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medium_divergent_branch_02043 | The gene POLE2 interacts with multiple partners. One specific interaction involves a complex where a 17 kDa subunit and p12 must be present together to interact with the p261 and p59 subunits of HeLa polymerase epsilon; neither the 17 kDa subunit nor p12 alone is sufficient for this interaction. Which disease is associ... | polyposis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLE2 interacts with multiple partners. One specific interaction involves a complex where a 17 kDa subunit and p12 must be present together ... | |
medium_divergent_branch_02044 | The HFE protein is involved in multiple biological processes. One specific process is supported by evidence stating: 'Using transient HFE transfection assays in a model of APCs, we show that WT HFE (HFEWT), but not C282Y-mutated HFE, inhibits secretion of MIP-1β from antigen-specific CD8+ T lymphocytes.' Which biologic... | T cell cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The HFE protein is involved in multiple biological processes. One specific process is supported by evidence stating: 'Using transient HFE transfectio... | |
medium_divergent_branch_02045 | The gene ZHX1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 14.58 TPM, a z-score of 1.66, and a fold enrichment of 2.02. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type ... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ZHX1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 14.58 TPM, a z... | |
medium_divergent_branch_02046 | EZH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By co-immunoprecipitation analyses, we demonstrated that both isoforms interact with EZH2 through their common TUDOR domain.' Which protein, connected to EZH2 via this specific interaction, is encoded by the gene in question? | PHD finger protein 19 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EZH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By co-immunoprecipitation analyses, we demonstrated that bo... | |
medium_divergent_branch_02047 | RUNX3 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 27.94 TPM, a z-score of 1.80, and a fold enrichment of 4.35. Which cell type is the parent class (is_a) of the cell type matching these expression statistics? | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX3 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 27.94 TPM, a z-score of 1.80, and a fold enrichment o... | |
medium_divergent_branch_02048 | Alpha-actinin-2 (ACTN2) is associated with multiple molecular functions. One specific function is supported by evidence describing the actinin-associated LIM protein, which binds to the spectrin-like repeats of alpha-actinin-2, and a new skeletal muscle protein containing a PDZ domain that binds to the COOH-terminal re... | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02048","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Alpha-actinin-2 (ACTN2) is associated with multiple molecular functions. One specific function is supported by evidence describing the actinin-associ... | |
medium_divergent_branch_02049 | The gene TUBGCP2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data demonstrate that pathogenic variants in TUBGCP2 cause an autosomal recessive neurodevelopmental trait consisting of a neuronal migration disorder, and our data implicate GCP2 as a core componen... | generation of neurons | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TUBGCP2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data demonstrate that patho... | |
medium_divergent_branch_02050 | HLA-DMA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'Here we provide evidence that in lysosomal compartments of B cells a considerable fraction of DM is stably associated with empty DR alphabeta dimers, thereby preventing thei... | MHC protein complex binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-DMA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'He... | |
medium_divergent_branch_02051 | POT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the [protein encoded by NCBIGene:7013] complex interacts with a single-stranded telomeric DNA-binding protein--protection of telomeres 1 (POT1)--and that human POT1 controls telomerase-mediated telomere elongatio... | Telomeric repeat-binding factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the [protein encoded by NCBIGene:7013] co... | |
medium_divergent_branch_02052 | The gene TRGV10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 151.00 TPM, a z-score of 1.52, and a fold enrichment of 4.50. Which cell type, defined by this specific expression profile, is a subtype of mature alpha-beta T cells? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRGV10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 151.00 TPM, a z-score o... | |
medium_divergent_branch_02053 | TRIM33 interacts with multiple genes. One of these interacting partners has been shown to interact with TIF1gamma in intact cells, based on immunoprecipitation studies. Which gene is this interacting partner of TRIM33? | IDI2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM33 interacts with multiple genes. One of these interacting partners has been shown to interact with TIF1gamma in intact cells, based on immunopre... | |
medium_divergent_branch_02054 | USP18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that USP18 binds, deubiquitinates, and thus, stabilizes a specific transcription factor, thereby regulating reactive astrogliosis.' Which protein is encoded by the gene corresponding to this interacting partner? | Transcription factor SOX-9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02054","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that USP18 binds, deubiquitinates, and thus, sta... | |
medium_divergent_branch_02055 | COPB1 interacts with multiple proteins. One of these interaction partners was identified in yeast two-hybrid screening experiments as directly interacting with β-COP, a subunit of Coat Protein Complex I (COPI). Which protein is this interaction partner? | Anoctamin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPB1 interacts with multiple proteins. One of these interaction partners was identified in yeast two-hybrid screening experiments as directly intera... | |
medium_divergent_branch_02056 | The gene RCHY1 (encoding Pirh2) has multiple interacting partners. One specific interaction is described by the statement: 'Here, we show that Pirh2 physically interacted with a protein encoded by the gene TP73 and downregulated its function through its E3 ligase activity.' Which protein is encoded by the gene that int... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RCHY1 (encoding Pirh2) has multiple interacting partners. One specific interaction is described by the statement: 'Here, we show that Pirh2 ... | |
medium_divergent_branch_02057 | GGA1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We found that these signals bind to the VHS domain of the Golgi-localized, gamma-ear-containing, ARF-binding proteins (GGAs).' Which disease is causally linked to the gene identified by this specific interaction evidence? | choriocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02057","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We found that these signals bind to the VHS domain o... | |
medium_divergent_branch_02058 | DNAJB6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known core mSin3 transcriptional complex components RBBP1 and mSDS3, the protein in question interacted with other proteins including three chaperones: DNAJB6 (MRJ), Hsp90, and Hsp70.' Which protein, connected to ... | Breast cancer metastasis-suppressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNAJB6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known core mSin3 transcriptional complex c... | |
medium_divergent_branch_02059 | BAK1 interacts with multiple proteins. One interaction is characterized by the observation that the formation of a p53-Bak complex coincides with the loss of an interaction between Bak and a specific anti-apoptotic Bcl-2 family member. Which protein, encoded by the gene connected to BAK1 via this specific interaction, ... | Induced myeloid leukemia cell differentiation protein Mcl-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAK1 interacts with multiple proteins. One interaction is characterized by the observation that the formation of a p53-Bak complex coincides with the... | |
medium_divergent_branch_02060 | AGAP2 interacts with multiple proteins. One of these interaction partners is part of a complex where PIKE-L directly interacts with both GluA2 and this partner, forming a tertiary complex upon glycine-induced NMDA receptor activation. Which protein is this interaction partner? | Glutamate receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGAP2 interacts with multiple proteins. One of these interaction partners is part of a complex where PIKE-L directly interacts with both GluA2 and th... | |
medium_divergent_branch_02061 | The gene RPL4P1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 3.86 TPM, a z-score of 1.72, and a fold enrichment of 3.97. Which cell type, connected to RPL4P1 via this specific enrichment evidence, is a subtype of mature T cells? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RPL4P1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 3.86 TPM, a ... | |
medium_divergent_branch_02062 | APAF1 interacts with multiple proteins. One specific interaction partner is characterized by high expression in skeletal muscle and heart, and it binds to the CARD domain of Apaf-1 in competition with caspase-9. Which protein is encoded by the gene corresponding to this specific interaction partner? | Methylthioribulose-1-phosphate dehydratase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02062","source_qa_id":"medium_divergent_branch_05898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"APAF1 interacts with multiple proteins. One specific interaction partner is characterized by high... | |
medium_divergent_branch_02063 | PRKCA interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using affinity chromatography and Western blot analysis, we found interaction with all PKC isotypes and casein kinase I isoforms, CKIalpha and CKI.' Identify the disease associated with the protein described in this evid... | mesothelioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02063","source_qa_id":"medium_divergent_branch_05211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PRKCA interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_02064 | APPL1 interacts with multiple proteins. One of these interaction partners facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT. This regulatory effect is mediated by the deacetylation of AKT at lysine 14 and 20 residues and by the interaction between this partner and the scaffold protein APPL1. Whi... | Histone deacetylase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APPL1 interacts with multiple proteins. One of these interaction partners facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT. ... | |
medium_divergent_branch_02065 | GNAI3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a central, conserved component of Gαs-coupled receptor cascades, the regulatory subunit type-II (RII) of protein kinase A undergoes adenosine 3'-5'-cyclic monophosphate (cAMP)-dependent binding to Gαi.' Which pr... | cAMP-dependent protein kinase type II-beta regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02065","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAI3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that a central, conserved component of Gαs-co... | |
medium_divergent_branch_02066 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.238 and an adjusted p-value of 0.0493. For which disease is that selected gene recorded as a biomarker? | ovarian neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02066","source_qa_id":"medium_divergent_branch_01111","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_02067 | GATA4 interacts with multiple genes. One of these interacting partners is characterized by evidence showing that it and GATA4 widely co-occupy and co-activate cardiac developmental genes, and that a specific missense variant in this partner disrupts its interaction with GATA4, impairing function in vitro and in vivo in... | Cytokine-like nuclear factor N-PAC | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple genes. One of these interacting partners is characterized by evidence showing that it and GATA4 widely co-occupy and co... | |
medium_divergent_branch_02068 | NCOA6 interacts with multiple genes. Evidence for one of these interactions indicates that ASC-2 also interacts with other nuclear receptors, including the retinoic acid receptor, thyroid hormone receptor, estrogen receptor alpha, and glucocorticoid receptor, as well as basal factors TFIIA and TBP, and transcription in... | Thyroid hormone receptor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02068","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA6 interacts with multiple genes. Evidence for one of these interactions indicates that ASC-2 also interacts with other nuclear receptors, includi... | |
medium_divergent_branch_02069 | BMP7 interacts with multiple proteins. One interaction is supported by evidence stating that OP-1 (BMP7) binds efficiently to ALK-2 and ALK-6, but less efficiently to ALK-3, whereas BMP-4 binds efficiently to ALK-3 and ALK-6. Which protein, encoded by the gene connected to BMP7 via this specific binding evidence, is th... | Activin receptor type-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP7 interacts with multiple proteins. One interaction is supported by evidence stating that OP-1 (BMP7) binds efficiently to ALK-2 and ALK-6, but le... | |
medium_divergent_branch_02070 | The gene MECOM (encoding EVI1) interacts with multiple partners. One specific interaction is supported by evidence stating: 'We find that EVI1 directly interacts with this protein and that the proteins form an active complex with methyltransferase activity in vitro.' Which protein is encoded by the gene that interacts ... | Histone-lysine N-methyltransferase SUV39H1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MECOM (encoding EVI1) interacts with multiple partners. One specific interaction is supported by evidence stating: 'We find that EVI1 direct... | |
medium_divergent_branch_02071 | BAZ2A interacts with multiple proteins. One interaction partner is described by the following evidence: 'TIP5 co-localizes with the basal RNA polymerase I transcription factor UBF in the nucleolus and is associated with SNF2h.' Identify the disease associated with this specific interaction partner via genomic alteratio... | extraskeletal Ewing sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02071","source_qa_id":"medium_divergent_branch_01037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BAZ2A interacts with multiple proteins. One interaction partner is described by the following evi... | |
medium_divergent_branch_02072 | The gene DCTN2 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We report that dynamitin is a Ca(2+)/calmodulin-binding protein and that dynamitin binds directly to a membrane-associated PKC substrate involved in macrophage spreading and integrin activation.' Which protei... | MARCKS-related protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02072","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCTN2 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We report that dynamitin is a Ca(2+)/... | |
medium_divergent_branch_02073 | WDR3 interacts with multiple genes. One specific interaction involves a partner that acts as a transcription factor for YAP1. Evidence indicates that the upregulation of YAP1 expression induced by WDR3 is dependent on its interaction with this partner, and this interaction triggers the nuclear translocation of the part... | myocardial infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02073","source_qa_id":"medium_divergent_branch_00320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"WDR3 interacts with multiple genes. One specific interaction involves a partner that acts as a tr... | |
medium_divergent_branch_02074 | Human mastadenovirus C downregulates multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.563 and an adjusted p-value of 0.03813. Which disease is associated with the gene corresponding to this specific expression profile? | hereditary sclerosing poikiloderma with tendon and pulmonary involvement | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02074","source_qa_id":"medium_divergent_branch_01805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Human mastadenovirus C downregulates multiple genes. One specific downregulation event is charact... | |
medium_divergent_branch_02075 | GIT1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that the encoded protein enhances the affinity of a specific modulator for K63-linked ubiquitin chains via interaction with its coiled-coil 2 domains. Which protein is encoded by the gene connected to GIT1 through thi... | NF-kappa-B essential modulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIT1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that the encoded protein enhances the affinity... | |
medium_divergent_branch_02076 | IRF3 interacts with multiple genes. One interaction is supported by evidence stating: 'While IRF-7 DN had no effect on virus-stimulated nuclear translocation of IRF-3 and IRF-7, the binding of IRF-7 DN to IRF-3 and IRF-7 was detected by GST pull-down assay as well as by immunoprecipitation in infected cells, indicating... | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF3 interacts with multiple genes. One interaction is supported by evidence stating: 'While IRF-7 DN had no effect on virus-stimulated nuclear trans... | |
medium_divergent_branch_02077 | The gene G6PC1 is associated with multiple molecular functions. One specific function is supported by evidence stating that His(176) acts as the phosphate acceptor in G6Pase. Which broader molecular function category, defined by an 'is a' relationship, encompasses this specific function? | anion binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02077","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene G6PC1 is associated with multiple molecular functions. One specific function is supported by evidence stating that His(176) acts as the phos... | |
medium_divergent_branch_02079 | FASLG interacts with multiple genes. One specific interaction is characterized by evidence showing that CD95 co-immunoprecipitates with the interacting partner exclusively in lymphoblastoid CD4(+) T cells and primary long-term activated T lymphocytes, which are susceptible to CD95-mediated apoptosis. This interaction i... | triple-negative breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02079","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FASLG interacts with multiple genes. One specific interaction is characterized by evidence showing that CD95 co-immunoprecipitates with the interacti... | |
medium_divergent_branch_02080 | TAOK1 is associated with multiple biological processes. One association is supported by evidence that altered TAOK1 expression levels in the embryonic mouse brain affect neural migration in vivo and neuronal maturation in vitro. Which biological process is a part of the process linked to TAOK1 by this specific evidence... | central nervous system neuron differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAOK1 is associated with multiple biological processes. One association is supported by evidence that altered TAOK1 expression levels in the embryoni... | |
medium_divergent_branch_02081 | FIS1 is reported to interact with multiple genes. One specific interaction is supported by evidence stating that the interacting partner also binds to hFis1, and that elevated levels of hFis1 partially reverse the fusion phenotype induced by this partner. Which gene is this interacting partner? | YWHAG | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02081","source_qa_id":"medium_divergent_branch_06657","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FIS1 is reported to interact with multiple genes. One specific interaction is supported by eviden... | |
medium_divergent_branch_02082 | The gene IL5 is linked via a binding interaction to more than one partner gene. One of these partners is supported by evidence stating: 'Human IL5 was shown by analytical ultracentrifugation to form a 1:1 complex with the soluble domain of the hIL5 receptor alpha subunit (shIL5R alpha).' Which protein is encoded by the... | Interleukin-5 receptor subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02082","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL5 is linked via a binding interaction to more than one partner gene. One of these partners is supported by evidence stating: 'Human IL5 wa... | |
medium_divergent_branch_02083 | The protein PEX6 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'These results strongly suggest that Pex1p and Pex6p interact with each other.' Which molecular function, connected to the function implied by this interaction evid... | binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein PEX6 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence st... | |
medium_divergent_branch_02084 | NCK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Consistently, epidermal growth factor receptor and platelet-derived growth factor receptor preferentially interact with Nckbeta over Nckalpha in vitro.' Which disease is therapeutically linked to the gene identified by this evidence? | extrahepatic cholestasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Consistently, epidermal growth factor receptor and platelet-de... | |
medium_divergent_branch_02085 | SNRPB interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Interestingly, GST-pulldown experiments show that the protein encoded by this gene also binds directly to SmB'. Which disease is associated with this specific gene via a biomarker relationship? | adult lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNRPB interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Interestingly, GST-pulldown experiments sho... | |
medium_divergent_branch_02086 | FLNB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid studies with deletion mutants localized the areas of interaction in the interacting partner to its N-terminal domain and in filamin B to repeats 10-13.' Which disease is associated with the gene involved in ... | secondary neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02086","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLNB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid studies with deletion mutants locali... | |
medium_divergent_branch_02087 | EIF2S3 interacts with multiple proteins. One interaction partner is displaced by eIF2α upon binding to eIF2γ, thereby completing the assembly process. What protein is encoded by this interaction partner? | Translation initiation factor eIF2 assembly protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2S3 interacts with multiple proteins. One interaction partner is displaced by eIF2α upon binding to eIF2γ, thereby completing the assembly process... | |
medium_divergent_branch_02089 | NUP98 interacts with multiple proteins. One of these interaction partners has been experimentally shown to strongly interact with wild-type NUP98 and other nucleoporins containing FG repeats. Which protein, encoded by the gene connected to NUP98 via this specific interaction, is described by this evidence? | Dynein light chain Tctex-type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP98 interacts with multiple proteins. One of these interaction partners has been experimentally shown to strongly interact with wild-type NUP98 and... | |
medium_divergent_branch_02090 | HTRA2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using cleavage and binding assays, we have demonstrated that HtrA2 specifically binds to and directly cleaves the E3 ubiquitin (Ub) ligase [interacting gene].' Which disease is connected to this specific interacting gene th... | autosomal recessive juvenile Parkinson disease 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HTRA2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using cleavage and binding assays, we have demonstra... | |
medium_divergent_branch_02091 | CNOT7 interacts with multiple genes. One of these interaction partners is physically associated with rCAF-1 in the nucleus of contact-inhibited RSMCs, as demonstrated by co-immunoprecipitation with anti-hCAF-1 antisera. Which disease is linked to this specific interaction partner through genomic alterations? | acute leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNOT7 interacts with multiple genes. One of these interaction partners is physically associated with rCAF-1 in the nucleus of contact-inhibited RSMCs... | |
medium_divergent_branch_02092 | AKAP1 interacts with multiple genes. One of these interaction partners is involved in a quaternary complex in rat testis and HeLa cells, where AAT-1alpha binds to the N-terminal half of S-AKAP84 (also known as AKAP1) along with AMY-1 and the regulatory subunit (RII) of cAMP-dependent kinase (PKA), with AAT-1alpha assoc... | spermatogenic failure 51 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP1 interacts with multiple genes. One of these interaction partners is involved in a quaternary complex in rat testis and HeLa cells, where AAT-1a... | |
medium_divergent_branch_02093 | RUFY1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'An interactor screen for proteins that function together with rabip4' yielded the adaptor protein complex AP-3, of which the hinge region in the β3 subunit bound directly to the FYVE domain of rabip4'.' Identify the disease... | albinism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02093","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUFY1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'An interactor screen for proteins that function toge... | |
medium_divergent_branch_02094 | GBA interacts with multiple proteins. One specific interaction partner is characterized by its ability to interact with and ubiquitinate GCase at lysine 293, thereby controlling its degradation via the ubiquitin-proteasomal pathway. Which disease is associated with this specific interacting protein? | Clark-Baraitser syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GBA interacts with multiple proteins. One specific interaction partner is characterized by its ability to interact with and ubiquitinate GCase at lys... | |
medium_divergent_branch_02095 | GRK2 interacts with multiple genes. One of these interaction partners is reported to be in a pre-formed complex with PDEgamma, and stimulation of cells with epidermal growth factor promotes the association of GRK2 with this complex. Which biological process is connected to this specific interaction partner through the ... | visual perception | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02095","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRK2 interacts with multiple genes. One of these interaction partners is reported to be in a pre-formed complex with PDEgamma, and stimulation of cel... | |
medium_divergent_branch_02096 | HMGB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both proteins and have shown that HMG2 and Oct2 interact via their HMG domains and POU homeodomains, respectively.' Which disease is associated with the gene identified in this int... | extranodal nasal NK/T cell lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both prot... | |
medium_divergent_branch_02097 | EID1 interacts with multiple proteins. One of these interaction partners is reported to associate with EID1 and is a component of the CBP/p300-EID1 complex in embryonic stem cells (ESCs). Which protein is encoded by the gene corresponding to this specific interaction partner? | PCI domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EID1 interacts with multiple proteins. One of these interaction partners is reported to associate with EID1 and is a component of the CBP/p300-EID1 c... | |
medium_divergent_branch_02098 | RARA forms a binding complex with a specific nuclear hormone receptor. Evidence for this interaction cites the use of SAXS, SANS, and FRET to determine the solution structures of three heterodimer NHR complexes: RXR-RAR, PPAR-RXR, and RXR-VDR. Which disease is associated with this partner gene via a biomarker relations... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02098","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RARA forms a binding complex with a specific nuclear hormone receptor. Evidence for this interaction cites the use of SAXS, SANS, and FRET to determi... | |
medium_divergent_branch_02099 | BCL6 interacts with multiple proteins. One of these interaction partners has been shown to interact with the transcriptional activator Miz-1 and, through this association, bind to the promoter of the cell cycle arrest gene CDKN1A to suppress its transcription. Which protein is encoded by the gene corresponding to this ... | Zinc finger and BTB domain-containing protein 17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL6 interacts with multiple proteins. One of these interaction partners has been shown to interact with the transcriptional activator Miz-1 and, thr... | |
medium_divergent_branch_02100 | FOXG1 interacts with multiple proteins. One specific interaction partner is described in evidence stating: 'The survival-promoting activity of this protein depends critically on interaction with FoxG1, another protein involved in the regulation of neurogenesis and shown previously to promote survival of postmitotic neu... | fibrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02100","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXG1 interacts with multiple proteins. One specific interaction partner is described in evidence stating: 'The survival-promoting activity of this p... | |
medium_divergent_branch_02101 | The gene ID4 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Here, we use affinity purification of tagged [protein encoded by TCF3] combined with mass spectrometry in order to show that [protein encoded by TCF3] interacts with the entire ensemble of Id proteins, ... | Transcription factor E2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02101","source_qa_id":"medium_divergent_branch_02976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ID4 is known to interact with multiple partners. One specific interaction is supported b... | |
medium_divergent_branch_02102 | MYCN interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'this [protein]-mediated MYCN degradation may depend on the physical interaction between [protein] and MYCN'. Which disease is associated with this specific interacting protein via genomic alterations? | Malignant tumor of urinary bladder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02102","source_qa_id":"medium_divergent_branch_01036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYCN interacts with multiple proteins. One specific interaction is characterized by the following... | |
medium_divergent_branch_02103 | CCR1 is associated with multiple biological processes. One association is supported by evidence that CCR1 expression is sufficient to induce inhibition of cAMP formation, increased F-actin content, and basal migration of human and murine leukocytes. Which biological process is positively regulated by the process linked... | cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCR1 is associated with multiple biological processes. One association is supported by evidence that CCR1 expression is sufficient to induce inhibiti... | |
medium_divergent_branch_02104 | The biological process 'negative regulation of antimicrobial humoral response' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response. This process is a subtype of several broader biological processes. One of these parent processes is specifically ... | humoral immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02104","source_qa_id":"medium_divergent_branch_00808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of antimicrobial humoral response' is defined as any ... | |
medium_divergent_branch_02105 | EPS8 is known to bind to multiple gene products. One of these binding partners is described in literature with the statement: 'Similarly to eps8, eps8Ls interact with Abi1 and Sos-1'. Based on this contextual clue, which specific gene product does EPS8 bind to, and what is the gene that this binding partner subsequentl... | COPS3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPS8 is known to bind to multiple gene products. One of these binding partners is described in literature with the statement: 'Similarly to eps8, eps... | |
medium_divergent_branch_02106 | MAGEH1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ligand stimulation.' Which disease is causally linked to the gene identified in... | brain neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGEH1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we identify two MAGE proteins, necdin and MAGE-H1, as i... | |
medium_divergent_branch_02107 | Folliculin (FLCN) is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we show that the lysosome associated Birt-Hoge-Dubé (BHD) syndrome renal tumour suppressor folliculin (FLCN) regulates this process.' Identify the biological process described in this ev... | vacuolar localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02107","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Folliculin (FLCN) is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we show that th... | |
medium_divergent_branch_02108 | TOB2 interacts with multiple proteins. Experimental evidence from glutathione S-transferase pull-down and coimmunoprecipitation assays indicates that TOB can simultaneously interact with the poly(A) nuclease complex CCR4-CAF1 and the cytoplasmic poly(A)-binding protein. Which protein, identified as the cytoplasmic poly... | Polyadenylate-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOB2 interacts with multiple proteins. Experimental evidence from glutathione S-transferase pull-down and coimmunoprecipitation assays indicates that... | |
medium_divergent_branch_02109 | The gene TOP2A interacts with multiple other genes. One of these interaction partners is supported by evidence stating: 'In our studies of human topoisomerase II, we have found that a substantial fraction of the enzyme exists as alpha/beta heterodimers in HeLa cells.' Which protein is encoded by the gene that interacts... | DNA topoisomerase 2-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TOP2A interacts with multiple other genes. One of these interaction partners is supported by evidence stating: 'In our studies of human topo... | |
medium_divergent_branch_02110 | In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -1.305 and an adjusted p-value of 0.027. Which protein is encoded by this specific gene? | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -1.305 and a... | |
medium_divergent_branch_02112 | The protein Ro60 (encoded by the TROVE2 gene) interacts with multiple partners. One interaction is supported by evidence stating: 'The majority of these complexes contained Ro60 and [interacting partner], whereas only a small proportion of Ro52 appeared to be associated with Ro RNPs.' Which protein is encoded by the ge... | Lupus La protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein Ro60 (encoded by the TROVE2 gene) interacts with multiple partners. One interaction is supported by evidence stating: 'The majority of th... | |
medium_divergent_branch_02113 | RFFL interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting protein is recruited to damaged mitochondria, and this stable recruitment is substantially reduced in the absence of RFFL. Which protein, encoded by the gene connected to RFFL via this specific interaction, is d... | E3 ubiquitin-protein ligase parkin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFFL interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting protein is recruited to damaged mitochon... | |
medium_divergent_branch_02114 | P2RX7 is associated with multiple biological processes. One association is supported by evidence that P2X7 receptor stimulation activates anoctamin 6 (ANO6/TMEM16F), a protein functioning as a Ca(2+)-dependent phospholipid scramblase and Ca(2+)-activated Cl(-) channel. Which biological process, connected to the process... | monoatomic ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"P2RX7 is associated with multiple biological processes. One association is supported by evidence that P2X7 receptor stimulation activates anoctamin 6... | |
medium_divergent_branch_02115 | The gene MYB is known to interact with multiple protein partners. One specific interaction is supported by evidence stating: 'Here we report that a specific transcriptional corepressor directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation.' Based on this evidence, which protein partner... | Transcription intermediary factor 1-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYB is known to interact with multiple protein partners. One specific interaction is supported by evidence stating: 'Here we report that a s... | |
medium_divergent_branch_02116 | GLIPR2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our study demonstrates that GLIPR-2 overexpression in HK-2 cells can potentiate EMT-like processes in this cell type through the ERK1/2 signaling pathway.' Identify the biological process that is positively regul... | epithelial to mesenchymal transition | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLIPR2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our study demonstrates that GLIPR-2 overe... | |
medium_divergent_branch_02117 | SLC27A2 interacts with multiple genes. One of these interacting partners is identified by evidence stating: 'Studies using a yeast two hybrid system and surface plasmon resonance techniques indicate that a peroxisomal membrane protein, physically interacts with VLCS.' Which disease is associated with this specific inte... | adrenoleukodystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC27A2 interacts with multiple genes. One of these interacting partners is identified by evidence stating: 'Studies using a yeast two hybrid system ... | |
medium_divergent_branch_02118 | PPP1R15A (GADD34) interacts with multiple genes. One specific interaction is supported by evidence describing the in vitro association of GADD34 with glutathione S-transferase fusion proteins containing the Src Homology 3 (SH3) domain of the interacting partner, as well as coimmunoprecipitation of GADD34 and that partn... | autoinflammatory disease, systemic, with vasculitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02118","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP1R15A (GADD34) interacts with multiple genes. One specific interaction is supported by evidence describing the in vitro association of GADD34 with... | |
medium_divergent_branch_02119 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.650 and an adjusted p-value of 0.0418. Which protein does that selected gene encode? | Sushi domain-containing protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02119","source_qa_id":"medium_divergent_branch_06786","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_02121 | MIR106A is associated with multiple biological processes. One association is supported by evidence that exogenous expression of miR-106a significantly represses IL-8 expression at both mRNA and protein levels in PBMCs, whereas a miR-106a inhibitor has the opposite effect. Which biological process, connected to the proc... | interleukin-8 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR106A is associated with multiple biological processes. One association is supported by evidence that exogenous expression of miR-106a significantl... | |
medium_divergent_branch_02123 | IFITM5 is associated with multiple biological processes. One association is supported by evidence that Osteogenesis imperfecta (OI) types V and VI are caused by mutations in IFITM5, which encodes BRIL, a transmembrane protein most strongly expressed in the skeletal system. Which biological process, connected to the pro... | animal organ morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02123","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFITM5 is associated with multiple biological processes. One association is supported by evidence that Osteogenesis imperfecta (OI) types V and VI ar... | |
medium_divergent_branch_02124 | DTX3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using this probe, we identified the E3 ligase DTX3 as an E2-selective probe target and demonstrated that DTX3 forms a thioester-linked intermediate with the interacting partner.' Which disease is associated with this specific interac... | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DTX3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using this probe, we identified the E3 ligase DTX3 as an E2-se... | |
medium_divergent_branch_02125 | FUT9 is associated with multiple biological processes. One association is supported by evidence stating: 'In this case, the third α1,3-fucosyltransferase played an important role because leukocyte adhesion was reduced by 50-60% in FUT9-HL-60, 70-80% in dual knockdown FUT7(-)9(-) cells, and ∼85% in FUT4(-)7(-)9(-) tripl... | regulation of cell-cell adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FUT9 is associated with multiple biological processes. One association is supported by evidence stating: 'In this case, the third α1,3-fucosyltransfe... | |
medium_divergent_branch_02126 | GABARAP interacts with multiple proteins. One interaction is supported by evidence stating: 'Through biophysical analyses, we confirm impaired binding of the L341V-AIM mutant to LC3A, LC3B, the shared protein, and GABARAPL1.' Which protein, encoded by the gene connected to GABARAP via this interaction, is the shared pr... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAP interacts with multiple proteins. One interaction is supported by evidence stating: 'Through biophysical analyses, we confirm impaired bindin... | |
medium_divergent_branch_02127 | ERCC8 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'In addition to interacting with XPA, immunoprecipitation experiments demonstrated that a fraction of this protein is able to interact with the transcription-coupled repair-specific proteins CSA and CSB as ... | Pre-mRNA-splicing factor SYF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC8 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'In addition to interacting with XP... | |
medium_divergent_branch_02128 | RNF19A interacts with multiple proteins. One of these interaction partners is a protein that, when mutated, is linked to a specific neurodegenerative disease and is specifically bound and ubiquitylated by the E3 ligase Dorfin, leading to its degradation. Which protein is encoded by the gene corresponding to this intera... | Superoxide dismutase [Cu-Zn] | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF19A interacts with multiple proteins. One of these interaction partners is a protein that, when mutated, is linked to a specific neurodegenerative... | |
medium_divergent_branch_02129 | PEX1 interacts with multiple proteins. Evidence indicates that one of these interacting partners co-immunoprecipitates with PEX1 and PEX6, which are members of the AAA ATPase family. Which protein is this interacting partner? | Peroxisome assembly protein 26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEX1 interacts with multiple proteins. Evidence indicates that one of these interacting partners co-immunoprecipitates with PEX1 and PEX6, which are ... | |
medium_divergent_branch_02130 | The gene HAVCR2 is enriched in multiple cell types. One specific cell type shows a mean expression of 106.11 TPM, a z-score of 1.75, and a fold enrichment of 5.89. Which broader cell category is this specific cell type a subtype of? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02130","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HAVCR2 is enriched in multiple cell types. One specific cell type shows a mean expression of 106.11 TPM, a z-score of 1.75, and a fold enric... | |
medium_divergent_branch_02131 | TNFAIP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein and TRAF2 interact with A20, a zinc finger protein, whose expression is induced by agents that activate NF-kappaB.' Which protein is encoded by the gene corresponding to this interaction partner? | TNF receptor-associated factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFAIP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein and TRAF2 interact with A... | |
medium_divergent_branch_02132 | RIG-I (encoded by DDX58) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation showed that a protein kinase encoded by PRKCA interacts with RIG-I under normal conditions, leading to its phosphorylation, which suppresses TRIM25 binding, RIG-I CARD ubiquitinat... | Protein kinase C alpha type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIG-I (encoded by DDX58) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation showed t... | |
medium_divergent_branch_02134 | Angiotensinogen (AGT) is involved in multiple biological processes. One such process is supported by evidence that rats harboring human renin and angiotensinogen genes (dTGR) exhibit angiotensin II/hypertension-induced cardiac damage. Which biological process is a part of the biological process linked to AGT by this sp... | blood circulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Angiotensinogen (AGT) is involved in multiple biological processes. One such process is supported by evidence that rats harboring human renin and ang... | |
medium_divergent_branch_02135 | Calsyntenin-1 (CLSTN1) interacts with multiple proteins. One specific interaction is described as a direct binding between calsyntenin-1 and the light chain of Kinesin-1. Which gene encodes this Kinesin-1 light chain protein? | Kinesin light chain 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02135","source_qa_id":"medium_divergent_branch_04334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Calsyntenin-1 (CLSTN1) interacts with multiple proteins. One specific interaction is described as... | |
medium_divergent_branch_02136 | USP4 interacts with multiple genes. One specific interaction is characterized by evidence stating that the partner protein binds USP4 at the opposite surface of the HAT-C dimer interface, utilizing the β-structured linker between the DUSP and the UBL domains. Which disease is associated with this specific interacting p... | urinary bladder neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP4 interacts with multiple genes. One specific interaction is characterized by evidence stating that the partner protein binds USP4 at the opposite... | |
medium_divergent_branch_02137 | UBE2N interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Peptide mass fingerprinting analysis reveals that this complex is composed of the ubiquitin conjugating enzyme Ubc13 and the Ubc-like protein [protein encoded by the gene in question].' Which protein, linked to UBE2N by ... | Ubiquitin-conjugating enzyme E2 variant 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02137","source_qa_id":"medium_divergent_branch_00376","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UBE2N interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_02138 | NFKB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a ribosomal protein, a KH domain protein, as a non-Rel subunit of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically enhances DNA binding.' Which protein is encoded by the gene correspo... | Small ribosomal subunit protein uS3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a ribosomal protein, a KH domain protein, as... | |
medium_divergent_branch_02139 | IRF3 interacts with multiple proteins. One of these interaction partners is targeted by the small molecule KYA1797K, which binds to its RGS domain, enhances the interaction with IRF3, and promotes the elimination of various highly pathogenic viruses. Which protein is this interaction partner? | Axin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF3 interacts with multiple proteins. One of these interaction partners is targeted by the small molecule KYA1797K, which binds to its RGS domain, e... | |
medium_divergent_branch_02140 | CRYAA interacts with multiple genes. One specific interaction is supported by evidence stating: 'For the R116C alphaA-crystallin, the interactions with betaB2- and gammaC-crystallin decreased and those with alphaB-crystallin and heat-shock protein (Hsp)27 increased.' Which disease is connected to the gene identified by... | atrial tachycardia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRYAA interacts with multiple genes. One specific interaction is supported by evidence stating: 'For the R116C alphaA-crystallin, the interactions wi... | |
medium_divergent_branch_02141 | BTBD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interactions were confirmed by co-precipitation assays demonstrating the physical interaction of BTBD1 and BTBD2 with 100 kDa topoisomerase I from HeLa cells.' Which protein is encoded by the gene that interacts with... | DNA topoisomerase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTBD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interactions were confirmed by co-precipitati... | |
medium_divergent_branch_02142 | GSK3B interacts with multiple proteins. One interaction is characterized by the statement: 'In addition, we show that the Ser/Thr rich cluster of this protein plays an important role in its binding to GSK3beta.' Which protein, connected to GSK3B via this specific binding evidence, is the gene product of the gene connec... | Low-density lipoprotein receptor-related protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSK3B interacts with multiple proteins. One interaction is characterized by the statement: 'In addition, we show that the Ser/Thr rich cluster of thi... | |
medium_divergent_branch_02143 | The gene IKBKG interacts with multiple proteins. One specific interaction was confirmed by co-immunoprecipitation and was found to be abrogated by panr2. Which protein product is encoded by the gene corresponding to this specific interacting partner? | Sharpin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKG interacts with multiple proteins. One specific interaction was confirmed by co-immunoprecipitation and was found to be abrogated by pa... | |
medium_divergent_branch_02144 | SHC1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report the identification of an interaction between the adapter protein ShcA and the cytoplasmic domain of a receptor tyrosine kinase through in vitro co-immunoprecipitation analysis.' Which protein, encoded by th... | Angiopoietin-1 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02144","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHC1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report the identification of an interactio... | |
medium_divergent_branch_02145 | The insulin receptor (INSR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In vitro both domains bind directly to activated insulin receptors.' Identify the cellular component where the protein involved in this specific interaction is primarily located. | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The insulin receptor (INSR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In vitro both domains bind ... | |
medium_divergent_branch_02146 | The NF2 gene interacts with multiple partners. One specific interaction involves Merlin being recruited to an E3 ligase complex following serum stimulation via a direct interaction with a WD40-containing adaptor protein. Identify the disease associated with this adaptor protein through a biomarker relationship. | prostate carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NF2 gene interacts with multiple partners. One specific interaction involves Merlin being recruited to an E3 ligase complex following serum stimu... | |
medium_divergent_branch_02147 | ASF1B interacts with multiple proteins. Evidence for one of these interactions states: 'The N- and C-terminal regions of ASF1a and ASF1b determine the different affinities of these two proteins for this interaction partner, by contacting regions outside the B domain of this interaction partner.' Which protein is encode... | Protein HIRA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASF1B interacts with multiple proteins. Evidence for one of these interactions states: 'The N- and C-terminal regions of ASF1a and ASF1b determine th... | |
medium_divergent_branch_02148 | The protein DISP3 is associated with multiple biological processes. One association is supported by evidence stating: 'We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis.' Identify the biological process that is positively regulated by... | neural precursor cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein DISP3 is associated with multiple biological processes. One association is supported by evidence stating: 'We found that ectopically expr... |
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