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medium_divergent_branch_03288 | LASP1 interacts with multiple proteins. One interaction is supported by evidence that LASP-1 directly binds to a transcription factor, potentially stabilizing it. Which protein corresponds to this specific interaction partner? | Zinc finger protein SNAI1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03288","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LASP1 interacts with multiple proteins. One interaction is supported by evidence that LASP-1 directly binds to a transcription factor, potentially st... | |
medium_divergent_branch_03289 | RFWD2 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We find that both transiently and stably expressed COP1 associates with the hetero-oligomeric TCP-1 chaperonin complex (TRiC), heat shock protein 70 (Hsp70) and BAG-family molecular chaperone regulator-2 (BAG... | intellectual developmental disorder with polymicrogyria and seizures | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03289","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFWD2 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We find that both transiently and sta... | |
medium_divergent_branch_03290 | The gene ADRB2 is known to interact with multiple other genes. One specific interaction is supported by experimental evidence showing that β(2)-Adrenergic receptors (β(2)AR) and D(4)-dopamine receptors (D(4)DR) co-immunoprecipitate when co-expressed in HEK 293 cells, indicating a signaling complex containing both recep... | D(4) dopamine receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRB2 is known to interact with multiple other genes. One specific interaction is supported by experimental evidence showing that β(2)-Adren... | |
medium_divergent_branch_03291 | MIR136 is associated with multiple biological processes. One association is supported by evidence stating that dual luciferase assays and western blot assays indicated that IL-17 was a target gene of miR-136. Which biological process, connected to the process supported by this evidence, is linked via a 'negatively regu... | interleukin-17 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03291","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR136 is associated with multiple biological processes. One association is supported by evidence stating that dual luciferase assays and western blo... | |
medium_divergent_branch_03292 | CDKN1C interacts with multiple genes. One interaction is supported by evidence stating: 'No in vivo interaction was found with either p21(Waf1/Cip1) or p27(KIP1), however, binding to p57(KIP2) was readily detectable in both in vivo and in vitro assays.' Which gene, connected to CDKN1C via an interaction, is the subject... | RBBP4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1C interacts with multiple genes. One interaction is supported by evidence stating: 'No in vivo interaction was found with either p21(Waf1/Cip1) ... | |
medium_divergent_branch_03294 | IL6R is associated with multiple biological processes. One association is supported by evidence that treating smooth muscle cells (SMC) with IL-6/sIL-6R leads to up-regulation of gp130, secretion of IL-6 creating an autocrine loop, and subsequent marked cell proliferation. Which biological process, connected to IL6R vi... | smooth muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03294","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL6R is associated with multiple biological processes. One association is supported by evidence that treating smooth muscle cells (SMC) with IL-6/sIL... | |
medium_divergent_branch_03295 | DAPK1 interacts with multiple proteins. One specific interaction is characterized by the phosphorylation of a target protein on Threonine 119, a residue located within its BH3 domain. This modification promotes the dissociation of the target from Bcl-XL and induces autophagy. Which gene encodes this specific interactin... | Beclin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAPK1 interacts with multiple proteins. One specific interaction is characterized by the phosphorylation of a target protein on Threonine 119, a resi... | |
medium_divergent_branch_03296 | GABARAPL1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Strikingly, in addition to ULK1 and ULK2, this protein and FIP200 interacted with human ATG8 proteins, all with strong preference for the GABARAP subfamily.' Which protein, connected to GABARAPL1 via an inter... | Autophagy-related protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Strikingly, in addition to ULK1 and U... | |
medium_divergent_branch_03298 | NUP54 interacts with multiple nucleoporins. One interaction is supported by evidence stating that a nucleoporin was associated with polypeptides of 58 and 54 kD (Finlay et al., 1991). Which disease is associated with the nucleoporin identified by this evidence? | familial infantile bilateral striatal necrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP54 interacts with multiple nucleoporins. One interaction is supported by evidence stating that a nucleoporin was associated with polypeptides of 5... | |
medium_divergent_branch_03299 | The pilosebaceous unit is composed of multiple anatomical structures. One of these components is described in evidence as part of an epidermal invagination that also includes a sebaceous gland and an arrector pili muscle. Which specific anatomical entity, connected to the pilosebaceous unit via a 'has part' relationshi... | skin appendage follicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pilosebaceous unit is composed of multiple anatomical structures. One of these components is described in evidence as part of an epidermal invagi... | |
medium_divergent_branch_03300 | MCRS1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'Furthermore, we have demonstrated that this protein interacts in vitro and in vivo with MSP58 via its NH(2)-terminal segment, which is distinct from the binding region of Fas, apoptosis signal-regulating kina... | leiomyosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03300","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCRS1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'Furthermore, we have demonstrated tha... | |
medium_divergent_branch_03301 | The gene KLRC4 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.18 TPM, a z-score of 1.63, and a fold enrichment of 4.18. Identify the cell type associated with these statistics, and then determine the cell type from which it develops. | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KLRC4 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.18 TPM, a z-score of 1... | |
medium_divergent_branch_03302 | ORC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By co-immunoprecipitation analyses, Ku was found to interact with DNA polymerases alpha, delta and epsilon, PCNA, topoisomerase II, RF-C, RP-A, DNA-PKcs, ORC-2, and Oct-1.' Which protein, encoded by the gene interacting with ORC2 ... | DNA repair protein Ku80 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By co-immunoprecipitation analyses, Ku was found to interac... | |
medium_divergent_branch_03303 | RHOA interacts with multiple proteins via binding. One piece of evidence notes that the sequence similarity between RhoE and a specific RHOA-binding partner suggests RhoE might compete with that partner for interaction with RHOA targets. Which protein, linked to RHOA by a binding relation, is implied by this competitiv... | VEGFA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03303","source_qa_id":"medium_divergent_branch_07106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RHOA interacts with multiple proteins via binding. One piece of evidence notes that the sequence ... | |
medium_divergent_branch_03305 | FBXO21 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, also known as the protein encoded by ABCB1, for proteasomal degradation.' Which protein is encoded by the gene ... | ATP-dependent translocase ABCB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03305","source_qa_id":"medium_divergent_branch_02459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FBXO21 interacts with multiple proteins. One specific interaction is described by the following e... | |
medium_divergent_branch_03306 | SLC2A9 is enriched in multiple cell types. One association is characterized by a mean expression of 50.02 TPM, a z-score of 2.16, and a fold enrichment of 8.18. What is the immediate parent category of the cell type that best matches this expression profile? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC2A9 is enriched in multiple cell types. One association is characterized by a mean expression of 50.02 TPM, a z-score of 2.16, and a fold enrichme... | |
medium_divergent_branch_03307 | The gene AP1S1 interacts with multiple partners. One specific interaction is supported by evidence from a yeast two-hybrid system, which revealed that gamma2-adaptin interacts with sigma1-like proteins (sigma1A and sigma1B) but, unlike gamma1-adaptin, is unable to interact with beta1-adaptin. Which protein is encoded b... | AP-1 complex subunit gamma-like 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AP1S1 interacts with multiple partners. One specific interaction is supported by evidence from a yeast two-hybrid system, which revealed tha... | |
medium_divergent_branch_03308 | The gene IL6ST is known to bind to multiple partners. One specific partner is characterized by its interaction with the Tyr(P)-759 peptide of gp130, in addition to SHP2. Which cellular component is this specific partner located in? | cytoplasmic side of plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03308","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL6ST is known to bind to multiple partners. One specific partner is characterized by its interaction with the Tyr(P)-759 peptide of gp130, ... | |
medium_divergent_branch_03309 | IFNAR1 interacts with multiple proteins. One interaction is described by the statement: 'Here, we sought to define the molecular basis of the interaction between this protein and IFNAR1, a component of the interferon alpha/beta receptor, by delimiting a minimal IFNAR1 binding region in this protein.' Which protein, con... | Non-receptor tyrosine-protein kinase TYK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFNAR1 interacts with multiple proteins. One interaction is described by the statement: 'Here, we sought to define the molecular basis of the interac... | |
medium_divergent_branch_03310 | The gene CRYAB is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'We find that αB-crystallin binds to wild-type Aβ(42) fibrils with micromolar affinity, and also binds to fibrils formed from the E22G Arctic mutation of Aβ(42).' Identify the protein encoded by the... | Amyloid-beta precursor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CRYAB is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'We find that αB-crystallin... | |
medium_divergent_branch_03311 | YME1L1 is implicated in multiple biological processes. One specific connection is supported by evidence stating that impaired YME1L1 function leads to proliferation defects and mitochondrial network fragmentation resulting from the abnormal processing of OPA1. Which broader biological process is the specific process li... | protein processing | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YME1L1 is implicated in multiple biological processes. One specific connection is supported by evidence stating that impaired YME1L1 function leads t... | |
medium_divergent_branch_03313 | ERBB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In addition, we demonstrate that a sortilin-related receptor interacts directly with HER3, forming a trimeric complex with HER2 and HER3 to attenuate lysosomal degradation of the dimer in a Ras-related protein Rab4-depen... | Sortilin-related receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In addition, we demonstrate that a sortilin-relat... | |
medium_divergent_branch_03315 | UBE2K interacts with multiple genes. One of these interacting partners is described in experimental evidence stating: 'The interaction of Hip-2 with this gene, one of the clones, was further confirmed through in vitro and in vivo experiments.' Which disease is associated with this specific interacting gene? | Luo-Schoch-Yamamoto syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2K interacts with multiple genes. One of these interacting partners is described in experimental evidence stating: 'The interaction of Hip-2 with ... | |
medium_divergent_branch_03317 | FBXO21 interacts with multiple proteins. One interaction is supported by evidence stating: 'The central and COOH-terminal portion of FBXO21 was found to interact with the COOH-terminal region of this protein in transfected cells.' What is the full name of the protein encoded by the gene corresponding to this interactio... | EP300-interacting inhibitor of differentiation 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03317","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO21 interacts with multiple proteins. One interaction is supported by evidence stating: 'The central and COOH-terminal portion of FBXO21 was found... | |
medium_divergent_branch_03318 | ATM interacts with multiple proteins. One interaction is supported by evidence showing that nucleoplasmic ATM co-immunoprecipitated with Ku70/86 (the DNA binding subunits of DNA-PK), an association that was diminished by vanillin. Which protein, encoded by the gene connected to ATM via this specific interaction, is the... | DNA repair protein Ku80 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03318","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATM interacts with multiple proteins. One interaction is supported by evidence showing that nucleoplasmic ATM co-immunoprecipitated with Ku70/86 (the... | |
medium_divergent_branch_03319 | T cell differentiation yields multiple distinct cell types. One of these outputs is described as a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions. Which cell type develops into this specific CD4-positive, alpha-beta... | activated CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"T cell differentiation yields multiple distinct cell types. One of these outputs is described as a CD4-positive, alpha-beta T cell that cooperates wi... | |
medium_divergent_branch_03320 | RXRA interacts with multiple proteins. One interaction partner forms a heterodimeric complex with RXRA and binds to vitamin D-responsive promoter elements to regulate transcription. Which protein is encoded by the gene corresponding to this interaction partner? | Vitamin D3 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RXRA interacts with multiple proteins. One interaction partner forms a heterodimeric complex with RXRA and binds to vitamin D-responsive promoter ele... | |
medium_divergent_branch_03321 | CDKN1B interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the interacting kinase bound directly to and phosphorylated p27(Kip1).' Which cell type is the gene identified in this evidence enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1B interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the interacting kinase bound directly to ... | |
medium_divergent_branch_03323 | The biological process of apoptotic cell clearance is enabled by more than one type of cell. One of these cells is described as a lymph node macrophage located in the cortex of lymph nodes, specifically in and around the germinal centers, which participates in the phagocytosis of apoptotic B cells from the germinal cen... | cortex of lymph node | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process of apoptotic cell clearance is enabled by more than one type of cell. One of these cells is described as a lymph node macropha... | |
medium_divergent_branch_03324 | RAB32 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that silencing the BLOC-3 subunits Hps1 and Hps4 leads to the mislocalization of RAB32 and Rab38, along with reduced pigmentation. Which cellular component is connected to this speci... | melanosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB32 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that silenc... | |
medium_divergent_branch_03325 | DYNLL1 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'In vivo DLC2 is found exclusively as a component of the myosin V motor complex and this protein binds DLC2 selectively.' What is the name of the protein encoded by the gene corresponding to this inter... | Bcl-2-modifying factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03325","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DYNLL1 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'In vivo DLC2 is found exclusi... | |
medium_divergent_branch_03326 | ORC1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Further analyses indicate that the interaction partner physically interacts with ORC1 on non-chromatin nuclear structures.' Which protein, connected to ORC1 via this specific interaction, is encoded by the gene in questi... | Origin recognition complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03326","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Further analyses indicate that the interaction pa... | |
medium_divergent_branch_03327 | The gene MOS interacts with multiple partners. One specific interaction partner is distinguished by evidence showing a physical interaction with a myogenic transcription factor (but not E12), demonstrated in vivo using a two-hybrid approach in C3H10T1/2 cells and in vitro via GST pull-down assays. Which cellular compon... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03327","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MOS interacts with multiple partners. One specific interaction partner is distinguished by evidence showing a physical interaction with a my... | |
medium_divergent_branch_03328 | The gene TRIB1 interacts with multiple other genes. One of these interacting partners is described in a study where the crystal structure of the partner protein in complex with C/EBPα was solved. The study revealed that this partner protein underwent a substantial conformational change relative to its substrate-free st... | CCAAT/enhancer-binding protein alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03328","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRIB1 interacts with multiple other genes. One of these interacting partners is described in a study where the crystal structure of the part... | |
medium_divergent_branch_03331 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.290 and an adjusted p-value of 0.0432. Which biological process is that selected gene involved in? | negative regulation of cold-induced thermogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03331","source_qa_id":"medium_divergent_branch_02524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_03332 | ARL1 is known to interact with multiple proteins. One specific interaction involves the GTP-bound form of ARL1 binding to the GRIP domains of Golgin-97 and Golgin-245, a process that relies on conserved residues within these GRIP domains essential for Golgi targeting. Which protein, encoded by a gene that interacts wit... | GRIP and coiled-coil domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL1 is known to interact with multiple proteins. One specific interaction involves the GTP-bound form of ARL1 binding to the GRIP domains of Golgin-... | |
medium_divergent_branch_03333 | MAP3K7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that cIAP1 and cIAP2 directly ubiquitinate a receptor-interacting serine/threonine-protein kinase and induce constitutive ubiquitination of this kinase in cancer cells and demonstrate that constitutively ubiquitinated ki... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that cIAP1 and cIAP2 directly ubiquitinate a rece... | |
medium_divergent_branch_03334 | EPHA1 is enriched in multiple cell types. One of these cell types shows a mean expression of 3.83 TPM, a z-score of 2.11, and a fold enrichment of 4.08. Which cell type does this specific EPHA1-enriched cell develop from? | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHA1 is enriched in multiple cell types. One of these cell types shows a mean expression of 3.83 TPM, a z-score of 2.11, and a fold enrichment of 4.... | |
medium_divergent_branch_03335 | ANKFY1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that RhoD binds to the Rab5 effector Rabankyrin-5, and RhoD and Rabankyrin-5 colocalize to Rab5-positive endosomes, which suggests a role for Rabankyrin-5 in the coordination of RhoD and Rab5 in endosomal trafficking.... | GTPase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKFY1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that RhoD binds to the Rab5 effector Rabankyri... | |
medium_divergent_branch_03336 | LAS1L interacts with multiple proteins. One specific interaction involves a partner that is part of the MLL1-WDR5 supercomplex involved in chromatin remodeling, as evidenced by reports identifying the interaction of this partner with LAS1L and SENP3. Which disease is associated with this specific interacting partner th... | familial glucocorticoid deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAS1L interacts with multiple proteins. One specific interaction involves a partner that is part of the MLL1-WDR5 supercomplex involved in chromatin ... | |
medium_divergent_branch_03337 | HCK interacts with multiple proteins. One interaction is supported by evidence stating: 'Interaction between a specific protein and src family kinases, Fyn, Hck and Lyn, was detected during monocytes/macrophage-differentiation of U937 cells.' Which protein is encoded by the gene corresponding to this specific protein? | Src kinase-associated phosphoprotein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCK interacts with multiple proteins. One interaction is supported by evidence stating: 'Interaction between a specific protein and src family kinase... | |
medium_divergent_branch_03338 | ARL8B interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the Rab7 effector [protein] simultaneously binds Rab7 and Arl8b, bringing about clustering and fusion of late endosomes and lysosomes.' Which protein is encoded by the gene that interacts with ARL8B in this spe... | Pleckstrin homology domain-containing family M member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL8B interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the Rab7 effector [protein] simultaneou... | |
medium_divergent_branch_03339 | The gene CDKN1C is enriched in multiple cell types. One specific cell type exhibits a mean expression of 155.54 TPM, a z-score of 2.18, and a fold enrichment of 6.36 for this gene. Which cell type does this specific cell develop from? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN1C is enriched in multiple cell types. One specific cell type exhibits a mean expression of 155.54 TPM, a z-score of 2.18, and a fold en... | |
medium_divergent_branch_03340 | UBE2N interacts with multiple genes. One of these interaction partners is described as a key factor promoting TACE maturation, with evidence showing that the Uev1A-Ubc13 complex interacts with it and that inhibiting Uev1A-Ubc13 activity interferes with its promotion of TACE maturation. Which gene is this interaction pa... | USP13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03340","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2N interacts with multiple genes. One of these interaction partners is described as a key factor promoting TACE maturation, with evidence showing ... | |
medium_divergent_branch_03341 | The entity 'tarsus pre-cartilage condensation' is defined as a pre-cartilage condensation with the potential to develop into a tarsal bone. This entity is a subtype of two distinct anatomical structures. One of these parent structures is defined as mesenchyme derived from the somatopleure. Which anatomical structure is... | mesenchyme from somatopleure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The entity 'tarsus pre-cartilage condensation' is defined as a pre-cartilage condensation with the potential to develop into a tarsal bone. This enti... | |
medium_divergent_branch_03342 | FBXL7 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that an FQ motif within FBXL7 serves as a molecular recognition site for the interaction. Which disease is associated with this specific interaction partner? | pneumonia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL7 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that an FQ motif within FBXL7 serves as a... | |
medium_divergent_branch_03343 | The gene MED13 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 13.31 TPM, a z-score of 1.78, and a fold enrichment of 2.46. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type hierarchy ... | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MED13 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 13.31 TPM, a z-score of ... | |
medium_divergent_branch_03344 | Ascorbic acid interacts with multiple drugs. One of these interactions is supported by evidence stating that ferroptotic effects were ameliorated by this drug and N-acetylcysteine. Which disease is this drug indicated for? | anemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03344","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ascorbic acid interacts with multiple drugs. One of these interactions is supported by evidence stating that ferroptotic effects were ameliorated by ... | |
medium_divergent_branch_03345 | The biological process 'negative regulation of L-glutamate import across plasma membrane' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of L-glutamate import into a cell. This process is a subtype of a broader regulatory process. Which biological process is negatively regulat... | amino acid transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03345","source_qa_id":"medium_divergent_branch_02320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of L-glutamate import across plasma membrane' is defi... | |
medium_divergent_branch_03346 | The gene ANKFY1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 7.58 TPM, a z-score of 1.71, and a fold enrichment of 2.26. Which cell type corresponds to this specific expression profile, and what is its immediate parent cell type in the classifi... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ANKFY1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 7.58 TPM, a ... | |
medium_divergent_branch_03347 | PPP2CB interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, in vivo studies with epitope-tagged Aalpha and Abeta subunits demonstrated that Abeta is a markedly weaker binder of regulatory B and catalytic C subunits than Aalpha.' Which protein, connected to PPP2CB via this sp... | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP2CB interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, in vivo studies with epitope-tagged Aalpha a... | |
medium_divergent_branch_03348 | TRIM21 interacts with multiple proteins. One specific interaction is characterized by the enhancement of the binding between the E3 ubiquitin ligase TRIM21 and its substrate through the formation of a complex involving SNORD50A/B, which promotes the substrate's ubiquitination and subsequent cytoplasmic sequestration. W... | GMP synthase [glutamine-hydrolyzing] | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03348","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM21 interacts with multiple proteins. One specific interaction is characterized by the enhancement of the binding between the E3 ubiquitin ligase ... | |
medium_divergent_branch_03349 | SEC61A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using chemical cross-linking we show that Sec61beta not only interacts with subunits of the Sec61 complex but also with the 25-kD subunit of the signal peptidase complex (SPC25), thus demonstrating for the first time a tight in... | Protein transport protein Sec61 subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SEC61A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using chemical cross-linking we show that Sec61beta not ... | |
medium_divergent_branch_03350 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.165 and an adjusted p-value of 0.0422. Which protein does that selected gene encode? | ERBB receptor feedback inhibitor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03350","source_qa_id":"medium_divergent_branch_05397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03351 | PIAS3 interacts with multiple proteins. One specific interaction partner was identified in an experiment described as: 'PIAS3 was thus identified as a binding protein for a specific transcription factor.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Zinc finger homeobox protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03351","source_qa_id":"medium_divergent_branch_00587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PIAS3 interacts with multiple proteins. One specific interaction partner was identified in an exp... | |
medium_divergent_branch_03353 | ACTN2 is associated with multiple biological processes. One association is supported by evidence stating that α-actinins are the major actin crosslinkers in muscle Z-disks. Which biological process is a parent term (via an 'is a' relationship) of the process linked to ACTN2 by this specific evidence? | actomyosin structure organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTN2 is associated with multiple biological processes. One association is supported by evidence stating that α-actinins are the major actin crosslin... | |
medium_divergent_branch_03355 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 2.146 and an adjusted p-value of 0.0425. For which disease is that selected gene recorded as a biomarker? | bacterial pneumonia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03355","source_qa_id":"medium_divergent_branch_02615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_03356 | AKAP8 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen for AKAP95 interaction partners as the minichromosome maintenance (MCM) 2 protein, a component of the pre-replication complex. Which disease is therapeutically connected to this specific interaction partne... | malignant colon neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP8 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen for AKAP95 interaction partners as... | |
medium_divergent_branch_03357 | The gene CSNK1D interacts with multiple other genes. One of these interactions is supported by evidence stating: 'Co-immunoprecipitation assays showed direct association of the protein encoded by the interacting gene and Ckidelta in situ, consistent with the protein encoded by the interacting gene being a Ckidelta subs... | Microtubule-associated protein tau | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CSNK1D interacts with multiple other genes. One of these interactions is supported by evidence stating: 'Co-immunoprecipitation assays showe... | |
medium_divergent_branch_03359 | SIVA1 interacts with multiple genes. One interaction partner is distinguished by a C-terminal tail containing a zinc finger-binding motif for interactions with LIM domain-containing TRIP6 and proapoptotic Siva-1, as well as a PDZ-binding motif for complexing with the NHERF2 scaffold protein. Which disease is associated... | benign neoplasm of stomach | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIVA1 interacts with multiple genes. One interaction partner is distinguished by a C-terminal tail containing a zinc finger-binding motif for interac... | |
medium_divergent_branch_03360 | Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Here, we provide evidence that FASN is a substrate of this protein and that interaction of these proteins induces FASN ubiquitination and proteasome-dependent degradation.' Identify the protein t... | SPOPL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03360","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Here, we provide evidenc... | |
medium_divergent_branch_03361 | Human gammaherpesvirus 4 is known to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.068 and an adjusted p-value of 0.02992. Identify the cell type in which the gene subject to this specific downregulation is enriched. | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is known to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approxi... | |
medium_divergent_branch_03362 | ESR2 interacts with multiple proteins. One of these interaction partners is a prominent component of the thyroid hormone receptor-associated protein (TRAP)/Mediator coactivator complex, which is known to interact with both ERalpha and ERbeta in unfractionated nuclear extracts and in purified form. Which disease is asso... | streptococcal pneumonia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESR2 interacts with multiple proteins. One of these interaction partners is a prominent component of the thyroid hormone receptor-associated protein ... | |
medium_divergent_branch_03363 | HSPA9 interacts with multiple genes. One interaction is supported by evidence stating that the Hsp70 family member mot-2/mthsp70/GRP75/PBP74 binds to the tumor suppressor protein TP53. Which disease is causally linked to the gene identified by this specific binding evidence? | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA9 interacts with multiple genes. One interaction is supported by evidence stating that the Hsp70 family member mot-2/mthsp70/GRP75/PBP74 binds to... | |
medium_divergent_branch_03364 | Calcium carbonate interacts with multiple drugs. For one of these interacting drugs, clinical evidence indicates that co-administration with calcium carbonate while fasting reduces the drug's plasma AUC(0-∞), Cmax, and C24 by 39%, 37%, and 39%, respectively. Which disease is this specific drug indicated for? | HIV infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03364","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Calcium carbonate interacts with multiple drugs. For one of these interacting drugs, clinical evidence indicates that co-administration with calcium ... | |
medium_divergent_branch_03365 | Cardiac muscle cells are responsible for heart contraction. In mammals, their contractile fibers resemble those of skeletal muscle but are only one-third as large in diameter, are richer in sarcoplasm, and contain centrally located nuclei instead of peripheral ones. Based on this description, which anatomical structure... | striated muscle tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cardiac muscle cells are responsible for heart contraction. In mammals, their contractile fibers resemble those of skeletal muscle but are only one-t... | |
medium_divergent_branch_03366 | Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.348 and an adjusted p-value of 0.0364. Which protein does that selected gene encode? | Ly6/PLAUR domain-containing protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03366","source_qa_id":"medium_divergent_branch_02127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03367 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.045 and an adjusted p-value of 0.00428. Which protein does that selected gene encode? | Interferon-induced protein with tetratricopeptide repeats 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03367","source_qa_id":"medium_divergent_branch_02628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_03369 | UBA1 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that truncation of its carboxyl-terminal β-grasp domain reduces cognate Ubc2b binding by 31-fold and kcat by 3.5×10(4)-fold, indicating contributions to E2 binding and transition state stabilization. Which protein... | Ubiquitin-conjugating enzyme E2 B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBA1 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that truncation of its carboxyl-terminal β... | |
medium_divergent_branch_03370 | UBA3 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a complex between the C-terminal domain of the NEDD8 heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of the NEDD8 E2 enzyme. Which protein, connected to UBA3 through this interaction... | NEDD8-conjugating enzyme Ubc12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBA3 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a complex between the C-... | |
medium_divergent_branch_03372 | MYSM1 interacts with multiple proteins. One specific interaction involves MYSM1 binding to a partner protein via its SWIRM domain, where it removes K63-linked polyubiquitin chains to decrease the stability of the complex formed between MYSM1 and that partner. Which protein, encoded by the gene connected to MYSM1 throug... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYSM1 interacts with multiple proteins. One specific interaction involves MYSM1 binding to a partner protein via its SWIRM domain, where it removes K... | |
medium_divergent_branch_03373 | YY1AP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Molecular studies revealed that loss of YY1AP1 in vascular smooth muscle cells leads to cell cycle arrest with decreased proliferation and increased levels of the cell cycle regulator p21/WAF/CDKN1A and disrupts ... | cellular developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YY1AP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Molecular studies revealed that loss of Y... | |
medium_divergent_branch_03374 | SMAD2 interacts with multiple genes. One interaction partner is characterized by evidence stating that Cam kinase II blocked its nuclear accumulation and induced hetero-oligomerization with SMAD2 independently of TGF-beta receptor activation, while preventing TGF-beta-dependent interactions between SMAD2 and SMAD3. Whi... | cleidocranial dysplasia 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD2 interacts with multiple genes. One interaction partner is characterized by evidence stating that Cam kinase II blocked its nuclear accumulation... | |
medium_divergent_branch_03375 | Matrix metalloproteinase-9 (MMP9) interacts with multiple gene products. One specific interaction is supported by evidence stating: 'In this study, transforming growth factor-β-induced protein (βig-h3) was identified as a substrate of matrix metalloproteinase-9 (MMP-9) by site-directed mutagenesis.' Which protein is en... | Transforming growth factor-beta-induced protein ig-h3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Matrix metalloproteinase-9 (MMP9) interacts with multiple gene products. One specific interaction is supported by evidence stating: 'In this study, t... | |
medium_divergent_branch_03379 | MAP3K1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In transformed B-lymphoblastoid cell lines and NT2/D1 cells transfected with wild-type or mutant MAP3K1 cDNAs under control of the constitutive CMV promoter, these mutations increased binding of RHOA, MAP3K4, FRAT1 and this prot... | Axin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03379","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In transformed B-lymphoblastoid cell lines and NT2/D1 cel... | |
medium_divergent_branch_03380 | The gene PPP1R12A interacts with multiple partners. One specific interaction involves a partner that, when bound to MYPT1, triggers the proteasomal degradation of MYPT1 in mammalian cells, including neurons and glia. Which disease is associated with this specific interacting partner? | cerebral infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R12A interacts with multiple partners. One specific interaction involves a partner that, when bound to MYPT1, triggers the proteasomal d... | |
medium_divergent_branch_03381 | CHFR interacts with multiple genes. One interaction is characterized by the following evidence: 'Here we report that CHFR interacts with a SWI/SNF-like BAF complex component, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway, and that... | arteriosclerosis disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHFR interacts with multiple genes. One interaction is characterized by the following evidence: 'Here we report that CHFR interacts with a SWI/SNF-li... | |
medium_divergent_branch_03382 | ITGB2 interacts with multiple genes. Evidence for one of these interactions indicates that the partner protein binds integrin and LUBAC in a mutually exclusive manner. Which gene is connected to ITGB2 through this interaction? | UBL4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB2 interacts with multiple genes. Evidence for one of these interactions indicates that the partner protein binds integrin and LUBAC in a mutually... | |
medium_divergent_branch_03383 | The gene PPP1R12A interacts with multiple partners. One specific interaction involves a partner described as 'Seven in absentia homolog 2', which binds to MYPT1 and causes its proteasomal degradation in mammalian cells, including neurons and glia. Which disease is associated with this specific interacting partner via a... | gastric cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03383","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R12A interacts with multiple partners. One specific interaction involves a partner described as 'Seven in absentia homolog 2', which bin... | |
medium_divergent_branch_03384 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.949 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Tumor-associated calcium signal transducer 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03384","source_qa_id":"medium_divergent_branch_03743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03385 | PTTG1IP interacts with multiple genes. One of these interactions is supported by evidence stating: 'Glutathione S-transferase pull-down and co-immunoprecipitation assays demonstrate that PBF interacts specifically with the gene product of PTTG1 under both in vitro and in vivo conditions.' Which protein is encoded by th... | Securin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTTG1IP interacts with multiple genes. One of these interactions is supported by evidence stating: 'Glutathione S-transferase pull-down and co-immuno... | |
medium_divergent_branch_03386 | CEP164 interacts with multiple proteins. One of these interactions is notably enhanced by UV irradiation. Which protein, among those interacting with CEP164, is the one whose interaction with CEP164 is strengthened by UV exposure? Identify the protein encoded by the gene corresponding to this specific interacting partn... | DNA repair protein complementing XP-A cells | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEP164 interacts with multiple proteins. One of these interactions is notably enhanced by UV irradiation. Which protein, among those interacting with... | |
medium_divergent_branch_03387 | MAPK8 interacts with multiple proteins. One interaction is supported by evidence stating: 'A search for SCCA-interacting molecules showed specific binding with phosphorylated JNK.' Which protein corresponds to this specific interaction evidence? | Serpin B4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8 interacts with multiple proteins. One interaction is supported by evidence stating: 'A search for SCCA-interacting molecules showed specific bi... | |
medium_divergent_branch_03389 | CD19 is associated with multiple biological processes. One association is supported by evidence stating that coligation of the membrane protein CD19 with the antigen receptor of B lymphocytes decreased the threshold for antigen receptor-dependent stimulation by two orders of magnitude. Which biological process, connect... | regulation of lymphocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD19 is associated with multiple biological processes. One association is supported by evidence stating that coligation of the membrane protein CD19 ... | |
medium_divergent_branch_03391 | TBX3 is implicated in multiple biological processes. One specific process is supported by evidence stating that Tbx2 and TBX3 trigger the development of cushions through a regulatory feed-forward loop involving Bmp2. Which biological process is this specific process a part of? | endocardial cushion morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03391","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBX3 is implicated in multiple biological processes. One specific process is supported by evidence stating that Tbx2 and TBX3 trigger the development... | |
medium_divergent_branch_03392 | mmu-miR-34a-5p regulates more than one cell type. Evidence for one of these regulatory connections reports that ectopic miR-34a expression suppresses DGKζ protein expression through seed match binding to both the 3' untranslated region and coding region of DGKζ mRNA, leading to increased ERK1/2 phosphorylation and surf... | T cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-34a-5p regulates more than one cell type. Evidence for one of these regulatory connections reports that ectopic miR-34a expression suppresses... | |
medium_divergent_branch_03394 | BMPR2 interacts with multiple proteins. One interaction is supported by evidence stating that BMPR-II is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which protein, connected to BMPR2 via this specific bind... | Bone morphogenetic protein receptor type-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR2 interacts with multiple proteins. One interaction is supported by evidence stating that BMPR-II is a transmembrane serine/threonine kinase that... | |
medium_divergent_branch_03395 | The gene THRA interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In mammalian two-hybrid experiments as well as in GST-pull down assays, hSrb7 interacts with TR but not with other nuclear receptors such as the retinoic acid receptor (RAR) or the vitamin D receptor (VDR).' Whic... | Mediator of RNA polymerase II transcription subunit 21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene THRA interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In mammalian two-hybrid experiments as we... | |
medium_divergent_branch_03396 | The gene POLR2I interacts with multiple proteins. One specific interaction is described as direct and mediated by the RPB1 subunit of RNA polymerase II. Which protein product is encoded by the gene involved in this specific interaction? | ATP-dependent DNA helicase Q5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03396","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLR2I interacts with multiple proteins. One specific interaction is described as direct and mediated by the RPB1 subunit of RNA polymerase ... | |
medium_divergent_branch_03397 | The gene AMOT interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that this protein binds a number of polarity-associated proteins, in particular members of the angiomotin (AMOT) family.' Based on this evidence, which interacting partner is identified, and in which cell... | cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AMOT interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that this protein binds a number ... | |
medium_divergent_branch_03398 | ADAM15 is associated with multiple biological processes. One association is supported by evidence that exosomes rich in ADAM15 suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration. Which biological process, connected to the process described by this evidence via a 'negatively regulates' re... | cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM15 is associated with multiple biological processes. One association is supported by evidence that exosomes rich in ADAM15 suppress vitronectin- ... | |
medium_divergent_branch_03400 | TRIM32 interacts with multiple proteins. One specific interaction involves a partner that localizes to spindle poles during mitosis, where TRIM32 facilitates its proteasomal degradation, leading to apoptosis with condensed chromatin (ACD). Which protein is encoded by the gene corresponding to this specific interaction ... | N-myc proto-oncogene protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM32 interacts with multiple proteins. One specific interaction involves a partner that localizes to spindle poles during mitosis, where TRIM32 fac... | |
medium_divergent_branch_03402 | CLIP3 interacts with multiple proteins. One specific interaction involves CLIPR-59 binding to a target protein, which then dissociates upon stimulation by TNF-α. Which protein, encoded by the gene connected to CLIP3 via this specific binding interaction, is the target of this dissociation event? | Tumor necrosis factor receptor superfamily member 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLIP3 interacts with multiple proteins. One specific interaction involves CLIPR-59 binding to a target protein, which then dissociates upon stimulati... | |
medium_divergent_branch_03403 | RAB7B is associated with multiple biological processes. One association is supported by evidence stating: 'We report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation.' Which biological process is positively regulat... | megakaryocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB7B is associated with multiple biological processes. One association is supported by evidence stating: 'We report that Rab7b, a late endosome/lyso... | |
medium_divergent_branch_03404 | BTN3A2 interacts with multiple proteins. One of these interaction partners has been shown to target the early stage of the SARS-CoV-2 viral life cycle by inhibiting viral attachment through interactions with the receptor-binding domain (RBD) of the Spike protein and itself. Which protein, encoded by the gene connected ... | Angiotensin-converting enzyme 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03404","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTN3A2 interacts with multiple proteins. One of these interaction partners has been shown to target the early stage of the SARS-CoV-2 viral life cycl... | |
medium_divergent_branch_03405 | BRCC3 interacts with multiple proteins. One interaction partner is known to associate with Abraxas through coiled-coil domains on each protein. Which protein, encoded by the gene connected to BRCC3 via this specific interaction, is the subject of this description? | BRCA1-A complex subunit RAP80 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCC3 interacts with multiple proteins. One interaction partner is known to associate with Abraxas through coiled-coil domains on each protein. Which... | |
medium_divergent_branch_03406 | The gene H3F3B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show by coimmunoprecipitation that this localization is dependent on the association of this protein with histone H3.3, and that mutating the K4 residue of H3.3 significantly diminishes the interaction between this pr... | Transcriptional regulator ATRX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene H3F3B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show by coimmunoprecipitation that this locali... | |
medium_divergent_branch_03407 | Paneth cells are a specific type of epithelial cell located in the basal part of the intestinal glands (crypts of Lieberkühn), including the appendix. These cells synthesize and secrete lysozyme and cryptdins. They are numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, are rich in zinc... | protein secreting cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Paneth cells are a specific type of epithelial cell located in the basal part of the intestinal glands (crypts of Lieberkühn), including the appendix... | |
medium_divergent_branch_03408 | The gene FGA is known to interact with multiple other genes. One specific interaction is supported by experimental evidence stating: 'In surface plasmon resonance experiments, both tPA and Pg bound to the immobilized alphaC-fragment with K(d)s of 33 and 32 nM, respectively.' Identify the protein that is encoded by the ... | Tissue-type plasminogen activator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FGA is known to interact with multiple other genes. One specific interaction is supported by experimental evidence stating: 'In surface plas... | |
medium_divergent_branch_03409 | The protein CCDC66 is associated with multiple biological processes. One specific association is supported by evidence stating that CCDC66 bundles microtubules in vitro and in cells via its C-terminal microtubule-binding domain. Identify the broader biological process category that encompasses this specific microtubule... | microtubule cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CCDC66 is associated with multiple biological processes. One specific association is supported by evidence stating that CCDC66 bundles mi... |
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