prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COCc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COCSc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
CC(=O)Sc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
O=C(CS)c1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
COc1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
|
O=C(CI)c1ccc(/C=N/N2CCN(Cc3ccccc3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)ccc1NC(=O)CC(C)(C)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)CC(C)(C)N1CCN([C@@H]2CCC[C@H]2O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)ccc1NC(=O)CCC(C)(C)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)CCC(C)(C)N1CCN([C@@H]2CCC[C@H]2O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)ccc1NC(=O)C[C@@H](Br)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1NC(=O)C[C@@H](Br)N1CCN([C@@H]2CCC[C@H]2O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)ccc1Nc1cc(C)n(N2CCN([C@@H]3CCC[C@H]3O)CC2)c(=O)c1
|
Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1Nc1cc(C)n(N2CCN([C@@H]3CCC[C@H]3O)CC2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)ccc1Nc1c(C)n(N2CCN([C@@H]3CCC[C@H]3O)CC2)ccc1=O
|
Cc1cc(Cl)ccc1NC(=O)N1CCN([C@@H]2CCC[C@H]2O)CC1
|
Cc1cc(Cl)ccc1Nc1c(C)n(N2CCN([C@@H]3CCC[C@H]3O)CC2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)NCSCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCSCc2ncnn2C)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N45"
}
|
Can you make molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)NC(=N)SCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NC(=N)SCc2ncnn2C)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)N(C)C(=S)SCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)N(C)C(=S)SCc2ncnn2C)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)N2CCN=C2SCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)N2CCN=C2SCc2ncnn2C)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)CN2CCC(Cc3ncnn3C)CC2)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@H](C)O1
|
C[C@@H]1CN(C(=O)CN2CCC(Cc3ncnn3C)CC2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N45"
}
|
Can you make molecule COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](NSC(=O)Cc1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NSC(=O)Cc1cc(C)on1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](NC(=O)CCCC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)CCCC(=O)c1cc(C)on1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](NC(=O)CC(C)(C)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)CC(C)(C)c1cc(C)on1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](NC(=O)CCC(C)(C)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)CCC(C)(C)c1cc(C)on1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](NSC(=O)[C@@H](C)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NC(=O)c1cc(C)on1)c1cccc(Cl)c1
|
COC(=O)C[C@H](NSC(=O)[C@@H](C)c1cc(C)on1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)C1(Cc2ccccc2)CCN(C(=O)c2cnc3ccc(F)cc3c2)C1
|
C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1
|
C[C@@H](CCO)C1(Cc2ccccc2)CCN(C(=O)c2cnc3ccc(F)cc3c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)C1(Cc2ccccc2)CCCN(C(=O)c2cnc3ccc(F)cc3c2)C1
|
C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1
|
C[C@@H](CCO)C1(Cc2ccccc2)CCCN(C(=O)c2cnc3ccc(F)cc3c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)c1oc(C(=O)c2cnc3ccc(F)cc3c2)c(C#N)c1Cc1ccccc1
|
C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1
|
C[C@@H](CCO)c1oc(C(=O)c2cnc3ccc(F)cc3c2)c(C#N)c1Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N345"
}
|
Can you make molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)C1(Cc2ccccc2)CCC(=O)N(C(=O)c2cnc3ccc(F)cc3c2)C1
|
C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1
|
C[C@@H](CCO)C1(Cc2ccccc2)CCC(=O)N(C(=O)c2cnc3ccc(F)cc3c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&&CCC1=O",
"old_substring": "N345"
}
|
Can you make molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)[C@@]1(Cc2ccccc2)CCCN(C(=O)c2cnc3ccc(F)cc3c2)C1
|
C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cnc2ccc(F)cc2c1
|
C[C@@H](CCO)[C@@]1(Cc2ccccc2)CCCN(C(=O)c2cnc3ccc(F)cc3c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N345"
}
|
Can you make molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCSC2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCSC2)[C@H]2CCSC2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@@H]18CCCO1"
}
|
Can you make molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2C=CCC2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2C=CCC2)[C@H]2CCSC2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=CCC1",
"old_substring": "[C@@H]18CCCO1"
}
|
Can you make molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCSC2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCSC2)[C@H]2CCSC2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCSC1",
"old_substring": "[C@@H]18CCCO1"
}
|
Can you make molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@H]2CCCOCC2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@H]2CCCOCC2)[C@H]2CCSC2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCOCC1",
"old_substring": "[C@@H]18CCCO1"
}
|
Can you make molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1OCCC[C@H]1CN(C(=O)[C@@H]1CC[C@H](C[NH3+])O1)[C@H]1CCSC1
|
[NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
|
C[C@@H]1OCCC[C@H]1CN(C(=O)[C@@H]1CC[C@H](C[NH3+])O1)[C@H]1CCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCO[C@H]1C",
"old_substring": "[C@@H]18CCCO1"
}
|
Can you make molecule CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(CC[C@H]2CN(C(N)=O)C[C@@H]2C)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[C@H]2CN(C(N)=O)C[C@@H]2C)C(C)(C)CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CN&C[C@@H]1C",
"old_substring": "[NH+]13CCC[C@@H]4C1"
}
|
Can you make molecule CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(CC[NH+]2CC=C(CCC(N)=O)CC2)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CC=C(CCC(N)=O)CC2)C(C)(C)CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(CC&)CC1",
"old_substring": "[NH+]13CCC[C@@H]4C1"
}
|
Can you make molecule CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(CC[C@H]2C=C[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[C@H]2C=C[C@@H](C(N)=O)C2)C(C)(C)CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[NH+]13CCC[C@@H]4C1"
}
|
Can you make molecule CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(CC[C@@H]2CC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[C@@H]2CC[C@@H](C(N)=O)C2)C(C)(C)CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[NH+]13CCC[C@@H]4C1"
}
|
Can you make molecule CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(CC[C@@H]2CN(C(N)=O)C[C@H]2C)C(C)(C)CCC1
|
CC1=C(CC[NH+]2CCC[C@@H](C(N)=O)C2)C(C)(C)CCC1
|
CC1=C(CC[C@@H]2CN(C(N)=O)C[C@H]2C)C(C)(C)CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CN&C[C@H]1C",
"old_substring": "[NH+]13CCC[C@@H]4C1"
}
|
Can you make molecule O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(c1ccccc1Cl)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(c1ccccc1Cl)N1CCC(c2c[nH]c3ncccc23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=S&(=O)c1ccccc1Cl",
"old_substring": "O=S4(=O)CCCF"
}
|
Can you make molecule O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(C)CC(=O)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1
|
C=C(C)CC(=O)N1CCC(c2c[nH]c3ncccc23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(C)CC&=O",
"old_substring": "O=S4(=O)CCCF"
}
|
Can you make molecule O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCN1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1
|
CC(=O)CCCN1CCC(c2c[nH]c3ncccc23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "O=S4(=O)CCCF"
}
|
Can you make molecule O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(C1CCCCC1)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(C1CCCCC1)N1CCC(c2c[nH]c3ncccc23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&(=O)(=O)C1CCCCC1",
"old_substring": "O=S4(=O)CCCF"
}
|
Can you make molecule O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(CC)CC(=O)N1CCC(c2c[nH]c3ncccc23)CC1
|
O=S(=O)(CCCF)N1CCC(c2c[nH]c3ncccc23)CC1
|
C=C(CC)CC(=O)N1CCC(c2c[nH]c3ncccc23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(CC)CC&=O",
"old_substring": "O=S4(=O)CCCF"
}
|
Can you make molecule Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccc(I)cc1
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-]
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccc(I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c13ccccc1[N+](=O)[O-]"
}
|
Can you make molecule Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1Cl
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-]
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c13ccccc1[N+](=O)[O-]"
}
|
Can you make molecule Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])cnc1-c1ccc2cc(oc(=O)cc1)O2
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-]
|
Cc1cc([N+](=O)[O-])cnc1-c1ccc2cc(oc(=O)cc1)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2ccc(=O)oc2c1",
"old_substring": "c13ccccc1[N+](=O)[O-]"
}
|
Can you make molecule Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])cnc1-c1ccccc2oc(c1)sc2=O
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-]
|
Cc1cc([N+](=O)[O-])cnc1-c1ccccc2oc(c1)sc2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2ccccc2c(=O)s1",
"old_substring": "c13ccccc1[N+](=O)[O-]"
}
|
Can you make molecule Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])cnc1Oc1cccc(F)c1
|
Cc1cc([N+](=O)[O-])cnc1Oc1ccccc1[N+](=O)[O-]
|
Cc1cc([N+](=O)[O-])cnc1Oc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Fc1cccc&c1",
"old_substring": "c13ccccc1[N+](=O)[O-]"
}
|
Can you make molecule CCOc1ccccc1OCC=CC[NH+](C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1OC1CCC(=CC[NH+](C)C)CC1
|
CCOc1ccccc1OCC=CC[NH+](C)C
|
CCOc1ccccc1OC1CCC(=CC[NH+](C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC=&CC1",
"old_substring": "C3C=7"
}
|
Can you make molecule CCOc1ccccc1OCC=CC[NH+](C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1ON1CCC=C(C=CC[NH+](C)C)C1
|
CCOc1ccccc1OCC=CC[NH+](C)C
|
CCOc1ccccc1ON1CCC=C(C=CC[NH+](C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "C3C=7"
}
|
Can you make molecule CCOc1ccccc1OCC=CC[NH+](C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1ON1CCCS/C1=N\CC=CC[NH+](C)C
|
CCOc1ccccc1OCC=CC[NH+](C)C
|
CCOc1ccccc1ON1CCCS/C1=N\CC=CC[NH+](C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCS/C1=N\\CC&",
"old_substring": "C3C=7"
}
|
Can you make molecule CCOc1ccccc1OCC=CC[NH+](C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1OC(CC)(CC)C(=O)CC=CC[NH+](C)C
|
CCOc1ccccc1OCC=CC[NH+](C)C
|
CCOc1ccccc1OC(CC)(CC)C(=O)CC=CC[NH+](C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C3C=7"
}
|
Can you make molecule CCOc1ccccc1OCC=CC[NH+](C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1OSC([SH]=CC[NH+](C)C)=C(C#N)C#N
|
CCOc1ccccc1OCC=CC[NH+](C)C
|
CCOc1ccccc1OSC([SH]=CC[NH+](C)C)=C(C#N)C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#CC(C#N)=C(S&)S&",
"old_substring": "C3C=7"
}
|
Can you make molecule CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1C1(Cc2cc(C)ccc2OC(F)F)CC[NH2+]C1
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1C1(Cc2cc(C)ccc2OC(F)F)CC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&&C1",
"old_substring": "[NH2+]34"
}
|
Can you make molecule CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[C@@]1(Cc2cc(C)ccc2OC(F)F)CCC[NH2+]C1
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[C@@]1(Cc2cc(C)ccc2OC(F)F)CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@]&&C1",
"old_substring": "[NH2+]34"
}
|
Can you make molecule CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1c[nH+]cn1Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1c[nH+]cn1Cc1cc(C)ccc1OC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]cn&c1&",
"old_substring": "[NH2+]34"
}
|
Can you make molecule CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1cc(Cc2cc(C)ccc2OC(F)F)[nH+][nH]1
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1cc(Cc2cc(C)ccc2OC(F)F)[nH+][nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&[nH+]c&cc1&",
"old_substring": "[NH2+]34"
}
|
Can you make molecule CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1c[nH+]n(C)c1Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F
|
CC[S@@+]([O-])[C@H]1CCCC[C@@H]1c1c[nH+]n(C)c1Cc1cc(C)ccc1OC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]n(C)c&c1&",
"old_substring": "[NH2+]34"
}
|
Can you make molecule Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(/N=C(\[O-])CNSC(=O)Cc2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNSC(=O)Cc2ccccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CCCC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CCCC(=O)c2ccccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CC(C)(C)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CC(C)(C)c2ccccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CCC(C)(C)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)CCC(C)(C)c2ccccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(/N=C(\[O-])CNSC(=O)[C@@H](C)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNC(=O)c2ccccc2F)n1
|
Cc1n[nH]c(/N=C(\[O-])CNSC(=O)[C@@H](C)c2ccccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1[C@@H](C)CCC[C@H]1NSC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NSC(=O)CSc1nnc(-c2cccnc2)n1N
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CCCC(=O)Sc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CCCC(=O)Sc1nnc(-c2cccnc2)n1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CC(C)(C)Sc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CC(C)(C)Sc1nnc(-c2cccnc2)n1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC[S@+]([O-])CCCSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC[S@+]([O-])CCCSc1nnc(-c2cccnc2)n1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CCC(C)(C)Sc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CSc1nnc(-c2cccnc2)n1N
|
C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)CCC(C)(C)Sc1nnc(-c2cccnc2)n1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)CCC(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C5(C)C"
}
|
Can you make molecule COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C(C)(C)CCC[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)CCC[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCC&",
"old_substring": "C3(=O)C5(C)C"
}
|
Can you make molecule COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C(C)(C)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)C&(C)C",
"old_substring": "C3(=O)C5(C)C"
}
|
Can you make molecule COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C(C[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1)=C(Cl)Cl
|
COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1)=C(Cl)Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C&)=C(Cl)Cl",
"old_substring": "C3(=O)C5(C)C"
}
|
Can you make molecule COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@@H](C(C)C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C(C)(C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
|
COC(=O)C[C@@H](C(C)C)[C@H]1CCCN(S(=O)(=O)c2ccc(F)c(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&C(C)C",
"old_substring": "C3(=O)C5(C)C"
}
|
Can you make molecule COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)c(NC(=O)NCc2cc3cnsc3s2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cc3cnsc3s2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cnsc2s1",
"old_substring": "c19cn2ccsc2n1"
}
|
Can you make molecule COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)c(NC(=O)NCc2cc3sccn3c2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cc3sccn3c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sccn2c1",
"old_substring": "c19cn2ccsc2n1"
}
|
Can you make molecule COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)c(NC(=O)NCc2cnc3ccsc3c2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cnc3ccsc3c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cnc2ccsc2c1",
"old_substring": "c19cn2ccsc2n1"
}
|
Can you make molecule COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)c(NC(=O)NCc2ccc3sncc3c2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2ccc3sncc3c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2sncc2c1",
"old_substring": "c19cn2ccsc2n1"
}
|
Can you make molecule COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)c(NC(=O)NCc2nc3ccccc3s2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1
|
COc1ccc(Cl)c(NC(=O)NCc2nc3ccccc3s2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2ccccc2s1",
"old_substring": "c19cn2ccsc2n1"
}
|
Can you make molecule CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)cc1I
|
CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2
|
CCOc1ccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16ccccc17"
}
|
Can you make molecule CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)ccc1Br
|
CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2
|
CCOc1cc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16ccccc17"
}
|
Can you make molecule CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)cc1Cl
|
CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2
|
CCOc1ccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16ccccc17"
}
|
Can you make molecule CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)c1Br
|
CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2
|
CCOc1cccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16ccccc17"
}
|
Can you make molecule CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)c1Cl
|
CCOc1ccccc1NC(=O)C1=C(C)Nc2nc(COC)nn2[C@@H]1c1ccc2c(c1)OCCCO2
|
CCOc1cccc(NC(=O)C2=C(C)Nc3nc(COC)nn3[C@@H]2c2ccc3c(c2)OCCCO3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16ccccc17"
}
|
Can you make molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCSC12CCN(C(=O)Nc1nncs1)CC2
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCSC12CCN(C(=O)Nc1nncs1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSC12CCN&CC2",
"old_substring": "N13CCC8CC1"
}
|
Can you make molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCCc2cc(C(=O)Nc3nncs3)ccc2C1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCCc2cc(C(=O)Nc3nncs3)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCc2cc&ccc2C1",
"old_substring": "N13CCC8CC1"
}
|
Can you make molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)C1CCN(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)C1CCN(C(=O)Nc2nncs2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "N13CCC8CC1"
}
|
Can you make molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)C1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)C1CCC(C(=O)Nc2nncs2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "N13CCC8CC1"
}
|
Can you make molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)CCCCCC(=O)Nc1nncs1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)N1CCC(C(=O)Nc2nncs2)CC1
|
C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)CCCCCC(=O)Nc1nncs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "N13CCC8CC1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(C2(S(=O)(=O)c3cn[nH]c3)CCN(Cc3cccs3)C2)c1
|
C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc(C2(S(=O)(=O)c3cn[nH]c3)CCN(Cc3cccs3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(C2(S(=O)(=O)c3cn[nH]c3)CCCN(Cc3cccs3)C2)c1
|
C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc(C2(S(=O)(=O)c3cn[nH]c3)CCCN(Cc3cccs3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(-c2c(S(=O)(=O)c3cn[nH]c3)oc(Cc3cccs3)c2C#N)c1
|
C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc(-c2c(S(=O)(=O)c3cn[nH]c3)oc(Cc3cccs3)c2C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N345"
}
|
Can you make molecule C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc([C@]2(S(=O)(=O)c3cn[nH]c3)CCCN(Cc3cccs3)C2)c1
|
C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc([C@]2(S(=O)(=O)c3cn[nH]c3)CCCN(Cc3cccs3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N345"
}
|
Can you make molecule C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc([C@@H]2N(Cc3cccs3)CCCN2S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc(N(Cc2cccs2)S(=O)(=O)c2cn[nH]c2)c1
|
C#Cc1cccc([C@@H]2N(Cc3cccs3)CCCN2S(=O)(=O)c2cn[nH]c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCN&[C@@H]1&",
"old_substring": "N345"
}
|
Can you make molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1Cl
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)ccc1Cl",
"old_substring": "c13cc(C)ccc1F"
}
|
Can you make molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(Br)c(Cl)c1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(Br)c(Cl)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c13cc(C)ccc1F"
}
|
Can you make molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)c(C)cc1Br
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)c(C)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)c(C)cc1Br",
"old_substring": "c13cc(C)ccc1F"
}
|
Can you make molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(Br)ccc1I
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(Br)ccc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1I",
"old_substring": "c13cc(C)ccc1F"
}
|
Can you make molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(Cl)c(C)cc1Cl
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(C)ccc1F
|
CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1c1cc(Cl)c(C)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)c(C)cc1Cl",
"old_substring": "c13cc(C)ccc1F"
}
|
Can you make molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCCCn1c(SCC(=O)[O-])nc2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C4C6"
}
|
Can you make molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N=CCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)N=CCCn1c(SCC(=O)[O-])nc2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C4C6"
}
|
Can you make molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCCCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCCCCn1c(SCC(=O)[O-])nc2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C4C6"
}
|
Can you make molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NC1CC(n2c(SCC(=O)[O-])nc3cccnc32)C1
|
CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NC1CC(n2c(SCC(=O)[O-])nc3cccnc32)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C4C6"
}
|
Can you make molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N=C(C)CCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21
|
CC(=O)N=C(C)CCn1c(SCC(=O)[O-])nc2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C4C6"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.