prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(C[NH+](C)CCS(C)(=O)=O)=N/ON1CCC[C@H]2CCCC[C@@H]21
|
C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
C/C(C[NH+](C)CCS(C)(=O)=O)=N/ON1CCC[C@H]2CCCC[C@@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C3=O"
}
|
Can you make molecule C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CN1CCC[C@H]2CCCC[C@@H]21)[NH+](C)CCS(C)(=O)=O
|
C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
CCC(CC)(C(=O)CN1CCC[C@H]2CCCC[C@@H]21)[NH+](C)CCS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C3=O"
}
|
Can you make molecule C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCS(C)(=O)=O)SSC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
C[NH+](CCS(C)(=O)=O)SSC(=O)N1CCC[C@H]2CCCC[C@@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C3=O"
}
|
Can you make molecule C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCN1CCC[C@H]2CCCC[C@@H]21)[NH+](C)CCS(C)(=O)=O
|
C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
CCC(CC)(C(=O)CCN1CCC[C@H]2CCCC[C@@H]21)[NH+](C)CCS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C3=O"
}
|
Can you make molecule C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)N1CCC[C@H]2CCCC[C@@H]21)C(=O)[NH+](C)CCS(C)(=O)=O
|
C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21
|
CC[C@@H](C(=O)N1CCC[C@H]2CCCC[C@@H]21)C(=O)[NH+](C)CCS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&=O)C&=O",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)c1cc(C#N)c(Cc2ccc(Br)o2)s1
|
Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1
|
Cc1ccc(F)cc1NC(=O)c1cc(C#N)c(Cc2ccc(Br)o2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N34C"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)c1ccc(Cc2ccc(Br)o2)c(C#N)c1
|
Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1
|
Cc1ccc(F)cc1NC(=O)c1ccc(Cc2ccc(Br)o2)c(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N34C"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)ON=C1CCN(Cc2ccc(Br)o2)CC1
|
Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1
|
Cc1ccc(F)cc1NC(=O)ON=C1CCN(Cc2ccc(Br)o2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N34C"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)N1CCC=C(CCc2ccc(Br)o2)C1
|
Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1
|
Cc1ccc(F)cc1NC(=O)N1CCC=C(CCc2ccc(Br)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N34C"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)N1CCC(C#N)(Cc2ccc(Br)o2)CC1
|
Cc1ccc(F)cc1NC(=O)N(C)Cc1ccc(Br)o1
|
Cc1ccc(F)cc1NC(=O)N1CCC(C#N)(Cc2ccc(Br)o2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&(C#N)CC1",
"old_substring": "N34C"
}
|
Can you make molecule CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C)C[C@@H](OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)OC1
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1
|
CC1=C(C)C[C@@H](OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)OC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1=C(C)C[C@@H]&OC1",
"old_substring": "CC1=C(C4=O)[C@@H](C)N(C)N1"
}
|
Can you make molecule CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)CCCO1
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1=C(C&=O)CCCO1",
"old_substring": "CC1=C(C4=O)[C@@H](C)N(C)N1"
}
|
Can you make molecule CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)[C@@H](O)COCC(=O)C1=c2ccccc2=[NH+][C@@H]1C
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1
|
CCC(CC)[C@@H](O)COCC(=O)C1=c2ccccc2=[NH+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)[C@@H](O)C&",
"old_substring": "CC1=C(C4=O)[C@@H](C)N(C)N1"
}
|
Can you make molecule CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(COCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)C(=O)N=N1
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1
|
CC1=C(COCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)C(=O)N=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1=C(C&)C(=O)N=N1",
"old_substring": "CC1=C(C4=O)[C@@H](C)N(C)N1"
}
|
Can you make molecule CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)[C@H](O)COCC(=O)C1=c2ccccc2=[NH+][C@@H]1C
|
CC1=C(C(=O)OCC(=O)C2=c3ccccc3=[NH+][C@@H]2C)[C@@H](C)N(C)N1
|
CCC(CC)[C@H](O)COCC(=O)C1=c2ccccc2=[NH+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)[C@H](O)C&",
"old_substring": "CC1=C(C4=O)[C@@H](C)N(C)N1"
}
|
Can you make molecule CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)NSC(=O)Cc1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NSC(=O)Cc1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)NC(=O)CCCC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)CCCC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)NC(=O)CC(C)(C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)CC(C)(C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)NC(=O)CCC(C)(C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)CCC(C)(C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)NSC(=O)[C@@H](C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NC(=O)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
|
CC[C@@H](C)NSC(=O)[C@@H](C)c1cccc2c1N[C@@H](c1ccc(Cl)cc1Cl)[C@H]1CC=C[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1ccc(C(=O)[O-])o1)[NH+](C)Cc1csc(C)n1
|
Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1
|
CC[C@@H](CCc1ccc(C(=O)[O-])o1)[NH+](C)Cc1csc(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]47C"
}
|
Can you make molecule Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C[NH+](C)[C@@H](CBr)CCc2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@@H](CBr)CCc2ccc(C(=O)[O-])o2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]47C"
}
|
Can you make molecule Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C[NH+](C)[C@@H](CBr)CCCc2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@@H](CBr)CCCc2ccc(C(=O)[O-])o2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]47C"
}
|
Can you make molecule Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C[NH+](C)[C@H](CCl)CCCc2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@H](CCl)CCCc2ccc(C(=O)[O-])o2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]47C"
}
|
Can you make molecule Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C[NH+](C)[C@H]2CCC[C@H](c3ccc(C(=O)[O-])o3)C2)cs1
|
Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1
|
Cc1nc(C[NH+](C)[C@H]2CCC[C@H](c3ccc(C(=O)[O-])o3)C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]47C"
}
|
Can you make molecule CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
C=CSn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)n1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
CC(C)n1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC6"
}
|
Can you make molecule CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
C=CCCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2c(nnn2CCCCl)c1=O)NC1CC1
|
CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
O=C(Cn1cnc2c(nnn2CCCCl)c1=O)NC1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC6"
}
|
Can you make molecule CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2c(nnn2CCCCS)c1=O)NC1CC1
|
CCn1nnc2c(=O)n(CC(=O)NC3CC3)cnc21
|
O=C(Cn1cnc2c(nnn2CCCCS)c1=O)NC1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC6"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@H]1CCc2sc(NC(=O)c3cc(Cl)c(OC)c(Cl)c3)cc2C1
|
COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1
|
COC(=O)[C@H]1CCc2sc(NC(=O)c3cc(Cl)c(OC)c(Cl)c3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCc2sc&cc2C1",
"old_substring": "[C@@H]16CCCC[C@H]15"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@H]1CCc2c(NC(=O)c3cc(Cl)c(OC)c(Cl)c3)csc2C1
|
COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1
|
COC(=O)[C@H]1CCc2c(NC(=O)c3cc(Cl)c(OC)c(Cl)c3)csc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCc2c&csc2C1",
"old_substring": "[C@@H]16CCCC[C@H]15"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCNC(=O)c1cc(Cl)c(OC)c(Cl)c1)C(=O)OC
|
COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1
|
CCCC[C@@H](CCNC(=O)c1cc(Cl)c(OC)c(Cl)c1)C(=O)OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "[C@@H]16CCCC[C@H]15"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)(CNC(=O)c1cc(Cl)c(OC)c(Cl)c1)CC(=O)OC
|
COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1
|
CCC[C@@](C)(CNC(=O)c1cc(Cl)c(OC)c(Cl)c1)CC(=O)OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@](C)(C&)C&",
"old_substring": "[C@@H]16CCCC[C@H]15"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)OP(=O)(ONC(=O)c1cc(Cl)c(OC)c(Cl)c1)N1CCCCC1
|
COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1
|
COC(=O)OP(=O)(ONC(=O)c1cc(Cl)c(OC)c(Cl)c1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&P(=O)(O&)N1CCCCC1",
"old_substring": "[C@@H]16CCCC[C@H]15"
}
|
Can you make molecule Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(CNC(=O)NC(C)(C)c2ccc([N+](=O)[O-])cc2)c1Cl
|
Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncc(CNC(=O)NC(C)(C)c2ccc([N+](=O)[O-])cc2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1ncc&c1Cl",
"old_substring": "Cn1ncnc16"
}
|
Can you make molecule Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nccc1C=CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1nccc1C=CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1nccc1C=&",
"old_substring": "Cn1ncnc16"
}
|
Can you make molecule Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnn(CNC(=O)NC(C)(C)c2ccc([N+](=O)[O-])cc2)c1=S
|
Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1cnn(CNC(=O)NC(C)(C)c2ccc([N+](=O)[O-])cc2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cnn&c1=S",
"old_substring": "Cn1ncnc16"
}
|
Can you make molecule Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(Cl)c1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncc(Cl)c1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1ncc(Cl)c1&",
"old_substring": "Cn1ncnc16"
}
|
Can you make molecule Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(Br)c1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncnc1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
|
Cn1ncc(Br)c1CNC(=O)NC(C)(C)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1ncc(Br)c1&",
"old_substring": "Cn1ncnc16"
}
|
Can you make molecule CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNSC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNSC(=O)CNC(=O)C1CCN(C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C2(=O)C6"
}
|
Can you make molecule CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNC(=O)CCCC(=O)NC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CCCC(=O)NC(=O)C1CCN(C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C2(=O)C6"
}
|
Can you make molecule CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNC(=O)CC(C)(C)NC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CC(C)(C)NC(=O)C1CCN(C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)C6"
}
|
Can you make molecule CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNC[S@+]([O-])CCCNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC[S@+]([O-])CCCNC(=O)C1CCN(C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C2(=O)C6"
}
|
Can you make molecule CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNC(=O)CCC(C)(C)NC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CNC(=O)C1CCN(C(N)=O)CC1
|
CCCNC(=O)CCC(C)(C)NC(=O)C1CCN(C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)C6"
}
|
Can you make molecule Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CC(=O)SNCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(CC(=O)SNCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)CCCC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)CCCC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(C)(C)CC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(C)(C)CC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(C)(C)CCC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(C)(C)CCC(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@H](C)C(=O)SNCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc(C(=O)NCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
|
Cc1ccc([C@H](C)C(=O)SNCCc2nnc3n2CC[NH+](Cc2ccc(C(C)C)cc2)CC3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)cc1I
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1
|
COc1ccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c14cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)ccc1Br
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1
|
COc1cc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c14cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)cc1Cl
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1
|
COc1ccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c14cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1Br
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c14cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1Cl
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1
|
COc1cccc([C@@H](CNC(=O)c2cc(F)c(F)cc2Cl)[NH+]2CCCC2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c14cccc8c1"
}
|
Can you make molecule CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCC2(C)C)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCC2(C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC1(C)C",
"old_substring": "[C@H]13CCCCO1"
}
|
Can you make molecule CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCC=CCCC2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCC=CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC=CCCC1",
"old_substring": "[C@H]13CCCCO1"
}
|
Can you make molecule CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CC=CC=C2Cl)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CC=CC=C2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC=CC=C1Cl",
"old_substring": "[C@H]13CCCCO1"
}
|
Can you make molecule CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CC23CCCC3)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CC23CCCC3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCCC2",
"old_substring": "[C@H]13CCCCO1"
}
|
Can you make molecule CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCC[C@@H]2I)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCCO2)CC1
|
CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NO[C@H]2CCCC[C@@H]2I)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@@H]1I",
"old_substring": "[C@H]13CCCCO1"
}
|
Can you make molecule [NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1C=C[C@H](CC(=O)SN2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](CC(=O)SN2CCC[C@@H]2C(=O)N2CCOCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule [NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1C=C[C@H](CC(=C=O)CN2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](CC(=C=O)CN2CCC[C@@H]2C(=O)N2CCOCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule [NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1C=C[C@H](C(=O)CCCC(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)CCCC(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule [NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)N1CCC[C@@H]1C(=O)N1CCOCC1)[C@H]1C=C[C@@H]([NH3+])C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
CC(C)(CC(=O)N1CCC[C@@H]1C(=O)N1CCOCC1)[C@H]1C=C[C@@H]([NH3+])C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule [NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1C=C[C@H](CCC[S@@+]([O-])CN2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](C(=O)N2CCC[C@@H]2C(=O)N2CCOCC2)C1
|
[NH3+][C@@H]1C=C[C@H](CCC[S@@+]([O-])CN2CCC[C@@H]2C(=O)N2CCOCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2I)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2I)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CNc2cc(NC(=O)C(C)C)ccc2Br)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C
|
Cc1cccc(NC(=O)CNc2cc(NC(=O)C(C)C)ccc2Br)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2Cl)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2Cl)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CNc2cccc(NC(=O)C(C)C)c2Br)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C
|
Cc1cccc(NC(=O)CNc2cccc(NC(=O)C(C)C)c2Br)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CNc2cccc(NC(=O)C(C)C)c2Cl)c1C
|
Cc1cccc(NC(=O)CNc2ccc(NC(=O)C(C)C)cc2)c1C
|
Cc1cccc(NC(=O)CNc2cccc(NC(=O)C(C)C)c2Cl)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1[C@H]2CN(c3nccc4nc(SC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(SC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1[C@H]2CN(c3nccc4nc(CCCC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(CCCC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1[C@H]2CN(c3nccc4nc(CCCCC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(CCCCC(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1[C@H]2CN(c3nccc4nc(CC(F)(F)C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
|
O=C1[C@H]2CN(c3nccc4nc(CC(F)(F)C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)([NH3+])c1nc2nc(SC(=S)OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(SC(=S)OCC)ccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O34"
}
|
Can you make molecule CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)([NH3+])c1nc2nc(CC(=N)OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(CC(=N)OCC)ccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O34"
}
|
Can you make molecule CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)([NH3+])c1nc2nc(C(=O)CCC(=O)CC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(C(=O)CCC(=O)CC)ccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O34"
}
|
Can you make molecule CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)([NH3+])c1nc2nc(CC[C@@H](O)CC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(CC[C@@H](O)CC)ccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O34"
}
|
Can you make molecule CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@](C)([NH3+])c1nc2nc(S/C=C/C(=O)CC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(OCC)ccc2[nH]1
|
CCC[C@@](C)([NH3+])c1nc2nc(S/C=C/C(=O)CC)ccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O34"
}
|
Can you make molecule CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)CC(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)CC(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CC(C)C",
"old_substring": "C2(=O)NNC(=O)C(C)(C)C"
}
|
Can you make molecule CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)C",
"old_substring": "C2(=O)NNC(=O)C(C)(C)C"
}
|
Can you make molecule CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)CCl)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)C(C)(C)CCl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCl",
"old_substring": "C2(=O)NNC(=O)C(C)(C)C"
}
|
Can you make molecule CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)N[C@H]1CCC[C@@H]([S@@+]([O-])CC)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1
|
CCC(CC)C(=O)N[C@H]1CCC[C@@H]([S@@+]([O-])CC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(CC)CC",
"old_substring": "C2(=O)NNC(=O)C(C)(C)C"
}
|
Can you make molecule CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)N/N=C\CC(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)NNC(=O)C(C)(C)C)C1
|
CC[S@+]([O-])[C@@H]1CCC[C@H](NC(=O)N/N=C\CC(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)N/N=C\\CC(C)C",
"old_substring": "C2(=O)NNC(=O)C(C)(C)C"
}
|
Can you make molecule COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCCCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(CCCCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C8C6"
}
|
Can you make molecule COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCCCCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(CCCCCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C8C6"
}
|
Can you make molecule COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C2CC(NC(=O)N(C)[C@H](C)Cc3ccsc3)C2)ccc1O
|
COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(C2CC(NC(=O)N(C)[C@H](C)Cc3ccsc3)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C8C6"
}
|
Can you make molecule COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C2CCN(NC(=O)N(C)[C@H](C)Cc3ccsc3)CC2)ccc1O
|
COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(C2CCN(NC(=O)N(C)[C@H](C)Cc3ccsc3)CC2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C8C6"
}
|
Can you make molecule COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H](C)CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc(CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
|
COc1cc([C@@H](C)CCNC(=O)N(C)[C@H](C)Cc2ccsc2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C8C6"
}
|
Can you make molecule Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CN2CCC[C@@H](CC(=O)SNCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](CC(=O)SNCC3CC3)C2)c(C)n1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CN2CCC[C@@H](CC(=C=O)CNCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](CC(=C=O)CNCC3CC3)C2)c(C)n1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)CCCC(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)CCCC(=O)NCC3CC3)C2)c(C)n1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CN2CCC[C@@H](C(C)(C)CC(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(C)(C)CC(=O)NCC3CC3)C2)c(C)n1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CN2CCC[C@@H](CCC[S@@+]([O-])CNCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](C(=O)NCC3CC3)C2)c(C)n1C1CC1
|
Cc1cc(C(=O)CN2CCC[C@@H](CCC[S@@+]([O-])CNCC3CC3)C2)c(C)n1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C47=O"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COSC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C27=O"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC(=C=O)C[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COCC(=C=O)C[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C27=O"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCCC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)CCCC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C27=O"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)CC(C)(C)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C27=O"
}
|
Can you make molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[S@+]([O-])CCC[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
|
COC[S@+]([O-])CCC[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C27=O"
}
|
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