prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Fc1ccccc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Fc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Fc1cccc&c1",
"old_substring": "c1%11ccccc1"
}
|
Can you make molecule Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Cc1ccccc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cccc&c1",
"old_substring": "c1%11ccccc1"
}
|
Can you make molecule Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Ic1ccccc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Ic1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c1%11ccccc1"
}
|
Can you make molecule Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Fc1ccc(F)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Fc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1F",
"old_substring": "c1%11ccccc1"
}
|
Can you make molecule Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Cc1ccccc1C
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)n(-c4ccccc4)n3)CC2)cc1
|
Cc1ccc(CN2CCN(C(=O)c3cc(NC(=O)C(C)C)[nH]n3)CC2)cc1.Cc1ccccc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c1%11ccccc1"
}
|
Can you make molecule CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N[C@H]1CC[C@@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
|
CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1
|
CC(=O)N[C@H]1CC[C@@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@H]46CC3=O"
}
|
Can you make molecule CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N[C@H]1CC[C@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
|
CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1
|
CC(=O)N[C@H]1CC[C@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@H]46CC3=O"
}
|
Can you make molecule CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N[C@@H](CCCc1ccc(C)cc1)C(C)(C)NCC(C)(C)c1ccncc1
|
CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1
|
CC(=O)N[C@@H](CCCc1ccc(C)cc1)C(C)(C)NCC(C)(C)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@H]46CC3=O"
}
|
Can you make molecule CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N[C@@H]1CCC[C@@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
|
CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1
|
CC(=O)N[C@@H]1CCC[C@@](NCC(C)(C)c2ccncc2)(c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@H]46CC3=O"
}
|
Can you make molecule CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1[nH]c(-c2ccc(C)cc2)c(C)c1NCC(C)(C)c1ccncc1
|
CC(=O)N[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccc(C)cc1
|
CC(=O)Nc1[nH]c(-c2ccc(C)cc2)c(C)c1NCC(C)(C)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH]c&c(C)c1&",
"old_substring": "[C@H]46CC3=O"
}
|
Can you make molecule CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(SC(=O)C[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(SC(=O)C[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(CC(=C=O)C[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(CC(=C=O)C[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C(=O)CCCC(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)CCCC(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C(=O)CC(C)(C)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)CC(C)(C)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C[S@+]([O-])CCC[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
|
CCN1CCN(C(=O)[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@H]42)[C@H]3Cl)CC1
|
CCN1CCN(C[S@+]([O-])CCC[C@H]2[C@@H]3C[C@H]4[C@H](OC(=O)[C@@H]24)[C@H]3Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C57=O"
}
|
Can you make molecule Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc2c(c1)[C@H](Nc1cc(-c3cccnc3)n3ccccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1cc(-c3cccnc3)n3ccccc13)CCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&n2ccccc12",
"old_substring": "c14nc5nc2ccccc12"
}
|
Can you make molecule Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc2c(c1)[C@H](Nc1cccc3c1ccn3-c1cccnc1)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1cccc3c1ccn3-c1cccnc1)CCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc2c1ccn2&",
"old_substring": "c14nc5nc2ccccc12"
}
|
Can you make molecule Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc2c(c1)[C@H](Nc1ccc3cc(-c4cccnc4)cn3c1)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1ccc3cc(-c4cccnc4)cn3c1)CCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2cc&cn2c1",
"old_substring": "c14nc5nc2ccccc12"
}
|
Can you make molecule Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc2c(c1)[C@H](Nc1ccc(-c3cccnc3)c3ncccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2
|
Fc1ccc2c(c1)[C@H](Nc1ccc(-c3cccnc3)c3ncccc13)CCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&c2ncccc12",
"old_substring": "c14nc5nc2ccccc12"
}
|
Can you make molecule Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(-c2cccnc2)cc2c(N[C@@H]3CCSc4ccc(F)cc43)cccc21
|
Fc1ccc2c(c1)[C@H](Nc1nc(-c3cccnc3)nc3ccccc13)CCS2
|
Cn1c(-c2cccnc2)cc2c(N[C@@H]3CCSc4ccc(F)cc43)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc2c1cc&n2C",
"old_substring": "c14nc5nc2ccccc12"
}
|
Can you make molecule C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1=C2CCN2CC(C(=O)Nc2cc(Cl)ccc2Cl)=NC([C@H]2CCS(=O)(=O)C2)=N1
|
C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1
|
C#CCC1=C2CCN2CC(C(=O)Nc2cc(Cl)ccc2Cl)=NC([C@H]2CCS(=O)(=O)C2)=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&nc&nc2C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1=C2OCCN2CC(C(=O)Nc2cc(Cl)ccc2Cl)=CC([C@H]2CCS(=O)(=O)C2)=C1
|
C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1
|
C#CCC1=C2OCCN2CC(C(=O)Nc2cc(Cl)ccc2Cl)=CC([C@H]2CCS(=O)(=O)C2)=C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2c&cc&cc2C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCN(C(=O)Nc2cc(Cl)ccc2Cl)C1
|
C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCN(C(=O)Nc2cc(Cl)ccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCCN(C(=O)Nc2cc(Cl)ccc2Cl)C1
|
C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCCN(C(=O)Nc2cc(Cl)ccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1oc(C(=O)Nc2cc(Cl)ccc2Cl)c(C#N)c1[C@H]1CCS(=O)(=O)C1
|
C#CCN(C(=O)Nc1cc(Cl)ccc1Cl)[C@H]1CCS(=O)(=O)C1
|
C#CCc1oc(C(=O)Nc2cc(Cl)ccc2Cl)c(C#N)c1[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N246"
}
|
Can you make molecule C#CCNC(=O)Nc1cccc(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1nc2c(s1)CN(C(=O)Nc1cccc(C)c1)C2
|
C#CCNC(=O)Nc1cccc(C)c1
|
C#CCc1nc2c(s1)CN(C(=O)Nc1cccc(C)c1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N24"
}
|
Can you make molecule C#CCNC(=O)Nc1cccc(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCn1ncc2c1CN(C(=O)Nc1cccc(C)c1)C2
|
C#CCNC(=O)Nc1cccc(C)c1
|
C#CCn1ncc2c1CN(C(=O)Nc1cccc(C)c1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2cnn&c2C1",
"old_substring": "N24"
}
|
Can you make molecule C#CCNC(=O)Nc1cccc(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1onc2c1CN(C(=O)Nc1cccc(C)c1)CC2
|
C#CCNC(=O)Nc1cccc(C)c1
|
C#CCc1onc2c1CN(C(=O)Nc1cccc(C)c1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2noc&c2C1",
"old_substring": "N24"
}
|
Can you make molecule C#CCNC(=O)Nc1cccc(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1cc2n(n1)CCCN2C(=O)Nc1cccc(C)c1
|
C#CCNC(=O)Nc1cccc(C)c1
|
C#CCc1cc2n(n1)CCCN2C(=O)Nc1cccc(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N24"
}
|
Can you make molecule C#CCNC(=O)Nc1cccc(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1ccc2c(c1)CCN2C(=O)Nc1cccc(C)c1
|
C#CCNC(=O)Nc1cccc(C)c1
|
C#CCc1ccc2c(c1)CCN2C(=O)Nc1cccc(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N24"
}
|
Can you make molecule COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[C@H](Cl)c1ccc(Cl)c(F)c1
|
COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1
|
COCC[C@H](Cl)c1ccc(Cl)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C2(=O)[C@@H]3Cl"
}
|
Can you make molecule COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@@H](Br)c1ccc(Cl)c(F)c1
|
COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1
|
COC(=O)C[C@@H](Br)c1ccc(Cl)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C2(=O)[C@@H]3Cl"
}
|
Can you make molecule COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CCc1ccc(Cl)c(F)c1
|
COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1
|
CO[C@@H](C)CCc1ccc(Cl)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C2(=O)[C@@H]3Cl"
}
|
Can you make molecule COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](CCc1ccc(Cl)c(F)c1)C(C)C
|
COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1
|
CO[C@@H](CCc1ccc(Cl)c(F)c1)C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "C2(=O)[C@@H]3Cl"
}
|
Can you make molecule COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](c1ccc(Cl)c(F)c1)C(C)C
|
COC(=O)[C@H](Cl)c1ccc(Cl)c(F)c1
|
COC(=O)C[C@H](c1ccc(Cl)c(F)c1)C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&C(C)C",
"old_substring": "C2(=O)[C@@H]3Cl"
}
|
Can you make molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCC(C)C)C1)c1ccccc1
|
CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCC(C)C)C1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCCCBr)C1)c1ccccc1
|
CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCCCBr)C1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
C=CCCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCCCCl)C1)c1ccccc1
|
CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
CCN(C)[C@H](C(=O)N1CCO[C@H](CCCCCl)C1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
|
C=CCCCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC6"
}
|
Can you make molecule CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(COc1ccc2c(c1)OCCO2)Cc1cccc(C#N)c1
|
CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1
|
CC(C)(COc1ccc2c(c1)OCCO2)Cc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "CC5(C)C3=O"
}
|
Can you make molecule CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCc1cccc(C#N)c1)CC(=O)Oc1ccc2c(c1)OCCO2
|
CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1
|
C[C@H](CCc1cccc(C#N)c1)CC(=O)Oc1ccc2c(c1)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "CC5(C)C3=O"
}
|
Can you make molecule CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)c1cccc(C#N)c1)Oc1ccc2c(c1)OCCO2
|
CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1
|
CC(C)(CC(=O)c1cccc(C#N)c1)Oc1ccc2c(c1)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "CC5(C)C3=O"
}
|
Can you make molecule CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCc1cccc(C#N)c1)CC(=O)Oc1ccc2c(c1)OCCO2
|
CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1
|
C[C@@H](CCc1cccc(C#N)c1)CC(=O)Oc1ccc2c(c1)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "CC5(C)C3=O"
}
|
Can you make molecule CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)c1cccc(C#N)c1)Oc1ccc2c(c1)OCCO2
|
CC(C)(C(=O)Oc1ccc2c(c1)OCCO2)c1cccc(C#N)c1
|
CC(C)(CCC(=O)c1cccc(C#N)c1)Oc1ccc2c(c1)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "CC5(C)C3=O"
}
|
Can you make molecule COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@H]2C=C[CH]C2)CC1
|
COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@H]2C=C[CH]C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[C@H]6%10C"
}
|
Can you make molecule COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@@H]2C[CH]CCC2)CC1
|
COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@@H]2C[CH]CCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]6%10C"
}
|
Can you make molecule COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C[C@H](NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)N=N1.COCc1ccccc1OC
|
COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC
|
CC1=C[C@H](NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)N=N1.COCc1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C(C&)N=N1",
"old_substring": "[C@H]6%10C"
}
|
Can you make molecule COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1=CN=N[C@H]1NC1CC[NH+]([C@@H]2CCCC[C@@H]2O)CC1.COCc1ccccc1OC
|
COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC
|
CCC1=CN=N[C@H]1NC1CC[NH+]([C@@H]2CCCC[C@@H]2O)CC1.COCc1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@H]6%10C"
}
|
Can you make molecule COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@H]2C=C[CH]C2)CC1
|
COCc1cc([C@@H](C)NC2CC[NH+]([C@@H]3CCCC[C@@H]3O)CC2)ccc1OC
|
COCc1ccccc1OC.O[C@H]1CCCC[C@H]1[NH+]1CCC(N[C@H]2C=C[CH]C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[C@H]6%10C"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)CC(C)(C)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)CC(C)(C)N[C@@H]1CCN(C(=O)c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)CCC(C)(C)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)CCC(C)(C)N[C@@H]1CCN(C(=O)c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C[C@@H](Br)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)C[C@@H](Br)N[C@@H]1CCN(C(=O)c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1Nc1cc(C)n(N[C@@H]2CCN(C(=O)c3ccccc3)C2)c(=O)c1
|
CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1Nc1cc(C)n(N[C@@H]2CCN(C(=O)c3ccccc3)C2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1Nc1c(C)n(N[C@@H]2CCN(C(=O)c3ccccc3)C2)ccc1=O
|
CCc1nn(C)cc1NC(=O)N[C@@H]1CCN(C(=O)c2ccccc2)C1
|
CCc1nn(C)cc1Nc1c(C)n(N[C@@H]2CCN(C(=O)c3ccccc3)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=C(C)C)C2)cc1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=C(C)C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&C",
"old_substring": "CC4"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
C=CSNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=C(C)I)C2)cc1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=C(C)I)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&I",
"old_substring": "CC4"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
C=CCCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=CCCl)C2)cc1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)[C@@H](C)c2ccc(CC)cc2)C1
|
CCc1ccc([C@H](C)C(=O)N2CC[C@@H](S(=O)(=O)N=CCCl)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCl",
"old_substring": "CC4"
}
|
Can you make molecule C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCc1ccccc1)Cc1ccc(-c2nc([O-])cc(C(F)(F)F)n2)cc1I
|
C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1
|
C[NH+](CCc1ccccc1)Cc1ccc(-c2nc([O-])cc(C(F)(F)F)n2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16ccccc17"
}
|
Can you make molecule C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCc1ccccc1)Cc1cc(-c2nc([O-])cc(C(F)(F)F)n2)ccc1Br
|
C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1
|
C[NH+](CCc1ccccc1)Cc1cc(-c2nc([O-])cc(C(F)(F)F)n2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16ccccc17"
}
|
Can you make molecule C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCc1ccccc1)Cc1ccc(-c2nc([O-])cc(C(F)(F)F)n2)cc1Cl
|
C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1
|
C[NH+](CCc1ccccc1)Cc1ccc(-c2nc([O-])cc(C(F)(F)F)n2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16ccccc17"
}
|
Can you make molecule C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCc1ccccc1)Cc1cccc(-c2nc([O-])cc(C(F)(F)F)n2)c1Br
|
C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1
|
C[NH+](CCc1ccccc1)Cc1cccc(-c2nc([O-])cc(C(F)(F)F)n2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16ccccc17"
}
|
Can you make molecule C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCc1ccccc1)Cc1cccc(-c2nc([O-])cc(C(F)(F)F)n2)c1Cl
|
C[NH+](CCc1ccccc1)Cc1ccccc1-c1nc([O-])cc(C(F)(F)F)n1
|
C[NH+](CCc1ccccc1)Cc1cccc(-c2nc([O-])cc(C(F)(F)F)n2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16ccccc17"
}
|
Can you make molecule Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc[nH]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cc1nc[nH]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc[nH]c1&",
"old_substring": "Cn1cc[nH+]c14"
}
|
Can you make molecule Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc[nH]/c1=N\C(=O)N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cc[nH]/c1=N\C(=O)N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc[nH]/c1=N\\C&=O",
"old_substring": "Cn1cc[nH+]c14"
}
|
Can you make molecule Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cncc1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cncc1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cncc1&",
"old_substring": "Cn1cc[nH+]c14"
}
|
Can you make molecule Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(N2CCN(C[C@@H](O)c3cccc(Br)c3)CC2)cn1
|
Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
Cn1cc(N2CCN(C[C@@H](O)c3cccc(Br)c3)CC2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc&cn1",
"old_substring": "Cn1cc[nH+]c14"
}
|
Can you make molecule Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](CN1CCN(c2cn[nH]c2)CC1)c1cccc(Br)c1
|
Cn1cc[nH+]c1N1CCN(C[C@@H](O)c2cccc(Br)c2)CC1
|
O[C@H](CN1CCN(c2cn[nH]c2)CC1)c1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cn[nH]c1",
"old_substring": "Cn1cc[nH+]c14"
}
|
Can you make molecule COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Ic1ccco1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Ic1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)o1",
"old_substring": "c1%12ccco1"
}
|
Can you make molecule COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Cc1ccco1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Cc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccoc1C",
"old_substring": "c1%12ccco1"
}
|
Can you make molecule COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.c1cc2ccsc2o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.c1cc2ccsc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2ccoc2s1",
"old_substring": "c1%12ccco1"
}
|
Can you make molecule COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Brc1ccco1.COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1
|
Brc1ccco1.COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)o1",
"old_substring": "c1%12ccco1"
}
|
Can you make molecule COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Clc1ccco1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3cccc(-c4ccco4)c3)CC2)o1
|
COCc1ccc(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)o1.Clc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)o1",
"old_substring": "c1%12ccco1"
}
|
Can you make molecule CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1Cl
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=S&(=O)c1ccccc1Cl",
"old_substring": "S3(=O)(=O)c1ccccc1"
}
|
Can you make molecule CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\O)c1ccccc1N(C)CC(=O)N/N=C/c1c(Cl)cccc1Cl
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1
|
C/C(=N\O)c1ccccc1N(C)CC(=O)N/N=C/c1c(Cl)cccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(=N\\O)c1ccccc1&",
"old_substring": "S3(=O)(=O)c1ccccc1"
}
|
Can you make molecule CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(C(=O)N(C)CC(=O)N/N=C/c1c(Cl)cccc1Cl)c1ccccc1
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1
|
C=C(C(=O)N(C)CC(=O)N/N=C/c1c(Cl)cccc1Cl)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(C&=O)c1ccccc1",
"old_substring": "S3(=O)(=O)c1ccccc1"
}
|
Can you make molecule CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S/C(N)=N/c1ccccc1
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S/C(N)=N/c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(N)=N/c1ccccc1",
"old_substring": "S3(=O)(=O)c1ccccc1"
}
|
Can you make molecule CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/C(=N/O)c1ccc(N(C)CC(=O)N/N=C/c2c(Cl)cccc2Cl)cc1
|
CN(CC(=O)N/N=C/c1c(Cl)cccc1Cl)S(=O)(=O)c1ccccc1
|
CC/C(=N/O)c1ccc(N(C)CC(=O)N/N=C/c2c(Cl)cccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC/C(=N/O)c1ccc&cc1",
"old_substring": "S3(=O)(=O)c1ccccc1"
}
|
Can you make molecule CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2CCCN(c3ccccc3)CC2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2CCCN(c3ccccc3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCN&CC1",
"old_substring": "[C@@H]47C#N"
}
|
Can you make molecule CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2CC23CCN(c2ccccc2)CC3)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2CC23CCN(c2ccccc2)CC3)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC12CCN&CC2",
"old_substring": "[C@@H]47C#N"
}
|
Can you make molecule CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2C=C(Cc3ccccc3)N=N2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H]2C=C(Cc3ccccc3)N=N2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=C(C&)N=N1",
"old_substring": "[C@@H]47C#N"
}
|
Can you make molecule CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@H]2CCCCN(c3ccccc3)C2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@H]2CCCCN(c3ccccc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1",
"old_substring": "[C@@H]47C#N"
}
|
Can you make molecule CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@H](CCl)CCCc2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1
|
CC(C)c1cnc(CN2CCC[C@@H]2[C@H](CCl)CCCc2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]47C#N"
}
|
Can you make molecule Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc1Br
|
Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1
|
Cc1ccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C=&)cc1Br",
"old_substring": "Cc1cccc(C=5)c1"
}
|
Can you make molecule Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc1C
|
Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1
|
Cc1cc(C)c(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(C)c(C=&)cc1C",
"old_substring": "Cc1cccc(C=5)c1"
}
|
Can you make molecule Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc(C)c1Cl
|
Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1
|
Cc1cc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(C=&)cc(C)c1Cl",
"old_substring": "Cc1cccc(C=5)c1"
}
|
Can you make molecule Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])C(=Cc1cccc(Cl)c1Cl)c1ccc(S(=O)(=O)N2CCCC2)s1
|
Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1
|
O=C([O-])C(=Cc1cccc(Cl)c1Cl)c1ccc(S(=O)(=O)N2CCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1cccc(Cl)c1Cl",
"old_substring": "Cc1cccc(C=5)c1"
}
|
Can you make molecule Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])C(=Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N2CCCC2)s1
|
Cc1cccc(C=C(C(=O)[O-])c2ccc(S(=O)(=O)N3CCCC3)s2)c1
|
O=C([O-])C(=Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N2CCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1C=&",
"old_substring": "Cc1cccc(C=5)c1"
}
|
Can you make molecule Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(COC(=O)CNC(=O)c1cccc(C)c1)=N/ON(C)C1CCCCC1
|
Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1
|
C/C(COC(=O)CNC(=O)c1cccc(C)c1)=N/ON(C)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(=O)CNC(=O)c1cccc(C)c1)C(=O)CN(C)C1CCCCC1
|
Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1
|
CCC(CC)(OC(=O)CNC(=O)c1cccc(C)c1)C(=O)CN(C)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C(=O)NCC(=O)OSSC(=O)N(C)C2CCCCC2)c1
|
Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1
|
Cc1cccc(C(=O)NCC(=O)OSSC(=O)N(C)C2CCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(=O)CNC(=O)c1cccc(C)c1)C(=O)CCN(C)C1CCCCC1
|
Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1
|
CCC(CC)(OC(=O)CNC(=O)c1cccc(C)c1)C(=O)CCN(C)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C(=O)OC(=O)CNC(=O)c1cccc(C)c1)C(=O)N(C)C1CCCCC1
|
Cc1cccc(C(=O)NCC(=O)OCC(=O)N(C)C2CCCCC2)c1
|
CC[C@H](C(=O)OC(=O)CNC(=O)c1cccc(C)c1)C(=O)N(C)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&=O)C&=O",
"old_substring": "C6C5=O"
}
|
Can you make molecule CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](C)NCCC(CO)=C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NCCC(CO)=C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](C)NSC(=O)CC1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NSC(=O)CC1CCN(Cn2c3c(sc2=O)CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](C)N=CC(=O)C=C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)N=CC(=O)C=C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C(=O)C=&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](C)NCC(=C=O)CC1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NCC(=C=O)CC1CCN(Cn2c3c(sc2=O)CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](C)NC(=O)CCCC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
|
CC(C)[C@H](C)NC(=O)CCCC(=O)C1CCN(Cn2c3c(sc2=O)CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
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