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medium_divergent_branch_03180 | The gene SNX24 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 3.46 TPM, a z-score of 1.94, and a fold enrichment of 3.98. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SNX24 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 3.46 TPM, a z-score of 1.94, and a fold enri... | |
medium_divergent_branch_03181 | TGFBR1 interacts with multiple proteins. One of these interaction partners is described as a deubiquitylating enzyme that directly binds to TβRI to regulate its levels at the plasma membrane. Which protein is encoded by the gene corresponding to this specific interaction partner? | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFBR1 interacts with multiple proteins. One of these interaction partners is described as a deubiquitylating enzyme that directly binds to TβRI to r... | |
medium_divergent_branch_03182 | Xist regulates more than one cell type. Evidence for one of these regulatory connections reports that Xist induction in four transgenic clones reproducibly corrected the over-production of the target cell and erythrocytes, which are key to Down syndrome myeloproliferative disorder and leukemia. Which cell type, connect... | megakaryocyte progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03182","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Xist regulates more than one cell type. Evidence for one of these regulatory connections reports that Xist induction in four transgenic clones reprod... | |
medium_divergent_branch_03183 | NOTCH4 is associated with multiple biological processes. One specific association is supported by evidence stating that the Notch4(int-3) mammary oncoprotein, an activated form of the Notch4 receptor, inhibited the branching morphogenesis normally induced by HGF and TGF-beta 2. Which anatomical structure is the result ... | mammary gland | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH4 is associated with multiple biological processes. One specific association is supported by evidence stating that the Notch4(int-3) mammary onc... | |
medium_divergent_branch_03184 | TWIST2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the N-terminal domain of ADD1/SREBP1c as bait, we identified Twist2 (also known as Dermo-1), a basic helix-loop-helix (bHLH) protein, as a novel ADD1/SREBP1c interacting protein.' Which protein is encoded by the gene that ... | Sterol regulatory element-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TWIST2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the N-terminal domain of ADD1/SREBP1c as bait, we i... | |
medium_divergent_branch_03185 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.314 and an adjusted p-value of 0.0389. Which protein does that selected gene encode? | Zinc finger protein 418 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03185","source_qa_id":"medium_divergent_branch_02501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_03186 | MAD2L1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Upon the completion of spindle attachment, formation of the [interacting protein]-MAD2 complex coincides with dissociation of the p55CDC-MAD2 complex.' Which disease is associated with the gene identified by this evidence... | Charcot-Marie-Tooth disease axonal type 2L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAD2L1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Upon the completion of spindle attachment, formati... | |
medium_divergent_branch_03187 | The gene GRIN2B interacts with multiple partners. One specific interaction is supported by evidence stating that the partner protein and phosphorylated NMDAR2B are physically associated, as demonstrated by co-immunoprecipitation, confocal immunofluorescence, and proximity ligation assays. Which protein is encoded by th... | Hepatocyte growth factor receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03187","source_qa_id":"medium_divergent_branch_07163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GRIN2B interacts with multiple partners. One specific interaction is supported by eviden... | |
medium_divergent_branch_03188 | DUOX2 is associated with multiple biological processes. One specific association is supported by evidence stating that alterations of the DUOXA2 NH(2)-terminal domain modify DUOX2 activity, triggering superoxide leaking. Which biological process, connected to the process implicated by this evidence via an 'is a' relati... | superoxide metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DUOX2 is associated with multiple biological processes. One specific association is supported by evidence stating that alterations of the DUOXA2 NH(2... | |
medium_divergent_branch_03189 | The COPA protein interacts with multiple partners. One interaction is supported by evidence stating: 'Here we show that SMN directly binds to the α-subunit of the coat protein I (COPI) vesicle coat protein.' Which protein is encoded by the gene corresponding to this specific interacting partner? | Survival motor neuron protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The COPA protein interacts with multiple partners. One interaction is supported by evidence stating: 'Here we show that SMN directly binds to the α-s... | |
medium_divergent_branch_03190 | The molecular function 'acetylcholine-gated monoatomic cation-selective channel activity' is defined by the evidence: 'Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.' This function is a subtype of a broader molecular function. Which biological process is t... | chemical synaptic transmission, postsynaptic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03190","source_qa_id":"medium_divergent_branch_01206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The molecular function 'acetylcholine-gated monoatomic cation-selective channel activity' is defi... | |
medium_divergent_branch_03191 | GABARAPL1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it and another related entity employ ATG8 family-interacting motifs to bind preferentially to GABARAP proteins. Which protein is connected to the gene GABARAPL1 through the 'interacts with' relationsh... | Kelch repeat and BTB domain-containing protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it and another related entity... | |
medium_divergent_branch_03192 | The gene IKZF1 interacts with multiple partners. One specific interaction is supported by evidence stating that Ikaros and its repression domains interact in vivo and in vitro with the mSin3 family of co-repressors, which bind to histone deacetylases. Which protein is encoded by the gene involved in this specific inter... | Paired amphipathic helix protein Sin3a | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03192","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKZF1 interacts with multiple partners. One specific interaction is supported by evidence stating that Ikaros and its repression domains int... | |
medium_divergent_branch_03193 | Human respirovirus 3 upregulates multiple genes. One such upregulation event is characterized by a log2 fold change of approximately 1.12 and an adjusted p-value of 0.0493. Which disease is associated with this specific upregulated gene via a biomarker relationship? | Borjeson-Forssman-Lehmann syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human respirovirus 3 upregulates multiple genes. One such upregulation event is characterized by a log2 fold change of approximately 1.12 and an adju... | |
medium_divergent_branch_03194 | HBEGF interacts with multiple genes. One of these interactions is supported by evidence from Yeast co-transformation and co-immunoprecipitation assays. Which disease is causally linked to the gene identified by this specific experimental evidence? | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HBEGF interacts with multiple genes. One of these interactions is supported by evidence from Yeast co-transformation and co-immunoprecipitation assay... | |
medium_divergent_branch_03195 | The gene AMPH interacts with multiple partners. One specific interaction is described by the statement: 'We show here that amphiphysin 1 interacts with the cdk5-activating subunit [interaction partner] and that this interaction is mediated by the conserved NH2-terminal region of amphiphysin.' Which protein is encoded b... | Cyclin-dependent kinase 5 activator 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AMPH interacts with multiple partners. One specific interaction is described by the statement: 'We show here that amphiphysin 1 interacts wi... | |
medium_divergent_branch_03196 | CDKN3 interacts with multiple proteins. One interaction is supported by evidence stating that Co-immunoprecipitation and western blot results confirmed that the interacting partner could interact with and abate the ubiquitination level of CDKN3, thus stabilizing the CDKN3 protein. Which protein is this interacting part... | 26S proteasome non-ATPase regulatory subunit 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN3 interacts with multiple proteins. One interaction is supported by evidence stating that Co-immunoprecipitation and western blot results confirm... | |
medium_divergent_branch_03197 | The protein encoded by the gene TNFSF13B (also known as TALL-1) interacts with multiple binding partners. One specific interaction is supported by structural evidence stating: 'Here we determine the crystal structures of sTALL-1 complexed with the extracellular domains of BCMA and BAFF-R at 2.6 and 2.5 A, respectively.... | Tumor necrosis factor receptor superfamily member 13C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein encoded by the gene TNFSF13B (also known as TALL-1) interacts with multiple binding partners. One specific interaction is supported by st... | |
medium_divergent_branch_03198 | CDAN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Codanin-1 is part of a cytosolic Asf1-H3.1-H4-Importin-4 complex and binds directly to Asf1 via a conserved B-domain, implying a mutually exclusive interaction with the chaperones CAF-1 and HIRA.' Which protein, linked t... | Histone chaperone ASF1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03198","source_qa_id":"medium_divergent_branch_04486","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CDAN1 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_03200 | The protein CAV3 is associated with multiple biological processes. One association is supported by evidence that overexpression of Cav-3 in neonatal mouse ventricular myocytes inhibits the peak T-type calcium current (I(Ca,T)). Identify the biological process that is directly regulated by the process linked to this spe... | calcium ion import | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03200","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CAV3 is associated with multiple biological processes. One association is supported by evidence that overexpression of Cav-3 in neonatal ... | |
medium_divergent_branch_03201 | ANKRA2 interacts with multiple genes. Evidence indicates that one of these interaction partners is a major partner of ANKRA2 in cells, but is not RFXANK. Which disease is associated with this specific interaction partner? | 3M syndrome 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03201","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKRA2 interacts with multiple genes. Evidence indicates that one of these interaction partners is a major partner of ANKRA2 in cells, but is not RFX... | |
medium_divergent_branch_03202 | OTULIN interacts with multiple proteins. One interaction partner is described as 'Gumby', which is also known by a synonym for the gene RNF31. This entity is a key component of the linear ubiquitin assembly complex (LUBAC) and its interaction with OTULIN decreases linear ubiquitination and activation of NF-κB-dependent... | E3 ubiquitin-protein ligase RNF31 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTULIN interacts with multiple proteins. One interaction partner is described as 'Gumby', which is also known by a synonym for the gene RNF31. This e... | |
medium_divergent_branch_03203 | IRS1 interacts with multiple proteins. One specific interaction involves SH2-B binding, via its PH and SH2 domains, to both IRS1 and IRS2 in vitro and in intact cells, mediating the formation of a tertiary complex containing the interacting partner, SH2-B, and either IRS1 or IRS2. Which protein, encoded by the gene con... | Tyrosine-protein kinase JAK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03203","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS1 interacts with multiple proteins. One specific interaction involves SH2-B binding, via its PH and SH2 domains, to both IRS1 and IRS2 in vitro an... | |
medium_divergent_branch_03204 | PYROXD2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The results showed that PYROXD2 was imported to the mitochondrial inner membrane/matrix by Tom40 and Tim23, but not Mia40.' Which cellular component is linked to the spe... | mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03204","source_qa_id":"medium_divergent_branch_00830","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PYROXD2 is associated with multiple cellular components via the 'located in' relationship. One sp... | |
medium_divergent_branch_03205 | FOXA1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Mechanistically, our results demonstrated that the interacting partner directly bound and ubiquitylated Forkhead box protein A1 (FOXA1), an important transcriptional repressor of EMT process.' Which disease is ass... | Malignant tumor of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXA1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Mechanistically, our results demonstrated ... | |
medium_divergent_branch_03206 | hsa-miR-126-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that inhibition of miR-126-5p in the selected cell type from chronic HIV-1 patients attenuated the responsiveness of these cells to lipopolysaccharide (LPS) stimulation. Which cell type is connected to the selec... | promonocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-126-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that inhibition of miR-126-5p in the sel... | |
medium_divergent_branch_03207 | GNB2 interacts with multiple G gamma subunits. One specific interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the Gbetag... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB2 interacts with multiple G gamma subunits. One specific interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital rol... | |
medium_divergent_branch_03208 | SCUBE1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence describing SCUBE1 as a secreted glycoprotein that forms oligomers and exhibits a stable association with the cell surface. Which cellular component is connected to this specific l... | extracellular region | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCUBE1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence describi... | |
medium_divergent_branch_03209 | The gene NR5A1 is involved in multiple biological processes. One of these processes is supported by evidence stating that loss-of-function changes in NR5A1 in 46,XY individuals are associated with a spectrum of phenotypes in humans ranging from a lack of testis formation to male infertility. Which biological process is... | gonad development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR5A1 is involved in multiple biological processes. One of these processes is supported by evidence stating that loss-of-function changes in... | |
medium_divergent_branch_03210 | VASH1 is associated with multiple biological processes. One association is supported by evidence that Vasohibin1 exhibits broad-spectrum antilymphangiogenic activity in the mouse cornea, inhibiting responses to factors such as VEGF-A, VEGF-C, FGF2, and PDGF-BB. Which biological process is negatively regulated by the sp... | lymphangiogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03210","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VASH1 is associated with multiple biological processes. One association is supported by evidence that Vasohibin1 exhibits broad-spectrum antilymphang... | |
medium_divergent_branch_03211 | ERBB4 interacts with multiple genes. One of these interaction partners is a transcription factor whose soluble intracellular domain, when released from the JM-a isoform of ERBB4 (but not the JM-b isoform), associates with AP-2 and enhances PDGFRA transcription. Which cellular component is this specific interaction part... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB4 interacts with multiple genes. One of these interaction partners is a transcription factor whose soluble intracellular domain, when released fr... | |
medium_divergent_branch_03212 | ARRB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In A549 lung carcinoma cells, cellular β-arrestin1/2 associated with a specific kinase and maintained the protein level of this kinase at a low level by recruiting the E3 ligase NEDD4L and facilitating consequent proteasom... | eIF-2-alpha kinase GCN2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARRB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In A549 lung carcinoma cells, cellular β-arrestin1/... | |
medium_divergent_branch_03213 | The gene PIK3CB is associated with multiple biological processes. One specific association is supported by evidence stating that PI3Kβ plays a significant role in platelets, functioning downstream of ITAM signaling, G protein-coupled receptors, and the αIIbβ3 integrin. Based on this evidence, which biological process i... | cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PIK3CB is associated with multiple biological processes. One specific association is supported by evidence stating that PI3Kβ plays a signif... | |
medium_divergent_branch_03214 | TNK2 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate ACK binds to all five PI3K regulatory subunit isoforms and directly phosphorylates the alpha, beta, 50-alpha, and 55-alpha isoforms on Tyr607 (or analogous residues).' Which protein is encoded by the gene connected to ... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNK2 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate ACK binds to all five PI3K regulatory subunit i... | |
medium_divergent_branch_03215 | ZBTB7A interacts with multiple proteins. One interaction is supported by evidence stating: 'Mechanistically, we show that LRF binds and stabilizes the catalytic subunit of DNA-dependent protein kinase on DSBs, in turn favouring DNA-PK activity.' Which protein, encoded by the gene interacting with ZBTB7A in this specifi... | DNA-dependent protein kinase catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03215","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB7A interacts with multiple proteins. One interaction is supported by evidence stating: 'Mechanistically, we show that LRF binds and stabilizes th... | |
medium_divergent_branch_03216 | SQSTM1 interacts with multiple proteins. One specific interaction is characterized by the finding that 'Remarkably, not only the mutant protein, but also wild-type [the interacting partner] interacts with SQSTM1, as shown by proximity ligation assays and co-immunoprecipitation experiments.' Which disease is associated ... | amyotrophic lateral sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SQSTM1 interacts with multiple proteins. One specific interaction is characterized by the finding that 'Remarkably, not only the mutant protein, but ... | |
medium_divergent_branch_03217 | RFWD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified a key regulator of mammalian autophagy, as a novel COP1-interacting protein by yeast two-hybrid screening.' Which protein, connected to RFWD2 via this specific evidence, is the gene that encodes the protein in... | RB1-inducible coiled-coil protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFWD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified a key regulator of mammalian autophagy... | |
medium_divergent_branch_03218 | PTPN23 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'HD-PTP, an ESCRT protein, forms complexes with ESCRT-0, -I and -III proteins, and binds to Endofin, a FYVE-domain protein confined to endosomes with poorly understood roles.' Identify the gene that is linked ... | RHOD | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03218","source_qa_id":"medium_divergent_branch_06821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTPN23 is reported to interact with multiple genes. One specific interaction is supported by evid... | |
medium_divergent_branch_03219 | Activating transcription factor 4 (ATF4) interacts with multiple proteins. One specific interaction was identified using a yeast-two-hybrid assay, where ATF4 was found to bind to SKIP3. Which protein is encoded by the gene corresponding to this SKIP3-binding partner? | Tribbles homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03219","source_qa_id":"medium_divergent_branch_03297","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Activating transcription factor 4 (ATF4) interacts with multiple proteins. One specific interacti... | |
medium_divergent_branch_03220 | UBE2L3 interacts with multiple E3 ubiquitin ligases. One specific interaction is characterized by the finding that the E3 ligase interacts with the E2 enzyme UBE2L3 and promotes its autoubiquitination. Which protein is encoded by the gene corresponding to this specific E3 ligase? | E3 ubiquitin-protein ligase TRIP12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03220","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2L3 interacts with multiple E3 ubiquitin ligases. One specific interaction is characterized by the finding that the E3 ligase interacts with the E... | |
medium_divergent_branch_03221 | The protein RPS4Y1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Using isoform-specific antisera, we determined that human S4X and S4Y are both present in translationally active ribosomes.' Based on this evidence, identify ... | enucleated reticulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RPS4Y1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by eviden... | |
medium_divergent_branch_03222 | Optineurin (OPTN) interacts with multiple proteins. Evidence for one specific interaction states: 'A non-catalytic region of this protein is required for direct interaction with optineurin.' What is the name of the protein encoded by the gene corresponding to this interaction partner? | TBC1 domain family member 17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Optineurin (OPTN) interacts with multiple proteins. Evidence for one specific interaction states: 'A non-catalytic region of this protein is required... | |
medium_divergent_branch_03223 | COMMD1 interacts with multiple proteins. One interaction is described by the statement: 'Here we demonstrate that the Wilson disease protein directly interacts with the human homologue of Murr1 in vitro and in vivo and that this interaction is mediated via the copper binding, amino terminus of this ATPase.' Which prote... | Copper-transporting ATPase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD1 interacts with multiple proteins. One interaction is described by the statement: 'Here we demonstrate that the Wilson disease protein directly... | |
medium_divergent_branch_03224 | The gene pair KLRC4-KLRK1 is enriched in multiple cell types. One specific cell type associated with this enrichment exhibits a mean expression of 26.61 TPM, a z-score of 1.59, and a fold enrichment of 3.86. Which cell type is the developmental precursor (connected via 'develops from') to this specific cell? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene pair KLRC4-KLRK1 is enriched in multiple cell types. One specific cell type associated with this enrichment exhibits a mean expression of 26... | |
medium_divergent_branch_03225 | SCUBE1 is implicated in multiple biological processes. One specific process is supported by evidence stating that SCUBE1 and SCUBE2 form a family of secreted proteins expressed in vascular endothelium, playing roles in development, inflammation, and thrombosis. Which cell type is associated with this specific biologica... | platelet | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03225","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCUBE1 is implicated in multiple biological processes. One specific process is supported by evidence stating that SCUBE1 and SCUBE2 form a family of ... | |
medium_divergent_branch_03227 | VAMP7 is reported to interact with multiple genes. One specific interaction is described by the evidence: 'Second, it interacts with the adaptor complex AP-3 and this interaction targets TI-VAMP to late endosomes.' Identify the gene involved in this specific interaction and determine which disease is linked to that gen... | albinism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03227","source_qa_id":"medium_divergent_branch_07229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"VAMP7 is reported to interact with multiple genes. One specific interaction is described by the e... | |
medium_divergent_branch_03229 | The gene CAMK2G is associated with multiple biological processes. One association is supported by evidence stating: 'We found that knockdown of CAMK2G results in inappropriate precocious neuronal maturation.' Identify the biological process that is a parent term (via an 'is a' relationship) of the process linked to CAM... | regulation of plasma membrane bounded cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CAMK2G is associated with multiple biological processes. One association is supported by evidence stating: 'We found that knockdown of CAMK2... | |
medium_divergent_branch_03230 | NFE2L2 interacts with multiple proteins. One specific interaction is characterized by the partner protein acting as an E3 ligase that facilitates the downregulation of NRF2 via the ubiquitination-degradation pathway, with the QSLVPDI motif on NRF2 serving as the active site for this binding. Which protein, encoded by t... | E3 ubiquitin-protein ligase synoviolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03230","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L2 interacts with multiple proteins. One specific interaction is characterized by the partner protein acting as an E3 ligase that facilitates the... | |
medium_divergent_branch_03231 | The gene SKI interacts with multiple partners. One interaction is described by the following evidence: 'Here we show that Ski interacts with a lineage-specific transcription factor essential for terminal myeloid differentiation, and thereby represses its dependent transcriptional activation.' Which protein is encoded b... | Transcription factor PU.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03231","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SKI interacts with multiple partners. One interaction is described by the following evidence: 'Here we show that Ski interacts with a lineag... | |
medium_divergent_branch_03232 | Hepatocytes are connected to a specific cell type via an 'is a' relationship. Evidence for this connection states: 'The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, ar... | eukaryotic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Hepatocytes are connected to a specific cell type via an 'is a' relationship. Evidence for this connection states: 'The main structural component of ... | |
medium_divergent_branch_03233 | The protein CCDC61 is associated with multiple molecular functions. One specific function is supported by experimental evidence stating: 'Furthermore, we show that CCDC61 binds microtubules.' Which molecular function, connected to this specific function via an 'is a' relationship, is the correct answer? | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CCDC61 is associated with multiple molecular functions. One specific function is supported by experimental evidence stating: 'Furthermore... | |
medium_divergent_branch_03234 | Trimethoprim is known to interact with several substances. One specific interaction involves a substance that, when consumed by patients taking the combination of trimethoprim and sulfamethoxazole (cotrimoxazole), can trigger a reaction similar to that caused by disulfiram. What condition is this interacting substance ... | trigeminal neuralgia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03234","source_qa_id":"medium_divergent_branch_07456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Trimethoprim is known to interact with several substances. One specific interaction involves a su... | |
medium_divergent_branch_03237 | Neurturin (NRTN) is reported to bind to multiple proteins. One specific piece of evidence states: 'Here we report that neurturin can bind to either GFRalpha-1 or GFRalpha-2, a novel receptor related to GFRalpha-1.' Based on this evidence, which protein is the binding partner of NRTN that is encoded by the gene in quest... | GDNF family receptor alpha-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03237","source_qa_id":"medium_divergent_branch_03386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Neurturin (NRTN) is reported to bind to multiple proteins. One specific piece of evidence states:... | |
medium_divergent_branch_03238 | ABI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also show that Eps8, E3b1 and Sos-1 form a tri-complex in vivo that exhibits Rac-specific GEF activity in vitro.' Which protein, connected to ABI1 via this specific evidence, is the gene that encodes the protein product associa... | Son of sevenless homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also show that Eps8, E3b1 and Sos-1 form a tri-complex i... | |
medium_divergent_branch_03239 | PIAS1 interacts with multiple proteins. One interaction was identified in a study where a specific protein was used as bait in a yeast two-hybrid screen to find additional associated proteins, resulting in the identification of a SUMO E3 ligase as an interaction partner. Which protein product is encoded by the gene cor... | CASP8-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03239","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS1 interacts with multiple proteins. One interaction was identified in a study where a specific protein was used as bait in a yeast two-hybrid scr... | |
medium_divergent_branch_03240 | AKAP5 interacts with multiple gene products via binding interactions. One specific interaction is supported by evidence stating that AKAP-IS associates with the type II PKA holoenzyme inside cells and displaces the kinase from natural anchoring sites. Which protein is encoded by the gene product involved in this specif... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP5 interacts with multiple gene products via binding interactions. One specific interaction is supported by evidence stating that AKAP-IS associat... | |
medium_divergent_branch_03241 | CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data indicate that IL-6 induces a STAT3.CDK9 complex mediated by bivalent STAT3 domains and CDK9 kinase activity is necessary for licensing Pol II to enter a transcriptional elongation mode.' Which biological p... | response to cytokine | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data indicate that IL-6 induces a STAT3... | |
medium_divergent_branch_03243 | Heterochromatin is a component of multiple cell types. One such cell is a neutrophil precursor in the granulocytic series, defined as an intermediate stage between a myelocyte and a band form neutrophil. In this stage, protein synthesis decreases or ceases, the nucleus becomes indented (with the indentation being less ... | neutrophilic myelocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Heterochromatin is a component of multiple cell types. One such cell is a neutrophil precursor in the granulocytic series, defined as an intermediate... | |
medium_divergent_branch_03244 | The retinoblastoma protein (RB1) interacts with multiple partners. One specific interaction partner is characterized by evidence showing that pRB mutants lacking the LXCXE binding site retain the ability to interact with this partner, which is a transcriptional corepressor containing LXCXE-like sequences. Which disease... | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03244","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The retinoblastoma protein (RB1) interacts with multiple partners. One specific interaction partner is characterized by evidence showing that pRB mut... | |
medium_divergent_branch_03245 | EPB41L2 interacts with multiple genes. One interaction is supported by evidence stating: 'The C-terminal region of erythroid cytoskeletal protein 4.1R, encoded by exons 20 and 21, contains a binding site for nuclear mitotic apparatus protein, a protein needed for the formation and stabilization of the mitotic spindle.'... | acute promyelocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03245","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPB41L2 interacts with multiple genes. One interaction is supported by evidence stating: 'The C-terminal region of erythroid cytoskeletal protein 4.1... | |
medium_divergent_branch_03246 | SUB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using a yeast two-hybrid screen to identify factors that interact with the polyadenylation factor [CSTF2 protein], we uncovered an interaction with the transcriptional coactivator PC4.' Which protein is encoded by the gene ... | Cleavage stimulation factor subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03246","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using a yeast two-hybrid screen to identify factors ... | |
medium_divergent_branch_03247 | LIN54 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating: 'Protein interaction studies demonstrated that a predicted helix-coil-helix motif is required for the interaction of LIN54 with p130 and this partner.' Which disease is associated with this specific interactio... | acute myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03247","source_qa_id":"medium_divergent_branch_04868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LIN54 interacts with multiple proteins. One specific interaction partner is characterized by evid... | |
medium_divergent_branch_03248 | The gene TNKS interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using proximity-dependent biotin identification (BioID) interaction proteomics, we have identified this protein and its paralogue as new substrates of the poly-ADP-ribose polymerase Tankyrase and the E3 ligase RN... | polycystic ovary syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03248","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNKS interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using proximity-dependent biotin identifi... | |
medium_divergent_branch_03249 | The NBN gene has multiple protein interaction partners. One specific interaction is supported by evidence stating: 'We show here that NBS1 forms foci at the centrosomes via an interaction with gamma-tubulin.' Which protein is encoded by the gene that interacts with NBN in this specific context? | Tubulin gamma-1 chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03249","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NBN gene has multiple protein interaction partners. One specific interaction is supported by evidence stating: 'We show here that NBS1 forms foci... | |
medium_divergent_branch_03250 | USP11 interacts with multiple genes. One specific interaction is characterized by evidence that USP11 interacts with the partner and cleaves monoubiquitinated forms of that partner in both cellular and in vitro systems. Which disease is associated with this specific interacting gene through genomic alterations? | Marfan syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP11 interacts with multiple genes. One specific interaction is characterized by evidence that USP11 interacts with the partner and cleaves monoubiq... | |
medium_divergent_branch_03251 | HIC1 interacts with multiple proteins. One specific interaction is supported by evidence stating that Co-immunoprecipitation assays in WI38 fibroblasts and in BRG1-/- SW13 cells demonstrated that endogenous HIC1 and the target protein interact in a BRG1-dependent manner. Which protein corresponds to this interaction pa... | AT-rich interactive domain-containing protein 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03251","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIC1 interacts with multiple proteins. One specific interaction is supported by evidence stating that Co-immunoprecipitation assays in WI38 fibroblas... | |
medium_divergent_branch_03252 | ZAP70 is associated with multiple biological processes. One specific association is supported by a review discussing the role of ZAP70 in this process, particularly focusing on pathological conditions linked to defective expression or activity of the ZAP70 kinase. Which broader biological category is this specific proc... | lymphocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZAP70 is associated with multiple biological processes. One specific association is supported by a review discussing the role of ZAP70 in this proces... | |
medium_divergent_branch_03253 | NCOA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, it is demonstrated that mutation of the H11 phenylalanine residues diminishes the ability of RXR to associate with the p160 coactivators TIF2 and p/CIP, but has little effect on ligand-dependent interactions of the receptor... | Retinoic acid receptor RXR-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, it is demonstrated that mutation of the H11 phenylal... | |
medium_divergent_branch_03254 | SH3GL2 interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro binding assays demonstrate that endophilin binds through its src homology 3 domain to synaptojanin, and immunoprecipitation analysis with the antiendophilin antibody reveals that endophilin is stably associated with synapt... | muscular dystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3GL2 interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro binding assays demonstrate that endophilin binds th... | |
medium_divergent_branch_03255 | CEBPE interacts with multiple proteins. One interaction partner is described as a protein involved in sumoylation, specifically identified as the protein inhibitor of activated STAT1. Which protein is encoded by the gene corresponding to this interaction partner? | E3 SUMO-protein ligase PIAS1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEBPE interacts with multiple proteins. One interaction partner is described as a protein involved in sumoylation, specifically identified as the pro... | |
medium_divergent_branch_03256 | FEN1 interacts with multiple proteins. One of these interaction partners is reported to form a complex with Cdk1-cyclin A both in vitro and in vivo. Which protein, encoded by the gene connected to FEN1 via this specific interaction, is the subject of this evidence? | Cyclin-A2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FEN1 interacts with multiple proteins. One of these interaction partners is reported to form a complex with Cdk1-cyclin A both in vitro and in vivo. ... | |
medium_divergent_branch_03257 | ERCC4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated with hRad52, a recombinational repair protein, in human cell-free extracts and that these factors interact directly via the N-terminal domain of hRad52 and the XPF protein.' Which dis... | cervical squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated with hRad52,... | |
medium_divergent_branch_03258 | GGA3 interacts with multiple proteins. One interaction is characterized by crystallographic evidence showing that a phosphoserine residue interacts electrostatically with two basic residues on the VHS domain of the interacting partner, thereby providing an additional attachment point for the acidic-cluster dileucine si... | Cation-independent mannose-6-phosphate receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA3 interacts with multiple proteins. One interaction is characterized by crystallographic evidence showing that a phosphoserine residue interacts e... | |
medium_divergent_branch_03259 | GABBR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two-hybrid screening showed that this new GABA(B)R2-receptor subtype forms heterodimers with GABA(B)R1 through an interaction at their intracellular carboxy-terminal tails.' Which protein, connected to GABBR1 via ... | Gamma-aminobutyric acid type B receptor subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABBR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two-hybrid screening showed that this new ... | |
medium_divergent_branch_03260 | PSMC3 interacts with multiple proteins. One interaction partner is involved in a regulatory mechanism where the turnover of a specific transcription factor is cooperatively regulated by association with the 19S proteasomal subunit TBP-1 and by a C-terminal degron regulated by RAS-ERK signaling. Which protein, encoded b... | Fos-related antigen 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC3 interacts with multiple proteins. One interaction partner is involved in a regulatory mechanism where the turnover of a specific transcription ... | |
medium_divergent_branch_03261 | Interleukin-13 production is enabled by multiple cell types. One of these cell types is described as a mature NK T cell that predominantly secretes type 2 cytokines, such as interleukin-4 and interleukin-13, and enhances type 2 immune responses. What is the parent class of this specific cell type in the cellular hierar... | CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-13 production is enabled by multiple cell types. One of these cell types is described as a mature NK T cell that predominantly secretes t... | |
medium_divergent_branch_03262 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.404 and an adjusted p-value of 0.00525. Which disease has a genomic-alteration link with that selected gene? | B-cell chronic lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03262","source_qa_id":"medium_divergent_branch_01770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_03263 | KLF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Third, in vitro assays demonstrate that CKIIalpha interacts with EKLF, and that the EKLF interaction domain is phosphorylated by CKII only at Thr-41; however, the CKII-site mutant is not phosphorylated.' Which protein, encoded by ... | Casein kinase II subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Third, in vitro assays demonstrate that CKIIalpha interacts... | |
medium_divergent_branch_03264 | The protein MS4A1 is associated with multiple cellular components via 'located in' relationships. One of these associations is supported by evidence stating that CD20 exists as homo-oligomers within that specific compartment. Identify the cellular component that is a parent term (via 'is a') of the compartment where CD... | membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03264","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein MS4A1 is associated with multiple cellular components via 'located in' relationships. One of these associations is supported by evidence ... | |
medium_divergent_branch_03265 | SGK1 interacts with multiple proteins. One specific interaction is characterized by the formation of a complex where the DSFL tail of SGK1 binds to the first PDZ domain of the partner protein, and the PIF motif of that partner binds to the PIF-binding pocket of PDK1. Which protein, encoded by the gene connected to SGK1... | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SGK1 interacts with multiple proteins. One specific interaction is characterized by the formation of a complex where the DSFL tail of SGK1 binds to t... | |
medium_divergent_branch_03266 | The gene FCAR is associated with multiple biological processes. One association is supported by evidence stating: 'Our data suggest that FcαRI has the ability to regulate neutrophil viability and to induce different forms of neutrophils depending on the inflammatory microenvironment and specific characteristics of the ... | myeloid leukocyte mediated immunity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FCAR is associated with multiple biological processes. One association is supported by evidence stating: 'Our data suggest that FcαRI has th... | |
medium_divergent_branch_03267 | TBK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, E3 ubiquitin ligase ankyrin repeat and SOCS box-containing 8 (ASB8) interacted with TBK1/IKBKE and phosphorylation modification of ASB8 at site of Ser17 to further strengthen its ubiquitination activity were verified.'... | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, E3 ubiquitin ligase ankyrin repeat and SOCS box... | |
medium_divergent_branch_03268 | SMAD7 interacts with multiple proteins. One specific interaction involves an E3 ubiquitin ligase that targets bone morphogenetic protein-specific Smads, induces SMAD7 ubiquitination, and causes its translocation into the cytoplasm. Which protein, connected to SMAD7 through this binding interaction, is encoded by the ge... | E3 ubiquitin-protein ligase SMURF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 interacts with multiple proteins. One specific interaction involves an E3 ubiquitin ligase that targets bone morphogenetic protein-specific Sma... | |
medium_divergent_branch_03269 | PSMD8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human proteasome by associating with it in the cytosol and nucleus via the RPN3/S3 subunit of the 19S regulatory particle (RP).' Identify the disease associated with the protein des... | extragonadal germ cell tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMD8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human prot... | |
medium_divergent_branch_03270 | The PYCARD gene interacts with multiple proteins. One specific interaction involves a deubiquitinating enzyme that binds to the ASC protein and regulates the inflammasome signaling pathway by removing lysine 63-linked polyubiquitin chains from ASC. Which protein is encoded by the gene corresponding to this deubiquitina... | Ubiquitin carboxyl-terminal hydrolase 50 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The PYCARD gene interacts with multiple proteins. One specific interaction involves a deubiquitinating enzyme that binds to the ASC protein and regul... | |
medium_divergent_branch_03271 | Dalteparin interacts with multiple drugs. One of these interacting agents is reported to have an augmenting thromboprophylactic effect when added to low molecular weight heparin (LMWH) in a specific model. Which disease is the drug exhibiting this specific effect indicated for? | xerophthalmia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Dalteparin interacts with multiple drugs. One of these interacting agents is reported to have an augmenting thromboprophylactic effect when added to ... | |
medium_divergent_branch_03272 | Fibrocytes are connected to multiple cell types via an 'is a' relationship. One of these connected cell types is described as a bone marrow-derived cell that predominantly develops from myeloid lineage-restricted progenitor cells and circulates in peripheral blood. It is characterized by the co-expression of hematopoie... | mesenchymal stem cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Fibrocytes are connected to multiple cell types via an 'is a' relationship. One of these connected cell types is described as a bone marrow-derived c... | |
medium_divergent_branch_03273 | PES1 interacts with multiple proteins. One interaction partner is described by the following evidence: 'We conclude that this protein can interact specifically with Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.' What is the full protein name e... | Probable ATP-dependent RNA helicase DDX27 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PES1 interacts with multiple proteins. One interaction partner is described by the following evidence: 'We conclude that this protein can interact sp... | |
medium_divergent_branch_03274 | FANCA interacts with multiple proteins. One interaction is supported by evidence stating: 'We have recently identified the structural protein nonerythroid alpha spectrin (alphaSpIISigma) as a component of a nuclear protein complex in normal human cells which is involved in the repair of DNA interstrand cross-links and ... | Sjogren syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCA interacts with multiple proteins. One interaction is supported by evidence stating: 'We have recently identified the structural protein noneryt... | |
medium_divergent_branch_03275 | CRKL interacts with multiple entities via binding interactions. Evidence for one specific interaction indicates that stimulating human embryonic kidney cells (HEK293) with a particular ligand induces the association of that ligand's target adaptor protein with CRKL. Which cellular component is the entity directly bound... | cell-cell junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRKL interacts with multiple entities via binding interactions. Evidence for one specific interaction indicates that stimulating human embryonic kidn... | |
medium_divergent_branch_03276 | The KCNA5 gene enables a specific molecular function related to voltage-gated potassium channel activity. Evidence indicates that functional analyses revealed consistent loss-of-function effects of mutant KCNA5 proteins on the ultrarapidly activating delayed rectifier potassium currents (IKur), which are known to be at... | atrial cardiac muscle cell action potential | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KCNA5 gene enables a specific molecular function related to voltage-gated potassium channel activity. Evidence indicates that functional analyses... | |
medium_divergent_branch_03277 | BRMS1 interacts with multiple proteins. One specific interaction involves cullin 3 (Cul3), a component of an E3 ubiquitin ligase, where the binding between BRMS1 and Cul3 is mediated by an adaptor protein. Which protein, encoded by the gene linked to BRMS1 via this specific interaction mechanism, is the adaptor protein... | Speckle-type POZ protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03277","source_qa_id":"medium_divergent_branch_05092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BRMS1 interacts with multiple proteins. One specific interaction involves cullin 3 (Cul3), a comp... | |
medium_divergent_branch_03278 | PELI2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate for the first time that human Pellino2 interacts with tumor necrosis factor receptor associated factor 6 and that both Pellino1 and Pellino2 also interact with TAK1 (transforming growth factor-beta activated k... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PELI2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate for the first time that human Pellino2... | |
medium_divergent_branch_03279 | DCAF6 interacts with multiple proteins. One specific interaction is supported by evidence stating that NRIP and DDB2 share the same AR binding domain and compete for AR binding, but not for binding to the protein in question, within the AR-DDB2-[protein]-CUL4A complex. Which protein is this? | DNA damage-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03279","source_qa_id":"medium_divergent_branch_06159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DCAF6 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_03280 | The gene MKNK1 is enriched in multiple cell types. One specific cell type shows a mean expression of 63.91 TPM, a z-score of 1.89, and a fold enrichment of 2.62. Which parent cell category is this specific cell type classified as? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MKNK1 is enriched in multiple cell types. One specific cell type shows a mean expression of 63.91 TPM, a z-score of 1.89, and a fold enrichm... | |
medium_divergent_branch_03281 | RNF123 interacts with multiple genes. One of these interaction partners is characterized by evidence showing it associates with RIG-I and a specific interferon-induced helicase in both endogenous and exogenous contexts in a viral infection-inducible manner. Which disease is linked to this specific interaction partner v... | viral hepatitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03281","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF123 interacts with multiple genes. One of these interaction partners is characterized by evidence showing it associates with RIG-I and a specific ... | |
medium_divergent_branch_03283 | RNF183 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we confirmed that RNF183 directly ubiquitinates M2 pyruvate kinase through co-immunoprecipitation (Co-IP) and liquid chromatography-mass spectrometry (LC-MS) experiments.' Which protein, connected to RNF183... | Pyruvate kinase PKM | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03283","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF183 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we confirmed that RNF183 directly u... | |
medium_divergent_branch_03284 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.149 and an adjusted p-value of 0.0348. Which protein does that selected gene encode? | Centrin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03284","source_qa_id":"medium_divergent_branch_06913","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_03286 | PDCD10 interacts with multiple genes. One of these interaction partners is part of the STRIPAK complex, which is described as containing the PP2A catalytic (PP2Ac) and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel proteins STRIP1 and STRIP2... | Striatin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDCD10 interacts with multiple genes. One of these interaction partners is part of the STRIPAK complex, which is described as containing the PP2A cat... | |
medium_divergent_branch_03287 | The gene PKM is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Our results identify the two muscular isoforms of pyruvate kinase (PKM1 and PKM2) as novel interaction partners of laforin.' Based on this specific evidence, which gene interacts with the protein encode... | BECN1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03287","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PKM is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Our results identify the two mu... |
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