prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
CC(C)CCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OC(=O)c1csc(-c2ccc(OCCCCBr)cc2)n1)[C@@H]1CCOC1
|
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
C[C@H](OC(=O)c1csc(-c2ccc(OCCCCBr)cc2)n1)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
C=CCCCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OC(=O)c1csc(-c2ccc(OCCCCCl)cc2)n1)[C@@H]1CCOC1
|
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
C[C@H](OC(=O)c1csc(-c2ccc(OCCCCCl)cc2)n1)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
|
C=CCCCCOc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)OC(C)(C)C)C1CCC1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
|
CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C
|
CN(C(=O)OC(C)(C)C)C1CCC1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C8%10"
}
|
Can you make molecule CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)OC(C)(C)C)C1CCNCC1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
|
CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C
|
CN(C(=O)OC(C)(C)C)C1CCNCC1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C8%10"
}
|
Can you make molecule CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1coc(N(C)C(=O)OC(C)(C)C)n1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
|
CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C
|
Cc1coc(N(C)C(=O)OC(C)(C)C)n1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc&oc1&",
"old_substring": "C8%10"
}
|
Can you make molecule CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(N(C)C(=O)OC(C)(C)C)s1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
|
CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C
|
Cc1cnc(N(C)C(=O)OC(C)(C)C)s1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1sc&nc1&",
"old_substring": "C8%10"
}
|
Can you make molecule CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N(C)C(=O)OC(C)(C)C)n1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
|
CN(C[C@@H]1CCCN(C(=O)NCCc2ccc(F)cc2)C1)C(=O)OC(C)(C)C
|
Cc1csc(N(C)C(=O)OC(C)(C)C)n1.O=C(NCCc1ccc(F)cc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc&sc1&",
"old_substring": "C8%10"
}
|
Can you make molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Cl)c(C)cc1NC(=O)[C@@H](C)CCN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@@H](C)CCN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@@H](C)CC&",
"old_substring": "C3(=O)[C@@H]5C"
}
|
Can you make molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Cl)c(C)cc1NSC(=O)[C@@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NSC(=O)[C@@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C3(=O)[C@@H]5C"
}
|
Can you make molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)CCN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)CCN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@H](C)CC&",
"old_substring": "C3(=O)[C@@H]5C"
}
|
Can you make molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](C)CN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](C)CN1CCN(S(=O)(=O)c2c(C)noc2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H](C)C&",
"old_substring": "C3(=O)[C@@H]5C"
}
|
Can you make molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](Br)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
|
COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](Br)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C3(=O)[C@@H]5C"
}
|
Can you make molecule Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Cl)s2)sc1CC(=O)SN[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1CC(=O)SN[C@H]1C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)CCCC(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)CCCC(=O)N[C@H]1C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Cl)s2)sc1C(C)(C)CC(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(C)(C)CC(=O)N[C@H]1C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Cl)s2)sc1C(C)(C)CCC(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(C)(C)CCC(=O)N[C@H]1C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Cl)s2)sc1[C@H](C)C(=O)SN[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1C(=O)N[C@H]1C[C@H]1C
|
Cc1nc(-c2ccc(Cl)s2)sc1[C@H](C)C(=O)SN[C@H]1C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COCc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COCSc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1SC(C)=O
|
COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1SC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1C(=O)CS
|
COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1C(=O)CS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1C(=O)CI
|
COc1cc(F)c([C@H]([NH3+])c2ccc(SC)cc2)cc1OC
|
COc1cc([C@H]([NH3+])c2ccc(SC)cc2)c(F)cc1C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2ccn(SCC(=O)N(CC(N)=O)C(C)C)c2=S)cc1C
|
Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C
|
Cc1ccc(-n2ccn(SCC(=O)N(CC(N)=O)C(C)C)c2=S)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccn&c1=S",
"old_substring": "n17ccnc18"
}
|
Can you make molecule Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)n(C)c2=S)cc1C
|
Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)n(C)c2=S)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&n(C)c1=S",
"old_substring": "n17ccnc18"
}
|
Can you make molecule Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2cc(Cl)nc(SCC(=O)N(CC(N)=O)C(C)C)c2=O)cc1C
|
Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C
|
Cc1ccc(-n2cc(Cl)nc(SCC(=O)N(CC(N)=O)C(C)C)c2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(Cl)nc&c1=O",
"old_substring": "n17ccnc18"
}
|
Can you make molecule Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)cc2Br)cc1C
|
Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)cc2Br)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&cc1Br",
"old_substring": "n17ccnc18"
}
|
Can you make molecule Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)ccc2=O)cc1C
|
Cc1ccc(-n2ccnc2SCC(=O)N(CC(N)=O)C(C)C)cc1C
|
Cc1ccc(-n2cc(SCC(=O)N(CC(N)=O)C(C)C)ccc2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&ccc1=O",
"old_substring": "n17ccnc18"
}
|
Can you make molecule Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C=CC2=CN=N[C@H]2c2c(C)cccc2C)c1
|
Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1
|
Cc1cccc(C=CC2=CN=N[C@H]2c2c(C)cccc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@H]&N=N1",
"old_substring": "C1=4SC(=S)N5C1=O"
}
|
Can you make molecule Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C=C2CC(F)(c3c(C)cccc3C)C2)c1
|
Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1
|
Cc1cccc(C=C2CC(F)(c3c(C)cccc3C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&(F)C1",
"old_substring": "C1=4SC(=S)N5C1=O"
}
|
Can you make molecule Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C=NC(=S)N2CCC(c3c(C)cccc3C)CC2)c1
|
Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1
|
Cc1cccc(C=NC(=S)N2CCC(c3c(C)cccc3C)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=S)N1CCC&CC1",
"old_substring": "C1=4SC(=S)N5C1=O"
}
|
Can you make molecule Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C=C2CC(C#N)(c3c(C)cccc3C)C2)c1
|
Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1
|
Cc1cccc(C=C2CC(C#N)(c3c(C)cccc3C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&(C#N)C1",
"old_substring": "C1=4SC(=S)N5C1=O"
}
|
Can you make molecule Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C=CC2=CN=N[C@@H]2c2c(C)cccc2C)c1
|
Cc1cccc(C=C2SC(=S)N(c3c(C)cccc3C)C2=O)c1
|
Cc1cccc(C=CC2=CN=N[C@@H]2c2c(C)cccc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@@H]&N=N1",
"old_substring": "C1=4SC(=S)N5C1=O"
}
|
Can you make molecule CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)c2ccc(O)c(C(C)C)c3onc2-3)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)c2ccc(O)c(C(C)C)c3onc2-3)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O24"
}
|
Can you make molecule CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)N2CCOc3ccc(C(C)C)cc3C2)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)N2CCOc3ccc(C(C)C)cc3C2)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O24"
}
|
Can you make molecule CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)c2cc3ccc-3ncn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)c2cc3ccc-3ncn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O24"
}
|
Can you make molecule CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)c2ccc3nc-3ccn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)c2ccc3nc-3ccn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O24"
}
|
Can you make molecule CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)c2cnc3nc-3ccn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)OC(C)C)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
|
CC1=C(C(=O)c2cnc3nc-3ccn(C(C)C)c2=O)[C@H](C)N=C1C(=O)Nc1ncc(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O24"
}
|
Can you make molecule COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)Cc1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COSC(=O)Cc1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCCC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)CCCC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)CC(C)(C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)CCC(C)(C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COC(=O)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
|
COSC(=O)[C@@H](C)c1cccc(C(=O)N2C[C@@H](c3ccc(F)cc3)C[C@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCCCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C4CC6"
}
|
Can you make molecule O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCn1ncccc1=O)=NC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
CC(CCn1ncccc1=O)=NC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C4CC6"
}
|
Can you make molecule O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CCC(n2ncccc2=O)CC1)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NC1CCC(n2ncccc2=O)CC1)[C@@H]1CC(=O)N(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C4CC6"
}
|
Can you make molecule O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1)Cn1ncccc1=O
|
O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
CC(C)(CNC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1)Cn1ncccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "C4CC6"
}
|
Can you make molecule O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCn1ncccc1=O)NC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCCCn1ncccc1=O)[C@@H]1CC(=O)N(c2ccccc2)C1
|
CCC[C@@H](CCn1ncccc1=O)NC(=O)[C@@H]1CC(=O)N(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C4CC6"
}
|
Can you make molecule CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCCCCCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCN1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)CCCN1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)=NON1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(=O)N1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
|
CCC(CC)=NON1CCCN(C(=O)N[C@@H]2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)=NO&",
"old_substring": "CCC4=O"
}
|
Can you make molecule Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1cccc(C)c1C)[NH2+]CCS(=O)(=O)C(C)(C)C
|
Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
CC[C@@H](CCc1cccc(C)c1C)[NH2+]CCS(=O)(=O)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]24C"
}
|
Can you make molecule Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CC[C@H](CBr)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc(CC[C@H](CBr)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]24C"
}
|
Can you make molecule Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CCC[C@H](CBr)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc(CCC[C@H](CBr)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]24C"
}
|
Can you make molecule Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C2=C([NH2+]CCS(=O)(=O)C(C)(C)C)O[C@@H]3CC3=CC=C2)c1C
|
Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc(C2=C([NH2+]CCS(=O)(=O)C(C)(C)C)O[C@@H]3CC3=CC=C2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&Cc2cccc&c2O1",
"old_substring": "[C@H]24C"
}
|
Can you make molecule Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CCC[C@@H](CCl)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc([C@@H](C)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
|
Cc1cccc(CCC[C@@H](CCl)[NH2+]CCS(=O)(=O)C(C)(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]24C"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNCC(C)(C)c1ccncc1)c1ncc(-c2ccc(C)cc2)o1
|
Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1
|
CCC(CC)(C(=O)CNCC(C)(C)c1ccncc1)c1ncc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNCC(C)(C)c1ccncc1)c1ncc(-c2ccc(C)cc2)o1
|
Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1
|
CCC(CC)(C(=O)CCNCC(C)(C)c1ccncc1)c1ncc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1ncc(-c2ccc(C)cc2)o1)[S@+]([O-])CNCC(C)(C)c1ccncc1
|
Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1
|
CC[C@H](c1ncc(-c2ccc(C)cc2)o1)[S@+]([O-])CNCC(C)(C)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&[S@](=O)C&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C(=O)NCC(C)(C)c1ccncc1)C(=O)c1ncc(-c2ccc(C)cc2)o1
|
Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1
|
CCCC[C@@H](C(=O)NCC(C)(C)c1ccncc1)C(=O)c1ncc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H](C&=O)C&=O",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cnc(CCC[S@+]([O-])[C@@H](C)NCC(C)(C)c3ccncc3)o2)cc1
|
Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1
|
Cc1ccc(-c2cnc(CCC[S@+]([O-])[C@@H](C)NCC(C)(C)c3ccncc3)o2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NN)c2cccc(CC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(CC(F)(F)F)c2[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NN)c2cccc(SC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(SC(F)(F)F)c2[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NN)c2cccc([C@@H](O)CCC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc([C@@H](O)CCC(F)(F)F)c2[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@H]&CCC(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NN)c2cccc(CCCC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(CCCC(F)(F)F)c2[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NN)c2cccc(C(=O)C(F)(F)C(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1
|
Cc1cc(NN)c2cccc(C(=O)C(F)(F)C(F)(F)F)c2[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C(F)(F)C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@@H](C(=O)Nc2ccc(OCCc3ccccc3)cc2I)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2ccc(OCCc3ccccc3)cc2I)[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@@H](C(=O)Nc2cc(OCCc3ccccc3)ccc2Br)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cc(OCCc3ccccc3)ccc2Br)[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@@H](C(=O)Nc2ccc(OCCc3ccccc3)cc2Cl)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2ccc(OCCc3ccccc3)cc2Cl)[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2Br)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2Br)[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2Cl)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2)[NH2+]1
|
C[C@H]1CCC[C@@H](C(=O)Nc2cccc(OCCc3ccccc3)c2Cl)[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CCCCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1CCCCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C5C3"
}
|
Can you make molecule Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CCCCCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1CCCCCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5C3"
}
|
Can you make molecule Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1C1CC(NC(=O)[C@H]2C[C@@H]2c2cc(Cl)cc(Cl)c2)C1
|
Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1C1CC(NC(=O)[C@H]2C[C@@H]2c2cc(Cl)cc(Cl)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C5C3"
}
|
Can you make molecule Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1C1CCN(NC(=O)[C@H]2C[C@@H]2c2cc(Cl)cc(Cl)c2)CC1
|
Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
Cn1ncnc1C1CCN(NC(=O)[C@H]2C[C@@H]2c2cc(Cl)cc(Cl)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C5C3"
}
|
Can you make molecule Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)c1ncnn1C
|
Cn1ncnc1CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1
|
C[C@@H](CCNC(=O)[C@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)c1ncnn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5C3"
}
|
Can you make molecule CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@](C)(CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
|
CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1
|
CC[C@@](C)(CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@]&(C)CC&=O",
"old_substring": "CC[C@H]6C4=O"
}
|
Can you make molecule CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@](C)(CCNc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
|
CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1
|
CC[C@](C)(CCNc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@]&(C)CC&",
"old_substring": "CC[C@H]6C4=O"
}
|
Can you make molecule CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1nnc(N[C@@H](Cl)CCSc2nnc3cc(C)c4cc(C)cc(C)c4n23)s1
|
CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1
|
COCc1nnc(N[C@@H](Cl)CCSc2nnc3cc(C)c4cc(C)cc(C)c4n23)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "CC[C@H]6C4=O"
}
|
Can you make molecule CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
|
CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1
|
CCC[C@@H](CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&=O",
"old_substring": "CC[C@H]6C4=O"
}
|
Can you make molecule CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
|
CC[C@H](Sc1nnc2cc(C)c3cc(C)cc(C)c3n12)C(=O)Nc1nnc(COC)s1
|
CCC[C@H](CC(=O)Nc1nnc(COC)s1)Sc1nnc2cc(C)c3cc(C)cc(C)c3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@@H]&CC&=O",
"old_substring": "CC[C@H]6C4=O"
}
|
Can you make molecule CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCCS4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCCS4)o3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCS1",
"old_substring": "C19CC1"
}
|
Can you make molecule CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CCCCC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CCCCC4)o3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C19CC1"
}
|
Can you make molecule CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCCCS4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCCCS4)o3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C19CC1"
}
|
Can you make molecule CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCSCS4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4SCSCS4)o3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C19CC1"
}
|
Can you make molecule CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CCCCCC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CC4)o3)CC2)cc1
|
CCOc1ccc(S(=O)(=O)N2CCC(c3nnc(C4CCCCCC4)o3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C19CC1"
}
|
Can you make molecule Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNC[C@@H](c1ccccc1)N1CCOCC1)c1c(C)nc2cc(C)nn2c1C
|
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
CCC(CC)(C(=O)CNC[C@@H](c1ccccc1)N1CCOCC1)c1c(C)nc2cc(C)nn2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C7CC4=O"
}
|
Can you make molecule Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNC[C@@H](c1ccccc1)N1CCOCC1)c1c(C)nc2cc(C)nn2c1C
|
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
CCC(CC)(C(=O)CCNC[C@@H](c1ccccc1)N1CCOCC1)c1c(C)nc2cc(C)nn2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C7CC4=O"
}
|
Can you make molecule Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1c(C)nc2cc(C)nn2c1C)[S@+]([O-])CNC[C@@H](c1ccccc1)N1CCOCC1
|
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
CC[C@H](c1c(C)nc2cc(C)nn2c1C)[S@+]([O-])CNC[C@@H](c1ccccc1)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&[S@](=O)C&",
"old_substring": "C7CC4=O"
}
|
Can you make molecule Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C(=O)NC[C@@H](c1ccccc1)N1CCOCC1)C(=O)c1c(C)nc2cc(C)nn2c1C
|
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
CCCC[C@@H](C(=O)NC[C@@H](c1ccccc1)N1CCOCC1)C(=O)c1c(C)nc2cc(C)nn2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H](C&=O)C&=O",
"old_substring": "C7CC4=O"
}
|
Can you make molecule Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc(C)c(CCC[S@+]([O-])[C@@H](C)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
|
Cc1cc2nc(C)c(CCC[S@+]([O-])[C@@H](C)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "C7CC4=O"
}
|
Can you make molecule COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2I)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2I)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2Br)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)c(I)c2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)c(I)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)CS[C@H]2c2cc(Cl)ccc2Cl)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2cc(Cl)ccc2Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)c(Cl)c2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl
|
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)c(Cl)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
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