prompt stringlengths 120 209 | completion stringlengths 15 103 | input_smiles stringlengths 14 103 | output_smiles stringlengths 15 103 | task_id int64 102 102 | winner_action dict |
|---|---|---|---|---|---|
Can you make molecule COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 less soluble in water? The output molecule should be similar to the input molecule. | COCSC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | COCSC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | 102 | {
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
} |
Can you make molecule COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)SC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | CC(=O)SC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
} |
Can you make molecule COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 less soluble in water? The output molecule should be similar to the input molecule. | CON(C)CCCC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | CON(C)CCCC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | 102 | {
"fragment_index": 0,
"new_substring": "CON(C)CCC&",
"old_substring": "CO3"
} |
Can you make molecule COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)CCCC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | CC(=O)CCCC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CO3"
} |
Can you make molecule COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](Oc1ccnc2c(F)cc(F)cc12)C(=O)C(=O)CCBr | COC(=O)[C@H](C)Oc1ccnc2c(F)cc(F)cc12 | C[C@H](Oc1ccnc2c(F)cc(F)cc12)C(=O)C(=O)CCBr | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCBr",
"old_substring": "CO3"
} |
Can you make molecule CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | CCCOc1ccc2c(c1)CCN(Cc1cc(C(C)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(C)=O)cs1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "C&(C)=O",
"old_substring": "C6(N)=O"
} |
Can you make molecule CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | CCCOc1ccc2c(c1)CCN(Cc1cc(CCCCC(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(CCCCC(N)=O)cs1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C6(N)=O"
} |
Can you make molecule CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | CCCOc1ccc2c(c1)CCN(Cc1cc(CC/C(N)=N/O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(CC/C(N)=N/O)cs1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C6(N)=O"
} |
Can you make molecule CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | CCCOc1ccc2c(c1)CCN(Cc1cc(CC/C(N)=N\O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(CC/C(N)=N\O)cs1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C6(N)=O"
} |
Can you make molecule CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | CCCOc1ccc2c(c1)CCN(Cc1cc(CC(N)=S)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(C(N)=O)cs1)C2 | CCCOc1ccc2c(c1)CCN(Cc1cc(CC(N)=S)cs1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "C6(N)=O"
} |
Can you make molecule Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(Cl)cc(Cl)c1[C@H](C/C(=N/NC(N)=O)c1cccs1)C(C#N)C#N | Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 | Cc1cc(Cl)cc(Cl)c1[C@H](C/C(=N/NC(N)=O)c1cccs1)C(C#N)C#N | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc(Cl)cc(Cl)c1&",
"old_substring": "Cc1cc(C)c3c(C)c1"
} |
Can you make molecule Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(Br)c(C)c1Cl | Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 | Cc1cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(Br)c(C)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(Br)c(C)c1Cl",
"old_substring": "Cc1cc(C)c3c(C)c1"
} |
Can you make molecule Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(Br)cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1C | Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 | Cc1c(Br)cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c(Br)cc&c(C)c1C",
"old_substring": "Cc1cc(C)c3c(C)c1"
} |
Can you make molecule Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)cc1Br | Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 | Cc1cc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1Br",
"old_substring": "Cc1cc(C)c3c(C)c1"
} |
Can you make molecule Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(Br)ccc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c1C | Cc1cc(C)c([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c(C)c1 | Cc1c(Br)ccc([C@H](C/C(=N/NC(N)=O)c2cccs2)C(C#N)C#N)c1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c(Br)ccc&c1C",
"old_substring": "Cc1cc(C)c3c(C)c1"
} |
Can you make molecule CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1noc(Cc2sc(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)cc2C#N)n1 | CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 | CCc1noc(Cc2sc(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)cc2C#N)n1 | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N35C"
} |
Can you make molecule CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1noc(Cc2ccc(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)cc2C#N)n1 | CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 | CCc1noc(Cc2ccc(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)cc2C#N)n1 | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N35C"
} |
Can you make molecule CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1noc(CN2CCC(=NOC(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)CC2)n1 | CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 | CCc1noc(CN2CCC(=NOC(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)CC2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N35C"
} |
Can you make molecule CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1noc(CCC2=CCCN(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)C2)n1 | CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 | CCc1noc(CCC2=CCCN(C(=O)N[C@@H](CS(C)(=O)=O)c3ccccc3)C2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N35C"
} |
Can you make molecule CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1noc(Cc2nc3c(s2)CN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C3)n1 | CCc1noc(CN(C)C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)n1 | CCc1noc(Cc2nc3c(s2)CN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C3)n1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N35C"
} |
Can you make molecule Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cn1c(Cl)cnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1c(Cl)cnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "Cn1c(Cl)cnc1&",
"old_substring": "Cn1ccnc14"
} |
Can you make molecule Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C=Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | C=Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "C=Cn1ccnc1&",
"old_substring": "Cn1ccnc14"
} |
Can you make molecule Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cn1ncc(Sc2ccc([C@@H]3NC(=O)c4ccccc4N3)cc2[N+](=O)[O-])c1Cl | Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1ncc(Sc2ccc([C@@H]3NC(=O)c4ccccc4N3)cc2[N+](=O)[O-])c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cn1ncc&c1Cl",
"old_substring": "Cn1ccnc14"
} |
Can you make molecule Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cn1cc(Sc2ccc([C@@H]3NC(=O)c4ccccc4N3)cc2[N+](=O)[O-])ccc1=O | Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1cc(Sc2ccc([C@@H]3NC(=O)c4ccccc4N3)cc2[N+](=O)[O-])ccc1=O | 102 | {
"fragment_index": 0,
"new_substring": "Cn1cc&ccc1=O",
"old_substring": "Cn1ccnc14"
} |
Can you make molecule Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cn1cc[nH]/c1=N\C(=O)Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1ccnc1Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | Cn1cc[nH]/c1=N\C(=O)Sc1ccc([C@@H]2NC(=O)c3ccccc3N2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "Cn1cc[nH]/c1=N\\C&=O",
"old_substring": "Cn1ccnc14"
} |
Can you make molecule Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(Br)ccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1c(Br)ccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c(Br)ccc&c1C",
"old_substring": "Cc1cccc7c1C"
} |
Can you make molecule Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(F)c(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1Cl | Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1ccc(F)c(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc(F)c&c1Cl",
"old_substring": "Cc1cccc7c1C"
} |
Can you make molecule Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c(C)cc1I | Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1cc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c(C)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1I",
"old_substring": "Cc1cccc7c1C"
} |
Can you make molecule Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc2occ(NC(=O)CNC(=O)c3nn(-c4ccccc4Cl)c(C)cc3=O)c2cc1Cl | Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1cc2occ(NC(=O)CNC(=O)c3nn(-c4ccccc4Cl)c(C)cc3=O)c2cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc2occ&c2cc1Cl",
"old_substring": "Cc1cccc7c1C"
} |
Can you make molecule Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c(C)cc1Br | Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C | Cc1cc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c(C)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1Br",
"old_substring": "Cc1cccc7c1C"
} |
Can you make molecule CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CCC1(C[C@H](C)C#N)CCN(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 | CCC1(C[C@H](C)C#N)CCN(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N345"
} |
Can you make molecule CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CCC1(C[C@H](C)C#N)CCCN(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 | CCC1(C[C@H](C)C#N)CCCN(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N345"
} |
Can you make molecule CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CCc1oc(C(=O)CN2CCC(=O)Nc3ccccc32)c(C#N)c1C[C@H](C)C#N | CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 | CCc1oc(C(=O)CN2CCC(=O)Nc3ccccc32)c(C#N)c1C[C@H](C)C#N | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N345"
} |
Can you make molecule CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CCC1(C[C@H](C)C#N)CCC(=O)N(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 | CCC1(C[C@H](C)C#N)CCC(=O)N(C(=O)CN2CCC(=O)Nc3ccccc32)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CC&&CCC1=O",
"old_substring": "N345"
} |
Can you make molecule CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CCc1nc(C[C@H](C)C#N)c(C#N)c(C(=O)CN2CCC(=O)Nc3ccccc32)n1 | CCN(C[C@H](C)C#N)C(=O)CN1CCC(=O)Nc2ccccc21 | CCc1nc(C[C@H](C)C#N)c(C#N)c(C(=O)CN2CCC(=O)Nc3ccccc32)n1 | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1c&nc&nc1&",
"old_substring": "N345"
} |
Can you make molecule C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br less soluble in water? The output molecule should be similar to the input molecule. | Cc1oc(C)c(C(=O)N2c3ccccc3N(C)CC[C@@H]2C)c1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br | Cc1oc(C)c(C(=O)N2c3ccccc3N(C)CC[C@@H]2C)c1Br | 102 | {
"fragment_index": 0,
"new_substring": "Cc1oc(C)c&c1Br",
"old_substring": "c14occc1Br"
} |
Can you make molecule C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br less soluble in water? The output molecule should be similar to the input molecule. | Cc1sc(C(=O)N2c3ccccc3N(C)CC[C@@H]2C)cc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br | Cc1sc(C(=O)N2c3ccccc3N(C)CC[C@@H]2C)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "Cc1sc&cc1Br",
"old_substring": "c14occc1Br"
} |
Can you make molecule C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1cc(F)ccc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1cc(F)ccc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c14occc1Br"
} |
Can you make molecule C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1ccc(F)cc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1ccc(F)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c14occc1Br"
} |
Can you make molecule C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1ccc(Br)c(F)c1 | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br | C[C@H]1CCN(C)c2ccccc2N1C(=O)c1ccc(Br)c(F)c1 | 102 | {
"fragment_index": 0,
"new_substring": "Fc1cc&ccc1Br",
"old_substring": "c14occc1Br"
} |
Can you make molecule COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Br)c(Cl)c1F | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Br)c(Cl)c1F | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c16ccc(F)c(Cl)c1"
} |
Can you make molecule COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c16ccc(F)c(Cl)c1"
} |
Can you make molecule COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Br)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Br)c1",
"old_substring": "c16ccc(F)c(Cl)c1"
} |
Can you make molecule COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1cc(F)c(Cl)cc1Cl | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1cc(F)c(Cl)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(F)c(Cl)cc1Cl",
"old_substring": "c16ccc(F)c(Cl)c1"
} |
Can you make molecule COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1Cl | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(F)c(Cl)c1 | COc1ccc(C)cc1[C@@H](C)NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1Cl",
"old_substring": "c16ccc(F)c(Cl)c1"
} |
Can you make molecule COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ccsc1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ccsc1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccsc1",
"old_substring": "c16nccs1"
} |
Can you make molecule COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1cnc(Br)s1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1cnc(Br)s1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "Brc1ncc&s1",
"old_substring": "c16nccs1"
} |
Can you make molecule COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ncc(Cl)s1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ncc(Cl)s1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ncc(Cl)s1",
"old_substring": "c16nccs1"
} |
Can you make molecule COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ncc(Br)s1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1ncc(Br)s1)C2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ncc(Br)s1",
"old_substring": "c16nccs1"
} |
Can you make molecule COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1scnc1Cl)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1nccs1)C2 | COc1cc(-c2cccs2)cc2c1OCCN(Cc1cccn1-c1scnc1Cl)C2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&scnc1Cl",
"old_substring": "c16nccs1"
} |
Can you make molecule CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C)[NH+]1Cc2cccc(SC(=S)N(C)Cc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(SC(=S)N(C)Cc3cc(=O)n4ccsc4[nH+]3)c2C1 | 102 | {
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N67"
} |
Can you make molecule CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C)[NH+]1Cc2cccc(SC3=NCCN3Cc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(SC3=NCCN3Cc3cc(=O)n4ccsc4[nH+]3)c2C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N67"
} |
Can you make molecule CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C)[NH+]1Cc2cccc(C3CCN(CCc4cc(=O)n5ccsc5[nH+]4)CC3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(C3CCN(CCc4cc(=O)n5ccsc5[nH+]4)CC3)c2C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N67"
} |
Can you make molecule CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C)[NH+]1Cc2cccc(-c3cccc(Cc4cc(=O)n5ccsc5[nH+]4)c3N)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(-c3cccc(Cc4cc(=O)n5ccsc5[nH+]4)c3N)c2C1 | 102 | {
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N67"
} |
Can you make molecule CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C)[NH+]1Cc2cccc(-c3cc(N)cc(Cc4cc(=O)n5ccsc5[nH+]4)c3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 | CC(C)[C@H](C)[NH+]1Cc2cccc(-c3cc(N)cc(Cc4cc(=O)n5ccsc5[nH+]4)c3)c2C1 | 102 | {
"fragment_index": 0,
"new_substring": "Nc1cc&cc&c1",
"old_substring": "N67"
} |
Can you make molecule COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | COCCc1ccc(OSC(=O)Cc2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OSC(=O)Cc2ccc3ccccc3n2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
} |
Can you make molecule COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | COCCc1ccc(OC(=O)CCCC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)CCCC(=O)c2ccc3ccccc3n2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
} |
Can you make molecule COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | COCCc1ccc(OC(=O)CC(C)(C)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)CC(C)(C)c2ccc3ccccc3n2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
} |
Can you make molecule COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | COCCc1ccc(OC(=O)CCC(C)(C)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)CCC(C)(C)c2ccc3ccccc3n2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
} |
Can you make molecule COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | COCCc1ccc(OSC(=O)[C@@H](C)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OC(=O)c2ccc3ccccc3n2)cc1 | COCCc1ccc(OSC(=O)[C@@H](C)c2ccc3ccccc3n2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
} |
Can you make molecule Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1I | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1I",
"old_substring": "c15ccc(Br)cc1"
} |
Can you make molecule Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1Br | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1Br",
"old_substring": "c15ccc(Br)cc1"
} |
Can you make molecule Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1cc(Br)ccc1I | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1cc(Br)ccc1I | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1I",
"old_substring": "c15ccc(Br)cc1"
} |
Can you make molecule Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)c(Cl)c1F | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)c(Cl)c1F | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c15ccc(Br)cc1"
} |
Can you make molecule Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1cc(Br)ccc1Cl | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1ccc(Br)cc1 | Nn1c(SCC(=O)N/N=C/c2ccco2)nnc1-c1cc(Br)ccc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Cl",
"old_substring": "c15ccc(Br)cc1"
} |
Can you make molecule O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1ccnn1C=Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1C=Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&c1cccc(Cl)c1Cl",
"old_substring": "c18cccc(Cl)c1Cl"
} |
Can you make molecule O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1ccnn1C=Cc1c(Cl)cccc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1C=Cc1c(Cl)cccc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1C=&",
"old_substring": "c18cccc(Cl)c1Cl"
} |
Can you make molecule O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1ccnn1C=Cc1ccc(Cl)cc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1C=Cc1ccc(Cl)cc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)cc1Cl",
"old_substring": "c18cccc(Cl)c1Cl"
} |
Can you make molecule O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1ccnn1Cc1c(Cl)cc(Br)cc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1c(Cl)cc(Br)cc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&c(Cl)cc(Br)cc1Cl",
"old_substring": "c18cccc(Cl)c1Cl"
} |
Can you make molecule O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1ccnn1C=Cc1cc(Cl)ccc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1Cc1cccc(Cl)c1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | O=C(Nc1ccnn1C=Cc1cc(Cl)ccc1Cl)[C@@H]1CCCN(S(=O)(=O)c2ccccc2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&c1cc(Cl)ccc1Cl",
"old_substring": "c18cccc(Cl)c1Cl"
} |
Can you make molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | C/C(=N\ON1CCN(c2ccc(Cl)cc2)CC1)[C@H](C)c1ccccc1 | O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | C/C(=N\ON1CCN(c2ccc(Cl)cc2)CC1)[C@H](C)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)[C@@H]&C",
"old_substring": "O=C3C[C@@H]5O"
} |
Can you make molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1CC[C@H](N2CCN(c3ccc(Cl)cc3)CC2)CCN1c1ccccc1 | O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | O=C1CC[C@H](N2CCN(c3ccc(Cl)cc3)CC2)CCN1c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "O=C1CC[C@H]&CCN1&",
"old_substring": "O=C3C[C@@H]5O"
} |
Can you make molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(C1=CC[C@H](c2ccccc2)S1)N1CCN(c2ccc(Cl)cc2)CC1 | O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | O=C(C1=CC[C@H](c2ccccc2)S1)N1CCN(c2ccc(Cl)cc2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C3C[C@@H]5O"
} |
Can you make molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](CC(=O)N1CCN(c2ccc(Cl)cc2)CC1)c1ccccc1 | O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | C[C@@H](CC(=O)N1CCN(c2ccc(Cl)cc2)CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "O=C3C[C@@H]5O"
} |
Can you make molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | C=C[C@H](CC(=O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | C=C[C@H](CC(=O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=C[C@@H]&CC&=O",
"old_substring": "O=C3C[C@@H]5O"
} |
Can you make molecule CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](SCSc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](SCSc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S45"
} |
Can you make molecule CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H]1C(=O)C2=CC=C(c3ccc(F)cc3)C=C(N[C@]3(C)CCS(=O)(=O)C3)N1CCS2 | CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H]1C(=O)C2=CC=C(c3ccc(F)cc3)C=C(N[C@]3(C)CCS(=O)(=O)C3)N1CCS2 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S45"
} |
Can you make molecule CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](C[S@@+]([O-])C(Cl)(Cl)c1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](C[S@@+]([O-])C(Cl)(Cl)c1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "S45"
} |
Can you make molecule CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](S/C(Cl)=C(\C#N)Nc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H](S/C(Cl)=C(\C#N)Nc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S45"
} |
Can you make molecule CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H]1C(=O)c2ccccc(N[C@]3(C)CCS(=O)(=O)C3)n1c(=S)n2-c1ccc(F)cc1 | CC(C)[C@H](Sc1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1 | CC(C)[C@H]1C(=O)c2ccccc(N[C@]3(C)CCS(=O)(=O)C3)n1c(=S)n2-c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S45"
} |
Can you make molecule CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | C=CSOc1cc2ccccc2cc1C(=O)N1CCOCC1 | CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | C=CSOc1cc2ccccc2cc1C(=O)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
} |
Can you make molecule CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | C=CCCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | C=CCCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
} |
Can you make molecule CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(c1cc2ccccc2cc1OCCCCl)N1CCOCC1 | CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | O=C(c1cc2ccccc2cc1OCCCCl)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
} |
Can you make molecule CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(c1cc2ccccc2cc1OCCCCS)N1CCOCC1 | CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | O=C(c1cc2ccccc2cc1OCCCCS)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
} |
Can you make molecule CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(c1cc2ccccc2cc1OCCCBr)N1CCOCC1 | CCOc1cc2ccccc2cc1C(=O)N1CCOCC1 | O=C(c1cc2ccccc2cc1OCCCBr)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC4"
} |
Can you make molecule C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)C)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)C)C(C)(C)C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)C",
"old_substring": "N1[S@](=O)C(C)(C)C"
} |
Can you make molecule C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@](C)(O)[C@H]([C@@H](C)C(=O)[O-])C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C | CC(C)[C@@](C)(O)[C@H]([C@@H](C)C(=O)[O-])C(C)(C)C | 102 | {
"fragment_index": 0,
"new_substring": "[C@]&(C)(O)C(C)C",
"old_substring": "N1[S@](=O)C(C)(C)C"
} |
Can you make molecule C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)CCl)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)CCl)C(C)(C)C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCl",
"old_substring": "N1[S@](=O)C(C)(C)C"
} |
Can you make molecule C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(Cl)(Cl)Cl)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(Cl)(Cl)Cl)C(C)(C)C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(Cl)(Cl)Cl",
"old_substring": "N1[S@](=O)C(C)(C)C"
} |
Can you make molecule C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)Br)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](N[S@+]([O-])C(C)(C)C)C(C)(C)C | C[C@@H](C(=O)[O-])[C@@H](C(=O)C(C)(C)Br)C(C)(C)C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)Br",
"old_substring": "N1[S@](=O)C(C)(C)C"
} |
Can you make molecule CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O less soluble in water? The output molecule should be similar to the input molecule. | CC[C@]1(c2ccc(F)cc2Cl)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2Cl)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c18ccc(F)cc1"
} |
Can you make molecule CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O less soluble in water? The output molecule should be similar to the input molecule. | CC[C@]1(c2ccc(F)cc2Br)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2Br)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c18ccc(F)cc1"
} |
Can you make molecule CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O less soluble in water? The output molecule should be similar to the input molecule. | CC[C@]1(c2ccc(F)c(Cl)c2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)c(Cl)c2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c18ccc(F)cc1"
} |
Can you make molecule CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O less soluble in water? The output molecule should be similar to the input molecule. | CC[C@]1(c2ccc(I)cc2F)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(I)cc2F)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c18ccc(F)cc1"
} |
Can you make molecule CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O less soluble in water? The output molecule should be similar to the input molecule. | CC[C@]1(c2cc3c(F)cccc3s2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | CC[C@]1(c2cc3c(F)cccc3s2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c18ccc(F)cc1"
} |
Can you make molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | C=CSOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | C=CSOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
} |
Can you make molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | C=CCCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | C=CCCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
} |
Can you make molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCCl)cc2)S/C1=N/c1cccc(Cl)c1 | CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCCl)cc2)S/C1=N/c1cccc(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC5"
} |
Can you make molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCCS)cc2)S/C1=N/c1cccc(Cl)c1 | CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCCS)cc2)S/C1=N/c1cccc(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC5"
} |
Can you make molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCBr)cc2)S/C1=N/c1cccc(Cl)c1 | CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(C)/C(=N\c3cccc(Cl)c3)S2)cc1 | CN1C(=O)C[C@@H](C(=O)Nc2ccc(OCCCBr)cc2)S/C1=N/c1cccc(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC5"
} |
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