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medium_divergent_branch_01927 | MAPK8IP2 interacts with multiple genes. One of these interaction partners is supported by evidence stating that IB2 interacts with both JNK and the JNK-kinase encoded by the gene connected to MAPK8IP2 via this specific interaction. Which protein is encoded by this gene? | Dual specificity mitogen-activated protein kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01927","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8IP2 interacts with multiple genes. One of these interaction partners is supported by evidence stating that IB2 interacts with both JNK and the J... | |
medium_divergent_branch_01928 | PSMC4 is known to interact with multiple genes. One specific interaction is supported by the following evidence: 'In the present study, we show that the interacting partner interacts with S6' ATPase, a subunit of the proteasomal 19 S regulatory complex.' Which disease is associated with this specific interacting gene? | Luo-Schoch-Yamamoto syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01928","source_qa_id":"medium_divergent_branch_04478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PSMC4 is known to interact with multiple genes. One specific interaction is supported by the foll... | |
medium_divergent_branch_01929 | The protein CCR1 is associated with multiple biological processes. One specific association is supported by evidence stating that multiple CC chemokines bind to CCR1, which plays important roles in immune and inflammatory responses. Which broader biological process is the one described by this evidence a subtype of (is... | cell surface receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01929","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CCR1 is associated with multiple biological processes. One specific association is supported by evidence stating that multiple CC chemoki... | |
medium_divergent_branch_01930 | SF3B3 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence showing that SAP130 binds to it, as well as to Cul2 and Cul4, with similar affinity, while binding to Cul3 more strongly. Which disease is associated with this specific interaction partner via a biomarker re... | malignant pleural mesothelioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SF3B3 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence showing that SAP130 binds to it, as ... | |
medium_divergent_branch_01931 | ERRFI1 interacts with multiple proteins. One of these interaction partners is stabilized by MIG6, which prevents its proteasomal degradation by interfering with the recruitment of the βTrCP-SCF E3 ubiquitin ligase. Which protein is encoded by the gene corresponding to this specific interaction partner? | Wee1-like protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERRFI1 interacts with multiple proteins. One of these interaction partners is stabilized by MIG6, which prevents its proteasomal degradation by inter... | |
medium_divergent_branch_01933 | UBN1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that, before deposition, H3.3 exists in two biochemically distinct complexes, associated with either Daxx or HIRA, Ubinuclein-1, and Cabin-1.' Which disease is connected to the gene identified by this evidence through g... | pediatric mesenchymal chondrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01933","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBN1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that, before deposition, H3.3 exists in two bioc... | |
medium_divergent_branch_01934 | MCM3 interacts with multiple proteins. One of these interaction partners has been experimentally shown to directly interact with MCM2, MCM6, and MCM7 in JeKo cells. Which protein is encoded by the gene corresponding to this specific interaction partner? | ATR-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM3 interacts with multiple proteins. One of these interaction partners has been experimentally shown to directly interact with MCM2, MCM6, and MCM7... | |
medium_divergent_branch_01935 | NR2F2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription factors (NR2F1, this gene, SATB1, SATB2, SOX5, YY1, and ZMYM2), noting that five of them have well-established roles in cortical development. Which cellular component is ... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01935","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR2F2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription... | |
medium_divergent_branch_01936 | MAP2K1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A protein called MP1 (MEK Partner 1) was identified that bound specifically to MEK1 and a specific mitogen-activated protein kinase and facilitated their activation.' Which protein, connected to MAP2K1 via this specific... | Mitogen-activated protein kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2K1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A protein called MP1 (MEK Partner 1) was identif... | |
medium_divergent_branch_01937 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.029 and an adjusted p-value of 1.31e-05. For which disease is that selected gene recorded as a biomarker? | adult glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01937","source_qa_id":"medium_divergent_branch_00667","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_01938 | NDRG1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Further, we showed that NDRG1 directly binds to the protein encoded by CTNNB1 and E-cadherin.' Which protein is encoded by the gene corresponding to this interaction partner? | Catenin beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01938","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDRG1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Further, we showed that NDRG1 directly b... | |
medium_divergent_branch_01939 | ROR1 is associated with multiple biological processes. One association is supported by evidence stating: 'We conclude that Ror1 is crucial for spiral ganglion neurons to innervate auditory hair cells. Impairment of ROR1 function largely affects development of the inner ear and hearing in humans and mice.' Which biologi... | sensory perception of mechanical stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROR1 is associated with multiple biological processes. One association is supported by evidence stating: 'We conclude that Ror1 is crucial for spiral... | |
medium_divergent_branch_01940 | CCL26 is associated with multiple molecular functions via the 'enables' relationship. One of these functions is supported by evidence stating that Eotaxin-3 is one of three related chemokines that specifically activate the chemokine receptor CCR3. Which molecular function, connected to this specific function via the 'i... | CCR chemokine receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01940","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL26 is associated with multiple molecular functions via the 'enables' relationship. One of these functions is supported by evidence stating that Eo... | |
medium_divergent_branch_01941 | MTOR interacts with multiple genes. One interaction is supported by evidence stating: 'Quantitative immunoblotting showed that the abundance of the interacting partner is low compared with the PIKKs, and the interacting partner preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs.' Which cell type is thi... | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01941","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple genes. One interaction is supported by evidence stating: 'Quantitative immunoblotting showed that the abundance of the i... | |
medium_divergent_branch_01942 | The IL4R gene is associated with multiple proteins via binding interactions. One specific interacting protein is characterized by preferential expression in committed Th1 cells and its ability to interact with the cytoplasmic region of the IL-4Ralpha chain irrespective of receptor tyrosine phosphorylation. Which protei... | Suppressor of cytokine signaling 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IL4R gene is associated with multiple proteins via binding interactions. One specific interacting protein is characterized by preferential expres... | |
medium_divergent_branch_01945 | The NF2 gene product, Merlin, interacts with multiple proteins. One specific interaction involves Merlin binding to a protein encoded by the HGS gene in its unfolded, or open, conformation. Which protein is encoded by the gene that corresponds to this specific interaction partner? | Hepatocyte growth factor-regulated tyrosine kinase substrate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01945","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NF2 gene product, Merlin, interacts with multiple proteins. One specific interaction involves Merlin binding to a protein encoded by the HGS gene... | |
medium_divergent_branch_01946 | The gene TERF2 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'We demonstrated that the TRF1-interacting protein [protein encoded by the interacting gene] binds TRF2 directly and in vivo, thereby bridging TRF2 to TRF1.' Based on this evidence, which protein produ... | TERF1-interacting nuclear factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01946","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TERF2 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'We demonstrated that the TRF1... | |
medium_divergent_branch_01948 | IFRD2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that IFRD2 binds to ribosomes where a tRNA occupies the noncanonical 'Z site'. Which broader molecular function category is connected to this specific function through an 'is_a... | ribonucleoprotein complex binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01948","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFRD2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that ... | |
medium_divergent_branch_01950 | FANCC interacts with multiple proteins. One interaction is characterized by evidence stating: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which protein, connected to FANCC via a binding interaction, is described by this speci... | Fanconi anemia group F protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCC interacts with multiple proteins. One interaction is characterized by evidence stating: 'The N terminus appears to stabilize the interaction wi... | |
medium_divergent_branch_01951 | UBA2 interacts with multiple proteins. One of these interaction partners is involved in the following biochemical process: In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and this specific protein, before the resulting thiolester complex... | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01951","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBA2 interacts with multiple proteins. One of these interaction partners is involved in the following biochemical process: In an ATP-dependent manner... | |
medium_divergent_branch_01952 | PIK3R1 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that FL and IL-7, respectively, induce and increase the association of tyrosine-phosphorylated SHC and the p85 subunit of phosphatidylinositol 3'-kinase with this entity. Which disease is connected to this speci... | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that FL and IL-7, respectively, induce a... | |
medium_divergent_branch_01953 | CNOT7 interacts with multiple genes. One interaction is supported by evidence stating that Western blot and immunohistochemical analysis showed that rCAF-1 localizes to the nucleus of contact-inhibited RSMCs, where it was physically associated with the target gene, as determined by co-immunoprecipitation with anti-hCAF... | CNOT8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01953","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNOT7 interacts with multiple genes. One interaction is supported by evidence stating that Western blot and immunohistochemical analysis showed that ... | |
medium_divergent_branch_01954 | MESP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that MESP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells.' Which biological process, connected to the process ... | cardiac muscle tissue development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MESP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that MESP1 is a key factor su... | |
medium_divergent_branch_01955 | The biological process 'positive regulation of cation channel activity' is a subtype of two distinct parent processes. One of these parent processes is defined by the evidence: 'Any process that activates or increases the frequency, rate or extent of cation channel activity.' Identify the molecular function that is pos... | monoatomic ion transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01955","source_qa_id":"medium_divergent_branch_00916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of cation channel activity' is a subtype of two disti... | |
medium_divergent_branch_01956 | BAIAP2 interacts with multiple genes. One of these interaction partners was identified as IRSp53 using a yeast two-hybrid screen that utilized the proline-rich region of the partner protein. Which gene, connected to BAIAP2 via an interaction, is the subject of this specific experimental evidence? | SHARPIN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01956","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAIAP2 interacts with multiple genes. One of these interaction partners was identified as IRSp53 using a yeast two-hybrid screen that utilized the pr... | |
medium_divergent_branch_01957 | The term 'muscle of larynx' is classified under multiple anatomical categories via the 'is a' relationship. One such classification is supported by the evidence: 'The muscles associated with the larynx.' Which anatomical structure is the parent category (linked by 'part of') of the specific anatomical class identified ... | respiratory system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01957","source_qa_id":"medium_divergent_branch_02409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The term 'muscle of larynx' is classified under multiple anatomical categories via the 'is a' rel... | |
medium_divergent_branch_01958 | TRIM71 interacts with multiple proteins. One of these interaction partners is distinguished by the fact that, compared to its paralog, a unique C-terminal stretch of approximately 50 amino acids is essential for its interaction with TRIM71 and subsequent polyubiquitination. Which protein is encoded by the gene correspo... | Protein lin-28 homolog B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM71 interacts with multiple proteins. One of these interaction partners is distinguished by the fact that, compared to its paralog, a unique C-ter... | |
medium_divergent_branch_01959 | The transcription factor PROX1 is associated with multiple biological processes. One specific association is supported by evidence that Prox-1 acts as a cell proliferation inducer and a fate determination factor for lymphatic endothelial cells (LECs). Which biological process, defined as being a part of the process lin... | lymph vessel development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01959","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The transcription factor PROX1 is associated with multiple biological processes. One specific association is supported by evidence that Prox-1 acts a... | |
medium_divergent_branch_01960 | STX4 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Within the syntaxin family, syntaxin 4 interacted with SNAP23 and all vesicle-associated membrane proteins (VAMPs) examined, except tetanus neurotoxin insensitive VAMP (TI-VAMP).' Based on this evidence, which ... | WASL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX4 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Within the syntaxin family, syntaxin 4 ... | |
medium_divergent_branch_01961 | The gene LCP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In vitro experiments show that the interaction between a specific adapter protein and SLP-76 is mediated via the adapter protein's SH2 domain.' Which protein, encoded by the gene involved in this specific interac... | SH2/SH3 adapter protein NCK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01961","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LCP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In vitro experiments show that the intera... | |
medium_divergent_branch_01962 | The gene CGAS (MB21D1) interacts with multiple proteins. One specific interaction is characterized by evidence stating that the partner protein interacted with the enzymatically active core of cGAS through its conserved RING-CH domain. Which protein corresponds to this specific interaction partner? | E3 ubiquitin-protein ligase MARCHF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CGAS (MB21D1) interacts with multiple proteins. One specific interaction is characterized by evidence stating that the partner protein inter... | |
medium_divergent_branch_01963 | MIR492 is associated with multiple biological processes. One association is supported by evidence stating: 'Among differentially expressed microRNAs, we analysed miR-492 and showed that its overexpression was able to reduce proliferation, migration and tube formation of HUVEC.' Which biological process is negatively re... | vascular endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR492 is associated with multiple biological processes. One association is supported by evidence stating: 'Among differentially expressed microRNAs,... | |
medium_divergent_branch_01964 | TGFBR2 interacts with multiple proteins. One of these interactors is described as directly deubiquitinating and stabilizing the type II TGF-β receptor (TβRII), which leads to increased expression of TβRII in the plasma membrane and in tumor-derived extracellular vesicles (TEVs). Which protein corresponds to this descri... | Ubiquitin carboxyl-terminal hydrolase 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01964","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFBR2 interacts with multiple proteins. One of these interactors is described as directly deubiquitinating and stabilizing the type II TGF-β recepto... | |
medium_divergent_branch_01965 | BTBD9 interacts with multiple proteins. One of these interaction partners is described as a specific adaptor component of the CRL3 complex that binds to and promotes the ubiquitination and degradation of its partner in cells. Which protein is encoded by the gene corresponding to this interaction partner? | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01965","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTBD9 interacts with multiple proteins. One of these interaction partners is described as a specific adaptor component of the CRL3 complex that binds... | |
medium_divergent_branch_01966 | The gene NFE4 interacts with multiple partners. One interaction is supported by evidence stating: 'We have shown that NF-E4 interacts directly with, and serves as a substrate for, the acetyltransferase co-activator [protein encoded by KAT2B].' Which protein is encoded by the gene that corresponds to this specific inter... | Histone acetyltransferase KAT2B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01966","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NFE4 interacts with multiple partners. One interaction is supported by evidence stating: 'We have shown that NF-E4 interacts directly with, ... | |
medium_divergent_branch_01968 | ERAP2 is associated with multiple biological processes. One association is supported by evidence stating: 'This trimming of a longer peptide required the concerted action of both ERAP1 and ERAP2, both for in vitro digestion and in vivo for cellular antigen presentation.' Which biological process, connected to the proce... | antigen processing and presentation of peptide antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01968","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERAP2 is associated with multiple biological processes. One association is supported by evidence stating: 'This trimming of a longer peptide required... | |
medium_divergent_branch_01969 | TAB3 interacts with multiple proteins. One specific interaction occurs in the endoplasmic reticulum, where the interacting partner induces K27-linked polyubiquitination of TAB3 on lysine 649, thereby promoting TAK1 activation. Which protein is encoded by the gene corresponding to this specific interacting partner? | E3 ubiquitin-protein ligase AMFR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01969","source_qa_id":"medium_divergent_branch_06998","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TAB3 interacts with multiple proteins. One specific interaction occurs in the endoplasmic reticul... | |
medium_divergent_branch_01970 | The gene GNB1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have used yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells to demonstrate a direct interaction between a specific Ras-related protein and the G(beta1) subunit of heterotrimeric G... | Dexamethasone-induced Ras-related protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01970","source_qa_id":"medium_divergent_branch_03658","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GNB1 interacts with multiple proteins. One specific interaction is supported by evidence... | |
medium_divergent_branch_01971 | ASAP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Both coimmunoprecipitation and in vitro pulldown assays confirmed that ASAP1 directly binds to FIP3 through its BAR domain.' Which protein, encoded by the gene identified in this specific interaction, is the target of th... | Rab11 family-interacting protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASAP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Both coimmunoprecipitation and in vitro pulldown ... | |
medium_divergent_branch_01972 | The gene C20orf204 is enriched in two distinct naive T cell populations. One of these populations exhibits a mean expression of 4.47 TPM, a z-score of 2.18, and a fold enrichment of 6.91. Identify the immediate precursor cell type from which the specific naive T cell population matching these expression statistics deve... | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01972","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene C20orf204 is enriched in two distinct naive T cell populations. One of these populations exhibits a mean expression of 4.47 TPM, a z-score o... | |
medium_divergent_branch_01973 | The gene LEPR interacts with multiple partners via binding. One specific interaction is characterized by the following evidence: 'Indeed, the interacting partner binds specifically to phosphorylated Tyr(985) of LRb, and the interacting partner fails to inhibit transcription by ELR following mutation of Tyr(985), sugges... | cytoplasmic side of plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LEPR interacts with multiple partners via binding. One specific interaction is characterized by the following evidence: 'Indeed, the interac... | |
medium_divergent_branch_01974 | EZH2 interacts with multiple proteins. One of these interaction partners is described by the finding: 'We found that this protein associates with PRC2 and stimulates its enzymatic activity in vitro.' Which disease is associated with this specific interaction partner through genomic alterations? | urinary bladder neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EZH2 interacts with multiple proteins. One of these interaction partners is described by the finding: 'We found that this protein associates with PRC... | |
medium_divergent_branch_01975 | CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that hCTF18, hCTF8, and hDCC1 interact with each other as well as with the p38 subunit of RFC.' Which protein, among those interacting with CHTF18, is encoded by the gene corresponding to the protein explicitly na... | Chromosome transmission fidelity protein 8 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that hCTF18, hCTF8, and hDCC1 interact wit... | |
medium_divergent_branch_01976 | NAA15 interacts with multiple proteins. One of these interaction partners is part of the human NatA complex, which is described as containing a catalytic subunit and an auxiliary subunit (NAA15), and associates with the intrinsically disordered Huntingtin yeast two-hybrid protein K (HYPK). Which protein, connected to N... | N-alpha-acetyltransferase 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NAA15 interacts with multiple proteins. One of these interaction partners is part of the human NatA complex, which is described as containing a catal... | |
medium_divergent_branch_01979 | The gene PKM is associated with multiple interacting proteins. One specific interaction is characterized by the following mechanism: the interacting protein directly binds to pyruvate kinase M2 (PKM2) and inhibits its ubiquitination by blocking the interaction between PKM2 and its ubiquitin E3 ligase Parkin, thereby en... | Ubiquitin thioesterase OTUB2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PKM is associated with multiple interacting proteins. One specific interaction is characterized by the following mechanism: the interacting ... | |
medium_divergent_branch_01981 | The SRC gene interacts with multiple partners via binding. One specific interaction is supported by evidence stating that von Willebrand factor, in the presence of botrocetin, induces the activation of p72 (assessed by autophosphorylation and kinase assays), leads to the transient association of p72 with p60(c-Src), an... | Tyrosine-protein kinase SYK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SRC gene interacts with multiple partners via binding. One specific interaction is supported by evidence stating that von Willebrand factor, in t... | |
medium_divergent_branch_01982 | The gene AGT is associated with multiple biological processes. One association is supported by evidence stating: 'We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angio... | renal system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGT is associated with multiple biological processes. One association is supported by evidence stating: 'We studied 11 individuals with rena... | |
medium_divergent_branch_01983 | The gene OCRL is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that OCRL1 interacts with several members of the rab family of small GTPases.' Based on this evidence, which protein does OCRL bind to, and what is the name of the protein product encoded ... | Ras-related protein Rab-5A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OCRL is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that OCRL1 intera... | |
medium_divergent_branch_01984 | SOD1 is associated with multiple biological processes. One association is supported by evidence stating: 'The steady-state concentration of superoxide was significantly increased after 12 h, when SOD1 was only slightly decreased, and progressively returned to values close to those observed in control cells.' Which biol... | response to oxygen radical | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOD1 is associated with multiple biological processes. One association is supported by evidence stating: 'The steady-state concentration of superoxid... | |
medium_divergent_branch_01985 | The gene EPB41L1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Coimmunoprecipitation demonstrated that a specific glutamate receptor subunit associated with 4.1 protein(s) in both HEK293 cells and rat brain.' Which protein is encoded by the gene that interacts... | Glutamate receptor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EPB41L1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Coimmunoprecipitation demo... | |
medium_divergent_branch_01986 | The SBDS protein interacts with multiple partners. One specific interaction partner is identified by evidence stating: 'We further explored the effect of these SBDS mutations on the interaction with this partner, and showed that all tested mutations disrupted the binding to this partner.' Which disease is associated wi... | Shwachman-Diamond syndrome 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01986","source_qa_id":"medium_divergent_branch_06147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The SBDS protein interacts with multiple partners. One specific interaction partner is identified... | |
medium_divergent_branch_01987 | NXF1 interacts with multiple genes. One of these interaction partners is described as binding avidly and directly to a specific protein and TAP, while not binding to other known components of the complex, and is found in mRNPs containing that specific protein in vivo. Which disease is associated with this specific gene... | Radial aplasia-thrombocytopenia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01987","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NXF1 interacts with multiple genes. One of these interaction partners is described as binding avidly and directly to a specific protein and TAP, whil... | |
medium_divergent_branch_01988 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.070 and an adjusted p-value of 0.0422. Which protein does that selected gene encode? | Cingulin-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01988","source_qa_id":"medium_divergent_branch_01186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_01989 | The gene AGTR2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we identified human angiotensin II type 2 receptor as such a partner, which is well known to be a regulator of cardiovascular homoeostasis.' This evidence refers to an interaction identified using a yeast ... | Metalloproteinase inhibitor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01989","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGTR2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we identified human angiotensin II... | |
medium_divergent_branch_01990 | IKZF1 interacts with multiple proteins. One interaction is characterized by evidence stating: 'We describe a novel physical and functional interaction between the proteins, which requires the central zinc finger domain of Ikaros.' Which protein product is encoded by the gene that interacts with IKZF1 in this specific c... | Forkhead box protein P1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IKZF1 interacts with multiple proteins. One interaction is characterized by evidence stating: 'We describe a novel physical and functional interactio... | |
medium_divergent_branch_01991 | The protein RP2 is associated with multiple biological processes. One specific association is supported by evidence that RP2 localizes to the Golgi apparatus and the periciliary ridge of photoreceptors, suggesting a role in regulating vesicle traffic and docking. Which biological process, connected to this specific RP2... | Golgi vesicle transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01991","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RP2 is associated with multiple biological processes. One specific association is supported by evidence that RP2 localizes to the Golgi a... | |
medium_divergent_branch_01992 | The PAF1 gene has multiple interaction partners. One specific interaction is supported by evidence stating: 'Using an unbiased biochemical approach, we discovered that the transcription elongation-associated PAF1 complex (PAF1c) directly interacts with H3R17me2a.' Identify the disease associated with the gene involved ... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The PAF1 gene has multiple interaction partners. One specific interaction is supported by evidence stating: 'Using an unbiased biochemical approach, ... | |
medium_divergent_branch_01993 | ADCYAP1R1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence showing that CHO-K1 cells transfected with the corresponding cDNA specifically bound PACAP and mediated PACAP-triggered intracellular accumulation of cAMP, indicating the encoding ... | molecular transducer activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADCYAP1R1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence showing t... | |
medium_divergent_branch_01994 | UCP2 is associated with multiple molecular functions. One association is supported by evidence stating: 'Extensive biochemical studies of UCP2 have provided ample evidence of its participation in proton and anion transport.' Which molecular function, connected to this specific activity via an 'is a' relationship, is th... | monoatomic cation transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01994","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UCP2 is associated with multiple molecular functions. One association is supported by evidence stating: 'Extensive biochemical studies of UCP2 have p... | |
medium_divergent_branch_01995 | ATOH7 is implicated in multiple biological processes. One specific process is supported by evidence stating: 'These dual enhancers may reinforce ATOH7 expression during early critical stages of eye development when retinal neurogenesis is initiated.' Which anatomical structure is the result of the development associate... | retinal neural layer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01995","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATOH7 is implicated in multiple biological processes. One specific process is supported by evidence stating: 'These dual enhancers may reinforce ATOH... | |
medium_divergent_branch_01996 | The protein KNL1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Here, we use X-ray crystallography, nuclear magnetic resonance spectroscopy, and biochemical assays to show how KNL1 binds both PP1 and microtubules.' Which molecu... | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01996","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein KNL1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence st... | |
medium_divergent_branch_01997 | The CAV3 gene is associated with multiple biological processes. One association is supported by evidence that mutations in CAV3 cause autosomal dominant rippling muscle disease (RMD). Given this clinical context, which biological process, linked to CAV3, is the regulator of a downstream physiological event via a 'regul... | skeletal muscle contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CAV3 gene is associated with multiple biological processes. One association is supported by evidence that mutations in CAV3 cause autosomal domin... | |
medium_divergent_branch_01999 | The alpha-beta T cell receptor complex is associated with multiple cell types via high plasma membrane abundance. One such cell type is described as a mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus, characterized by low CD24 expression and high T cell receptor expression. Which cell type, conne... | CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01999","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The alpha-beta T cell receptor complex is associated with multiple cell types via high plasma membrane abundance. One such cell type is described as ... | |
medium_divergent_branch_02000 | The VHL protein interacts with multiple partners. One specific interaction is described as follows: 'Here, we report that the Von Hippel-Lindau gene product, pVHL, physically interacts with this partner and regulates its rapid turnover observed in both differentiated and stem cells.' Based on this description, identify... | thrombotic disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02000","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The VHL protein interacts with multiple partners. One specific interaction is described as follows: 'Here, we report that the Von Hippel-Lindau gene ... | |
medium_divergent_branch_02003 | HDAC7 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid screening system, we found that the inhibitory domain of the protein encoded by the gene interacting with HDAC7 strongly interacted with the C-terminal domain of histone deacetylase (HDAC) 7.' ... | Hypoxia-inducible factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02003","source_qa_id":"medium_divergent_branch_05971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HDAC7 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_02004 | The gene CYLD is known to bind to multiple protein partners. One specific interaction partner is characterized by the following evidence: 'We find that this protein interacts via its PUB domain with CYLD, while a PUB interaction motif (PIM) of this protein interacts with the PUB domain of the LUBAC component HOIP.' Whi... | Spermatogenesis-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CYLD is known to bind to multiple protein partners. One specific interaction partner is characterized by the following evidence: 'We find th... | |
medium_divergent_branch_02005 | ERCC3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Also, VCP/p97 interacts with XPB upon treatment of spironolactone and proteasome inhibitor MG132, while the VCP/p97 adaptor [protein] binds XPB and its ubiquitin conjugates.' Which protein is connected to the gene identi... | UBX domain-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Also, VCP/p97 interacts with XPB upon treatment o... | |
medium_divergent_branch_02006 | The gene ACTR2 is known to interact with multiple proteins. One of these interacting partners has been experimentally demonstrated to interact with the Arp2/3 complex, a protein complex that catalyzes actin filament branching. Which protein is encoded by the gene that interacts with ACTR2 and exhibits this specific int... | Sharpin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTR2 is known to interact with multiple proteins. One of these interacting partners has been experimentally demonstrated to interact with t... | |
medium_divergent_branch_02007 | JAK1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In addition, we found that a suppressor of cytokine signaling protein was associated with JAK1 and JAK2 and that these associations were stimulated by TSH.' Based on this evidence, which cellular component is the interact... | cytoplasmic side of plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In addition, we found that a suppressor of cytokin... | |
medium_divergent_branch_02009 | GTF2I interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction of a protein encoded by the gene interacting with GTF2I in this context with transcription factor TFII-I, which binds to DICE elements in Igh promoters, that affects transcriptio... | POU domain class 2-associating factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF2I interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction of a pr... | |
medium_divergent_branch_02010 | ERLIN1 interacts with multiple genes. One specific interaction is characterized by the following observation: 'Whereas interaction of this protein with 14-3-3 proteins was strongly reduced upon infection with Shigella, erlin-1 and erlin-2 (erlin-1/2) specifically bound to this protein complexes.' Which disease is conne... | allergic asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERLIN1 interacts with multiple genes. One specific interaction is characterized by the following observation: 'Whereas interaction of this protein wi... | |
medium_divergent_branch_02011 | NXF2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We characterize two of four human TAP homologues and show that one of them, NXF2, binds RNA, localizes to the nuclear envelope, and exhibits RNA export activity.' Which molecu... | nucleic acid binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02011","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NXF2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We c... | |
medium_divergent_branch_02012 | REP15 interacts with multiple proteins. One of these interactions is supported by biochemical validation and crystal structures of the complex formed between REP15 and the target protein, as well as a complex with Rab3C, providing mechanistic insight. Which protein is connected to the gene REP15 through the 'interacts ... | Ras-related protein Rab-3B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"REP15 interacts with multiple proteins. One of these interactions is supported by biochemical validation and crystal structures of the complex formed... | |
medium_divergent_branch_02013 | The gene ADRB2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The association of this protein with beta-adrenergic receptors was established using antibodies to this protein as well as a this protein-glutathione S-transferase fusion protein.' What is the name of the prote... | Growth factor receptor-bound protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02013","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRB2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The association of this protein with be... | |
medium_divergent_branch_02014 | CBX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies.' Which protein, connected to CBX4 via this interaction, is encoded by the gene in question? | C-terminal-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02014","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CBX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The human PcG protein, Pc2, has been shown to recruit the t... | |
medium_divergent_branch_02015 | ORC2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Biochemical analyses showed that human ORC binds to a telomere sequence-binding protein that protects telomeres and functions in telomere length homeostasis, via the ORC1 subunit.' Which disease is linked to this specific in... | adult T-cell leukemia/lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02015","source_qa_id":"medium_divergent_branch_03329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ORC2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'B... | |
medium_divergent_branch_02016 | TRAF5 interacts with multiple genes. One of these interactions is supported by evidence showing that the gene, along with TRAF2, interacts with the D2 subdomain of a receptor protein both in vitro and in vivo. Which gene is connected to this selected gene through a 'binds' relationship? | TNFSF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF5 interacts with multiple genes. One of these interactions is supported by evidence showing that the gene, along with TRAF2, interacts with the D... | |
medium_divergent_branch_02017 | MCM7 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified minichromosome maintenance 7 (Mcm7), an essential component of the pre-replication complex, as a novel Smc1-interacting protein.' Which disease is associated with the gene identified in this evidence through a biomarker... | acute promyelocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02017","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM7 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified minichromosome maintenance 7 (Mcm7), an essentia... | |
medium_divergent_branch_02019 | NCOA2 interacts with multiple proteins. One of these interaction partners was shown in a study to specifically and dramatically enhance the C-terminal transactivation activity of GRIP1 by directly binding to GRIP1, but only when GRIP1 was sumoylated. Which protein is encoded by the gene corresponding to this interactio... | Protein PML | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA2 interacts with multiple proteins. One of these interaction partners was shown in a study to specifically and dramatically enhance the C-termina... | |
medium_divergent_branch_02020 | WDFY3 interacts with multiple proteins. One interaction is supported by evidence stating that the binding of ALFY to GABARAP is indispensable for its recruitment to LC3B-positive structures and, thus, for the clearance of certain p62 structures by autophagy. Which protein is encoded by the gene corresponding to this sp... | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDFY3 interacts with multiple proteins. One interaction is supported by evidence stating that the binding of ALFY to GABARAP is indispensable for its... | |
medium_divergent_branch_02021 | PKN1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation and in vitro pull-down assays independently confirmed the interaction between the two proteins.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Cyclin-T2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKN1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation and in vitro pull-down ... | |
medium_divergent_branch_02022 | ANXA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report the first structure of a complex between a specific S100 family protein and its cognate peptide, the N-terminus of annexin II, as well as that of the S100 protein alone.' Which protein, encoded by the gene connected to ... | Protein S100-A10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report the first structure of a complex between a speci... | |
medium_divergent_branch_02023 | MIR146A is associated with multiple biological processes. One specific association is supported by evidence that miR-146a regulates IL-6 expression by binding to its 3'-untranslated region. Which biological process, connected to this specific association, is linked via a 'negatively regulates' relationship? | interleukin-6 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02023","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR146A is associated with multiple biological processes. One specific association is supported by evidence that miR-146a regulates IL-6 expression b... | |
medium_divergent_branch_02024 | SMARCD1 interacts with multiple proteins. Evidence for one specific interaction reports that the confirmed interacting proteins include the target protein itself and three transcription controlling proteins (SAP30L, DRAP1, and BAF60a). What is the full protein name encoded by this interaction partner? | Fasciculation and elongation protein zeta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCD1 interacts with multiple proteins. Evidence for one specific interaction reports that the confirmed interacting proteins include the target pr... | |
medium_divergent_branch_02025 | Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we show that the isopeptidase USP2a (ubiquitin-specific protease-2a) interacts with and stabilizes fatty acid synthase (FAS), which is often overexpressed in biologically aggressive human ... | DCAF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02025","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we show that the ... | |
medium_divergent_branch_02026 | The HTT gene interacts with multiple partners. One interaction is supported by evidence stating: 'We found that huntingtin is associated with Grb2, RasGAP, and tyrosine-phosphorylated EGF receptor.' Which protein is encoded by the gene that interacts with HTT in this specific context? | Ras GTPase-activating protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The HTT gene interacts with multiple partners. One interaction is supported by evidence stating: 'We found that huntingtin is associated with Grb2, R... | |
medium_divergent_branch_02027 | HMGA2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'here we show that HMGA2 associates with the E1A-regulated transcriptional repressor p120(E4F).' Identify the molecular function linked to this specific evidence-supported fun... | DNA-binding transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGA2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'her... | |
medium_divergent_branch_02028 | Ascorbic acid interacts with multiple drugs. One specific interaction is described by the following evidence: 'The behavioural excitation induced by d-[drug] (2.5 mg/kg SC) was significantly potentiated by ascorbic acid (100-200 mg/kg IP).' Identify the disease for which this specific interacting drug is indicated. | narcolepsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02028","source_qa_id":"medium_divergent_branch_01129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Ascorbic acid interacts with multiple drugs. One specific interaction is described by the followi... | |
medium_divergent_branch_02029 | RNF13 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that 'GST-pulldown and co-immunoprecipitation show that RNF13 variants disrupt association with AP-3 complex.' Which disease is connected to this specific interaction partner through a biomarker relationship? | albinism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF13 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that 'GST-pulldown and co-immunoprecipita... | |
medium_divergent_branch_02030 | UPF2 interacts with multiple proteins. One of these interaction partners is described in experimental evidence as a 'proven 5'-->3' exonuclease' that coimmunopurifies with NMD factors Upf1 and Upf3X, the decapping enzyme Dcp2, the putative 5'-->3' exonuclease Rat1, exosomal components PM/Scl100, Rrp4, and Rrp41, and PA... | 5'-3' exoribonuclease 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UPF2 interacts with multiple proteins. One of these interaction partners is described in experimental evidence as a 'proven 5'-->3' exonuclease' that... | |
medium_divergent_branch_02031 | ANGPTL3 is associated with multiple biological processes. One association is supported by evidence that ANGPTL3 activates lipolysis to stimulate the release of free fatty acids and glycerol from adipocytes. Which biological process is positively regulated by the process linked to this specific evidence? | lipid catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPTL3 is associated with multiple biological processes. One association is supported by evidence that ANGPTL3 activates lipolysis to stimulate the ... | |
medium_divergent_branch_02034 | SLMAP interacts with multiple proteins. One specific interaction is part of the STRIPAK assembly, which establishes mutually exclusive interactions with either CTTNBP2 proteins or a second subcomplex. This second subcomplex consists of SLMAP and related coiled-coil proteins, including a suppressor of IKKepsilon protein... | Suppressor of IKBKE 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02034","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLMAP interacts with multiple proteins. One specific interaction is part of the STRIPAK assembly, which establishes mutually exclusive interactions w... | |
medium_divergent_branch_02035 | FANCM interacts with multiple proteins. One interaction is supported by evidence stating that MM2 interacts with RM1 and topoisomerase IIIalpha, which are components of the BS complex. Which protein, encoded by the gene connected to FANCM via this specific interaction, is the subject of this evidence? | DNA topoisomerase 3-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCM interacts with multiple proteins. One interaction is supported by evidence stating that MM2 interacts with RM1 and topoisomerase IIIalpha, whic... | |
medium_divergent_branch_02036 | IGBP1 interacts with multiple genes. One of these interaction partners is a putative E3 ubiquitin ligase that binds to the C-terminal domain of the Alpha4 regulatory subunit of protein phosphatase 2A. Which disease is associated with this specific interaction partner through genomic alterations? | syndactyly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGBP1 interacts with multiple genes. One of these interaction partners is a putative E3 ubiquitin ligase that binds to the C-terminal domain of the A... | |
medium_divergent_branch_02037 | RNF2 interacts with multiple genes. One of these interaction partners is reported to interact with PRC1 subunits, specifically Ring1A and Ring1B. Which gene, connected to RNF2 via an interaction, is the subject of this specific evidence? | UBE2S | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF2 interacts with multiple genes. One of these interaction partners is reported to interact with PRC1 subunits, specifically Ring1A and Ring1B. Whi... | |
medium_divergent_branch_02038 | DLK1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Thus we identified Dlk1 as a novel regulator of bone mass that functions to inhibit bone formation and to stimulate bone resorption.' Which biological process is negative... | ossification | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02038","source_qa_id":"medium_divergent_branch_03497","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DLK1 is associated with multiple biological processes via the 'involved in' relationship. One spe... | |
medium_divergent_branch_02039 | BNIP3 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we report that an additional mitochondrial outer membrane protein, BNIP3, is also involved in MALM.' Identify the biological process linked to this specific association via an 'is a' relationship. | protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BNIP3 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we report that an additiona... | |
medium_divergent_branch_02040 | MCM3 interacts with multiple proteins. One of these interaction partners is described as an acetylating protein that binds to MCM3, acetylates it, and inhibits cell cycle progression, functioning within the context of pre-replication complexes that limit DNA replication. Which protein is encoded by the gene correspondi... | Germinal-center associated nuclear protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02040","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM3 interacts with multiple proteins. One of these interaction partners is described as an acetylating protein that binds to MCM3, acetylates it, an... | |
medium_divergent_branch_02041 | ZMYND11 interacts with multiple genes. One of these interaction partners is described in the literature as a well-characterized SUMO E3 enzyme that interacts with Ubc9 (the only SUMO E2 enzyme identified so far) through distinct regions. Which disease is associated with this specific interaction partner? | essential thrombocythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYND11 interacts with multiple genes. One of these interaction partners is described in the literature as a well-characterized SUMO E3 enzyme that i... | |
medium_divergent_branch_02042 | GPR37 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca(2+) mobilisation assays revealed nanomolar affinities of HA to GPR37.' Identify the molecular function linked to th... | peptide binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR37 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Electrophysiological recordings in... |
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