prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1cc(Br)c(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)n1
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1
|
CCCn1cc(Br)c(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(Br)c&n1",
"old_substring": "n18cc6cn1"
}
|
Can you make molecule CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ccn(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)c1=S
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1
|
CCCn1ccn(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccn&c1=S",
"old_substring": "n18cc6cn1"
}
|
Can you make molecule CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1cc2cc(NC(=O)c3cc4nc(-c5ccccc5)cc(-c5ccccc5)n4n3)ccc2n1
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1
|
CCCn1cc2cc(NC(=O)c3cc4nc(-c5ccccc5)cc(-c5ccccc5)n4n3)ccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc2cc&ccc2n1",
"old_substring": "n18cc6cn1"
}
|
Can you make molecule CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)c2cccnc21
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)c2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&c2cccnc21",
"old_substring": "n18cc6cn1"
}
|
Can you make molecule CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ccc2nc(NC(=O)c3cc4nc(-c5ccccc5)cc(-c5ccccc5)n4n3)ccc21
|
CCCn1cc(NC(=O)c2cc3nc(-c4ccccc4)cc(-c4ccccc4)n3n2)cn1
|
CCCn1ccc2nc(NC(=O)c3cc4nc(-c5ccccc5)cc(-c5ccccc5)n4n3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc2nc&ccc21",
"old_substring": "n18cc6cn1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCSC23CCN(C(=O)N2CCCc4ccccc42)CC3)cc1C
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)N2CCSC23CCN(C(=O)N2CCCc4ccccc42)CC3)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSC12CCN&CC2",
"old_substring": "N16CCC7CC1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCCc3cc(C(=O)N4CCCc5ccccc54)ccc3C2)cc1C
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)N2CCCc3cc(C(=O)N4CCCc5ccccc54)ccc3C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCc2cc&ccc2C1",
"old_substring": "N16CCC7CC1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)C2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)C2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "N16CCC7CC1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)CCCCCC(=O)N2CCCc3ccccc32)cc1C
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)CCCCCC(=O)N2CCCc3ccccc32)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "N16CCC7CC1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)C2(C#N)CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
|
Cc1ccc(S(=O)(=O)C2(C#N)CCC(C(=O)N3CCCc4ccccc43)CC2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "N16CCC7CC1"
}
|
Can you make molecule C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC1=NC(CC=C)=C2CCN2CC(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)=N1
|
C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1
|
C=CCC1=NC(CC=C)=C2CCN2CC(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&nc&nc2C1",
"old_substring": "N245"
}
|
Can you make molecule C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC1=CC(CC=C)=C2OCCN2CC(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)=C1
|
C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1
|
C=CCC1=CC(CC=C)=C2OCCN2CC(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)=C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2c&cc&cc2C1",
"old_substring": "N245"
}
|
Can you make molecule C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC1(CC=C)CCN(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)C1
|
C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1
|
C=CCC1(CC=C)CCN(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N245"
}
|
Can you make molecule C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC1(CC=C)CCCN(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)C1
|
C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1
|
C=CCC1(CC=C)CCCN(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N245"
}
|
Can you make molecule C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCc1oc(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)c(C#N)c1CC=C
|
C=CCN(CC=C)C(=O)C1CCN(C(=O)C(C)(C)C)CC1
|
C=CCc1oc(C(=O)C2CCN(C(=O)C(C)(C)C)CC2)c(C#N)c1CC=C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N245"
}
|
Can you make molecule Cc1nc(CSc2nncc3ccccc23)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCCCSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CCCCSc2nncc3ccccc23)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C45"
}
|
Can you make molecule Cc1nc(CSc2nncc3ccccc23)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCCCCSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CCCCCSc2nncc3ccccc23)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C45"
}
|
Can you make molecule Cc1nc(CSc2nncc3ccccc23)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C2CC(Sc3nncc4ccccc34)C2)nc2ccccc12
|
Cc1nc(CSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(C2CC(Sc3nncc4ccccc34)C2)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C45"
}
|
Can you make molecule Cc1nc(CSc2nncc3ccccc23)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(SC(=S)OSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(SC(=S)OSc2nncc3ccccc23)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C45"
}
|
Can you make molecule Cc1nc(CSc2nncc3ccccc23)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NC(=S)SSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(CSc2nncc3ccccc23)nc2ccccc12
|
Cc1nc(NC(=S)SSc2nncc3ccccc23)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C45"
}
|
Can you make molecule C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCCN1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCCN1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCCCN1&",
"old_substring": "C[C@H]1CCCC[NH+]12"
}
|
Can you make molecule C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC=CC[C@H]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CC=CC[C@H]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CC=CC[C@H]1&",
"old_substring": "C[C@H]1CCCC[NH+]12"
}
|
Can you make molecule C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCCCN1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCCCN1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCCCCN1&",
"old_substring": "C[C@H]1CCCC[NH+]12"
}
|
Can you make molecule C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C[C@@H]2CCC(C)(C)[C@@H]2[NH3+])C1
|
C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCN(C[C@@H]2CCC(C)(C)[C@@H]2[NH3+])C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCCN&C1",
"old_substring": "C[C@H]1CCCC[NH+]12"
}
|
Can you make molecule C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1SCCC[C@@H]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1CCCC[NH+]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
|
C[C@H]1SCCC[C@@H]1C[C@@H]1CCC(C)(C)[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1SCCC[C@@H]1&",
"old_substring": "C[C@H]1CCCC[NH+]12"
}
|
Can you make molecule COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccn(C(=O)Nc2ccccc2Oc2ccccc2)c1
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1
|
COc1ccn(C(=O)Nc2ccccc2Oc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccn&c1",
"old_substring": "c14cc8on1"
}
|
Can you make molecule COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)Nc2ccccc2Oc2ccccc2)o1
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1
|
COc1ccc(C(=O)Nc2ccccc2Oc2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&o1",
"old_substring": "c14cc8on1"
}
|
Can you make molecule COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)oc1C
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&oc1C",
"old_substring": "c14cc8on1"
}
|
Can you make molecule COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2oc(C(=O)Nc3ccccc3Oc3ccccc3)nc2c1
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1
|
COc1ccc2oc(C(=O)Nc3ccccc3Oc3ccccc3)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2oc&nc2c1",
"old_substring": "c14cc8on1"
}
|
Can you make molecule COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc2occc2c(C(=O)Nc2ccccc2Oc2ccccc2)n1
|
COc1cc(C(=O)Nc2ccccc2Oc2ccccc2)on1
|
COc1cc2occc2c(C(=O)Nc2ccccc2Oc2ccccc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2occc2c&n1",
"old_substring": "c14cc8on1"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NSC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NSC(=O)C=Cc1ccc(F)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C=7"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C1=C(N=Cc2ccc(F)c(Cl)c2)CCS1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C1=C(N=Cc2ccc(F)c(Cl)c2)CCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=C(N&)CCS1",
"old_substring": "C3(=O)C=7"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C(N=Cc1ccc(F)c(Cl)c1)=C(Cl)Cl
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C(N=Cc1ccc(F)c(Cl)c1)=C(Cl)Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(N&)=C(Cl)Cl",
"old_substring": "C3(=O)C=7"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C(C=Cc1ccc(F)c(Cl)c1)=C(Cl)Cl
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C(C=Cc1ccc(F)c(Cl)c1)=C(Cl)Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C&)=C(Cl)Cl",
"old_substring": "C3(=O)C=7"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC[S@+]([O-])CCC=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)C=Cc1ccc(F)c(Cl)c1
|
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC[S@+]([O-])CCC=Cc1ccc(F)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C=7"
}
|
Can you make molecule Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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CC(CBr)=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1
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Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1
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CC(CBr)=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CBr",
"old_substring": "C5(C)C"
}
|
Can you make molecule Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC3(C)CCCC3)CC2)c1
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Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1
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Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC3(C)CCCC3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CCCC1",
"old_substring": "C5(C)C"
}
|
Can you make molecule Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(Cl)(Cl)Cl)CC2)c1
|
Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1
|
Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(Cl)(Cl)Cl)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C5(C)C"
}
|
Can you make molecule Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(C)=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1
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Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1
|
CCC(CC)C(C)=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)C(CC)CC",
"old_substring": "C5(C)C"
}
|
Can you make molecule Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1)N1CCCC1
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Cc1ccc(F)c(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1
|
CC(=NC(=O)C1CC[NH+](Cc2cc(C)ccc2F)CC1)N1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)N1CCCC1",
"old_substring": "C5(C)C"
}
|
Can you make molecule CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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CCn1nc(C)c(CNSC(=O)C[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
|
CCn1nc(C)c(CNSC(=O)C[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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CCn1nc(C)c(CNCC(=C=O)C[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
|
CCn1nc(C)c(CNCC(=C=O)C[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(CNC(=O)CCCC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)CCCC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(CNC(=O)CC(C)(C)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)CC(C)(C)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(CNC[S@+]([O-])CCC[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
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CCn1nc(C)c(CNC(=O)[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
|
CCn1nc(C)c(CNC[S@+]([O-])CCC[C@H]2[NH+]=c3ccccc3=C2NC(=O)c2cccc(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C47=O"
}
|
Can you make molecule COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)c(C)cc3Cl)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)c(C)cc3Cl)C2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)c(C)cc1Cl",
"old_substring": "c17cc(Cl)ccc1F"
}
|
Can you make molecule COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3ccc(Cl)cc3Br)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3ccc(Cl)cc3Br)C2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c17cc(Cl)ccc1F"
}
|
Can you make molecule COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)cc(Cl)c3Br)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)cc(Cl)c3Br)C2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cc(Cl)c1Br",
"old_substring": "c17cc(Cl)ccc1F"
}
|
Can you make molecule COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)sc3Cl)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)sc3Cl)C2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)sc1Cl",
"old_substring": "c17cc(Cl)ccc1F"
}
|
Can you make molecule COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Br)ccc3I)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Cl)ccc3F)C2)c2ccccc12
|
COc1ccc(C(=O)N2CCC[C@H](C(=O)Nc3cc(Br)ccc3I)C2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1I",
"old_substring": "c17cc(Cl)ccc1F"
}
|
Can you make molecule CCc1ccc(C=C(C#N)C(N)=O)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(C=C(C#N)C(N)=S)s1
|
CCc1ccc(C=C(C#N)C(N)=O)s1
|
CCc1ccc(C=C(C#N)C(N)=S)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C#N)C(N)=S",
"old_substring": "C=2(C#N)C(N)=O"
}
|
Can you make molecule CCc1ccc(C=C(C#N)C(N)=O)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(C=C(C#N)C#N)s1
|
CCc1ccc(C=C(C#N)C(N)=O)s1
|
CCc1ccc(C=C(C#N)C#N)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C#N)C#N",
"old_substring": "C=2(C#N)C(N)=O"
}
|
Can you make molecule CCc1ccc(C=C(C#N)C(N)=O)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(C=C(C)/N=N/C(N)=O)s1
|
CCc1ccc(C=C(C#N)C(N)=O)s1
|
CCc1ccc(C=C(C)/N=N/C(N)=O)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)/N=N/C(N)=O",
"old_substring": "C=2(C#N)C(N)=O"
}
|
Can you make molecule CCc1ccc(C=C(C#N)C(N)=O)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(C=C2SC(=S)N(N)C2=O)s1
|
CCc1ccc(C=C(C#N)C(N)=O)s1
|
CCc1ccc(C=C2SC(=S)N(N)C2=O)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&SC(=S)N(N)C1=O",
"old_substring": "C=2(C#N)C(N)=O"
}
|
Can you make molecule CCc1ccc(C=C(C#N)C(N)=O)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(C=CC(=O)NN=C(C)C)s1
|
CCc1ccc(C=C(C#N)C(N)=O)s1
|
CCc1ccc(C=CC(=O)NN=C(C)C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)=NNC(=O)C&",
"old_substring": "C=2(C#N)C(N)=O"
}
|
Can you make molecule COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COCc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COCSc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
CC(=O)Sc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
O=C(CS)c1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
COc1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
|
O=C(CI)c1cccc(N2C(=O)Nc3ccccc3[C@]2(O)C(=O)NCc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1sccc1NSC(=O)C[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NSC(=O)C[C@@H]1CC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1sccc1NCC(=C=O)C[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NCC(=C=O)C[C@@H]1CC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1sccc1NC(=O)CCCC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)CCCC(=O)[C@@H]1CC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1sccc1NC(=O)CC(C)(C)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)CC(C)(C)[C@@H]1CC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1sccc1NC[S@+]([O-])CCC[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC(=O)[C@@H]1CC[NH2+][C@@H]1C
|
COC(=O)c1sccc1NC[S@+]([O-])CCC[C@@H]1CC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C36=O"
}
|
Can you make molecule C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCCCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCCCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C35"
}
|
Can you make molecule C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/N=CCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/N=CCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C35"
}
|
Can you make molecule C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCCCCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCCCCCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C35"
}
|
Can you make molecule C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NC1CC(c2ccc([N+]3=CCCC3)cc2)C1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NC1CC(c2ccc([N+]3=CCCC3)cc2)C1)N[C@H]1CC[C@@H](SC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C35"
}
|
Can you make molecule C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NOC(=S)Sc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NCc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
|
C/[NH+]=C(/NOC(=S)Sc1ccc([N+]2=CCCC2)cc1)N[C@H]1CC[C@@H](SC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C35"
}
|
Can you make molecule N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1c(C(=O)N2CC[C@H]3CCCC[C@@H]32)sc2c1CCCC2
|
N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1c(C(=O)N2CC[C@H]3CCCC[C@@H]32)sc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&sc2c1CCCC2",
"old_substring": "N#Cc1csc5c1"
}
|
Can you make molecule N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1c(C(=O)N2CC[C@H]3CCCC[C@@H]32)sc2c1CCCCC2
|
N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1c(C(=O)N2CC[C@H]3CCCC[C@@H]32)sc2c1CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&sc2c1CCCCC2",
"old_substring": "N#Cc1csc5c1"
}
|
Can you make molecule N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1Br
|
N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1cccc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cccc&c1Br",
"old_substring": "N#Cc1csc5c1"
}
|
Can you make molecule N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(Cl)c(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1ccc(Cl)c(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1ccc(Cl)c&c1",
"old_substring": "N#Cc1csc5c1"
}
|
Can you make molecule N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(F)c(C(=O)N2CC[C@H]3CCCC[C@@H]32)cc1Cl
|
N#Cc1csc(C(=O)N2CC[C@H]3CCCC[C@@H]32)c1
|
N#Cc1cc(F)c(C(=O)N2CC[C@H]3CCCC[C@@H]32)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc(F)c&cc1Cl",
"old_substring": "N#Cc1csc5c1"
}
|
Can you make molecule Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(Cl)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(Cl)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c15ccc(F)c(F)c1"
}
|
Can you make molecule Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(Cl)c2F)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(Cl)c2F)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1F",
"old_substring": "c15ccc(F)c(F)c1"
}
|
Can you make molecule Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(Cl)c(I)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(Cl)c(I)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c15ccc(F)c(F)c1"
}
|
Can you make molecule Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(I)c(C)c2C)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(I)c(C)c2C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)c(C)c1C",
"old_substring": "c15ccc(F)c(F)c1"
}
|
Can you make molecule Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C=C[S@+]([O-])[C@@H](C)C(=O)Nc2cccc(C)c2C)ccc1F
|
Cc1cccc(NC(=O)[C@H](C)[S@@+]([O-])Cc2ccc(F)c(F)c2)c1C
|
Cc1cc(C=C[S@+]([O-])[C@@H](C)C(=O)Nc2cccc(C)c2C)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccc(F)c(C)c1",
"old_substring": "c15ccc(F)c(F)c1"
}
|
Can you make molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(CCC[C@@H](CCl)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc(CCC[C@@H](CCl)NC(=O)c2ccc(Cn3cccn3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]59C"
}
|
Can you make molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(CCC2=CN=N[C@H]2NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc(CCC2=CN=N[C@H]2NC(=O)c2ccc(Cn3cccn3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]59C"
}
|
Can you make molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc([C@@H]2CC[C@@H](NC(=O)c3ccc(Cn4cccn4)cc3)C2)c1
|
CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc([C@@H]2CC[C@@H](NC(=O)c3ccc(Cn4cccn4)cc3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]59C"
}
|
Can you make molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(CC(C)(C)[C@@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CNS(=O)(=O)c1cccc(CC(C)(C)[C@@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]59C"
}
|
Can you make molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1cccc(S(=O)(=O)NC)c1)NC(=O)c1ccc(Cn2cccn2)cc1
|
CNS(=O)(=O)c1cccc([C@H](C)NC(=O)c2ccc(Cn3cccn3)cc2)c1
|
CC[C@@H](CCc1cccc(S(=O)(=O)NC)c1)NC(=O)c1ccc(Cn2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]59C"
}
|
Can you make molecule CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2Cl)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccc(I)cc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccc(I)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccc(C)c(I)c2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccc(C)c(I)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2cccc(Br)c2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2cccc(Br)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2cccc(C)c2C)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2ccccc2)C1
|
CC[NH2+][C@@]1(C(=O)OC)CCC[C@@H](Oc2cccc(C)c2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCn1c(C)c(C)c(C#N)c1NSC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NSC(=O)C[NH+]1CC(C)(C)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CCCC(=O)[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CCCC(=O)[NH+]1CC(C)(C)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CC(C)(C)[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CC(C)(C)[NH+]1CC(C)(C)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCn1c(C)c(C)c(C#N)c1NC[S@+]([O-])CCC[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC[S@+]([O-])CCC[NH+]1CC(C)(C)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CCC(C)(C)[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)C[NH+]1CC(C)(C)C1(C)C
|
COCCCn1c(C)c(C)c(C#N)c1NC(=O)CCC(C)(C)[NH+]1CC(C)(C)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C=C[C@H](c2ccccc2Cl)C1
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C=C[C@H](c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[C@H]13C[C@H]14"
}
|
Can you make molecule C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCC[C@H](c2ccccc2Cl)C1
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCC[C@H](c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]13C[C@H]14"
}
|
Can you make molecule C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C=C[C@@H](c2ccccc2Cl)C1
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C=C[C@@H](c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[C@H]13C[C@H]14"
}
|
Can you make molecule C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCCC[C@H](c2ccccc2Cl)C1
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCCC[C@H](c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@H]13C[C@H]14"
}
|
Can you make molecule C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCC[C@H](c2ccccc2Cl)CC1
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1C[C@H]1c1ccccc1Cl
|
C[C@@H]1CCC[C@H](C)N1C(=O)[C@H]1CCC[C@H](c2ccccc2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@H]13C[C@H]14"
}
|
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