prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
C=CSOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
C=CCCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCCl)c1C
|
CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCCl)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCCS)c1C
|
CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCCS)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCBr)c1C
|
CCOc1ccc(CN2CC[NH2+][C@H](C(=O)[O-])C2)c(OCC)c1C
|
CCOc1c(CN2CC[NH2+][C@H](C(=O)[O-])C2)ccc(OCCCBr)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cc(OC2CCC(Cc3nccn3C(F)F)CC2)ccn1
|
NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1
|
NC(=O)c1cc(OC2CCC(Cc3nccn3C(F)F)CC2)ccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C14CCN6CC1"
}
|
Can you make molecule NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cc(OC2CCC(=Cc3nccn3C(F)F)CC2)ccn1
|
NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1
|
NC(=O)c1cc(OC2CCC(=Cc3nccn3C(F)F)CC2)ccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC=&CC1",
"old_substring": "C14CCN6CC1"
}
|
Can you make molecule NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(Cc2nccn2C(F)F)CCC(Oc2ccnc(C(N)=O)c2)CC1
|
NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1
|
CC1(Cc2nccn2C(F)F)CCC(Oc2ccnc(C(N)=O)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&(C)CC1",
"old_substring": "C14CCN6CC1"
}
|
Can you make molecule NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1(Oc2ccnc(C(N)=O)c2)CCC(Cc2nccn2C(F)F)CC1
|
NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1
|
N#CC1(Oc2ccnc(C(N)=O)c2)CCC(Cc2nccn2C(F)F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "C14CCN6CC1"
}
|
Can you make molecule NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cc(OCCCCCCc2nccn2C(F)F)ccn1
|
NC(=O)c1cc(OC2CCN(Cc3nccn3C(F)F)CC2)ccn1
|
NC(=O)c1cc(OCCCCCCc2nccn2C(F)F)ccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C14CCN6CC1"
}
|
Can you make molecule N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)Nc1ccc(Cl)cc1)C(=S)Sc1ccc(F)c(C#N)c1F
|
N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F
|
CN(C(=O)Nc1ccc(Cl)cc1)C(=S)Sc1ccc(F)c(C#N)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1c(F)ccc(SC2=NCCN2C(=O)Nc2ccc(Cl)cc2)c1F
|
N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F
|
N#Cc1c(F)ccc(SC2=NCCN2C(=O)Nc2ccc(Cl)cc2)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1c(F)ccc(C2CCN(CC(=O)Nc3ccc(Cl)cc3)CC2)c1F
|
N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F
|
N#Cc1c(F)ccc(C2CCN(CC(=O)Nc3ccc(Cl)cc3)CC2)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N35"
}
|
Can you make molecule N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(C(=O)Nc2ccc(Cl)cc2)sc1-c1ccc(F)c(C#N)c1F
|
N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F
|
N#Cc1cc(C(=O)Nc2ccc(Cl)cc2)sc1-c1ccc(F)c(C#N)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N35"
}
|
Can you make molecule N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1-c1ccc(F)c(C#N)c1F
|
N#Cc1c(F)ccc(NC(=O)Nc2ccc(Cl)cc2)c1F
|
N#Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1-c1ccc(F)c(C#N)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N35"
}
|
Can you make molecule CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(C(C)C)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)C(C(C)C)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&C(C)C",
"old_substring": "CC(C)C3"
}
|
Can you make molecule CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCCC(=O)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CCCC(=O)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CCCC&=O",
"old_substring": "CC(C)C3"
}
|
Can you make molecule CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC#N)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)(CCC#N)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)CCC#N",
"old_substring": "CC(C)C3"
}
|
Can you make molecule CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CI)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)[C@H](CI)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CI",
"old_substring": "CC(C)C3"
}
|
Can you make molecule CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCBr)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)CN([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
|
CC(C)(CCBr)N([C@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)OCCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&(C)CCBr",
"old_substring": "CC(C)C3"
}
|
Can you make molecule CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
C=CCC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCl)C1
|
CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCS)C1
|
CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCS)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCBr)C1
|
CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCBr)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCF)C1
|
CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1
|
[NH3+]C[C@@]1([C@H](O)c2ccccc2)CC[C@@H](CCCCF)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCF",
"old_substring": "CC3"
}
|
Can you make molecule [NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1CCC[NH+]2CC1
|
[NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-]
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1CCC[NH+]2CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@H]&CC1",
"old_substring": "[NH3+][C@H]2CO"
}
|
Can you make molecule [NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1CN[C@H]2O1
|
[NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-]
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1CN[C@H]2O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&NC[C@H]&O1",
"old_substring": "[NH3+][C@H]2CO"
}
|
Can you make molecule [NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1NN[C@H]2O1
|
[NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-]
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1NN[C@H]2O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&NN[C@H]&O1",
"old_substring": "[NH3+][C@H]2CO"
}
|
Can you make molecule [NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[NH+]1CCS[C@@H]2C1
|
[NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-]
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[NH+]1CCS[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C[NH+]&CCS1",
"old_substring": "[NH3+][C@H]2CO"
}
|
Can you make molecule [NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1NO[C@@H]2N1
|
[NH3+][C@@H](CO)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1[O-]
|
FC(F)F.O=[N+]([O-])c1cc2cc(c1[O-])[C@H]1NO[C@@H]2N1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&N[C@@H]&NO1",
"old_substring": "[NH3+][C@H]2CO"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(N[C@H]1C[C@H]2CCCc3cccc1c32)c1ccccc1Cl
|
O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1
|
O=S(=O)(N[C@H]1C[C@H]2CCCc3cccc1c32)c1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=S&(=O)c1ccccc1Cl",
"old_substring": "O=[N+]([O-])c1ccc5nc1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C=Nc1ccccc1N[C@H]1C[C@H]2CCCc3cccc1c32
|
O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1
|
O=C=Nc1ccccc1N[C@H]1C[C@H]2CCCc3cccc1c32
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C=Nc1ccccc1&",
"old_substring": "O=[N+]([O-])c1ccc5nc1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(N[C@H]1C[C@H]2CCCc3cccc1c32)c1sccc1Br
|
O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1
|
O=S(=O)(N[C@H]1C[C@H]2CCCc3cccc1c32)c1sccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "O=S&(=O)c1sccc1Br",
"old_substring": "O=[N+]([O-])c1ccc5nc1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=N[C@H]1C[C@H]2CCCc3cccc1c32)c1cccnc1
|
O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1
|
CC(=N[C@H]1C[C@H]2CCCc3cccc1c32)c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)c1cccnc1",
"old_substring": "O=[N+]([O-])c1ccc5nc1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NNc1ccccc1Cl)N[C@H]1C[C@H]2CCCc3cccc1c32
|
O=[N+]([O-])c1ccc(N[C@H]2C[C@H]3CCCc4cccc2c43)nc1
|
O=C(NNc1ccccc1Cl)N[C@H]1C[C@H]2CCCc3cccc1c32
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NNc1ccccc1Cl",
"old_substring": "O=[N+]([O-])c1ccc5nc1"
}
|
Can you make molecule COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CCCC2(C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CCCC2(C)C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCC1(C)C",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[N+](C)(C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[N+](C)(C)C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[N+]&(C)C",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CC(C)(C)C2)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CC(C)(C)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC(C)(C)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CC3(CC3)C2)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CC3(CC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CC2)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CCC(C)(C)C2)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+](C)C)n1
|
COc1ccnc(NNC(=O)NC[C@H](c2ccccc2)[NH+]2CCC(C)(C)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC(C)(C)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
C=CSN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
C=CCCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCCCl)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CCCCl)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCCCS)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CCCCS)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCCBr)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CC)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
|
CCN(CCCBr)S(=O)(=O)c1cc(C(=O)/N=c2/sccn2C)n(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(CCC(CO)=NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(CCC(CO)=NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C8C4=O"
}
|
Can you make molecule COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(C/C(C)=N\ONCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(C/C(C)=N\ONCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C8C4=O"
}
|
Can you make molecule COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNCc1ccc2c(c1)OCO2)n1cc(OC)c(=O)cc1C[NH+]1CCCCC1
|
COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
CCC(CC)(C(=O)CNCc1ccc2c(c1)OCO2)n1cc(OC)c(=O)cc1C[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C8C4=O"
}
|
Can you make molecule COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(SSC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
COc1cn(SSC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C8C4=O"
}
|
Can you make molecule COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNCc1ccc2c(c1)OCO2)n1cc(OC)c(=O)cc1C[NH+]1CCCCC1
|
COc1cn(CC(=O)NCc2ccc3c(c2)OCO3)c(C[NH+]2CCCCC2)cc1=O
|
CCC(CC)(C(=O)CCNCc1ccc2c(c1)OCO2)n1cc(OC)c(=O)cc1C[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C8C4=O"
}
|
Can you make molecule O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
O=C(NCCCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5CC7"
}
|
Can you make molecule O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCc1cccc(F)c1)=NC(=O)C(=O)Nc1cnc2ccccc2c1
|
O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
CC(CCc1cccc(F)c1)=NC(=O)C(=O)Nc1cnc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C5CC7"
}
|
Can you make molecule O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cnc2ccccc2c1)C(=O)NC1CCC(c2cccc(F)c2)CC1
|
O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
O=C(Nc1cnc2ccccc2c1)C(=O)NC1CCC(c2cccc(F)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C5CC7"
}
|
Can you make molecule O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)C(=O)Nc1cnc2ccccc2c1)Cc1cccc(F)c1
|
O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
CC(C)(CNC(=O)C(=O)Nc1cnc2ccccc2c1)Cc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "C5CC7"
}
|
Can you make molecule O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1cccc(F)c1)NC(=O)C(=O)Nc1cnc2ccccc2c1
|
O=C(NCCCc1cccc(F)c1)C(=O)Nc1cnc2ccccc2c1
|
CCC[C@@H](CCc1cccc(F)c1)NC(=O)C(=O)Nc1cnc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C5CC7"
}
|
Can you make molecule CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cc1ccccc1)[NH2+][C@@H](C)CCc1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+][C@@H](C)CCc1c(F)cccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C3[C@H]5O"
}
|
Can you make molecule CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](C)C(=O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](C)C(=O)c1c(F)cccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](C)C&=O",
"old_substring": "C3[C@H]5O"
}
|
Can you make molecule CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cc1ccccc1)[NH2+][C@@H](C)C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+][C@@H](C)C[C@@H](O)c1c(F)cccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&C[C@H]&O",
"old_substring": "C3[C@H]5O"
}
|
Can you make molecule CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cc1ccccc1)[NH2+]CC[C@@H](C)CC(=O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]CC[C@@H](C)CC(=O)c1c(F)cccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C3[C@H]5O"
}
|
Can you make molecule CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)C(C)(C)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F
|
CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)C(C)(C)c1c(F)cccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](O)C&(C)C",
"old_substring": "C3[C@H]5O"
}
|
Can you make molecule O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
O=C(/C=C/SSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1c2[nH]c3ccccc3c2nc(SN2CCC(=NONc3ccc4c(c3)OCO4)CC2)n1-c1ccccc1
|
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
O=c1c2[nH]c3ccccc3c2nc(SN2CCC(=NONc3ccc4c(c3)OCO4)CC2)n1-c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(Sc2nc3c([nH]c4ccccc43)c(=O)n2-c2ccccc2)CC1)Nc1ccc2c(c1)OCO2
|
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
O=C(NN=C1CCN(Sc2nc3c([nH]c4ccccc43)c(=O)n2-c2ccccc2)CC1)Nc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(Sc2nc3c([nH]c4ccccc43)c(=O)n2-c2ccccc2)CC1)Nc1ccc2c(c1)OCO2
|
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
O=C(NN=C1CCC(Sc2nc3c([nH]c4ccccc43)c(=O)n2-c2ccccc2)CC1)Nc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccc2c(c1)OCO2)C(=O)SSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1
|
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1)Nc1ccc2c(c1)OCO2
|
C/C(=N\ONc1ccc2c(c1)OCO2)C(=O)SSc1nc2c([nH]c3ccccc32)c(=O)n1-c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C4C5"
}
|
Can you make molecule COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccn(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)c1
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1
|
COc1ccn(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccn&c1",
"old_substring": "c15cc7ncn1"
}
|
Can you make molecule COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncc1I
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1
|
COc1nc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc&ncc1I",
"old_substring": "c15cc7ncn1"
}
|
Can you make molecule COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccnc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)c1
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1
|
COc1ccnc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccnc&c1",
"old_substring": "c15cc7ncn1"
}
|
Can you make molecule COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1csc2nc(NS(=O)(=O)c3ccc(NC(=O)c4cnn(C)c4)cc3)cn12
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1
|
COc1csc2nc(NS(=O)(=O)c3ccc(NC(=O)c4cnn(C)c4)cc3)cn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc2nc&cn12",
"old_substring": "c15cc7ncn1"
}
|
Can you make molecule COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)nc(Cl)n1
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)ncn1
|
COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cnn(C)c3)cc2)nc(Cl)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc(Cl)n1",
"old_substring": "c15cc7ncn1"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)C2CC[NH+]([C@@H](C)CCc3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+]([C@@H](C)CCc3ccc(F)cc3F)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5[C@H]7O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](C)C(=O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](C)C(=O)c3ccc(F)cc3F)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](C)C&=O",
"old_substring": "C5[C@H]7O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)C2CC[NH+]([C@@H](C)C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+]([C@@H](C)C[C@@H](O)c3ccc(F)cc3F)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&C[C@H]&O",
"old_substring": "C5[C@H]7O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC[NH+]1CCC(C(=O)N2CCC[C@H](C)C2)CC1)CC(=O)c1ccc(F)cc1F
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H](CC[NH+]1CCC(C(=O)N2CCC[C@H](C)C2)CC1)CC(=O)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C5[C@H]7O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)C(C)(C)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1
|
C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)C(C)(C)c3ccc(F)cc3F)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](O)C&(C)C",
"old_substring": "C5[C@H]7O"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(-c3snc(C(=O)C(=O)NC4CCC(C)(C)CC4)c3N)cc12
|
Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(-c3snc(C(=O)C(=O)NC4CCC(C)(C)CC4)c3N)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N46"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(SC(=S)N(C)C(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(SC(=S)N(C)C(=O)C(=O)NC3CCC(C)(C)CC3)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N46"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(-c3cc(C(=O)C(=O)NC4CCC(C)(C)CC4)oc3N)cc12
|
Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(-c3cc(C(=O)C(=O)NC4CCC(C)(C)CC4)oc3N)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N46"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(SC3=NCCN3C(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(SC3=NCCN3C(=O)C(=O)NC3CCC(C)(C)CC3)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N46"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(C3CCN(CC(=O)C(=O)NC4CCC(C)(C)CC4)CC3)cc12
|
Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12
|
Cc1nn(C)c2ncc(C3CCN(CC(=O)C(=O)NC4CCC(C)(C)CC4)CC3)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N46"
}
|
Can you make molecule COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1I
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)ccc1Br
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1
|
COc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1Cl
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)c1Br
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1
|
COc1cccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)c1Cl
|
COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)cc1
|
COc1cccc(-n2c(C)cc(C(=O)CSc3nnc(-c4ccoc4C)n3C)c2C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1ncc2cc(CC(=O)SN3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(CC(=O)SN3CCOC[C@@H]3C(N)=O)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1ncc2cc(C(=O)CCCC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)CCCC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1ncc2cc(C(C)(C)CC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(C)(C)CC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1ncc2cc(C(C)(C)CCC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(C)(C)CCC(=O)N3CCOC[C@@H]3C(N)=O)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1ncc2cc([C@H](C)C(=O)SN3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc(C(=O)N3CCOC[C@@H]3C(N)=O)cnc21
|
CC(C)Cn1ncc2cc([C@H](C)C(=O)SN3CCOC[C@@H]3C(N)=O)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CC(C)(C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C5(=O)CC6"
}
|
Can you make molecule COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCC(C)(C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C5(=O)CC6"
}
|
Can you make molecule COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)C[C@H](C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "C5(=O)CC6"
}
|
Can you make molecule COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@@H](Br)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)C[C@@H](Br)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C5(=O)CC6"
}
|
Can you make molecule COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
|
COSC(=O)[C@@H](C)n1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C5(=O)CC6"
}
|
Can you make molecule Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CBr)CCc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CBr)CCc3ccsc3)cnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]5(C)C7"
}
|
Can you make molecule Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CBr)CCCc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CBr)CCCc3ccsc3)cnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]5(C)C7"
}
|
Can you make molecule Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1ccsc1)N(C)C(=O)CCn1cnc2c(C)cccc2c1=O
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12
|
CC[C@@H](CCc1ccsc1)N(C)C(=O)CCn1cnc2c(C)cccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]5(C)C7"
}
|
Can you make molecule Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CCl)CCc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](CCl)CCc3ccsc3)cnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCl)CC&",
"old_substring": "[C@H]5(C)C7"
}
|
Can you make molecule Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)CC(C)(C)Cc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)Cc3ccsc3)cnc12
|
Cc1cccc2c(=O)n(CCC(=O)N(C)[C@@H](C)CC(C)(C)Cc3ccsc3)cnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]5(C)C7"
}
|
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