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medium_divergent_branch_03410 | AP1B1 interacts with multiple proteins. One interaction partner is described by evidence stating: 'Recombinantly expressed [protein] interacts directly with the gamma-appendage domain of AP-1, with the clathrin N-terminal domain through the peptide motif (423)LFDLM, with the gamma-adaptin ear homology domain of Golgi-l... | Clathrin interactor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03410","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP1B1 interacts with multiple proteins. One interaction partner is described by evidence stating: 'Recombinantly expressed [protein] interacts direct... | |
medium_divergent_branch_03411 | AKT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, in BMDMs, the catalytic subunit of DNA-dependent protein kinase associates with Akt upon CpG-DNA stimulation and triggers transient nuclear translocation of Akt.' Which protein is encoded by the gene corresponding to ... | DNA-dependent protein kinase catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03411","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, in BMDMs, the catalytic subunit of DNA-depende... | |
medium_divergent_branch_03412 | CHEK1 interacts with multiple genes. One of these interacting partners is described in evidence stating that its wild-type form, but not catalytically defective or nuclear localization sequence-deficient mutants, reduces CHK1 K63-linked ubiquitination. Which cellular component is this specific interacting partner locat... | chromatin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03412","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple genes. One of these interacting partners is described in evidence stating that its wild-type form, but not catalyticall... | |
medium_divergent_branch_03413 | The gene PPP1R13L interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'iASPP lacks a PP-1c-binding RVXF motif; however, we show it interacts with PP-1c via a RARL sequence with a Kd value of 26 nM.' Which protein is encoded by the gene that interacts with PPP1R13L and matches... | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03413","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R13L interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'iASPP lacks a PP-1c-binding RVXF m... | |
medium_divergent_branch_03414 | BAK1 interacts with multiple genes. One specific interaction involves the loss of binding between Bak and an anti-apoptotic Bcl-2 family member upon the formation of a p53-Bak complex. Which disease is causally linked to this specific anti-apoptotic partner? | latent tuberculosis infection | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAK1 interacts with multiple genes. One specific interaction involves the loss of binding between Bak and an anti-apoptotic Bcl-2 family member upon ... | |
medium_divergent_branch_03415 | SMC1A interacts with multiple proteins. One interaction is supported by evidence stating that protein complexes containing heterodimers of Smc1 and the interacting partner are specifically implicated in both sister chromatid cohesion and DNA recombination. Which protein, connected to SMC1A via this interaction, is the ... | Structural maintenance of chromosomes protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMC1A interacts with multiple proteins. One interaction is supported by evidence stating that protein complexes containing heterodimers of Smc1 and t... | |
medium_divergent_branch_03416 | The gene ACVR1 is known to interact with multiple proteins. One specific interaction partner is distinguished by binding evidence showing that a specific ligand binds to ALK-2 and ALK-6 efficiently, and to ALK-3 less efficiently, whereas BMP-4 binds to ALK-3 and ALK-6 efficiently. Which protein is encoded by the gene c... | Bone morphogenetic protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACVR1 is known to interact with multiple proteins. One specific interaction partner is distinguished by binding evidence showing that a spec... | |
medium_divergent_branch_03417 | Adipocytes are structural components of multiple anatomical entities. One such entity is described as a portion of connective tissue composed of adipocytes enmeshed in areolar tissue. Which anatomical entity, connected to the adipocyte via a 'part of' relationship, fits this description and is classified as a type of c... | dense irregular connective tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03417","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Adipocytes are structural components of multiple anatomical entities. One such entity is described as a portion of connective tissue composed of adip... | |
medium_divergent_branch_03418 | The short descending thin limb is anatomically connected to a specific tissue type via an 'is a' relationship. Evidence indicates that the short descending thin limb is the descending thin limb of a short nephron characterized by a squamous epithelial morphology. Which tissue type is connected to the short descending t... | epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The short descending thin limb is anatomically connected to a specific tissue type via an 'is a' relationship. Evidence indicates that the short desc... | |
medium_divergent_branch_03420 | UHRF1 interacts with multiple proteins. Evidence for one specific interaction indicates that the interaction with a methylated form of the partner protein promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylation maintenance. Which protein, encoded by the gene connected to UHRF1 via... | DNA ligase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03420","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UHRF1 interacts with multiple proteins. Evidence for one specific interaction indicates that the interaction with a methylated form of the partner pr... | |
medium_divergent_branch_03421 | MALT1 interacts with multiple genes. One of these interaction partners is an NF-κB family member that is cleaved by MALT1 after Arg-85. Which disease is associated with this specific gene through genomic alterations? | Familial X-linked hypophosphatemic vitamin D refractory rickets | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MALT1 interacts with multiple genes. One of these interaction partners is an NF-κB family member that is cleaved by MALT1 after Arg-85. Which disease... | |
medium_divergent_branch_03422 | The RB1 gene interacts with multiple partners. One specific interaction partner was originally identified as a retinoblastoma protein (RB) pocket domain-binding protein known as Retinoblastoma-binding protein 2 (Rbp2). Which disease is associated with this specific interaction partner via a biomarker relationship? | childhood leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 gene interacts with multiple partners. One specific interaction partner was originally identified as a retinoblastoma protein (RB) pocket dom... | |
medium_divergent_branch_03423 | STX7 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding assays established that syntaxin 7 in membrane extracts interacts with immobilized recombinant alpha-soluble N-ethylmaleimide-sensitive factor attachment proteins fused to glutathione S-transferase.' Which protein... | Alpha-soluble NSF attachment protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX7 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding assays established that syntaxin 7 in memb... | |
medium_divergent_branch_03424 | The gene FAM174B is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.42 TPM, a z-score of 1.56, and a fold enrichment of 2.79. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type hierarchy... | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FAM174B is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.42 TPM, a z-score of... | |
medium_divergent_branch_03425 | POLR2H interacts with multiple proteins. One of these interaction partners forms a complex that polyubiquitinates RPB8 both in vivo and in vitro. Which protein is encoded by the gene corresponding to this specific interaction partner? | BRCA1-associated RING domain protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLR2H interacts with multiple proteins. One of these interaction partners forms a complex that polyubiquitinates RPB8 both in vivo and in vitro. Whi... | |
medium_divergent_branch_03426 | Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.791 and an adjusted p-value of 0.00498. Which protein does that selected gene encode? | Rho GTPase-activating protein 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03426","source_qa_id":"medium_divergent_branch_07448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03427 | CIB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we isolated a protein that interacts with caspase-2S, designated as Ich-1S (caspase-2S)-binding protein (ISBP), by yeast two-hybrid screening using full-length caspase-2S cDNA as a bait.' Which protein, among those interacti... | Caspase-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03427","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CIB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we isolated a protein that interacts with caspase-2S,... | |
medium_divergent_branch_03428 | ATF3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that ATF3 and this interaction partner form a complex capable of binding to the NOXA promoter, which is required for NOXA activation.' What is the name of the protein encoded by this interaction partner? | Cyclic AMP-dependent transcription factor ATF-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03428","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that ATF3 and this interaction partner for... | |
medium_divergent_branch_03429 | GH1 is associated with multiple biological processes. One specific association is supported by evidence stating that the process was significantly accelerated in the GH-treated group compared with the controls (1.6 (0.4) versus 1.0 (0.2) years per year, respectively). What is the parent biological process of this speci... | animal organ maturation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03429","source_qa_id":"medium_divergent_branch_05246","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GH1 is associated with multiple biological processes. One specific association is supported by ev... | |
medium_divergent_branch_03430 | APPL1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Here, we show that APPL1 localizes to dendritic spines and synapses.' Which cellular component, connected to the component identified by this evidence through an 'is a' re... | synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APPL1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_03431 | Type I pneumocytes are structurally part of a specific anatomical entity. One potential connection is supported by evidence describing 'The epithelial layer of the alveoli' and 'The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles.' Which anatomical entity is connected to the type I... | alveolar wall | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Type I pneumocytes are structurally part of a specific anatomical entity. One potential connection is supported by evidence describing 'The epithelia... | |
medium_divergent_branch_03433 | RNF38 interacts with multiple proteins. One interaction is supported by evidence stating that mechanistic investigations suggested RNF38 inactivates the NF-κB and ERK1/2 signaling pathways by inducing ubiquitination and degradation of the interacting partner. Which protein is encoded by the gene corresponding to this i... | Alpha-actinin-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03433","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF38 interacts with multiple proteins. One interaction is supported by evidence stating that mechanistic investigations suggested RNF38 inactivates ... | |
medium_divergent_branch_03434 | HDAC4 interacts with multiple proteins. One specific interaction involves HDAC4 binding to a MADS-box transcription factor through a small region located at its N-terminal domain. Which disease is causally linked to this specific interacting partner? | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC4 interacts with multiple proteins. One specific interaction involves HDAC4 binding to a MADS-box transcription factor through a small region loc... | |
medium_divergent_branch_03435 | Dendrites are anatomically associated with multiple structures via part-of relationships. One such structure is described as the molecular layer of the dentate gyrus, which is bounded superficially by the pial surface and deeply by the dentate gyrus granule cell layer, and is divided into two or more sublayers. What is... | layer of dentate gyrus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Dendrites are anatomically associated with multiple structures via part-of relationships. One such structure is described as the molecular layer of t... | |
medium_divergent_branch_03436 | The gene EVL interacts with multiple partners. One interaction is supported by surface plasmon resonance analyses revealing that MENA, the partner protein, and EVL mutually interacted. Which protein is encoded by the gene that interacts with EVL in this specific context? | Vasodilator-stimulated phosphoprotein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03436","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EVL interacts with multiple partners. One interaction is supported by surface plasmon resonance analyses revealing that MENA, the partner pr... | |
medium_divergent_branch_03437 | The protein CUBN is associated with multiple molecular functions via the 'enables' relationship. One specific function is supported by the following evidence: 'The present report shows the molecular characterization of the rat 460-kDa epithelial glycoprotein that functions as the receptor facilitating uptake of intrins... | molecular_function | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03437","source_qa_id":"medium_divergent_branch_02874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein CUBN is associated with multiple molecular functions via the 'enables' relationship. ... | |
medium_divergent_branch_03438 | The gene MECOM (encoding EVI1) interacts with multiple partners. One specific interaction is characterized by the formation of an active complex with methyltransferase activity in vitro. Which disease is associated with the gene that forms this methyltransferase-active complex with EVI1? | squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MECOM (encoding EVI1) interacts with multiple partners. One specific interaction is characterized by the formation of an active complex with... | |
medium_divergent_branch_03439 | GRIN1 interacts with multiple proteins. One interaction partner is supported by evidence showing that Neto1(HA) co-immunoprecipitates with assembled NMDA receptors via GluN2A or a specific GluN2 subunit, but does not co-immunoprecipitate with APP695(FLAG). Which protein, connected to GRIN1 through this specific interac... | Glutamate receptor ionotropic, NMDA 2B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03439","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRIN1 interacts with multiple proteins. One interaction partner is supported by evidence showing that Neto1(HA) co-immunoprecipitates with assembled ... | |
medium_divergent_branch_03440 | WNT2 is implicated in multiple biological processes. One line of evidence notes that several Wnts, including WNT2, are expressed in the lens anterior epithelium, while others like Wnt5a, Wnt5b, Wnt7a, and Wnt7b are found in differentiating lens fiber cells. Based on this tissue-specific expression context, which biolog... | anatomical structure development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03440","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT2 is implicated in multiple biological processes. One line of evidence notes that several Wnts, including WNT2, are expressed in the lens anterior... | |
medium_divergent_branch_03441 | ADRM1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We also report the crystal structures of the RPN13 PRU domain in complex with peptides corresponding to the RPN2 C terminus and ubiquitin.' Which protein, among those interacting with ADRM1, is the one described... | Polyubiquitin-B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADRM1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We also report the crystal structures of... | |
medium_divergent_branch_03443 | INSIG2 interacts with multiple proteins. One interaction is described as follows: 'This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to the SREBP cleavage-activating protein in a sterol-regulated fashi... | Sterol regulatory element-binding protein cleavage-activating protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03443","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"INSIG2 interacts with multiple proteins. One interaction is described as follows: 'This paper describes insig-2, a second protein of the endoplasmic ... | |
medium_divergent_branch_03444 | ZNF746 interacts with multiple proteins. One of these interaction partners is a deSUMOylase that was reported to interact with PARIS and enhance the ubiquitination of PARIS independently of its SUMOylation in HeLa cells. Which protein is this interaction partner? | Sentrin-specific protease 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNF746 interacts with multiple proteins. One of these interaction partners is a deSUMOylase that was reported to interact with PARIS and enhance the ... | |
medium_divergent_branch_03445 | MIR150 is associated with multiple biological processes. One association is supported by evidence stating that 'miRNA gain/loss-of-function analyses revealed that miR-150 and miR-200c were crucial in EC differentiation.' Identify the biological process that is positively regulated by the specific process linked to MIR1... | endothelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR150 is associated with multiple biological processes. One association is supported by evidence stating that 'miRNA gain/loss-of-function analyses ... | |
medium_divergent_branch_03446 | Vimentin (VIM) interacts with multiple genes. One of these interacting partners has been shown to interact with vimentin and control vimentin stabilization through ubiquitination, specifically in the form of K63 chains. Which biological process is this specific interacting gene involved in? | protein ubiquitination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Vimentin (VIM) interacts with multiple genes. One of these interacting partners has been shown to interact with vimentin and control vimentin stabili... | |
medium_divergent_branch_03447 | The sebaceous gland placode is classified as a type of two different anatomical entities. One of these entities is described in the evidence as 'a thickening of the ectoderm that will give rise to the sebaceous gland bud'. Which anatomical entity is the sebaceous gland placode a subtype of, based on this description? | ectodermal placode | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The sebaceous gland placode is classified as a type of two different anatomical entities. One of these entities is described in the evidence as 'a th... | |
medium_divergent_branch_03448 | ANGPT1 is associated with multiple biological processes. One specific association is supported by evidence showing that Ang1/Tie-2 signaling, via the ERK1/2 pathway, decreases muscle progenitor cell (MPC) proliferation and differentiation, increases the number of cells in G0, upregulates regenerative cell-associated ma... | regulation of skeletal muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPT1 is associated with multiple biological processes. One specific association is supported by evidence showing that Ang1/Tie-2 signaling, via the... | |
medium_divergent_branch_03449 | RPTOR interacts with multiple proteins. One interaction is characterized by the following evidence: 'In addition, the protein was found to bind raptor, induce its phosphorylation, and inhibit the kinase activity of mTORC1.' What is the name of the protein encoded by the gene corresponding to this interaction partner? | Serine/threonine-protein kinase ULK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03449","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPTOR interacts with multiple proteins. One interaction is characterized by the following evidence: 'In addition, the protein was found to bind rapto... | |
medium_divergent_branch_03450 | PKD1 interacts with multiple genes. One specific interaction is supported by evidence stating that the polycystin-1 C-terminus interacts with the regulatory D2 phosphatase domain of RPTPγ. Which gene, connected to PKD1 via an 'interacts with' relationship, corresponds to this specific molecular evidence? | RAC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03450","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKD1 interacts with multiple genes. One specific interaction is supported by evidence stating that the polycystin-1 C-terminus interacts with the reg... | |
medium_divergent_branch_03451 | ADAM15 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using glutathione S-transferase pull-down assays, we showed that the cytoplasmic domains of ADAM-15A, ADAM-15B, and ADAM-15C show equivalent abilities to interact with extracellular signal-regulated kinase and the adaptor molecu... | SH3 and PX domain-containing protein 2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03451","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM15 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using glutathione S-transferase pull-down assays, we show... | |
medium_divergent_branch_03452 | The gene IL1B interacts with multiple partners. One specific interaction involves a protein that, when chaperoned by Cdc37/Hsp90, recruits an E3 ligase to catalyze the polyubiquitination of pro-IL-1β, a process that signals cargo loading into secretory vesicles. Which protein is encoded by the gene that interacts with ... | E3 ubiquitin-protein ligase NEDD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03452","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL1B interacts with multiple partners. One specific interaction involves a protein that, when chaperoned by Cdc37/Hsp90, recruits an E3 liga... | |
medium_divergent_branch_03453 | The gene DRD2 interacts with multiple partners. One specific interaction was identified using the yeast two-hybrid system, revealing a protein described as 'kelch repeat and BTB (POZ) domain containing 7', which functions as a substrate adaptor for the CUL3-RING ubiquitin ligase complex. Which protein is encoded by the... | Kelch repeat and BTB domain-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03453","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DRD2 interacts with multiple partners. One specific interaction was identified using the yeast two-hybrid system, revealing a protein descri... | |
medium_divergent_branch_03454 | APEX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis now indicates protein-protein contact between Polbeta and human AP endonuclease (Ape protein).' Which protein, encoded by the gene connected to APEX1 via this specific interaction, is the subject of this... | DNA polymerase beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03454","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APEX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis now indicates protein-protein co... | |
medium_divergent_branch_03455 | mmu-miR-142a regulates more than one cell type. Evidence for one of these regulatory connections reports that genetic ablation of miR-142 caused impaired maturation of this cell type, inhibition of polyploidization, abnormal proplatelet formation, and thrombocytopenia. Which cell type does this regulated cell develop f... | megakaryocyte progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03455","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-142a regulates more than one cell type. Evidence for one of these regulatory connections reports that genetic ablation of miR-142 caused impa... | |
medium_divergent_branch_03456 | The gene UBXN10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.64 TPM, a z-score of 1.72, and a fold enrichment of 3.76. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene UBXN10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.64 TPM, a ... | |
medium_divergent_branch_03457 | DNAAF3 (also known as PF22) is essential for the preassembly of dyneins into complexes before their transport into cilia. Which specific molecular complex is the direct result of this assembly process? | axonemal dynein complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNAAF3 (also known as PF22) is essential for the preassembly of dyneins into complexes before their transport into cilia. Which specific molecular co... | |
medium_divergent_branch_03458 | SAMM50 interacts with multiple proteins. One specific interaction involves a partner that facilitates the processing and degradation of SAMM50. Which protein is encoded by the gene corresponding to this specific interacting partner? | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03458","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAMM50 interacts with multiple proteins. One specific interaction involves a partner that facilitates the processing and degradation of SAMM50. Which... | |
medium_divergent_branch_03459 | CDC25B interacts with multiple 14-3-3 family proteins. One specific interaction is characterized by strong binding to 14-3-3eta, beta, and zeta isoforms, but poor binding to epsilon and theta isoforms in a two-hybrid assay. Which cell type is enriched for the 14-3-3 protein that exhibits this specific binding profile w... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDC25B interacts with multiple 14-3-3 family proteins. One specific interaction is characterized by strong binding to 14-3-3eta, beta, and zeta isofo... | |
medium_divergent_branch_03460 | PPARGC1B is associated with multiple molecular functions. One specific association is supported by evidence stating that the coactivation function of PERC relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AF2 domain of ERalpha in an estrogen-dependent manner. Which mole... | nuclear receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03460","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARGC1B is associated with multiple molecular functions. One specific association is supported by evidence stating that the coactivation function of... | |
medium_divergent_branch_03461 | HLA-E is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'Using a newly characterised antibody recognising HLA-E, we show that HLA-E is expressed at the cell surface.' Based on this evidence, which cellular component is linked to HLA-E, and what is the paren... | membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-E is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'Using a newly characterised a... | |
medium_divergent_branch_03464 | CHMP4B interacts with multiple proteins. One interaction partner is identified by evidence stating: 'In the yeast two-hybrid assay, HD-PTP showed positive interactions with CHMP4b/Shax1, TSG101, endophilin A1 and ALG-2 but not with either RabGAPLP or CIN85.' Which disease is associated with this specific interaction pa... | microcephaly 29, primary, autosomal recessive | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP4B interacts with multiple proteins. One interaction partner is identified by evidence stating: 'In the yeast two-hybrid assay, HD-PTP showed pos... | |
medium_divergent_branch_03465 | The gene COL2A1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Binding assays showed that the association equilibrium constant of collagen IX-collagen II interaction is 15 x 10(6) M(-1).' Which protein is encoded by the gene that interacts with COL2A1 in this specific c... | Collagen alpha-1(IX) chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene COL2A1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Binding assays showed that the assoc... | |
medium_divergent_branch_03466 | SIAH2 interacts with multiple proteins. One of these interaction partners has been shown to bind SIAH2 and inhibit its self-ubiquitination and degradation, thereby increasing SIAH2 protein levels. Which protein, encoded by the gene interacting with SIAH2 in this specific manner, is the subject of this description? | Aldo-keto reductase family 1 member C3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH2 interacts with multiple proteins. One of these interaction partners has been shown to bind SIAH2 and inhibit its self-ubiquitination and degrad... | |
medium_divergent_branch_03467 | PDS5B interacts with multiple genes. One of these interaction partners is reported to interact directly with APRIN, PALB2, and BRCA2. Which disease is causally linked to this specific interaction partner? | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03467","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDS5B interacts with multiple genes. One of these interaction partners is reported to interact directly with APRIN, PALB2, and BRCA2. Which disease i... | |
medium_divergent_branch_03468 | SMAD3 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'We also demonstrate that the binding of phospho-Smad3 to Smad4 prevents Smad4 from interacting with the nuclear export receptor chromosome region maintenance 1. In this way, TGF-beta signaling suppresses nuclea... | protein import into nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD3 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'We also demonstrate that the binding of... | |
medium_divergent_branch_03469 | ETS1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In two different yeast assays, ETS-1 interacted with huUBC9.' Which protein corresponds to this interaction partner? | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03469","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETS1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In two different yeast assays, ETS-1 in... | |
medium_divergent_branch_03470 | COPS4 interacts with multiple proteins. One interaction is supported by evidence stating that 'TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes.' Identify the disease associated with the protein referred to as 'TA' in this context, where the association is defined by a bi... | influenza | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPS4 interacts with multiple proteins. One interaction is supported by evidence stating that 'TA binds CSN4 and the synaptic regulator snapin in neu... | |
medium_divergent_branch_03471 | The biological process 'positive regulation of T-helper 1 type immune response' is enabled by more than one cell type. One of these cell types is described as a mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. Which cell type does this specific NK T cell develop from? | activated CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'positive regulation of T-helper 1 type immune response' is enabled by more than one cell type. One of these cell types is des... | |
medium_divergent_branch_03472 | TBX20 is involved in multiple biological processes. One of these processes is linked to evidence stating that Ostium secundum atrial septal defects (ASDII) account for approximately 10% of all congenital heart defects, and mutations in cardiac transcription factors, including TBX20, are an underlying cause. Which anato... | interatrial septum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03472","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBX20 is involved in multiple biological processes. One of these processes is linked to evidence stating that Ostium secundum atrial septal defects (... | |
medium_divergent_branch_03473 | KCNE1 interacts with multiple proteins. One interaction partner forms a complex with KCNE1 that recapitulates the slow delayed rectifier potassium current (I(Ks)), whereas co-expression of KCNE1 with another partner augments the amplitude of an I(Kr)-like current. Which protein, connected to KCNE1 via a binding interac... | Potassium voltage-gated channel subfamily KQT member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03473","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNE1 interacts with multiple proteins. One interaction partner forms a complex with KCNE1 that recapitulates the slow delayed rectifier potassium cu... | |
medium_divergent_branch_03474 | Pleiotrophin (PTN) interacts with multiple proteins. One specific interaction is described by the evidence: 'We have found that PTN binds to and functionally inactivates the catalytic activity of RPTP beta/zeta.' Which protein, encoded by the gene associated with this specific interaction, is the target of PTN binding? | Receptor-type tyrosine-protein phosphatase zeta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pleiotrophin (PTN) interacts with multiple proteins. One specific interaction is described by the evidence: 'We have found that PTN binds to and func... | |
medium_divergent_branch_03475 | TAB3 interacts with multiple proteins. One interaction partner is described in evidence stating that it interacts with the NZF domain of TAB2 and TAB3, as well as components of the linear ubiquitin chain assembly complex, to block ubiquitin-chain binding and negatively regulate NF-κB signaling. Which protein is encoded... | Peptidyl-prolyl cis-trans isomerase-like 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB3 interacts with multiple proteins. One interaction partner is described in evidence stating that it interacts with the NZF domain of TAB2 and TAB... | |
medium_divergent_branch_03476 | FEN1 interacts with multiple proteins. One interaction is characterized by evidence stating that a PCNA-interacting box (PIP box)-containing peptide derived from hFen1 binds tightly to the interdomain connecting loop of hRad1, providing the molecular basis for the damage repair-specific activity of the 9-1-1 complex in... | Checkpoint protein HUS1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03476","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FEN1 interacts with multiple proteins. One interaction is characterized by evidence stating that a PCNA-interacting box (PIP box)-containing peptide ... | |
medium_divergent_branch_03477 | ANGPTL7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that ANGPTL7 modulates the trabecular meshwork's ECM as well as the response of this tissue to steroids.' Which biological process, connected to the process described by this evidence via ... | regulation of cellular component organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03477","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPTL7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that ANGPTL7 modu... | |
medium_divergent_branch_03478 | The MSH2 protein interacts with multiple partners. One specific interaction involves a kinase that forms a signaling module with MSH2 to regulate the phosphorylation of Chk1 and SMC1. Which gene encodes this interacting kinase? | Serine/threonine-protein kinase ATR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MSH2 protein interacts with multiple partners. One specific interaction involves a kinase that forms a signaling module with MSH2 to regulate the... | |
medium_divergent_branch_03479 | FKBP8 interacts with multiple proteins. One of these interaction partners is known to interact directly with FKBP38, preventing FKBP38's association with mTOR in a GTP-dependent manner. Which protein, encoded by the gene connected to FKBP8 via this specific interaction, is the subject of this description? | GTP-binding protein Rheb | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03479","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP8 interacts with multiple proteins. One of these interaction partners is known to interact directly with FKBP38, preventing FKBP38's association ... | |
medium_divergent_branch_03480 | The transcription factor SP1 interacts with multiple proteins. One specific interaction partner is described as an ACEI-activated deubiquitinating enzyme that translocates into the nucleus to bind SP1 (and Sp3), where these factors are deacetylated by HDAC1. Which protein is encoded by the gene corresponding to this sp... | Ubiquitin carboxyl-terminal hydrolase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03480","source_qa_id":"medium_divergent_branch_02381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The transcription factor SP1 interacts with multiple proteins. One specific interaction partner i... | |
medium_divergent_branch_03481 | BCL2L13 interacts with multiple genes. One of these interaction partners is described as binding to proapoptotic ceramide synthases 2 and 6 via a unique C-terminal 250-amino acid sequence located between its Bcl-2 homology and membrane anchor domains, thereby blocking homo- and heteromeric complex formation and activit... | invasive breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2L13 interacts with multiple genes. One of these interaction partners is described as binding to proapoptotic ceramide synthases 2 and 6 via a uni... | |
medium_divergent_branch_03483 | RAB5C interacts with multiple genes. One of these interactions is supported by evidence stating: 'Although the homologous C(2)H(2) Zn(2+) finger of the Rab5 effector Rabenosyn binds to Rab5 with comparable affinity, the analogous C(2)H(2) Zn(2+) finger of the yeast homologue Vac1 shows no detectable interaction with Ra... | VPS45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03483","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB5C interacts with multiple genes. One of these interactions is supported by evidence stating: 'Although the homologous C(2)H(2) Zn(2+) finger of t... | |
medium_divergent_branch_03484 | Type II interferon production is enabled by more than one cell type. One of these cell types is described as a recently activated type I NK T cell that secretes interferon-gamma and IL-4, exhibits a CD4-positive and CD69-positive phenotype, and shows downregulated NK markers. Which cell type does this specific activate... | CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Type II interferon production is enabled by more than one cell type. One of these cell types is described as a recently activated type I NK T cell th... | |
medium_divergent_branch_03485 | CETN2 interacts with multiple proteins. One of these interaction partners is described as a binding determinant of SCF (SKP1-CUL1-F-box)-family E3 ubiquitin ligases, enriched at centrosomes, and interacting with Centrin-2, Centrin-3, CEP152, and CEP192. Which protein corresponds to this description? | F-box and leucine-rich repeat protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03485","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CETN2 interacts with multiple proteins. One of these interaction partners is described as a binding determinant of SCF (SKP1-CUL1-F-box)-family E3 ub... | |
medium_divergent_branch_03486 | Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.115 and an adjusted p-value of 0.03399. Which molecular function is enabled by the gene corresponding to this specific evidence? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03486","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.115 and an adjusted p-value... | |
medium_divergent_branch_03487 | The gene ACOT9 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 82.72 TPM, a z-score of 2.20, and a fold enrichment of 3.81. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03487","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACOT9 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 82.72 TPM, a z-score of 2.20, and a fold enr... | |
medium_divergent_branch_03489 | Iron interacts with multiple drugs. One of these drugs, referred to as DP, is described in evidence as representing a novel iron-chelating strategy for the treatment of iron-induced gut disorders. Which disease is this specific drug indicated for? | mercury poisoning | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03489","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Iron interacts with multiple drugs. One of these drugs, referred to as DP, is described in evidence as representing a novel iron-chelating strategy f... | |
medium_divergent_branch_03491 | NOTCH1 is associated with multiple biological processes. One association is supported by evidence stating that 'NotchIC was unable to block muscle cell differentiation in myoblasts expressing antisense SKIP.' Identify the biological process connected to this specific NOTCH1-associated process via the relation 'negative... | myoblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 is associated with multiple biological processes. One association is supported by evidence stating that 'NotchIC was unable to block muscle ce... | |
medium_divergent_branch_03492 | The gene ITPR1 interacts with multiple other genes. One specific interaction is characterized by a Ca(2+)-independent binding between the partner protein and the NH(2)-terminal 159 amino acids of the type 1 InsP(3)R. Which protein is encoded by the gene that interacts with ITPR1 in this specific manner? | Calcium-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03492","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITPR1 interacts with multiple other genes. One specific interaction is characterized by a Ca(2+)-independent binding between the partner pro... | |
medium_divergent_branch_03493 | The interrenal epinephrin secreting cell is a subclass of two distinct cell types. One of these parent types is characterized by evidence describing an entity found in teleosts that contains small, homogeneous electron-lucent granules separated from the vesicular membrane by a visible halo. Which of the two parent cell... | chromaffin cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03493","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The interrenal epinephrin secreting cell is a subclass of two distinct cell types. One of these parent types is characterized by evidence describing ... | |
medium_divergent_branch_03494 | ZNRF2 interacts with multiple genes. One interaction is supported by evidence stating: 'Searching for potential regulators of this variant polyubiquitylation we have identified four proteins, namely RNF8, KIA00675, KF1, and the shared gene, that interact with a ubiquitin-conjugating enzyme through their RING finger dom... | fetal alcohol syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNRF2 interacts with multiple genes. One interaction is supported by evidence stating: 'Searching for potential regulators of this variant polyubiqui... | |
medium_divergent_branch_03495 | SMARCA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Biochemical studies indicated that a nuclear receptor was associated with the mSin3A-Swi/Snf complex by direct interaction with Brm and mSin3A through its repression domain.' Which protein, connected to SMARCA2 via this interac... | Nuclear receptor subfamily 0 group B member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Biochemical studies indicated that a nuclear receptor wa... | |
medium_divergent_branch_03496 | TERT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, Ku associated with the in vitro translated catalytic subunit of telomerase (hTERT) in the absence of telomerase RNA (hTR) or telomeric DNA.' Which gene, known to interact with TERT, is identified in this context? | XRCC6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03496","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TERT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, Ku associated with the in vitro translated ... | |
medium_divergent_branch_03497 | The gene SLC38A2 (also known as SNAT2) is associated with multiple molecular functions via the 'enables' relationship. One specific piece of evidence notes that transfection with siRNAs targeting SNAT2 suppressed the increase in SNAT2 mRNA and the stimulation of system A transport activity. Based on this evidence, whic... | transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03497","source_qa_id":"medium_divergent_branch_00491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene SLC38A2 (also known as SNAT2) is associated with multiple molecular functions via the 'e... | |
medium_divergent_branch_03498 | The protein AGER (also known as RAGE) is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia... | molecular transducer activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein AGER (also known as RAGE) is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here ... | |
medium_divergent_branch_03499 | The PTPN22 gene is associated with multiple biological processes. One specific association is supported by evidence that the CT genotype of the rs2476601 SNP is significantly associated with a reduced fraction of CD3(-) CD56(+) natural killer (NK) cells in culture. Identify the biological process that is directly regul... | natural killer cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03499","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The PTPN22 gene is associated with multiple biological processes. One specific association is supported by evidence that the CT genotype of the rs247... | |
medium_divergent_branch_03500 | UBE2N interacts with multiple proteins. One interaction is supported by evidence stating: 'Structural, biochemical, and functional characterization of the [Protein]α:Ubc13-Ub interactions reveals that activation of the Ubc13-Ub conjugate requires dimerization of the [Protein]α RING domain.' Which protein, connected to ... | Tripartite motif-containing protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2N interacts with multiple proteins. One interaction is supported by evidence stating: 'Structural, biochemical, and functional characterization o... | |
medium_divergent_branch_03501 | IL17B is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that in the human immune system, IL-17B is functionally similar to IL-25 and elicits type 2 cytokine secretion from innate type 2 lymphocytes, NKT, and CD4+ CRTH2+ Th2 cells.' Which biological proce... | interleukin-5 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL17B is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that in the human immune sy... | |
medium_divergent_branch_03504 | The biological process 'positive regulation of antimicrobial humoral response' is defined as any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response. This process is a subtype of several broader biological processes. One of these parent processes is specifically chara... | humoral immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03504","source_qa_id":"medium_divergent_branch_06555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of antimicrobial humoral response' is defined as any ... | |
medium_divergent_branch_03505 | EIF4A1 interacts with multiple proteins. One interaction partner is supported by evidence stating that Far-Western analysis and coimmunoprecipitation experiments demonstrated direct interaction with eIF4A and eIF3. Which disease is associated with this specific interaction partner? | Parkinson disease 18, autosomal dominant, susceptibility to | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03505","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4A1 interacts with multiple proteins. One interaction partner is supported by evidence stating that Far-Western analysis and coimmunoprecipitation... | |
medium_divergent_branch_03506 | KDM1A interacts with multiple genes. One of these interaction partners is part of a complex that includes HDAC1/2, CoREST (a SANT domain-containing corepressor), and a PHF21A homolog (a PHD domain-containing protein). Which disease is associated with this specific interaction partner? | intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03506","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KDM1A interacts with multiple genes. One of these interaction partners is part of a complex that includes HDAC1/2, CoREST (a SANT domain-containing c... | |
medium_divergent_branch_03507 | LEF1 is associated with multiple biological processes. One association is supported by evidence showing that LEF-1 rescue in CD34(+) cells from patients with congenital neutropenia led to granulocytic differentiation and increased levels of functionally active ELA2/NE. Which biological process, connected to the process... | granulocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LEF1 is associated with multiple biological processes. One association is supported by evidence showing that LEF-1 rescue in CD34(+) cells from patie... | |
medium_divergent_branch_03508 | MIR548C is associated with multiple biological processes. One association is supported by evidence that miR-548c-3p, miR-509-3p, and miR-23b-3p induce significant proliferation in adult cardiomyocytes through translational inhibition of Meis1. Which biological process is positively regulated by the specific process lin... | cardiac muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR548C is associated with multiple biological processes. One association is supported by evidence that miR-548c-3p, miR-509-3p, and miR-23b-3p induc... | |
medium_divergent_branch_03509 | GRK2 interacts with multiple G-protein beta subunits. One specific interaction is characterized by the finding that the subunit binds to DDB1 and assembles a DDB1-CUL4A-ROC1 E3 ubiquitin ligase complex to target GRK2 for ubiquitination. Which disease is associated with this specific interacting gene as a biomarker? | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03509","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRK2 interacts with multiple G-protein beta subunits. One specific interaction is characterized by the finding that the subunit binds to DDB1 and ass... | |
medium_divergent_branch_03510 | FGFR1 interacts with multiple proteins. One specific interaction partner is characterized by a PTB domain that recognizes tyrosine-phosphorylated TRKs at an NPXpY motif, while its constitutive association with FGFR involves a receptor juxtamembrane region lacking Tyr and Asn residues. Which protein, connected to FGFR1 ... | Fibroblast growth factor receptor substrate 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03510","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGFR1 interacts with multiple proteins. One specific interaction partner is characterized by a PTB domain that recognizes tyrosine-phosphorylated TRK... | |
medium_divergent_branch_03511 | CD274 (PD-L1) interacts with multiple proteins. One interaction partner is described in a study stating: 'Furthermore, we discovered that [protein encoded by NCBIGene:8239] could be combined with PD-L1 to induce its deubiquitination and stabilize its protein expression in OSCC.' Which protein is encoded by the gene cor... | Ubiquitin carboxyl-terminal hydrolase 9X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03511","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD274 (PD-L1) interacts with multiple proteins. One interaction partner is described in a study stating: 'Furthermore, we discovered that [protein en... | |
medium_divergent_branch_03513 | The protein TMIGD1 is associated with multiple biological processes. One specific association is supported by evidence stating that TMIGD1 controls cell migration, cell morphology, and protects renal epithelial cells from oxidative- and nutrient-deprivation-induced cell injury. Identify the biological process that is a... | regulation of cell motility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03513","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein TMIGD1 is associated with multiple biological processes. One specific association is supported by evidence stating that TMIGD1 controls c... | |
medium_divergent_branch_03514 | SMAD7 interacts with multiple proteins. One specific interaction involves a partner that binds to SMAD7 and prevents its ubiquitination. Which disease is associated with this specific interacting partner? | cervical cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 interacts with multiple proteins. One specific interaction involves a partner that binds to SMAD7 and prevents its ubiquitination. Which diseas... | |
medium_divergent_branch_03515 | RAD17 interacts with multiple proteins. One interaction is supported by evidence stating that 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes play crucial roles in the activation of the ATR-mediated DNA damage and DNA replication stress response pathways.' Which protein, connected to RAD17 via this interaction, is... | Replication factor C subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD17 interacts with multiple proteins. One interaction is supported by evidence stating that 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes pl... | |
medium_divergent_branch_03516 | MAD2L2 interacts with multiple proteins. One of these interaction partners was identified through yeast two-hybrid screening using hREV7 as bait, with the binding confirmed by in vitro and in vivo assays. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Translesion synthesis protein REV1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAD2L2 interacts with multiple proteins. One of these interaction partners was identified through yeast two-hybrid screening using hREV7 as bait, wit... | |
medium_divergent_branch_03517 | CCNDBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified the Grap2 and cyclin D interacting protein (GCIP)/DIP1/CCNDBP1/HHM, a cell cycle-inhibitory molecule, as a binding partner of the gene interacting with CCNDBP1.' Which biological process is the gene identified in thi... | small GTPase-mediated signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNDBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified the Grap2 and cyclin D interacting protein (G... | |
medium_divergent_branch_03519 | DBF4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunoprecipitation... | DNA replication licensing factor MCM7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03519","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DBF4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also identified an interaction between MCM-BP a... | |
medium_divergent_branch_03520 | Otic fibrocytes are components of multiple anatomical structures. One such structure is described as a spiral thickening of the fibrous lining of the cochlear wall that secures the membranous cochlear duct to the bony spiral canal. The fibrocytes within this structure function in conjunction with the stria vascularis t... | nonskeletal ligament | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03520","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Otic fibrocytes are components of multiple anatomical structures. One such structure is described as a spiral thickening of the fibrous lining of the... | |
medium_divergent_branch_03521 | The enzyme OGT is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that a large proportion of the signaling enzyme O-linked-N-acetylglucosaminyl transferase (OGT) is complexed with HCF-1 and this interaction is essential for HCF-1 cleavage.' Which biologic... | proteolysis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The enzyme OGT is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that a large propo... |
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