Datasets:
MaIlz
/
replace_102

Dataset card Data Studio Files
xet
Community
prompt
stringlengths
120
209
completion
stringlengths
15
103
input_smiles
stringlengths
14
103
output_smiles
stringlengths
15
103
task_id
int64
102
102
winner_action
dict
Can you make molecule C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
C[C@H](OC(=S)Sc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](OC(=S)Sc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
102
{ "fragment_index": 0, "new_substring": "O&C(=S)S&", "old_substring": "O34" }
Can you make molecule C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
C[C@H](OC(=N)Cc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](OC(=N)Cc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
102
{ "fragment_index": 0, "new_substring": "O&C(=N)C&", "old_substring": "O34" }
Can you make molecule C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
C[C@H](C(=O)CCC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](C(=O)CCC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
102
{ "fragment_index": 0, "new_substring": "O=C&CCC&=O", "old_substring": "O34" }
Can you make molecule C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](C(=O)NC[C@H]1CCC[C@@H]1O)[C@H](O)CCc1ccc(Cl)c(Cl)c1
C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@@H](C(=O)NC[C@H]1CCC[C@@H]1O)[C@H](O)CCc1ccc(Cl)c(Cl)c1
102
{ "fragment_index": 0, "new_substring": "O[C@@H]&CC&", "old_substring": "O34" }
Can you make molecule C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
C[C@H](C(=O)/C=C/Sc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
C[C@H](C(=O)/C=C/Sc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
102
{ "fragment_index": 0, "new_substring": "O=C&/C=C/S&", "old_substring": "O34" }
Can you make molecule COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
COC[C@H]1CN(Cc2cc(C)n(Cc3ccco3)c2C)C[C@@H]1C
COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CN(Cc2cc(C)n(Cc3ccco3)c2C)C[C@@H]1C
102
{ "fragment_index": 0, "new_substring": "[C@H]1&CN&C[C@@H]1C", "old_substring": "[C@H]18CCC[NH+]5C1" }
Can you make molecule COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
COC[C@H]1C=C[C@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1C=C[C@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
102
{ "fragment_index": 0, "new_substring": "[C@H]1&C=C[C@H]&C1", "old_substring": "[C@H]18CCC[NH+]5C1" }
Can you make molecule COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
COC[C@H]1CCC[C@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CCC[C@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
102
{ "fragment_index": 0, "new_substring": "[C@H]1&CCC[C@H]&C1", "old_substring": "[C@H]18CCC[NH+]5C1" }
Can you make molecule COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
COC[C@H]1C=C[C@@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1C=C[C@@H](Cc2cc(C)n(Cc3ccco3)c2C)C1
102
{ "fragment_index": 0, "new_substring": "[C@H]1&C=C[C@@H]&C1", "old_substring": "[C@H]18CCC[NH+]5C1" }
Can you make molecule COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
COC[C@H]1CCC[C@H](Cc2cc(C)n(Cc3ccco3)c2C)CC1
COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1
COC[C@H]1CCC[C@H](Cc2cc(C)n(Cc3ccco3)c2C)CC1
102
{ "fragment_index": 0, "new_substring": "[C@H]1&CCC[C@H]&CC1", "old_substring": "[C@H]18CCC[NH+]5C1" }
Can you make molecule Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc(CCC[C@@H](CCl)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc(CCC[C@@H](CCl)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
102
{ "fragment_index": 0, "new_substring": "[C@@H]&(CCl)CCC&", "old_substring": "[C@@H]68C" }
Can you make molecule Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc(CCC2=CN=N[C@H]2NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc(CCC2=CN=N[C@H]2NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
102
{ "fragment_index": 0, "new_substring": "[C@@H]1&N=NC=C1CC&", "old_substring": "[C@@H]68C" }
Can you make molecule Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc([C@@H]2CC[C@@H](NC(=O)CN(C)C(=O)OC(C)(C)C)C2)cc1F
Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc([C@@H]2CC[C@@H](NC(=O)CN(C)C(=O)OC(C)(C)C)C2)cc1F
102
{ "fragment_index": 0, "new_substring": "[C@@H]1&CC[C@@H]&C1", "old_substring": "[C@@H]68C" }
Can you make molecule Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc(CC(C)(C)[C@@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
Cc1ccc(CC(C)(C)[C@@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
102
{ "fragment_index": 0, "new_substring": "[C@@H]&(C)C(C)(C)C&", "old_substring": "[C@@H]68C" }
Can you make molecule Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](CCc1ccc(C)c(F)c1)NC(=O)CN(C)C(=O)OC(C)(C)C
Cc1ccc([C@H](C)NC(=O)CN(C)C(=O)OC(C)(C)C)cc1F
CC[C@@H](CCc1ccc(C)c(F)c1)NC(=O)CN(C)C(=O)OC(C)(C)C
102
{ "fragment_index": 0, "new_substring": "[C@H]&(CC)CC&", "old_substring": "[C@@H]68C" }
Can you make molecule CC(=O)NCCC(=O)N1CCC[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
CCC(CO)=NCCC(=O)N1CCC[C@@H](C)C1
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CCC(CO)=NCCC(=O)N1CCC[C@@H](C)C1
102
{ "fragment_index": 0, "new_substring": "CCC=&CO", "old_substring": "CC2=O" }
Can you make molecule CC(=O)NCCC(=O)N1CCC[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CCCC(=O)NCCC(=O)N1CCC[C@@H](C)C1
102
{ "fragment_index": 0, "new_substring": "CCCC&=O", "old_substring": "CC2=O" }
Can you make molecule CC(=O)NCCC(=O)N1CCC[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
CC(=O)SNCCC(=O)N1CCC[C@@H](C)C1
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CC(=O)SNCCC(=O)N1CCC[C@@H](C)C1
102
{ "fragment_index": 0, "new_substring": "CC(=O)S&", "old_substring": "CC2=O" }
Can you make molecule CC(=O)NCCC(=O)N1CCC[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
CCCCC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CCCCC(=O)NCCC(=O)N1CCC[C@@H](C)C1
102
{ "fragment_index": 0, "new_substring": "CCCCC&=O", "old_substring": "CC2=O" }
Can you make molecule CC(=O)NCCC(=O)N1CCC[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
CCC(C=O)=NCCC(=O)N1CCC[C@@H](C)C1
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1
CCC(C=O)=NCCC(=O)N1CCC[C@@H](C)C1
102
{ "fragment_index": 0, "new_substring": "CCC=&C=O", "old_substring": "CC2=O" }
Can you make molecule COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
COc1ccc(N2CCn3c2nn(CCCCC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CCCCC(N)=O)c(=O)c3=O)cc1
102
{ "fragment_index": 0, "new_substring": "C&CCCC(N)=O", "old_substring": "C6C(N)=O" }
Can you make molecule COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
COc1ccc(N2CCn3c2nn(CC(N)=S)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=S)c(=O)c3=O)cc1
102
{ "fragment_index": 0, "new_substring": "C&C(N)=S", "old_substring": "C6C(N)=O" }
Can you make molecule COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
COc1ccc(N2CCn3c2nn(CC(C)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(C)=O)c(=O)c3=O)cc1
102
{ "fragment_index": 0, "new_substring": "C&C(C)=O", "old_substring": "C6C(N)=O" }
Can you make molecule COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
COc1ccc(N2CCn3c2nn(CC/C(N)=N/O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC/C(N)=N/O)c(=O)c3=O)cc1
102
{ "fragment_index": 0, "new_substring": "C&C/C(N)=N/O", "old_substring": "C6C(N)=O" }
Can you make molecule COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
COc1ccc(N2CCn3c2nn(CC/C(N)=N\O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC(N)=O)c(=O)c3=O)cc1
COc1ccc(N2CCn3c2nn(CC/C(N)=N\O)c(=O)c3=O)cc1
102
{ "fragment_index": 0, "new_substring": "C&C/C(N)=N\\O", "old_substring": "C6C(N)=O" }
Can you make molecule ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl less soluble in water? The output molecule should be similar to the input molecule.
ClC(Cl)=C(Cl)Cc1nonc1C(Cl)(Cl)Cl
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl
ClC(Cl)=C(Cl)Cc1nonc1C(Cl)(Cl)Cl
102
{ "fragment_index": 0, "new_substring": "C&C(Cl)=C(Cl)Cl", "old_substring": "ClC2(Cl)Cl" }
Can you make molecule ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C(c1nonc1C(Cl)(Cl)Cl)C(C)C
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl
CC(C)C(c1nonc1C(Cl)(Cl)Cl)C(C)C
102
{ "fragment_index": 0, "new_substring": "CC(C)C&C(C)C", "old_substring": "ClC2(Cl)Cl" }
Can you make molecule ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl less soluble in water? The output molecule should be similar to the input molecule.
CC1(C)CCC(c2nonc2C(Cl)(Cl)Cl)CC1
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl
CC1(C)CCC(c2nonc2C(Cl)(Cl)Cl)CC1
102
{ "fragment_index": 0, "new_substring": "CC1(C)CCC&CC1", "old_substring": "ClC2(Cl)Cl" }
Can you make molecule ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl less soluble in water? The output molecule should be similar to the input molecule.
Clc1cccc(Cl)c1-c1nonc1C(Cl)(Cl)Cl
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl
Clc1cccc(Cl)c1-c1nonc1C(Cl)(Cl)Cl
102
{ "fragment_index": 0, "new_substring": "Clc1cccc(Cl)c1&", "old_substring": "ClC2(Cl)Cl" }
Can you make molecule ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl less soluble in water? The output molecule should be similar to the input molecule.
CC(C)CC[C@H](C)c1nonc1C(Cl)(Cl)Cl
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl
CC(C)CC[C@H](C)c1nonc1C(Cl)(Cl)Cl
102
{ "fragment_index": 0, "new_substring": "CC(C)CC[C@@H]&C", "old_substring": "ClC2(Cl)Cl" }
Can you make molecule CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
CCc1sc(C(=O)N2CCN([C@@H]3CCCN(c4ccccc4)C3=O)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H]3CCCN(c4ccccc4)C3=O)CC2)cc1C
102
{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCN&C1=O", "old_substring": "[C@@H]58C(N)=O" }
Can you make molecule CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
CCc1sc(C(=O)N2CCN([C@H](C)N(C)Oc3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@H](C)N(C)Oc3ccccc3)CC2)cc1C
102
{ "fragment_index": 0, "new_substring": "[C@@H]&(C)N(C)O&", "old_substring": "[C@@H]58C(N)=O" }
Can you make molecule CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
CCc1sc(C(=O)N2CCN([C@@H]3C=C(Cc4ccccc4)N=N3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H]3C=C(Cc4ccccc4)N=N3)CC2)cc1C
102
{ "fragment_index": 0, "new_substring": "[C@@H]1&C=C(C&)N=N1", "old_substring": "[C@@H]58C(N)=O" }
Can you make molecule CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
CCc1sc(C(=O)N2CCN([C@@H]3CCCCN(c4ccccc4)C3=O)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H]3CCCCN(c4ccccc4)C3=O)CC2)cc1C
102
{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCCN&C1=O", "old_substring": "[C@@H]58C(N)=O" }
Can you make molecule CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
CCc1sc(C(=O)N2CCN([C@H]3CC(Cc4ccccc4)=NO3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@@H](C(N)=O)c3ccccc3)CC2)cc1C
CCc1sc(C(=O)N2CCN([C@H]3CC(Cc4ccccc4)=NO3)CC2)cc1C
102
{ "fragment_index": 0, "new_substring": "[C@H]1&CC(C&)=NO1", "old_substring": "[C@@H]58C(N)=O" }
Can you make molecule C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH+]1CCC(=Cc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
C[NH+]1CCC(=Cc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
102
{ "fragment_index": 0, "new_substring": "C[NH+]1CCC=&CC1", "old_substring": "C[NH+]5C" }
Can you make molecule C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH+]1CCC(=NOCc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
C[NH+]1CCC(=NOCc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
102
{ "fragment_index": 0, "new_substring": "C[NH+]1CCC(=NO&)CC1", "old_substring": "C[NH+]5C" }
Can you make molecule C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 less soluble in water? The output molecule should be similar to the input molecule.
C[N+](C)(C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
C[N+](C)(C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
102
{ "fragment_index": 0, "new_substring": "C[N+]&(C)C", "old_substring": "C[NH+]5C" }
Can you make molecule C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(CCCC(=O)N1CCCCCC1)Nc1cc(CC[NH+]2CCCSCC2)n[nH]1
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
O=C(CCCC(=O)N1CCCCCC1)Nc1cc(CC[NH+]2CCCSCC2)n[nH]1
102
{ "fragment_index": 0, "new_substring": "C&[NH+]1CCCSCC1", "old_substring": "C[NH+]5C" }
Can you make molecule C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 less soluble in water? The output molecule should be similar to the input molecule.
C[N+]1(C)CCC(Cc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1
C[N+]1(C)CCC(Cc2cc(NC(=O)CCCC(=O)N3CCCCCC3)[nH]n2)CC1
102
{ "fragment_index": 0, "new_substring": "C[N+]1(C)CCC&CC1", "old_substring": "C[NH+]5C" }
Can you make molecule C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](Nc1ccc(COC(C)(C)C)cc1I)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1I)c1ccc(C#N)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc&cc1I", "old_substring": "c15ccc7cc1" }
Can you make molecule C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](Nc1cc(COC(C)(C)C)ccc1Br)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1
C[C@@H](Nc1cc(COC(C)(C)C)ccc1Br)c1ccc(C#N)cc1
102
{ "fragment_index": 0, "new_substring": "c1&cc&ccc1Br", "old_substring": "c15ccc7cc1" }
Can you make molecule C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](Nc1ccc(COC(C)(C)C)cc1Cl)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1Cl)c1ccc(C#N)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc&cc1Cl", "old_substring": "c15ccc7cc1" }
Can you make molecule C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](Nc1cccc(COC(C)(C)C)c1Br)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1
C[C@@H](Nc1cccc(COC(C)(C)C)c1Br)c1ccc(C#N)cc1
102
{ "fragment_index": 0, "new_substring": "c1&cccc&c1Br", "old_substring": "c15ccc7cc1" }
Can you make molecule C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H](Nc1cccc(COC(C)(C)C)c1Cl)c1ccc(C#N)cc1
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1
C[C@@H](Nc1cccc(COC(C)(C)C)c1Cl)c1ccc(C#N)cc1
102
{ "fragment_index": 0, "new_substring": "c1&cccc&c1Cl", "old_substring": "c15ccc7cc1" }
Can you make molecule NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1I
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1I
102
{ "fragment_index": 0, "new_substring": "c1&ccc&cc1I", "old_substring": "c16ccc5cc1" }
Can you make molecule NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
NC(=O)c1cc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)ccc1Br
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1
NC(=O)c1cc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)ccc1Br
102
{ "fragment_index": 0, "new_substring": "c1&cc&ccc1Br", "old_substring": "c16ccc5cc1" }
Can you make molecule NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1Cl
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1Cl
102
{ "fragment_index": 0, "new_substring": "c1&ccc&cc1Cl", "old_substring": "c16ccc5cc1" }
Can you make molecule NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
NC(=O)c1cccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)c1Br
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1
NC(=O)c1cccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)c1Br
102
{ "fragment_index": 0, "new_substring": "c1&cccc&c1Br", "old_substring": "c16ccc5cc1" }
Can you make molecule NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
NC(=O)c1cccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)c1Cl
NC(=O)c1ccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)cc1
NC(=O)c1cccc(NC(=O)c2cccn(Cc3ccc(F)cc3)c2=O)c1Cl
102
{ "fragment_index": 0, "new_substring": "c1&cccc&c1Cl", "old_substring": "c16ccc5cc1" }
Can you make molecule Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](CCCl)CC(=O)c1cc(C)nc2c1c(C)nn2C
Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1
CC[C@@H](CCCl)CC(=O)c1cc(C)nc2c1c(C)nn2C
102
{ "fragment_index": 0, "new_substring": "CC[C@H](C&)CCCl", "old_substring": "N13CC[C@H](C)C[C@H]1C" }
Can you make molecule Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](C)C[C@H](CC)C(=O)c1cc(C)nc2c1c(C)nn2C
Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1
CC[C@@H](C)C[C@H](CC)C(=O)c1cc(C)nc2c1c(C)nn2C
102
{ "fragment_index": 0, "new_substring": "CC[C@H]&C[C@H](C)CC", "old_substring": "N13CC[C@H](C)C[C@H]1C" }
Can you make molecule Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
C=CC[C@H](C)[C@@H](C)C(=O)c1cc(C)nc2c1c(C)nn2C
Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1
C=CC[C@H](C)[C@@H](C)C(=O)c1cc(C)nc2c1c(C)nn2C
102
{ "fragment_index": 0, "new_substring": "C=CC[C@H](C)[C@H]&C", "old_substring": "N13CC[C@H](C)C[C@H]1C" }
Can you make molecule Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CC[C@H](CCCl)CC(=O)c1cc(C)nc2c1c(C)nn2C
Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1
CC[C@H](CCCl)CC(=O)c1cc(C)nc2c1c(C)nn2C
102
{ "fragment_index": 0, "new_substring": "CC[C@@H](C&)CCCl", "old_substring": "N13CC[C@H](C)C[C@H]1C" }
Can you make molecule Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](Cl)CCCC(=O)c1cc(C)nc2c1c(C)nn2C
Cc1cc(C(=O)N2CC[C@H](C)C[C@H]2C)c2c(C)nn(C)c2n1
CC[C@@H](Cl)CCCC(=O)c1cc(C)nc2c1c(C)nn2C
102
{ "fragment_index": 0, "new_substring": "CC[C@@H](Cl)CCC&", "old_substring": "N13CC[C@H](C)C[C@H]1C" }
Can you make molecule Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2 less soluble in water? The output molecule should be similar to the input molecule.
C/C(Cn1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2)=N/ON1C[C@H](C)C[C@H](C)C1
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
C/C(Cn1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2)=N/ON1C[C@H](C)C[C@H](C)C1
102
{ "fragment_index": 0, "new_substring": "C/C(C&)=N/O&", "old_substring": "C7C5=O" }
Can you make molecule Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2 less soluble in water? The output molecule should be similar to the input molecule.
CCC(CC)(C(=O)CN1C[C@H](C)C[C@H](C)C1)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
CCC(CC)(C(=O)CN1C[C@H](C)C[C@H](C)C1)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
102
{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)C&", "old_substring": "C7C5=O" }
Can you make molecule Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(SSC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(SSC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
102
{ "fragment_index": 0, "new_substring": "S&SC&=O", "old_substring": "C7C5=O" }
Can you make molecule Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2 less soluble in water? The output molecule should be similar to the input molecule.
CCC(CC)(C(=O)CCN1C[C@H](C)C[C@H](C)C1)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
CCC(CC)(C(=O)CCN1C[C@H](C)C[C@H](C)C1)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
102
{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)CC&", "old_substring": "C7C5=O" }
Can you make molecule Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2 less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](C(=O)N1C[C@H](C)C[C@H](C)C1)C(=O)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2
CC[C@@H](C(=O)N1C[C@H](C)C[C@H](C)C1)C(=O)n1cc2c(n1)-c1c(oc(C(=O)N3CCCC3)c1C)CC2
102
{ "fragment_index": 0, "new_substring": "CC[C@H](C&=O)C&=O", "old_substring": "C7C5=O" }
Can you make molecule Cc1cc(C)cc(NC(=O)CC(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cc(C)cc(NC(=O)CCCC(C)(C)C)c1
Cc1cc(C)cc(NC(=O)CC(C)C)c1
Cc1cc(C)cc(NC(=O)CCCC(C)(C)C)c1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCCC(C)(C)C", "old_substring": "C2(=O)CC(C)C" }
Can you make molecule Cc1cc(C)cc(NC(=O)CC(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cc(C)cc(N=CC(C)(C)C)c1
Cc1cc(C)cc(NC(=O)CC(C)C)c1
Cc1cc(C)cc(N=CC(C)(C)C)c1
102
{ "fragment_index": 0, "new_substring": "CC(C)(C)C=&", "old_substring": "C2(=O)CC(C)C" }
Can you make molecule Cc1cc(C)cc(NC(=O)CC(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cc(C)cc(NC(=O)CCCCCCl)c1
Cc1cc(C)cc(NC(=O)CC(C)C)c1
Cc1cc(C)cc(NC(=O)CCCCCCl)c1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCCCCCl", "old_substring": "C2(=O)CC(C)C" }
Can you make molecule Cc1cc(C)cc(NC(=O)CC(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cc(C)cc(NC(=O)CCC(C)(C)C)c1
Cc1cc(C)cc(NC(=O)CC(C)C)c1
Cc1cc(C)cc(NC(=O)CCC(C)(C)C)c1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCC(C)(C)C", "old_substring": "C2(=O)CC(C)C" }
Can you make molecule Cc1cc(C)cc(NC(=O)CC(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cc(C)cc(NCC(C)(C)CBr)c1
Cc1cc(C)cc(NC(=O)CC(C)C)c1
Cc1cc(C)cc(NCC(C)(C)CBr)c1
102
{ "fragment_index": 0, "new_substring": "C&C(C)(C)CBr", "old_substring": "C2(=O)CC(C)C" }
Can you make molecule COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COCc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COCc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
102
{ "fragment_index": 0, "new_substring": "COC&", "old_substring": "CO3" }
Can you make molecule COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COCSc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COCSc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
102
{ "fragment_index": 0, "new_substring": "COCS&", "old_substring": "CO3" }
Can you make molecule COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COc1cc(SC(C)=O)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(SC(C)=O)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
102
{ "fragment_index": 0, "new_substring": "CC(=O)S&", "old_substring": "CO3" }
Can you make molecule COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COc1cc(C(=O)CS)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(C(=O)CS)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CS", "old_substring": "CO3" }
Can you make molecule COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COc1cc(C(=O)CI)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(OC)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
COc1cc(C(=O)CI)cc([C@H]2CC[NH+](CCC(F)(F)F)C2)c1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CI", "old_substring": "CO3" }
Can you make molecule CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O less soluble in water? The output molecule should be similar to the input molecule.
CCn1ccnc(N2CCCC[C@@H](N3CCN(C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CCN(C)CC3)C2)c1=O
102
{ "fragment_index": 0, "new_substring": "N1&CCN(C)CC1", "old_substring": "N15CC[NH+](C)CC1" }
Can you make molecule CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O less soluble in water? The output molecule should be similar to the input molecule.
CCn1ccnc(N2CCCC[C@@H](N3CC(C)C3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC(C)C3)C2)c1=O
102
{ "fragment_index": 0, "new_substring": "N1&CC(C)C1", "old_substring": "N15CC[NH+](C)CC1" }
Can you make molecule CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O less soluble in water? The output molecule should be similar to the input molecule.
CCn1ccnc(N2CCCC[C@@H](N3C[C@@H](C)CC3=O)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3C[C@@H](C)CC3=O)C2)c1=O
102
{ "fragment_index": 0, "new_substring": "N1&C[C@@H](C)CC1=O", "old_substring": "N15CC[NH+](C)CC1" }
Can you make molecule CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O less soluble in water? The output molecule should be similar to the input molecule.
CCn1ccnc(N2CCCC[C@@H](N3CC[C@H](C)C3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[C@H](C)C3)C2)c1=O
102
{ "fragment_index": 0, "new_substring": "N1&CC[C@H](C)C1", "old_substring": "N15CC[NH+](C)CC1" }
Can you make molecule CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O less soluble in water? The output molecule should be similar to the input molecule.
CCn1ccnc(N2CCCC[C@@H](N3C[C@H](C#N)CC3=O)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3CC[NH+](C)CC3)C2)c1=O
CCn1ccnc(N2CCCC[C@@H](N3C[C@H](C#N)CC3=O)C2)c1=O
102
{ "fragment_index": 0, "new_substring": "N1&C[C@H](C#N)CC1=O", "old_substring": "N15CC[NH+](C)CC1" }
Can you make molecule C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H]1CCC[C@](O)(c2ccc(Cl)cc2I)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)cc2I)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1I", "old_substring": "c13ccc(Cl)s1" }
Can you make molecule C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H]1CCC[C@](O)(c2ccc(Cl)cc2Br)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)cc2Br)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1Br", "old_substring": "c13ccc(Cl)s1" }
Can you make molecule C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H]1CCC[C@](O)(c2ccc(Cl)c(I)c2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)c(I)c2)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)c(I)c1", "old_substring": "c13ccc(Cl)s1" }
Can you make molecule C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H]1CCC[C@](O)(c2cc(Cl)sc2Cl)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1
C[C@@H]1CCC[C@](O)(c2cc(Cl)sc2Cl)CC1
102
{ "fragment_index": 0, "new_substring": "c1&cc(Cl)sc1Cl", "old_substring": "c13ccc(Cl)s1" }
Can you make molecule C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@@H]1CCC[C@](O)(c2ccc(Cl)c(Cl)c2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1
C[C@@H]1CCC[C@](O)(c2ccc(Cl)c(Cl)c2)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)c(Cl)c1", "old_substring": "c13ccc(Cl)s1" }
Can you make molecule CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
C=CSOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
C=CSOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
102
{ "fragment_index": 0, "new_substring": "C=CS&", "old_substring": "CC6" }
Can you make molecule CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
C=CCCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
C=CCCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
102
{ "fragment_index": 0, "new_substring": "C=CCC&", "old_substring": "CC6" }
Can you make molecule CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCCl)CC2
CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCCl)CC2
102
{ "fragment_index": 0, "new_substring": "C&CCCl", "old_substring": "CC6" }
Can you make molecule CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCCS)CC2
CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCCS)CC2
102
{ "fragment_index": 0, "new_substring": "C&CCCS", "old_substring": "CC6" }
Can you make molecule CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCBr)CC2
CCOC(=O)C[C@H](C)CNC(=O)C(=O)N1CCc2ccc(C)cc21
Cc1ccc2c(c1)N(C(=O)C(=O)NC[C@@H](C)CC(=O)OCCCBr)CC2
102
{ "fragment_index": 0, "new_substring": "C&CCBr", "old_substring": "CC6" }
Can you make molecule COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
COCc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COCc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
102
{ "fragment_index": 0, "new_substring": "COC&", "old_substring": "CO3" }
Can you make molecule COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
COCSc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COCSc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
102
{ "fragment_index": 0, "new_substring": "COCS&", "old_substring": "CO3" }
Can you make molecule COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
CC(=O)Sc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
CC(=O)Sc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
102
{ "fragment_index": 0, "new_substring": "CC(=O)S&", "old_substring": "CO3" }
Can you make molecule COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(CS)c1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
O=C(CS)c1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CS", "old_substring": "CO3" }
Can you make molecule COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(CI)c1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
COc1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
O=C(CI)c1ccccc1C[NH+]1CCC[C@H](N2CCCC2=O)C1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CI", "old_substring": "CO3" }
Can you make molecule CCNc1ccc2c(OC)ccc(F)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN(C)C(=S)Sc1ccc2c(OC)ccc(F)c2n1
CCNc1ccc2c(OC)ccc(F)c2n1
CCN(C)C(=S)Sc1ccc2c(OC)ccc(F)c2n1
102
{ "fragment_index": 0, "new_substring": "CN&C(=S)S&", "old_substring": "N45" }
Can you make molecule CCNc1ccc2c(OC)ccc(F)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CCc1cc(-c2ccc3c(OC)ccc(F)c3n2)c(N)o1
CCNc1ccc2c(OC)ccc(F)c2n1
CCc1cc(-c2ccc3c(OC)ccc(F)c3n2)c(N)o1
102
{ "fragment_index": 0, "new_substring": "Nc1oc&cc1&", "old_substring": "N45" }
Can you make molecule CCNc1ccc2c(OC)ccc(F)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN1CCN=C1Sc1ccc2c(OC)ccc(F)c2n1
CCNc1ccc2c(OC)ccc(F)c2n1
CCN1CCN=C1Sc1ccc2c(OC)ccc(F)c2n1
102
{ "fragment_index": 0, "new_substring": "N1&CCN=C1S&", "old_substring": "N45" }
Can you make molecule CCNc1ccc2c(OC)ccc(F)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CCCN1CCC(c2ccc3c(OC)ccc(F)c3n2)CC1
CCNc1ccc2c(OC)ccc(F)c2n1
CCCN1CCC(c2ccc3c(OC)ccc(F)c3n2)CC1
102
{ "fragment_index": 0, "new_substring": "C&N1CCC&CC1", "old_substring": "N45" }
Can you make molecule CCNc1ccc2c(OC)ccc(F)c2n1 less soluble in water? The output molecule should be similar to the input molecule.
CCc1cccc(-c2ccc3c(OC)ccc(F)c3n2)c1N
CCNc1ccc2c(OC)ccc(F)c2n1
CCc1cccc(-c2ccc3c(OC)ccc(F)c3n2)c1N
102
{ "fragment_index": 0, "new_substring": "Nc1c&cccc1&", "old_substring": "N45" }
Can you make molecule Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2Cl)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2Cl)c(O)c1
102
{ "fragment_index": 0, "new_substring": "c1&ccccc1Cl", "old_substring": "c17ccccc1" }
Can you make molecule Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccc(I)cc2)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccc(I)cc2)c(O)c1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c17ccccc1" }
Can you make molecule Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc(C[NH+]2CC[NH+](Cc3ccccc3)C2c2ccc(O)cc2O)cc1I
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1
Cc1ccc(C[NH+]2CC[NH+](Cc3ccccc3)C2c2ccc(O)cc2O)cc1I
102
{ "fragment_index": 0, "new_substring": "Cc1ccc&cc1I", "old_substring": "c17ccccc1" }
Can you make molecule Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2cccc(Br)c2)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2cccc(Br)c2)c(O)c1
102
{ "fragment_index": 0, "new_substring": "Brc1cccc&c1", "old_substring": "c17ccccc1" }
Can you make molecule Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cccc(C[NH+]2CC[NH+](Cc3ccccc3)C2c2ccc(O)cc2O)c1C
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1
Cc1cccc(C[NH+]2CC[NH+](Cc3ccccc3)C2c2ccc(O)cc2O)c1C
102
{ "fragment_index": 0, "new_substring": "c1&cccc(C)c1C", "old_substring": "c17ccccc1" }