Datasets:
MaIlz
/
replace_102

Dataset card Data Studio Files
xet
Community
prompt
stringlengths
120
209
completion
stringlengths
15
103
input_smiles
stringlengths
14
103
output_smiles
stringlengths
15
103
task_id
int64
102
102
winner_action
dict
Can you make molecule O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2 less soluble in water? The output molecule should be similar to the input molecule.
O=C1N(C[NH+]2CCN(c3ccccc3Cl)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3ccccc3Cl)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
102
{ "fragment_index": 0, "new_substring": "c1&ccccc1Cl", "old_substring": "c14ccccc1" }
Can you make molecule O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2 less soluble in water? The output molecule should be similar to the input molecule.
O=C1N(C[NH+]2CCN(c3ccc(I)cc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3ccc(I)cc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c14ccccc1" }
Can you make molecule O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc(N2CC[NH+](CN3C(=O)C4(O[C@@H]5CCCC[C@H]5O4)c4ccccc43)CC2)cc1I
O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
Cc1ccc(N2CC[NH+](CN3C(=O)C4(O[C@@H]5CCCC[C@H]5O4)c4ccccc43)CC2)cc1I
102
{ "fragment_index": 0, "new_substring": "Cc1ccc&cc1I", "old_substring": "c14ccccc1" }
Can you make molecule O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2 less soluble in water? The output molecule should be similar to the input molecule.
O=C1N(C[NH+]2CCN(c3cccc(Br)c3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
O=C1N(C[NH+]2CCN(c3cccc(Br)c3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
102
{ "fragment_index": 0, "new_substring": "Brc1cccc&c1", "old_substring": "c14ccccc1" }
Can you make molecule O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1cccc(N2CC[NH+](CN3C(=O)C4(O[C@@H]5CCCC[C@H]5O4)c4ccccc43)CC2)c1C
O=C1N(C[NH+]2CCN(c3ccccc3)CC2)c2ccccc2C12O[C@@H]1CCCC[C@H]1O2
Cc1cccc(N2CC[NH+](CN3C(=O)C4(O[C@@H]5CCCC[C@H]5O4)c4ccccc43)CC2)c1C
102
{ "fragment_index": 0, "new_substring": "c1&cccc(C)c1C", "old_substring": "c14ccccc1" }
Can you make molecule CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
O=C([O-])c1nc(CCCCBr)n(-c2ccccc2F)n1
CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F
O=C([O-])c1nc(CCCCBr)n(-c2ccccc2F)n1
102
{ "fragment_index": 0, "new_substring": "C&CCCBr", "old_substring": "CC3C" }
Can you make molecule CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
C=CCCCCc1nc(C(=O)[O-])nn1-c1ccccc1F
CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F
C=CCCCCc1nc(C(=O)[O-])nn1-c1ccccc1F
102
{ "fragment_index": 0, "new_substring": "C=CCCCC&", "old_substring": "CC3C" }
Can you make molecule CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
O=C([O-])c1nc(CCCCCBr)n(-c2ccccc2F)n1
CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F
O=C([O-])c1nc(CCCCCBr)n(-c2ccccc2F)n1
102
{ "fragment_index": 0, "new_substring": "C&CCCCBr", "old_substring": "CC3C" }
Can you make molecule CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
O=C([O-])c1nc(CCCCCS)n(-c2ccccc2F)n1
CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F
O=C([O-])c1nc(CCCCCS)n(-c2ccccc2F)n1
102
{ "fragment_index": 0, "new_substring": "SCCCCC&", "old_substring": "CC3C" }
Can you make molecule CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
O=C([O-])c1nc(CCCCCCS)n(-c2ccccc2F)n1
CC(C)c1nc(C(=O)[O-])nn1-c1ccccc1F
O=C([O-])c1nc(CCCCCCS)n(-c2ccccc2F)n1
102
{ "fragment_index": 0, "new_substring": "SCCCCCC&", "old_substring": "CC3C" }
Can you make molecule C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](SC2=CCCCCC2)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](SC2=CCCCCC2)CC1
102
{ "fragment_index": 0, "new_substring": "C1=C(S&)CCCCC1", "old_substring": "C14CCCCCC1" }
Can you make molecule C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCCCCCCC2)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCCCCCCC2)CC1
102
{ "fragment_index": 0, "new_substring": "C1&CCCCCCCCCCC1", "old_substring": "C14CCCCCC1" }
Can you make molecule C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C1=CC=C2CCCCC(=C1)C2[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1
C1=CC=C2CCCCC(=C1)C2[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
102
{ "fragment_index": 0, "new_substring": "C1&C2=CC=CC=C1CCCC2", "old_substring": "C14CCCCCC1" }
Can you make molecule C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCCCC[C@@H](C)[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1
CCCCCC[C@@H](C)[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
102
{ "fragment_index": 0, "new_substring": "CCCCCC[C@H]&C", "old_substring": "C14CCCCCC1" }
Can you make molecule C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCCCC(C)(C)C[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1
CCCCCC(C)(C)C[NH+]1CCN(C[C@@H]2C[C@@H]3C=C[C@H]2C3)CC1
102
{ "fragment_index": 0, "new_substring": "CCCCCC(C)(C)C&", "old_substring": "C14CCCCCC1" }
Can you make molecule CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C[C@H](C[NH+]1CCCC1(C)C)Nc1ncncc1N
CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N
CC(C)C[C@H](C[NH+]1CCCC1(C)C)Nc1ncncc1N
102
{ "fragment_index": 0, "new_substring": "[NH+]1&CCCC1(C)C", "old_substring": "[NH+]3(C)C" }
Can you make molecule CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C[C@H](C[N+](C)(C)C)Nc1ncncc1N
CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N
CC(C)C[C@H](C[N+](C)(C)C)Nc1ncncc1N
102
{ "fragment_index": 0, "new_substring": "C[N+]&(C)C", "old_substring": "[NH+]3(C)C" }
Can you make molecule CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C[C@H](C[NH+]1CC(C)(C)C1)Nc1ncncc1N
CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N
CC(C)C[C@H](C[NH+]1CC(C)(C)C1)Nc1ncncc1N
102
{ "fragment_index": 0, "new_substring": "[NH+]1&CC(C)(C)C1", "old_substring": "[NH+]3(C)C" }
Can you make molecule CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C[C@H](C[NH+]1CCC(C)(C)C1)Nc1ncncc1N
CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N
CC(C)C[C@H](C[NH+]1CCC(C)(C)C1)Nc1ncncc1N
102
{ "fragment_index": 0, "new_substring": "[NH+]1&CCC(C)(C)C1", "old_substring": "[NH+]3(C)C" }
Can you make molecule CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N less soluble in water? The output molecule should be similar to the input molecule.
CC(C)C[C@@H]1C[NH+]2CC1(CCCNc1ncncc1N)C2
CC(C)C[C@H](C[NH+](C)C)Nc1ncncc1N
CC(C)C[C@@H]1C[NH+]2CC1(CCCNc1ncncc1N)C2
102
{ "fragment_index": 0, "new_substring": "[NH+]1&CC2(CCC2)C1", "old_substring": "[NH+]3(C)C" }
Can you make molecule O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1 less soluble in water? The output molecule should be similar to the input molecule.
Cn1c(=O)cnn([C@@H]2C(=O)C=C(c3cccs3)C[C@@H]2c2cccs2)c1=O
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1
Cn1c(=O)cnn([C@@H]2C(=O)C=C(c3cccs3)C[C@@H]2c2cccs2)c1=O
102
{ "fragment_index": 0, "new_substring": "n1&ncc(=O)n(C)c1=O", "old_substring": "n13cnc([N+](=O)[O-])n1" }
Can you make molecule O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1 less soluble in water? The output molecule should be similar to the input molecule.
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1c1cn[nH]c(=O)n1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1c1cn[nH]c(=O)n1
102
{ "fragment_index": 0, "new_substring": "c1&cn[nH]c(=O)n1", "old_substring": "n13cnc([N+](=O)[O-])n1" }
Can you make molecule O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1 less soluble in water? The output molecule should be similar to the input molecule.
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1c1n[nH]c(=O)[nH]1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1c1n[nH]c(=O)[nH]1
102
{ "fragment_index": 0, "new_substring": "c1&n[nH]c(=O)[nH]1", "old_substring": "n13cnc([N+](=O)[O-])n1" }
Can you make molecule O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1 less soluble in water? The output molecule should be similar to the input molecule.
Cn1ccc(S(=O)(=O)[C@@H]2C(=O)C=C(c3cccs3)C[C@@H]2c2cccs2)c1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1
Cn1ccc(S(=O)(=O)[C@@H]2C(=O)C=C(c3cccs3)C[C@@H]2c2cccs2)c1
102
{ "fragment_index": 0, "new_substring": "Cn1ccc(S&(=O)=O)c1", "old_substring": "n13cnc([N+](=O)[O-])n1" }
Can you make molecule O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1 less soluble in water? The output molecule should be similar to the input molecule.
Cc1nnc([S-])n1[C@@H]1C(=O)C=C(c2cccs2)C[C@@H]1c1cccs1
O=C1C=C(c2cccs2)C[C@H](c2cccs2)[C@@H]1n1cnc([N+](=O)[O-])n1
Cc1nnc([S-])n1[C@@H]1C(=O)C=C(c2cccs2)C[C@@H]1c1cccs1
102
{ "fragment_index": 0, "new_substring": "Cc1nnc([S-])n1&", "old_substring": "n13cnc([N+](=O)[O-])n1" }
Can you make molecule C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(I)o2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(I)o2)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)o1", "old_substring": "c18ccco1" }
Can you make molecule C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(Br)o2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(Br)o2)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Br)o1", "old_substring": "c18ccco1" }
Can you make molecule C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(Cl)o2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccc(Cl)o2)CC1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)o1", "old_substring": "c18ccco1" }
Can you make molecule C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2occc2Br)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2occc2Br)CC1
102
{ "fragment_index": 0, "new_substring": "c1&occc1Br", "old_substring": "c18ccco1" }
Can you make molecule C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2sccc2C)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2ccco2)CC1
C[NH2+]C1CCC([NH+](C)CC(=O)N[C@H](C)c2sccc2C)CC1
102
{ "fragment_index": 0, "new_substring": "c1&sccc1C", "old_substring": "c18ccco1" }
Can you make molecule CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCBr)nc32)C1
CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCBr)nc32)C1
102
{ "fragment_index": 0, "new_substring": "C&CCCBr", "old_substring": "CC4C" }
Can you make molecule CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
C=CCCCCc1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
C=CCCCCc1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
102
{ "fragment_index": 0, "new_substring": "C=CCCCC&", "old_substring": "CC4C" }
Can you make molecule CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCBr)nc32)C1
CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCBr)nc32)C1
102
{ "fragment_index": 0, "new_substring": "C&CCCCBr", "old_substring": "CC4C" }
Can you make molecule CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCS)nc32)C1
CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCS)nc32)C1
102
{ "fragment_index": 0, "new_substring": "SCCCCC&", "old_substring": "CC4C" }
Can you make molecule CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCCS)nc32)C1
CC(C)c1nc2n(n1)CCC[C@H]2[NH2+]C[C@@H]1CCC[C@H](C)C1
C[C@H]1CCC[C@@H](C[NH2+][C@@H]2CCCn3nc(CCCCCCS)nc32)C1
102
{ "fragment_index": 0, "new_substring": "SCCCCCC&", "old_substring": "CC4C" }
Can you make molecule CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
CCCOC(=O)c1ccc(NC(=O)c2cc[n+](CCBr)cc2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1
CCCOC(=O)c1ccc(NC(=O)c2cc[n+](CCBr)cc2)cc1
102
{ "fragment_index": 0, "new_substring": "c1&cc[n+](CCBr)cc1", "old_substring": "c18ccc[n+]([O-])c1" }
Can you make molecule CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
CCCOC(=O)c1ccc(NC(=O)c2ccc(=O)oc2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc(=O)oc2)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(=O)oc1", "old_substring": "c18ccc[n+]([O-])c1" }
Can you make molecule CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
CCCOC(=O)c1ccc(NC(=O)c2ccc([S-])cc2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc([S-])cc2)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc([S-])cc1", "old_substring": "c18ccc[n+]([O-])c1" }
Can you make molecule CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
CCCOC(=O)c1ccc(NC(=O)c2ccc(I)nc2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc(I)nc2)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)nc1", "old_substring": "c18ccc[n+]([O-])c1" }
Can you make molecule CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
CCCOC(=O)c1ccc(NC(=O)c2ccc[nH]c2=S)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1
CCCOC(=O)c1ccc(NC(=O)c2ccc[nH]c2=S)cc1
102
{ "fragment_index": 0, "new_substring": "c1&ccc[nH]c1=S", "old_substring": "c18ccc[n+]([O-])c1" }
Can you make molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
CCOc1cc(CO)cc(Br)c1OCc1ccc(I)cc1F
CCOc1cc(CO)cc(Br)c1OCc1ccccc1F
CCOc1cc(CO)cc(Br)c1OCc1ccc(I)cc1F
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1F", "old_substring": "c17ccccc1F" }
Can you make molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
CCOc1cc(CO)cc(Br)c1OCc1cc(I)ccc1F
CCOc1cc(CO)cc(Br)c1OCc1ccccc1F
CCOc1cc(CO)cc(Br)c1OCc1cc(I)ccc1F
102
{ "fragment_index": 0, "new_substring": "c1&cc(I)ccc1F", "old_substring": "c17ccccc1F" }
Can you make molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
CCOc1cc(CO)cc(Br)c1OCc1ccccc1Cl
CCOc1cc(CO)cc(Br)c1OCc1ccccc1F
CCOc1cc(CO)cc(Br)c1OCc1ccccc1Cl
102
{ "fragment_index": 0, "new_substring": "c1&ccccc1Cl", "old_substring": "c17ccccc1F" }
Can you make molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
CCOc1cc(CO)cc(Br)c1OC=C(C)c1ccccc1F
CCOc1cc(CO)cc(Br)c1OCc1ccccc1F
CCOc1cc(CO)cc(Br)c1OC=C(C)c1ccccc1F
102
{ "fragment_index": 0, "new_substring": "CC=&c1ccccc1F", "old_substring": "c17ccccc1F" }
Can you make molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
CCOc1cc(CO)cc(Br)c1OCc1cc(F)ccc1Br
CCOc1cc(CO)cc(Br)c1OCc1ccccc1F
CCOc1cc(CO)cc(Br)c1OCc1cc(F)ccc1Br
102
{ "fragment_index": 0, "new_substring": "c1&cc(F)ccc1Br", "old_substring": "c17ccccc1F" }
Can you make molecule O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Cn1nnn(-c2ccc(Cl)s2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2ccc(Cl)s2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)s1", "old_substring": "c19cccs1" }
Can you make molecule O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Cn1nnn(-c2ccc(Br)s2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2ccc(Br)s2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
102
{ "fragment_index": 0, "new_substring": "c1&ccc(Br)s1", "old_substring": "c19cccs1" }
Can you make molecule O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Cn1nnn(-c2sccc2Br)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2sccc2Br)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
102
{ "fragment_index": 0, "new_substring": "c1&sccc1Br", "old_substring": "c19cccs1" }
Can you make molecule O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Cn1nnn(-c2csc(I)c2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2csc(I)c2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
102
{ "fragment_index": 0, "new_substring": "c1&csc(I)c1", "old_substring": "c19cccs1" }
Can you make molecule O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Cn1nnn(-c2cc3c(s2)CSC3)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cccs2)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
O=C(Cn1nnn(-c2cc3c(s2)CSC3)c1=O)NC[C@@H]1CN(Cc2ccccc2)CCO1
102
{ "fragment_index": 0, "new_substring": "c1&cc2c(s1)CSC2", "old_substring": "c19cccs1" }
Can you make molecule CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)[C@H](O)CCNC(=O)CCCC(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)CCCC(=O)Nc1ccn(-c2ncccc2Cl)n1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCCC&=O", "old_substring": "C3(=O)C4=O" }
Can you make molecule CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)[C@H](O)CCNC(=O)CCC(=O)CNc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)CCC(=O)CNc1ccn(-c2ncccc2Cl)n1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCC(=O)C&", "old_substring": "C3(=O)C4=O" }
Can you make molecule CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)[C@H](O)CCNC[S@+]([O-])CCC(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC[S@+]([O-])CCC(=O)Nc1ccn(-c2ncccc2Cl)n1
102
{ "fragment_index": 0, "new_substring": "C&[S@](=O)CCC&=O", "old_substring": "C3(=O)C4=O" }
Can you make molecule CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)[C@H](O)CCNC(=O)CCCS(=O)(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)CCCS(=O)(=O)Nc1ccn(-c2ncccc2Cl)n1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCCS&(=O)=O", "old_substring": "C3(=O)C4=O" }
Can you make molecule CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)[C@H](O)CCNC(=O)C(C)(F)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(=O)Nc1ccn(-c2ncccc2Cl)n1
CC(C)[C@H](O)CCNC(=O)C(C)(F)C(=O)Nc1ccn(-c2ncccc2Cl)n1
102
{ "fragment_index": 0, "new_substring": "C&(=O)C(C)(F)C&=O", "old_substring": "C3(=O)C4=O" }
Can you make molecule Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
CC[C@H](NC(=O)c1cccc(C)c1C)S(=O)(=O)CNCC1CCC1
Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C
CC[C@H](NC(=O)c1cccc(C)c1C)S(=O)(=O)CNCC1CCC1
102
{ "fragment_index": 0, "new_substring": "CC[C@H]&S(=O)(=O)C&", "old_substring": "C4CS6(=O)=O" }
Can you make molecule Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
Cc1cccc(C(=O)N=CC(=O)C=NCC2CCC2)c1C
Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C
Cc1cccc(C(=O)N=CC(=O)C=NCC2CCC2)c1C
102
{ "fragment_index": 0, "new_substring": "C=&C(=O)C=&", "old_substring": "C4CS6(=O)=O" }
Can you make molecule Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
CC[C@@H](C(=O)NCC1CCC1)C(=O)NC(=O)c1cccc(C)c1C
Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C
CC[C@@H](C(=O)NCC1CCC1)C(=O)NC(=O)c1cccc(C)c1C
102
{ "fragment_index": 0, "new_substring": "CC[C@H](C&=O)C&=O", "old_substring": "C4CS6(=O)=O" }
Can you make molecule Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
CC(=O)[C@@H](CC(=O)NCC1CCC1)NC(=O)c1cccc(C)c1C
Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C
CC(=O)[C@@H](CC(=O)NCC1CCC1)NC(=O)c1cccc(C)c1C
102
{ "fragment_index": 0, "new_substring": "CC(=O)[C@H]&CC&=O", "old_substring": "C4CS6(=O)=O" }
Can you make molecule Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
Cc1cccc(C(=O)NC[S@+]([O-])CCCC(=O)NCC2CCC2)c1C
Cc1cccc(C(=O)NCCS(=O)(=O)NCC2CCC2)c1C
Cc1cccc(C(=O)NC[S@+]([O-])CCCC(=O)NCC2CCC2)c1C
102
{ "fragment_index": 0, "new_substring": "C&[S@](=O)CCCC&=O", "old_substring": "C4CS6(=O)=O" }
Can you make molecule CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)N1CCSC12CCN(C(=O)NN=C(c1ccccc1)c1ccccc1)CC2
CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)N1CCSC12CCN(C(=O)NN=C(c1ccccc1)c1ccccc1)CC2
102
{ "fragment_index": 0, "new_substring": "N1&CCSC12CCN&CC2", "old_substring": "N13CCC4CC1" }
Can you make molecule CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)N1CCCc2cc(C(=O)NN=C(c3ccccc3)c3ccccc3)ccc2C1
CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)N1CCCc2cc(C(=O)NN=C(c3ccccc3)c3ccccc3)ccc2C1
102
{ "fragment_index": 0, "new_substring": "N1&CCCc2cc&ccc2C1", "old_substring": "N13CCC4CC1" }
Can you make molecule CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)C1CCN(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)C1CCN(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
102
{ "fragment_index": 0, "new_substring": "C1&CCN&CC1", "old_substring": "N13CCC4CC1" }
Can you make molecule CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)C1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)C1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
102
{ "fragment_index": 0, "new_substring": "C1&CCC&CC1", "old_substring": "N13CCC4CC1" }
Can you make molecule CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(=O)CCCCCC(=O)NN=C(c1ccccc1)c1ccccc1
CCCC(=O)N1CCC(C(=O)NN=C(c2ccccc2)c2ccccc2)CC1
CCCC(=O)CCCCCC(=O)NN=C(c1ccccc1)c1ccccc1
102
{ "fragment_index": 0, "new_substring": "C&CCCC&", "old_substring": "N13CCC4CC1" }
Can you make molecule O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
N=C(N[C@@H](NC(=O)c1cccc(Br)c1)C(Cl)(Cl)Cl)Sc1ccccc1
O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
N=C(N[C@@H](NC(=O)c1cccc(Br)c1)C(Cl)(Cl)Cl)Sc1ccccc1
102
{ "fragment_index": 0, "new_substring": "N&C(=N)S&", "old_substring": "N4C(=S)N5" }
Can you make molecule O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(N[C@H](SC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](SC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
102
{ "fragment_index": 0, "new_substring": "S&C(=S)N&", "old_substring": "N4C(=S)N5" }
Can you make molecule O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(N[C@H](NC(=S)N1CCC(c2ccccc2)CC1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)N1CCC(c2ccccc2)CC1)C(Cl)(Cl)Cl)c1cccc(Br)c1
102
{ "fragment_index": 0, "new_substring": "N&C(=S)N1CCC&CC1", "old_substring": "N4C(=S)N5" }
Can you make molecule O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(N[C@H](NC(=S)N1CC[C@H](c2ccccc2)C1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)N1CC[C@H](c2ccccc2)C1)C(Cl)(Cl)Cl)c1cccc(Br)c1
102
{ "fragment_index": 0, "new_substring": "N&C(=S)N1CC[C@H]&C1", "old_substring": "N4C(=S)N5" }
Can you make molecule O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(N[C@H](NC(=S)NN=C1CCC(c2ccccc2)CC1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
O=C(N[C@H](NC(=S)NN=C1CCC(c2ccccc2)CC1)C(Cl)(Cl)Cl)c1cccc(Br)c1
102
{ "fragment_index": 0, "new_substring": "N&C(=S)NN=C1CCC&CC1", "old_substring": "N4C(=S)N5" }
Can you make molecule CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN(Cc1ccccc1)C(=O)c1cc(NSC(C)=O)n(C)n1.c1ccccc1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1
CCN(Cc1ccccc1)C(=O)c1cc(NSC(C)=O)n(C)n1.c1ccccc1
102
{ "fragment_index": 0, "new_substring": "S&C(=O)C&", "old_substring": "C4(=O)C%10" }
Can you make molecule CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)C2=C(N)CCS2)n(C)n1.c1ccccc1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)C2=C(N)CCS2)n(C)n1.c1ccccc1
102
{ "fragment_index": 0, "new_substring": "C&(=O)C1=C(N&)CCS1", "old_substring": "C4(=O)C%10" }
Can you make molecule CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)CCCC=O)n(C)n1.c1ccccc1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)CCCC=O)n(C)n1.c1ccccc1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CCCC&=O", "old_substring": "C4(=O)C%10" }
Can you make molecule CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)CC(C)C)n(C)n1.c1ccccc1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)CC(C)C)n(C)n1.c1ccccc1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CC&(C)C", "old_substring": "C4(=O)C%10" }
Can you make molecule CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
CCC[S@@+]([O-])CNc1cc(C(=O)N(CC)Cc2ccccc2)nn1C.c1ccccc1
CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1
CCC[S@@+]([O-])CNc1cc(C(=O)N(CC)Cc2ccccc2)nn1C.c1ccccc1
102
{ "fragment_index": 0, "new_substring": "C&[S@](=O)CCC&", "old_substring": "C4(=O)C%10" }
Can you make molecule CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)CCCC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CCCC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
102
{ "fragment_index": 0, "new_substring": "CC(C)CCCC&=O", "old_substring": "CC(C)CC4=O" }
Can you make molecule CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)(C)CC(=O)CCN1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)(C)CC(=O)CCN1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
102
{ "fragment_index": 0, "new_substring": "CC(C)(C)CC(=O)CC&", "old_substring": "CC(C)CC4=O" }
Can you make molecule CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CC(C)(C)C(=O)CCCCN1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)(C)C(=O)CCCCN1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
102
{ "fragment_index": 0, "new_substring": "CC(C)(C)C(=O)CCCC&", "old_substring": "CC(C)CC4=O" }
Can you make molecule CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCC(CC)=NON1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CCC(CC)=NON1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
102
{ "fragment_index": 0, "new_substring": "CCC(CC)=NO&", "old_substring": "CC(C)CC4=O" }
Can you make molecule CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
CCCC(CCC)C(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
CCCC(CCC)C(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1
102
{ "fragment_index": 0, "new_substring": "CCCC(CCC)C&=O", "old_substring": "CC(C)CC4=O" }
Can you make molecule O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(/C=C/Sc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
O=C(/C=C/Sc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
102
{ "fragment_index": 0, "new_substring": "O=C&/C=C/S&", "old_substring": "O=C3C9" }
Can you make molecule O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(NCCc1ccc(Cl)cc1)NN=C1CCC(c2csc(NC(=O)Nc3ccc(Cl)cc3)n2)CC1
O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
O=C(NCCc1ccc(Cl)cc1)NN=C1CCC(c2csc(NC(=O)Nc3ccc(Cl)cc3)n2)CC1
102
{ "fragment_index": 0, "new_substring": "O=C&NN=C1CCC&CC1", "old_substring": "O=C3C9" }
Can you make molecule O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
C/C(=N\ONCCc1ccc(Cl)cc1)C(=O)Sc1csc(NC(=O)Nc2ccc(Cl)cc2)n1
O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
C/C(=N\ONCCc1ccc(Cl)cc1)C(=O)Sc1csc(NC(=O)Nc2ccc(Cl)cc2)n1
102
{ "fragment_index": 0, "new_substring": "O&/N=C(\\C)C(=O)S&", "old_substring": "O=C3C9" }
Can you make molecule O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(Nc1ccc(Cl)cc1)Nc1nc([C@H]2CC=C(C(=O)NCCc3ccc(Cl)cc3)S2)cs1
O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
O=C(Nc1ccc(Cl)cc1)Nc1nc([C@H]2CC=C(C(=O)NCCc3ccc(Cl)cc3)S2)cs1
102
{ "fragment_index": 0, "new_substring": "O=C&C1=CC[C@H]&S1", "old_substring": "O=C3C9" }
Can you make molecule O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
O=C(NCCc1ccc(Cl)cc1)NN=Cc1ccc(-c2csc(NC(=O)Nc3ccc(Cl)cc3)n2)cc1
O=C(Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1)NCCc1ccc(Cl)cc1
O=C(NCCc1ccc(Cl)cc1)NN=Cc1ccc(-c2csc(NC(=O)Nc3ccc(Cl)cc3)n2)cc1
102
{ "fragment_index": 0, "new_substring": "O=C&NN=Cc1ccc&cc1", "old_substring": "O=C3C9" }
Can you make molecule Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1Cl)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1Cl)O2
102
{ "fragment_index": 0, "new_substring": "c1&ccc(F)cc1Cl", "old_substring": "c14ccc(F)cc1" }
Can you make molecule Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1Br)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1Br)O2
102
{ "fragment_index": 0, "new_substring": "c1&ccc(F)cc1Br", "old_substring": "c14ccc(F)cc1" }
Can you make molecule Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)c(Cl)c1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)c(Cl)c1)O2
102
{ "fragment_index": 0, "new_substring": "c1&ccc(F)c(Cl)c1", "old_substring": "c14ccc(F)cc1" }
Can you make molecule Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(I)cc1F)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(I)cc1F)O2
102
{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1F", "old_substring": "c14ccc(F)cc1" }
Can you make molecule Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2 less soluble in water? The output molecule should be similar to the input molecule.
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1cc3c(F)cccc3s1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1ccc(F)cc1)O2
Cc1ccc2c(c1)C[C@@H](C[C@@H](C[NH3+])c1cc3c(F)cccc3s1)O2
102
{ "fragment_index": 0, "new_substring": "c1&cc2c(F)cccc2s1", "old_substring": "c14ccc(F)cc1" }
Can you make molecule CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
CC1=C(C(=O)OC2(C)CCCC2)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC2(C)CCCC2)[C@@H](c2ccc(C)s2)NC(=O)N1C
102
{ "fragment_index": 0, "new_substring": "C1&(C)CCCC1", "old_substring": "C4(C)C" }
Can you make molecule CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
CC1=C(C(=O)OC(Cl)(Cl)Cl)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC(Cl)(Cl)Cl)[C@@H](c2ccc(C)s2)NC(=O)N1C
102
{ "fragment_index": 0, "new_substring": "C&(Cl)(Cl)Cl", "old_substring": "C4(C)C" }
Can you make molecule CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
CCCC(C)(C)OC(=O)C1=C(C)N(C)C(=O)N[C@@H]1c1ccc(C)s1
CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C
CCCC(C)(C)OC(=O)C1=C(C)N(C)C(=O)N[C@@H]1c1ccc(C)s1
102
{ "fragment_index": 0, "new_substring": "CCCC&(C)C", "old_substring": "C4(C)C" }
Can you make molecule CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
CCC(C)(CC)OC(=O)C1=C(C)N(C)C(=O)N[C@@H]1c1ccc(C)s1
CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C
CCC(C)(CC)OC(=O)C1=C(C)N(C)C(=O)N[C@@H]1c1ccc(C)s1
102
{ "fragment_index": 0, "new_substring": "CCC&(C)CC", "old_substring": "C4(C)C" }
Can you make molecule CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
CC1=C(C(=O)OC2(C=O)CCCCCC2)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC(C)C)[C@@H](c2ccc(C)s2)NC(=O)N1C
CC1=C(C(=O)OC2(C=O)CCCCCC2)[C@@H](c2ccc(C)s2)NC(=O)N1C
102
{ "fragment_index": 0, "new_substring": "C1&(C=O)CCCCCC1", "old_substring": "C4(C)C" }
Can you make molecule COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COCc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
COCc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
102
{ "fragment_index": 0, "new_substring": "COC&", "old_substring": "CO3" }
Can you make molecule COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
COCSc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
COCSc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
102
{ "fragment_index": 0, "new_substring": "COCS&", "old_substring": "CO3" }
Can you make molecule COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
CC(=O)Sc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
CC(=O)Sc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
102
{ "fragment_index": 0, "new_substring": "CC(=O)S&", "old_substring": "CO3" }
Can you make molecule COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cn1cc([C@H](O)CNc2cc(C(=O)CS)cc(F)c2[N+](=O)[O-])cn1
COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
Cn1cc([C@H](O)CNc2cc(C(=O)CS)cc(F)c2[N+](=O)[O-])cn1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CS", "old_substring": "CO3" }
Can you make molecule COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
Cn1cc([C@H](O)CNc2cc(C(=O)CI)cc(F)c2[N+](=O)[O-])cn1
COc1cc(F)c([N+](=O)[O-])c(NC[C@@H](O)c2cnn(C)c2)c1
Cn1cc([C@H](O)CNc2cc(C(=O)CI)cc(F)c2[N+](=O)[O-])cn1
102
{ "fragment_index": 0, "new_substring": "C&(=O)CI", "old_substring": "CO3" }