856","source_qa_id":"medium_divergent_branch_07080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CXCL12 (also known as SDF-1alpha) is involved in multiple biological processes. One specific proc... | |
medium_divergent_branch_01857 | EIF5 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Furthermore, eIF3 isolated from transfected cell lysates contains bound eIF5 indicating that a specific physical interaction between eIF5 and eIF3 may play an important role in the function of eIF5 during translatio... | narcolepsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF5 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Furthermore, eIF3 isolated from transfected ... | |
medium_divergent_branch_01858 | CRY2 interacts with multiple proteins. One specific interaction partner is implicated in a mechanism where a CRY2 variant exhibits resistance to proteasomal degradation due to lost interactions with E3 ligases, specifically FBXL3 and this partner, suggesting that Ser-420 of CRY2 is required for this binding. Which cell... | ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01858","source_qa_id":"medium_divergent_branch_05843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CRY2 interacts with multiple proteins. One specific interaction partner is implicated in a mechan... | |
medium_divergent_branch_01859 | VAV2 interacts with multiple proteins. One of these interaction partners has a physical interaction with VAV2 that was confirmed using GST-pull down assays and immuno-based experiments. Which protein is this interaction partner? | Solute carrier family 12 member 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01859","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAV2 interacts with multiple proteins. One of these interaction partners has a physical interaction with VAV2 that was confirmed using GST-pull down ... | |
medium_divergent_branch_01860 | GIGYF1 interacts with multiple proteins. One of these interaction partners is characterized by harboring three proline-rich motifs that bind the GYF domain of GIGYF1, a feature similar to that of TTP. Which protein corresponds to this description? | E3 ubiquitin-protein ligase ZNF598 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01860","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIGYF1 interacts with multiple proteins. One of these interaction partners is characterized by harboring three proline-rich motifs that bind the GYF ... | |
medium_divergent_branch_01861 | PSMD6 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human proteasome by associating with it in the cytosol and nucleus via the RPN3/S3 subunit of the 19S regulatory particle (RP).' Identify the disease associated with the gene linked to... | extragonadal germ cell tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01861","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMD6 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human proteas... | |
medium_divergent_branch_01862 | Phospholamban (PLN) is associated with multiple biological processes. One association is supported by evidence that PLN is a small integral membrane protein modulating the activity of the Sarcoplasmic Reticulum Ca(2+)-ATPase (SERCA) in cardiac myocytes. Which biological process, connected to PLN via an 'involved in' re... | cardiac muscle cell contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01862","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Phospholamban (PLN) is associated with multiple biological processes. One association is supported by evidence that PLN is a small integral membrane ... | |
medium_divergent_branch_01863 | USP10 interacts with multiple genes. One of these interaction partners exhibits a specific regulatory dynamic with Caprin1 regarding G3BP: their binding to G3BP is mutually exclusive, where Caprin1 binding promotes stress granule (SG) formation, whereas the binding of this specific partner inhibits it. Which cellular c... | cytoplasmic stress granule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP10 interacts with multiple genes. One of these interaction partners exhibits a specific regulatory dynamic with Caprin1 regarding G3BP: their bind... | |
medium_divergent_branch_01864 | PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'The present data show that a specific protein and PAR-4 do not compete for PKCzeta binding but directly interact each other and form a ternary complex with PKCzeta.' Which protein, encoded by the gene connected to PRKCZ via this ... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'The present data show that a specific protein and PAR-4 do... | |
medium_divergent_branch_01865 | PPFIA1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that LAR, HPTP delta, and HPTP sigma exhibit similar in vitro PTPase activities and all three interact with LIP1, which has been postulated to recruit LAR to focal adhesions. Which gene is connected to PPFIA1 throug... | NTRK3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPFIA1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that LAR, HPTP delta, and HPTP sigma exhibit... | |
medium_divergent_branch_01866 | The biological process 'regulation of ecdysteroid metabolic process' is defined as any process that modulates the frequency, rate, or extent of chemical reactions involving ecdysteroids, which are polyhydroxylated ketosteroids initiating post-embryonic development. This process is a subtype of a broader regulatory cate... | steroid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01866","source_qa_id":"medium_divergent_branch_01247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of ecdysteroid metabolic process' is defined as any process th... | |
medium_divergent_branch_01867 | MIR195 is associated with multiple biological processes. One association is supported by evidence that MiR-195 mimics inhibited proliferation and growth and induced apoptosis of eutopic ESCs. Which biological process is negatively regulated by the process linked to this specific evidence? | cell population proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01867","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR195 is associated with multiple biological processes. One association is supported by evidence that MiR-195 mimics inhibited proliferation and gro... | |
medium_divergent_branch_01868 | RABAC1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Binding of NDRG2 (and NDRG1-4) with PRA1 in vitro was confirmed by GST pull-down assay and immunoprecipitation, and colocalization was verified by confocal microscopy in HCT116 cells.' Which protein is encoded by ... | Protein NDRG4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RABAC1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Binding of NDRG2 (and NDRG1-4) with PRA1 i... | |
medium_divergent_branch_01869 | LRP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screens, we identified a novel scaffold protein with tetratrico peptide repeats, the megalin-binding protein (MegBP) that associates with the receptor.' Which protein is encoded by the gene corresponding to ... | LRP2-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01869","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screens, we identified a novel scaff... | |
medium_divergent_branch_01870 | MIR449A is associated with multiple biological processes. One association is supported by evidence that miR-449a acts as a tumor suppressor by reducing cell proliferation, migration, and invasion, and inducing apoptosis in human glioblastoma cell lines and glioma stem cells. Which biological process, connected to the p... | cell population proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01870","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR449A is associated with multiple biological processes. One association is supported by evidence that miR-449a acts as a tumor suppressor by reduci... | |
medium_divergent_branch_01871 | PAK4 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We also demonstrated that the PAK4 protein is degraded by the ubiquitin-proteasome system and that [the partner] inhibits PAK4 ubiquitination via physical interaction-mediated steric hindrance, which results in th... | E3 ubiquitin-protein ligase SH3RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01871","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAK4 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We also demonstrated that the PAK4 protein... | |
medium_divergent_branch_01872 | LRP8 interacts with multiple proteins. One interaction involves a ligand that binds to ApoER2, a cell surface molecule, to elicit intracellular signal transduction. Which protein is encoded by the gene corresponding to this ligand? | Reelin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP8 interacts with multiple proteins. One interaction involves a ligand that binds to ApoER2, a cell surface molecule, to elicit intracellular signa... | |
medium_divergent_branch_01873 | CNNM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a protein tyrosine phosphatase regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3.' Which protein, encoded by the gene interacting with CNNM3 in thi... | Protein tyrosine phosphatase type IVA 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNNM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a protein tyrosine phosphatase regulates... | |
medium_divergent_branch_01875 | The gene SNCA is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Using sensitive fluorescent resonance energy transfer (FRET) techniques, we find evidence of a close association between torsinA and alpha-synuclein in Lewy bodies.' Which protein is encoded by the gen... | Torsin-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01875","source_qa_id":"medium_divergent_branch_05962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene SNCA is known to interact with multiple proteins. One specific interaction is supported ... | |
medium_divergent_branch_01876 | The gene FXR1 is associated with multiple biological processes. One specific association is supported by evidence describing FXR1 as an alternatively spliced gene encoding RNA-binding proteins involved in muscle development. Which anatomical structure is the result of the biological process linked to this specific evid... | skeletal muscle organ, vertebrate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01876","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FXR1 is associated with multiple biological processes. One specific association is supported by evidence describing FXR1 as an alternatively... | |
medium_divergent_branch_01877 | IGF1R interacts with multiple proteins. One interaction is supported by evidence stating: 'Among several receptors tested, LL-37 bound with the highest affinity to insulin-like growth factor 1 receptor (IGF-1R), a receptor that is strongly linked to malignant cellular transformation.' Which protein is encoded by the ge... | Cathelicidin antimicrobial peptide | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF1R interacts with multiple proteins. One interaction is supported by evidence stating: 'Among several receptors tested, LL-37 bound with the highe... | |
medium_divergent_branch_01878 | MAPK9 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'This docking site was both necessary and sufficient for the high affinity binding of the MAPKs JNK1, JNK2, JNK3, p38 alpha, and p38 beta to this gene.' Which disease is associated with this specific interacti... | rheumatoid arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK9 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'This docking site was both necessary ... | |
medium_divergent_branch_01879 | The gene PHB1 is known to interact with multiple partners. One specific interaction involves a partner that forms heteromers with the repressor of estrogen receptor activity to enhance the protein stability of both corepressors. Which protein is encoded by the gene corresponding to this specific interaction partner? | Prohibitin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01879","source_qa_id":"medium_divergent_branch_07007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene PHB1 is known to interact with multiple partners. One specific interaction involves a pa... | |
medium_divergent_branch_01880 | ID1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'All three Ids bound with high affinity to E proteins, but a much broader range of interactions was observed between Ids and the class B factors.' Which protein, linked to ID1 by this specific interaction, is encoded by the... | Transcription factor E2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01880","source_qa_id":"medium_divergent_branch_02078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ID1 interacts with multiple proteins. One specific interaction is supported by evidence stating: ... | |
medium_divergent_branch_01881 | ARF6 interacts with multiple genes. One of these interacting partners is known to associate directly with ARF6 specifically in its GDP-bound state, but not in its GTP-bound state. Which disease is associated with this specific interacting gene through genomic alterations? | nodular fasciitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARF6 interacts with multiple genes. One of these interacting partners is known to associate directly with ARF6 specifically in its GDP-bound state, b... | |
medium_divergent_branch_01883 | PSMD4 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Finally, we establish that PSMD4 binds MDC1 and this interacting partner in a DNA damage-induced, RNF4-dependent manner and that PSMD4 depletion causes MDC1 and γH2AX persistence in irradiated cells.' Which diseas... | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01883","source_qa_id":"medium_divergent_branch_00438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PSMD4 interacts with multiple genes. One specific interaction is characterized by the following e... | |
medium_divergent_branch_01884 | IRF3 interacts with multiple proteins. One specific interaction involves a kinase that is inhibited by the SARS-CoV-2 N protein, which disrupts the association between this kinase and IRF3, thereby preventing IRF3 nuclear translocation. Which protein corresponds to this kinase? | Serine/threonine-protein kinase TBK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF3 interacts with multiple proteins. One specific interaction involves a kinase that is inhibited by the SARS-CoV-2 N protein, which disrupts the a... | |
medium_divergent_branch_01885 | UBE2L3 interacts with multiple genes. One of these interacting partners is an E3 ligase that was found to interact with the E2 enzyme UBE2L3 and promote UBE2L3 ubiquitination. Which disease is connected to this specific interacting gene through a biomarker relationship? | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01885","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2L3 interacts with multiple genes. One of these interacting partners is an E3 ligase that was found to interact with the E2 enzyme UBE2L3 and prom... | |
medium_divergent_branch_01886 | The SRC gene has multiple interacting partners. One specific interaction is characterized by the following evidence: 'Using an established in vitro binding assay, we find that caveolin interacts with wild-type Src (c-Src) but does not form a stable complex with mutationally activated Src (v-Src).' Which protein is enco... | Caveolin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01886","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SRC gene has multiple interacting partners. One specific interaction is characterized by the following evidence: 'Using an established in vitro b... | |
medium_divergent_branch_01887 | Prazosin interacts with multiple drugs. One of these interacting drugs is characterized by the following experimental finding: in denuded vascular rings, the reversal of contraction by L-NAME or L-NMMA was prevented following pretreatment with this drug. Which disease is this specific interacting drug indicated for? | acute otitis externa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Prazosin interacts with multiple drugs. One of these interacting drugs is characterized by the following experimental finding: in denuded vascular ri... | |
medium_divergent_branch_01888 | RUFY1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'An interactor screen for proteins that function together with rabip4' yielded the adaptor protein complex AP-3, of which the hinge region in the β3 subunit bound directly to the FYVE domain of rabip4'.' Identify the gene co... | developmental and epileptic encephalopathy, 48 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01888","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUFY1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'An interactor screen for proteins that function toge... | |
medium_divergent_branch_01889 | Lymphocytes are components of multiple anatomical structures. One such structure is described as the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells, and serves as the site where foreign material removed from the blood initiates an immune reaction ... | spleen pulp | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Lymphocytes are components of multiple anatomical structures. One such structure is described as the parenchymatous tissue of the spleen that surroun... | |
medium_divergent_branch_01890 | The gene ITGB3 is reported to interact with multiple partners. One specific interaction is supported by evidence describing the colocalization of β3 integrin and kindlin-3 in focal adhesions, as well as an enhanced association between β3 integrin and kindlin-3 in immunoprecipitates. Which protein is encoded by the gene... | Fermitin family homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01890","source_qa_id":"medium_divergent_branch_01051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ITGB3 is reported to interact with multiple partners. One specific interaction is suppor... | |
medium_divergent_branch_01891 | MARCH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that MARCH6 and SM physically interact.' Which protein, connected to MARCH6 via this interaction, is encoded by the gene in question? | Squalene monooxygenase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01891","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that MARCH6 and SM physically interact.' Which pr... | |
medium_divergent_branch_01892 | The anatomical entity 'sublaminar layer S5' is defined as a retinal neural layer immediately adjacent to the retinal ganglion cell layer, comprising 20 percent of the ganglion plexiform layer of the retina. This definition supports its classification under a specific parent category. Which parent category is 'sublamina... | sublaminar layers S3 or S4 or S5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01892","source_qa_id":"medium_divergent_branch_00085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The anatomical entity 'sublaminar layer S5' is defined as a retinal neural layer immediately adja... | |
medium_divergent_branch_01893 | VAV1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Among the proteins from T cells that co-immunoprecipitate with the proto-Vav product and bind to its SH2 domain, specific antibodies identified the 70-kDa tyrosine phosphoprotein as a protein tyrosine kinase (PTK) involved in TCR ... | Tyrosine-protein kinase ZAP-70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01893","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAV1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Among the proteins from T cells that co-immunoprecipitate w... | |
medium_divergent_branch_01894 | FOXP3 is involved in multiple biological processes. One such process is distinguished by the fact that while the differentiation of both T(H)17 and T(reg) cells requires transforming growth factor-beta (TGF-beta), it depends on distinct transcription factors: RORgammat for T(H)17 cells and FOXP3 for T(reg) cells. Which... | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP3 is involved in multiple biological processes. One such process is distinguished by the fact that while the differentiation of both T(H)17 and T... | |
medium_divergent_branch_01895 | CTNND1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We report that delta-catenin interacts with a tyrosine phosphorylation-dependent binding partner.' Which disease is associated with the gene identified by this evidence? | ethmoid sinus adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNND1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We report that delta-catenin interacts with a tyros... | |
medium_divergent_branch_01896 | Orthohepevirus A is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.143 and an adjusted p-value of 0.03983. Which cell type is the target gene of this specific event enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.143 and a... | |
medium_divergent_branch_01898 | COPRS is known to interact with multiple proteins. One specific interaction is characterized by tight binding both in vitro and in living cells, a property that distinguishes this partner from other members of the PRMT family. Which protein is encoded by the gene corresponding to this specific binding partner? | Protein arginine N-methyltransferase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01898","source_qa_id":"medium_divergent_branch_07133","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"COPRS is known to interact with multiple proteins. One specific interaction is characterized by t... | |
medium_divergent_branch_01899 | RASA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that both cytoplasmic precursor and mitochondrial mature forms of mTid-1 associate with GAP in vivo.' Which protein, among those interacting with RASA1, is the subject of this specific evidence, and what is the ful... | DnaJ homolog subfamily A member 3, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01899","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that both cytoplasmic precursor and mitocho... | |
medium_divergent_branch_01901 | ZC3H4 interacts with multiple genes. One of these interaction partners is a subunit of the ZWC complex, which preferentially localizes at the transcription start sites (TSSs) of active genes through direct interactions of its subunits, including this gene and WDR82, with the S5p RNAPII C-terminal domain. Which disease ... | neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZC3H4 interacts with multiple genes. One of these interaction partners is a subunit of the ZWC complex, which preferentially localizes at the transcr... | |
medium_divergent_branch_01902 | TTBK2 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings indicate that TTBK2 with EB1/3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at MT plus ends for cell migration.' Identify the biological process described by this evidence, an... | regulation of cell motility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01902","source_qa_id":"medium_divergent_branch_02470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TTBK2 is associated with multiple biological processes. One association is supported by evidence ... | |
medium_divergent_branch_01904 | MSH2 interacts with multiple proteins. One interaction involves a chromatin remodeling protein that recruits the MSH2-MSH3 mismatch repair complex to DNA double-strand break (DSB) sites. Which protein is encoded by the gene corresponding to this chromatin remodeling partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH2 interacts with multiple proteins. One interaction involves a chromatin remodeling protein that recruits the MSH2-MSH3 mismatch repair complex to... | |
medium_divergent_branch_01905 | S100P interacts with multiple genes. Evidence for one specific interaction indicates that the complex formation is Ca2+ dependent and likely occurs within cells, as both proteins colocalize at the plasma membrane following growth factor or Ca2+ ionophore stimulation. Which disease is associated with this specific inter... | triple-negative breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100P interacts with multiple genes. Evidence for one specific interaction indicates that the complex formation is Ca2+ dependent and likely occurs w... | |
medium_divergent_branch_01906 | IGFBP3 is associated with multiple biological processes. One association is supported by evidence that IGFBP-3 stimulates a phosphotyrosine phosphatase activity, which down-regulates the IGF-I signaling pathway. Which biological process, connected to the process supported by this evidence, is the target of a 'negativel... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFBP3 is associated with multiple biological processes. One association is supported by evidence that IGFBP-3 stimulates a phosphotyrosine phosphata... | |
medium_divergent_branch_01907 | MCM4 interacts with multiple proteins. One interaction is supported by evidence stating that glycerol gradient sedimentation analysis indicated a specific binding partner interacts most strongly with MCM4 and MCM7. Which protein, encoded by the gene connected to MCM4 via this specific interaction, is the subject of thi... | Mini-chromosome maintenance complex-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01907","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM4 interacts with multiple proteins. One interaction is supported by evidence stating that glycerol gradient sedimentation analysis indicated a spe... | |
medium_divergent_branch_01908 | TSG101 interacts with multiple proteins. One specific interaction is supported by evidence stating that the interacting protein and TSG101 co-immunoprecipitated with VPS37B-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approximately 350 kDa). Which protein ... | Vacuolar protein sorting-associated protein 28 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01908","source_qa_id":"medium_divergent_branch_01916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TSG101 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_01909 | STXBP5 interacts with multiple syntaxin family members. One interaction is supported by evidence describing a novel syntaxin-1-binding protein, tomosyn, which dissociates Munc18 from syntaxin-1 and forms a 10S complex with syntaxin-1, SNAP-25, and synaptotagmin. Which protein is encoded by the gene that interacts with ... | Syntaxin-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01909","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STXBP5 interacts with multiple syntaxin family members. One interaction is supported by evidence describing a novel syntaxin-1-binding protein, tomos... | |
medium_divergent_branch_01910 | The gene LIPN is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.36 TPM, a z-score of 1.79, and a fold enrichment of 5.15. Which cell type, connected to LIPN via this specific enrichment evidence, develops from another cell type? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LIPN is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.36 TPM, a z-score of 1.... | |
medium_divergent_branch_01911 | TNK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated tyrosine kinase 1 (ACK1; also known as Tnk2, tyrosine kinase non-receptor 2) as a novel binding partner of the gene LCP2.'... | immunodeficiency 81 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01911","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we have identified SAM domain-carrying non-rece... | |
medium_divergent_branch_01912 | SIRT6 interacts with multiple proteins. One specific interaction is characterized by the partner protein physically binding to and stabilizing SIRT6 through K48-linked deubiquitination at the K33 and K128 sites of SIRT6. Which protein corresponds to this specific interaction partner? | Ubiquitin carboxyl-terminal hydrolase 48 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01912","source_qa_id":"medium_divergent_branch_03845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIRT6 interacts with multiple proteins. One specific interaction is characterized by the partner ... | |
medium_divergent_branch_01913 | The gene CSTA is known to interact with multiple proteins. One specific interaction is supported by evidence describing the determination of the crystal structure of human stefin A bound to an aminopeptidase, porcine [interacting protein], in monoclinic and orthorhombic crystal forms at 2.8A and 2.4A resolutions, respe... | Pro-cathepsin H | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01913","source_qa_id":"medium_divergent_branch_05073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CSTA is known to interact with multiple proteins. One specific interaction is supported ... | |
medium_divergent_branch_01915 | RAF1 interacts with multiple proteins. One interaction is characterized by evidence that Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it binds a specific anti-apoptotic protein and displaces BAD. Which protein is connected to the gene corre... | Apoptosis regulator Bcl-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01915","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAF1 interacts with multiple proteins. One interaction is characterized by evidence that Raf-1 protects cells from apoptosis, independently of its si... | |
medium_divergent_branch_01916 | WDFY3 interacts with multiple proteins. One specific interaction was identified using co-immunoprecipitation and tandem mass spectrometry in human osteoclast-like cells, involving WDFY3 (also known as ALFY) and another protein. Which protein, connected to WDFY3 via this interaction, is the subject of the 'encodes' rela... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDFY3 interacts with multiple proteins. One specific interaction was identified using co-immunoprecipitation and tandem mass spectrometry in human os... | |
medium_divergent_branch_01917 | UCHL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We further report that one of the proteins interacting with UCH-L1 is tubulin, and that aberrant interaction of mutant or carbonyl-modified UCH-L1 with tubulin modulates tubulin polymerization.' Which gene encodes the pr... | Tubulin alpha-1A chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UCHL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We further report that one of the proteins intera... | |
medium_divergent_branch_01918 | Human polyomavirus 2 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.080 and an adjusted p-value of 0.0123. Which protein does that selected gene encode? | Protein S100-P | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01918","source_qa_id":"medium_divergent_branch_04822","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 2 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_01919 | Protein Kinase X (PRKX) is associated with multiple biological processes. One specific association is supported by evidence stating that PRKX induces renal epithelial cell migration, tubulogenesis in vitro, and branching morphogenesis of the ureteric bud in developing kidneys. Which anatomical structure is the result o... | epithelial tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Protein Kinase X (PRKX) is associated with multiple biological processes. One specific association is supported by evidence stating that PRKX induces... | |
medium_divergent_branch_01920 | The gene CSN2 interacts with multiple other genes. One of these interacting partners is supported by evidence describing a direct association between His6-tagged human recombinant forms of the eIF2beta subunit and both the catalytic (CK2alpha) and regulatory (CK2beta) subunits of CK2. Which protein is encoded by the ge... | Casein kinase II subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CSN2 interacts with multiple other genes. One of these interacting partners is supported by evidence describing a direct association between... | |
medium_divergent_branch_01921 | PTGIR interacts with multiple proteins. One interaction involves a protein described as an intestinal and kidney enriched PDZ protein, which binds to the human IP receptor via its PDZ domains. Which protein, connected to PTGIR through this specific interaction, is encoded by the gene in question? | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01921","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTGIR interacts with multiple proteins. One interaction involves a protein described as an intestinal and kidney enriched PDZ protein, which binds to... | |
medium_divergent_branch_01922 | Gelsolin (GSN) interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that gelsolin, a secretory protein, also binds to Abeta in a concentration-dependent manner.' Which protein, encoded by the gene interacting with GSN in this specific context, is the target of this binding... | Amyloid-beta precursor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01922","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Gelsolin (GSN) interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that gelsolin, a secretory protein... | |
medium_divergent_branch_01924 | SKP2 interacts with multiple genes. One of these interaction partners is an entity that serves as a substrate for SKP2, where SKP2 (acting as part of an E3 ubiquitin ligase complex) directly binds to the Prd domain of this entity via its LRR domain. This interaction leads to the recognition of lysine 275 on the entity ... | benign neoplasm of large intestine | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01924","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKP2 interacts with multiple genes. One of these interaction partners is an entity that serves as a substrate for SKP2, where SKP2 (acting as part of... | |
medium_divergent_branch_01925 | BMPR1A is involved in multiple biological processes. One specific process is supported by evidence showing that RNA interference-mediated knockdown of BMPR1A in human pulmonary artery smooth muscle cells reduced MMP2 and MMP9 activity, attenuated serum-induced proliferation, and impaired PDGF-BB-directed migration. Whi... | vascular associated smooth muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR1A is involved in multiple biological processes. One specific process is supported by evidence showing that RNA interference-mediated knockdown o... |
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