prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1Cl
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c12ccc(F)cc1"
}
|
Can you make molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1Br
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c12ccc(F)cc1"
}
|
Can you make molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1cc2c(F)cccc2s1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1cc2c(F)cccc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c12ccc(F)cc1"
}
|
Can you make molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)c(Cl)c1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c12ccc(F)cc1"
}
|
Can you make molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(I)cc1F
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1
|
[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(I)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c12ccc(F)cc1"
}
|
Can you make molecule O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1OCCC[C@H]1c1ccc([N+](=O)[O-])cc1
|
O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1
|
C[C@@H]1OCCC[C@H]1c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCO[C@H]1C",
"old_substring": "[C@@H]14OC[NH+]2COC[C@@H]12"
}
|
Can you make molecule O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc([C@@H]2CCCCO2)cc1
|
O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1
|
O=[N+]([O-])c1ccc([C@@H]2CCCCO2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCCO1",
"old_substring": "[C@@H]14OC[NH+]2COC[C@@H]12"
}
|
Can you make molecule O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc([C@@H]2C=CCC2)cc1
|
O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1
|
O=[N+]([O-])c1ccc([C@@H]2C=CCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=CCC1",
"old_substring": "[C@@H]14OC[NH+]2COC[C@@H]12"
}
|
Can you make molecule O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc([C@@H]2CCCSC2)cc1
|
O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1
|
O=[N+]([O-])c1ccc([C@@H]2CCCSC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCSC1",
"old_substring": "[C@@H]14OC[NH+]2COC[C@@H]12"
}
|
Can you make molecule O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc([C@@H]2COCCO2)cc1
|
O=[N+]([O-])c1ccc([C@@H]2OC[NH+]3COC[C@@H]23)cc1
|
O=[N+]([O-])c1ccc([C@@H]2COCCO2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&COCCO1",
"old_substring": "[C@@H]14OC[NH+]2COC[C@@H]12"
}
|
Can you make molecule Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(CCS(=O)(=O)[O-])c(C[NH2+]C[C@@H]2CCCO2)c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1
|
Cc1c(CCS(=O)(=O)[O-])c(C[NH2+]C[C@@H]2CCCO2)c(C)n1Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)CO)c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)CO)c(C)n1Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(O)O)c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(O)O)c(C)n1Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)[O-])c1c(C[NH2+]C[C@@H]2CCCO2)c(C)n(Cc2ccc(F)cc2)c1C
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1
|
CCC(CC)(C(=O)[O-])c1c(C[NH2+]C[C@@H]2CCCO2)c(C)n(Cc2ccc(F)cc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(CCCS(=O)(=O)[O-])c(C[NH2+]C[C@@H]2CCCO2)c(C)n1Cc1ccc(F)cc1
|
Cc1c(C[NH2+]C[C@@H]2CCCO2)c(C(=O)[O-])c(C)n1Cc1ccc(F)cc1
|
Cc1c(CCCS(=O)(=O)[O-])c(C[NH2+]C[C@@H]2CCCO2)c(C)n1Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(Oc2cc3cccc(Br)c3o2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2cc3cccc(Br)c3o2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cccc(Br)c2o1",
"old_substring": "c15ccc2ccc(=O)oc2c1"
}
|
Can you make molecule N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(Oc2ccc3ccccc3c2Br)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc3ccccc3c2Br)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2ccccc2c1Br",
"old_substring": "c15ccc2ccc(=O)oc2c1"
}
|
Can you make molecule N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(Oc2cc3cc(Br)ccc3o2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2cc3cc(Br)ccc3o2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(Br)ccc2o1",
"old_substring": "c15ccc2ccc(=O)oc2c1"
}
|
Can you make molecule N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(Oc2ccc(Cl)c3ccccc23)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12
|
N#Cc1cc(Oc2ccc(Cl)c3ccccc23)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c2ccccc12",
"old_substring": "c15ccc2ccc(=O)oc2c1"
}
|
Can you make molecule N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(Oc3cc(C#N)c4cc(Cl)ccc4n3)cc(Cl)c2o1
|
N#Cc1cc(Oc2ccc3ccc(=O)oc3c2)nc2ccc(Cl)cc12
|
Cc1cc2cc(Oc3cc(C#N)c4cc(Cl)ccc4n3)cc(Cl)c2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc2cc&cc(Cl)c2o1",
"old_substring": "c15ccc2ccc(=O)oc2c1"
}
|
Can you make molecule O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SC1CCN(C2=NC=NC3=NC=N[C@H]32)CC1)NC1CCCCC1
|
O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C(/C=C/SC1CCN(C2=NC=NC3=NC=N[C@H]32)CC1)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C46"
}
|
Can you make molecule O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NC2CCCCC2)nc1C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=Cc1sc(NC2CCCCC2)nc1C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C46"
}
|
Can you make molecule O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NC2CCCCC2)sc1C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=Cc1nc(NC2CCCCC2)sc1C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C46"
}
|
Can you make molecule O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N/N=C/CC1CCN(C2=NC=NC3=NC=N[C@H]32)CC1)NC1CCCCC1
|
O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C(N/N=C/CC1CCN(C2=NC=NC3=NC=N[C@H]32)CC1)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&N/N=C/C&",
"old_substring": "O=C46"
}
|
Can you make molecule O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=NC2CCCCC2)CCC1=C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C(NC1CCCCC1)C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
|
O=C1C(=NC2CCCCC2)CCC1=C1CCN(C2=NC=NC3=NC=N[C@H]32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C46"
}
|
Can you make molecule COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N1C[C@H](CC(=O)SNc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](CC(=O)SNc2cccc(Cl)c2C)CC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N1C[C@H](CC(=C=O)CNc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](CC(=C=O)CNc2cccc(Cl)c2C)CC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N1C[C@H](C(=O)CCCC(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)CCCC(=O)Nc2cccc(Cl)c2C)CC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N1C[C@H](C(C)(C)CC(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(C)(C)CC(=O)Nc2cccc(Cl)c2C)CC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N1C[C@H](CCC[S@@+]([O-])CNc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](C(=O)Nc2cccc(Cl)c2C)CC1=O
|
COc1ccccc1N1C[C@H](CCC[S@@+]([O-])CNc2cccc(Cl)c2C)CC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)cc1C1(S(=O)(=O)c2ccc(C)cc2)CCN(CC(=O)NN=C2CCN(C)CC2)C1
|
COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
|
COc1ccc(Cl)cc1C1(S(=O)(=O)c2ccc(C)cc2)CCN(CC(=O)NN=C2CCN(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)cc1C1(S(=O)(=O)c2ccc(C)cc2)CCCN(CC(=O)NN=C2CCN(C)CC2)C1
|
COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
|
COc1ccc(Cl)cc1C1(S(=O)(=O)c2ccc(C)cc2)CCCN(CC(=O)NN=C2CCN(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N345"
}
|
Can you make molecule COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)cc1-c1c(S(=O)(=O)c2ccc(C)cc2)oc(CC(=O)NN=C2CCN(C)CC2)c1C#N
|
COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
|
COc1ccc(Cl)cc1-c1c(S(=O)(=O)c2ccc(C)cc2)oc(CC(=O)NN=C2CCN(C)CC2)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N345"
}
|
Can you make molecule COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Cl)cc1[C@]1(S(=O)(=O)c2ccc(C)cc2)CCCN(CC(=O)NN=C2CCN(C)CC2)C1
|
COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
|
COc1ccc(Cl)cc1[C@]1(S(=O)(=O)c2ccc(C)cc2)CCCN(CC(=O)NN=C2CCN(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N345"
}
|
Can you make molecule COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1=C2c3cc(Cl)ccc3C(=NN2S(=O)(=O)c2ccc(C)cc2)CN(CC(=O)NN=C2CCN(C)CC2)C1
|
COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
|
COC1=C2c3cc(Cl)ccc3C(=NN2S(=O)(=O)c2ccc(C)cc2)CN(CC(=O)NN=C2CCN(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nn&c&c2C1",
"old_substring": "N345"
}
|
Can you make molecule CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NSC(=O)Cc1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NSC(=O)Cc1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CCCC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)CCCC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CC(C)(C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)CC(C)(C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CCC(C)(C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)CCC(C)(C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNC(C)(C)C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
|
C[C@H](C(=O)SNC(C)(C)C)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C37=O"
}
|
Can you make molecule COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCNC(=O)N[C@@H]1N=NC=C1CCS(=O)(=O)c1ccc(C)cc1
|
COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@@H]1N=NC=C1CCS(=O)(=O)c1ccc(C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]18CCCN7C1"
}
|
Can you make molecule COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCNC(=O)N[C@@H]1CC[C@@H](S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@@H]1CC[C@@H](S(=O)(=O)c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]18CCCN7C1"
}
|
Can you make molecule COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCNC(=O)N[C@H](CCl)CCCS(=O)(=O)c1ccc(C)cc1
|
COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@H](CCl)CCCS(=O)(=O)c1ccc(C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]18CCCN7C1"
}
|
Can you make molecule COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCNC(=O)N[C@H]1CCC[C@H](S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@H]1CCC[C@H](S(=O)(=O)c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@@H]18CCCN7C1"
}
|
Can you make molecule COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCNC(=O)N[C@H]1CCCC[C@H](S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccc(C)cc2)C1
|
COCCNC(=O)N[C@H]1CCCC[C@H](S(=O)(=O)c2ccc(C)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]18CCCN7C1"
}
|
Can you make molecule Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3Cl)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3Cl)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c17ccncc1"
}
|
Can you make molecule Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccccc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccccc3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c17ccncc1"
}
|
Can you make molecule Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(CCCC(=O)N2CCN(Cc3cnccc3Cl)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3cnccc3Cl)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cnccc1Cl",
"old_substring": "c17ccncc1"
}
|
Can you make molecule Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(CCCC(=O)N2CCN(Cc3cc(Br)ncc3F)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3cc(Br)ncc3F)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ncc1F",
"old_substring": "c17ccncc1"
}
|
Can you make molecule Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(CCCC(=O)N2CCN(Cc3cc(C)c(Br)cn3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3ccncc3)CC2)n1
|
Cc1noc(CCCC(=O)N2CCN(Cc3cc(C)c(Br)cn3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&ncc1Br",
"old_substring": "c17ccncc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccccc1I
|
Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccccc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccc%10cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccccc1Cl
|
Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccc%10cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2scnc2c1
|
Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2scnc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&nc2c1",
"old_substring": "Cc1ccc%10cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2sccc2c1
|
Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2sccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&cc2c1",
"old_substring": "Cc1ccc%10cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2ncsc2c1
|
Cc1ccc(-c2cc(C(F)F)n3ncc(C(=O)N(C)Cc4ccccc4)c3n2)cc1
|
CN(Cc1ccccc1)C(=O)c1cnn2c(C(F)F)ccnc12.Cc1ccc2ncsc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2nc&sc2c1",
"old_substring": "Cc1ccc%10cc1"
}
|
Can you make molecule COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1c(C(=O)Nc2ccc(-c3ncon3)cc2I)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21
|
COCCn1c(C(=O)Nc2ccc(-c3ncon3)cc2I)cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1c(C(=O)Nc2cc(-c3ncon3)ccc2Br)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21
|
COCCn1c(C(=O)Nc2cc(-c3ncon3)ccc2Br)cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1c(C(=O)Nc2ccc(-c3ncon3)cc2Cl)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21
|
COCCn1c(C(=O)Nc2ccc(-c3ncon3)cc2Cl)cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2Br)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2Br)cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2Cl)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2)cc2ccccc21
|
COCCn1c(C(=O)Nc2cccc(-c3ncon3)c2Cl)cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(=O)[O-])c1nc2c(s1)CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)C2
|
C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])c1nc2c(s1)CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(=O)[O-])n1ncc2c1CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)C2
|
C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])n1ncc2c1CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2cnn&c2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(=O)[O-])c1onc2c1CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)CC2
|
C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])c1onc2c1CN(C(=O)CS[C@H]1CCS(=O)(=O)C1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2noc&c2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(=O)[O-])c1cc2n(n1)CCCN2C(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])c1cc2n(n1)CCCN2C(=O)CS[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N23"
}
|
Can you make molecule C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(=O)[O-])c1ccc2c(c1)CCN2C(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])NC(=O)CS[C@H]1CCS(=O)(=O)C1
|
C[C@H](CC(=O)[O-])c1ccc2c(c1)CCN2C(=O)CS[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N23"
}
|
Can you make molecule N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccc2c(c1)OCCCO2)C(=S)Sc1nc2c(c(=O)[nH]1)[C@@H](c1ccc(F)cc1)[C@@H](C#N)C(=O)N2
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N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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CN(Cc1ccc2c(c1)OCCCO2)C(=S)Sc1nc2c(c(=O)[nH]1)[C@@H](c1ccc(F)cc1)[C@@H](C#N)C(=O)N2
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N56"
}
|
Can you make molecule N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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N#C[C@H]1C(=O)Nc2nc(SC3=NCCN3Cc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
|
N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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N#C[C@H]1C(=O)Nc2nc(SC3=NCCN3Cc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N56"
}
|
Can you make molecule N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@H]1C(=O)Nc2nc(C3CCN(CCc4ccc5c(c4)OCCCO5)CC3)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
|
N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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N#C[C@H]1C(=O)Nc2nc(C3CCN(CCc4ccc5c(c4)OCCCO5)CC3)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N56"
}
|
Can you make molecule N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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N#C[C@H]1C(=O)Nc2nc(-c3cccc(Cc4ccc5c(c4)OCCCO5)c3N)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
|
N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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N#C[C@H]1C(=O)Nc2nc(-c3cccc(Cc4ccc5c(c4)OCCCO5)c3N)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N56"
}
|
Can you make molecule N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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N#C[C@H]1C(=O)Nc2nc(-c3cc(N)cc(Cc4ccc5c(c4)OCCCO5)c3)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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N#C[C@H]1C(=O)Nc2nc(NCc3ccc4c(c3)OCCCO4)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
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N#C[C@H]1C(=O)Nc2nc(-c3cc(N)cc(Cc4ccc5c(c4)OCCCO5)c3)[nH]c(=O)c2[C@H]1c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1cc&cc&c1",
"old_substring": "N56"
}
|
Can you make molecule CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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CCn1ncc(C[NH+]2CCC(Cc3ccc(F)cc3)(C[C@H]3CCCO3)C2)c1C
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CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C
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CCn1ncc(C[NH+]2CCC(Cc3ccc(F)cc3)(C[C@H]3CCCO3)C2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&&C1",
"old_substring": "[NH+]345"
}
|
Can you make molecule CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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CCn1ncc(C[NH+]2CCC[C@](Cc3ccc(F)cc3)(C[C@H]3CCCO3)C2)c1C
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CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C
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CCn1ncc(C[NH+]2CCC[C@](Cc3ccc(F)cc3)(C[C@H]3CCCO3)C2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@]&&C1",
"old_substring": "[NH+]345"
}
|
Can you make molecule CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(Cc2[nH+]cn(Cc3ccc(F)cc3)c2C[C@H]2CCCO2)c1C
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CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C
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CCn1ncc(Cc2[nH+]cn(Cc3ccc(F)cc3)c2C[C@H]2CCCO2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]cn&c1&",
"old_substring": "[NH+]345"
}
|
Can you make molecule CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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CCn1ncc(Cn2[nH+]c(Cc3ccc(F)cc3)cc2C[C@H]2CCCO2)c1C
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CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C
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CCn1ncc(Cn2[nH+]c(Cc3ccc(F)cc3)cc2C[C@H]2CCCO2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&[nH+]c&cc1&",
"old_substring": "[NH+]345"
}
|
Can you make molecule CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(Cc2[nH+]n(C)c(Cc3ccc(F)cc3)c2C[C@H]2CCCO2)c1C
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CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C
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CCn1ncc(Cc2[nH+]n(C)c(Cc3ccc(F)cc3)c2C[C@H]2CCCO2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]n(C)c&c1&",
"old_substring": "[NH+]345"
}
|
Can you make molecule O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(Cc1cccs1)N[C@@H]1CCC[C@@](c2ccc(Cl)cc2)(C2CC2)C1
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O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1
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O=C(Cc1cccs1)N[C@@H]1CCC[C@@](c2ccc(Cl)cc2)(C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@@H]356"
}
|
Can you make molecule O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(Cc1cccs1)N[C@H]1CC[C@@](c2ccc(Cl)cc2)(C2CC2)C1
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O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1
|
O=C(Cc1cccs1)N[C@H]1CC[C@@](c2ccc(Cl)cc2)(C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@@H]356"
}
|
Can you make molecule O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1cccs1)N[C@H]1CC[C@](c2ccc(Cl)cc2)(C2CC2)C1
|
O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1
|
O=C(Cc1cccs1)N[C@H]1CC[C@](c2ccc(Cl)cc2)(C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@@H]356"
}
|
Can you make molecule O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(c1ccc(Cl)cc1)[C@H](CCCC1CC1)NC(=O)Cc1cccs1
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O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1
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CC(C)(c1ccc(Cl)cc1)[C@H](CCCC1CC1)NC(=O)Cc1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@@H]356"
}
|
Can you make molecule O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(Cc1cccs1)NCC[C@H](CC1CC1)C(=O)c1ccc(Cl)cc1
|
O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1
|
O=C(Cc1cccs1)NCC[C@H](CC1CC1)C(=O)c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@H](C&)C&=O",
"old_substring": "[C@@H]356"
}
|
Can you make molecule COc1cc2c(cc1OC)CC([NH3+])C2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc2c(cc1OC)CC([NH3+])C2
|
COc1cc2c(cc1OC)CC([NH3+])C2
|
COCc1cc2c(cc1OC)CC([NH3+])C2
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc2c(cc1OC)CC([NH3+])C2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc2c(cc1OC)CC([NH3+])C2
|
COc1cc2c(cc1OC)CC([NH3+])C2
|
COCSc1cc2c(cc1OC)CC([NH3+])C2
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc2c(cc1OC)CC([NH3+])C2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc2c(cc1SC(C)=O)CC([NH3+])C2
|
COc1cc2c(cc1OC)CC([NH3+])C2
|
COc1cc2c(cc1SC(C)=O)CC([NH3+])C2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc2c(cc1OC)CC([NH3+])C2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc2c(cc1C(=O)CS)CC([NH3+])C2
|
COc1cc2c(cc1OC)CC([NH3+])C2
|
COc1cc2c(cc1C(=O)CS)CC([NH3+])C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc2c(cc1OC)CC([NH3+])C2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc2c(cc1C(=O)CI)CC([NH3+])C2
|
COc1cc2c(cc1OC)CC([NH3+])C2
|
COc1cc2c(cc1C(=O)CI)CC([NH3+])C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(Oc2ccccc2Cl)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2ccccc2Cl)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(Oc2ccc(I)cc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2ccc(I)cc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2cccc(C(=O)N3CCN(S(=O)(=O)c4ccccc4F)CC3)c2)cc1I
|
O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
Cc1ccc(Oc2cccc(C(=O)N3CCN(S(=O)(=O)c4ccccc4F)CC3)c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(Oc2cccc(Br)c2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
O=C(c1cccc(Oc2cccc(Br)c2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(Oc2cccc(C(=O)N3CCN(S(=O)(=O)c4ccccc4F)CC3)c2)c1C
|
O=C(c1cccc(Oc2ccccc2)c1)N1CCN(S(=O)(=O)c2ccccc2F)CC1
|
Cc1cccc(Oc2cccc(C(=O)N3CCN(S(=O)(=O)c4ccccc4F)CC3)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)C1(C2CC2)CCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
|
CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1
|
CC(C)[C@@H](C)C1(C2CC2)CCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N357"
}
|
Can you make molecule CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)C1(C2CC2)CCCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
|
CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1
|
CC(C)[C@@H](C)C1(C2CC2)CCCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N357"
}
|
Can you make molecule CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)c1oc(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)c(C#N)c1C1CC1
|
CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1
|
CC(C)[C@@H](C)c1oc(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)c(C#N)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N357"
}
|
Can you make molecule CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)C1(C2CC2)CCC(=O)N(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
|
CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1
|
CC(C)[C@@H](C)C1(C2CC2)CCC(=O)N(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&&CCC1=O",
"old_substring": "N357"
}
|
Can you make molecule CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)[C@@]1(C2CC2)CCCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
|
CC(C)[C@@H](C)N(C(=O)N[C@@H](C)c1ccc(N2CCCC2=O)cc1)C1CC1
|
CC(C)[C@@H](C)[C@@]1(C2CC2)CCCN(C(=O)N[C@@H](C)c2ccc(N3CCCC3=O)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N357"
}
|
Can you make molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NSC(=O)Cc2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NSC(=O)Cc2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CCCC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)CCCC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CC(C)(C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)CC(C)(C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CCC(C)(C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)CCC(C)(C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NSC(=O)[C@@H](C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
|
Cc1cccc(NSC(=O)[C@@H](C)c2cc3ccccc3o/c2=[NH+]\c2ccc(F)c(F)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
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