prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NSC(=O)C[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NSC(=O)C[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C26=O"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NCC(=C=O)C[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NCC(=C=O)C[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C26=O"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)CCCC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)CCCC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C26=O"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)CC(C)(C)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)CC(C)(C)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C26=O"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC[S@+]([O-])CCC[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
|
COc1ccc(C)cc1NC[S@+]([O-])CCC[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C26=O"
}
|
Can you make molecule CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2SC(=O)Cc1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2SC(=O)Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CCCC(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CCCC(=O)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CC(C)(C)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CC(C)(C)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CCC(C)(C)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)CCC(C)(C)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2SC(=O)[C@@H](C)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2C(=O)c1ccc(F)cc1
|
CC[NH+]1CCC2(CC1)OC[C@H](C(=O)[O-])N2SC(=O)[C@@H](C)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1I)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1I)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c14ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1Br)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1Br)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c14ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)c(I)c1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)c(I)c1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c14ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1cc(Cl)ccc1Cl)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1cc(Cl)ccc1Cl)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c14ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)c(Cl)c1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)cc1)CC2
|
Cc1ccc2c(c1)N(C(=O)C[C@H](O)c1ccc(Cl)c(Cl)c1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c14ccc(Cl)cc1"
}
|
Can you make molecule O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1OC[C@H](CO)O1
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1OC[C@H](CO)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&OC[C@H]&O1",
"old_substring": "[C@@H]14O[C@H]3[C@@H](O)[C@H]1O"
}
|
Can you make molecule O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@@H](CO)O1
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@@H](CO)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&O1",
"old_substring": "[C@@H]14O[C@H]3[C@@H](O)[C@H]1O"
}
|
Can you make molecule O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1N=C[C@H](CO)O1
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1N=C[C@H](CO)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=C[C@H]&O1",
"old_substring": "[C@@H]14O[C@H]3[C@@H](O)[C@H]1O"
}
|
Can you make molecule O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@@H](CO)C1
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@@H](CO)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]14O[C@H]3[C@@H](O)[C@H]1O"
}
|
Can you make molecule O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@H](CO)O1
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
O=c1[nH]cnc2c1[nH]c(=S)n2[C@@H]1CC[C@H](CO)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@H]&O1",
"old_substring": "[C@@H]14O[C@H]3[C@@H](O)[C@H]1O"
}
|
Can you make molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2c(n1NC(=O)C[C@@H]1CCCc3ccccc31)CCCC2
|
Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2
|
Cc1cc2c(n1NC(=O)C[C@@H]1CCCc3ccccc31)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc2c(n1&)CCCC2",
"old_substring": "Cc1cn2c([nH+]1)CC[C@H]5C2"
}
|
Can you make molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1CCCc2ccccc21)Nc1nc2c([nH]1)CCCC2
|
Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2
|
O=C(C[C@@H]1CCCc2ccccc21)Nc1nc2c([nH]1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2c([nH]1)CCCC2",
"old_substring": "Cc1cn2c([nH+]1)CC[C@H]5C2"
}
|
Can you make molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2c(cc1NC(=O)C[C@@H]1CCCc3ccccc31)CCCC2
|
Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2
|
Cc1cc2c(cc1NC(=O)C[C@@H]1CCCc3ccccc31)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc2c(cc1&)CCCC2",
"old_substring": "Cc1cn2c([nH+]1)CC[C@H]5C2"
}
|
Can you make molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NC(=O)C[C@@H]2CCCc3ccccc32)nc2c1CCCC2
|
Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2
|
Cc1nc(NC(=O)C[C@@H]2CCCc3ccccc32)nc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc&nc2c1CCCC2",
"old_substring": "Cc1cn2c([nH+]1)CC[C@H]5C2"
}
|
Can you make molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2nc(NC(=O)C[C@@H]3CCCc4ccccc43)[nH]c12
|
Cc1cn2c([nH+]1)CC[C@H](NC(=O)C[C@@H]1CCCc3ccccc31)C2
|
Cc1cccc2nc(NC(=O)C[C@@H]3CCCc4ccccc43)[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cccc2nc&[nH]c12",
"old_substring": "Cc1cn2c([nH+]1)CC[C@H]5C2"
}
|
Can you make molecule CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CCCC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC6=O"
}
|
Can you make molecule CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CCCCC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC6=O"
}
|
Can you make molecule CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)CCCc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CC6=O"
}
|
Can you make molecule CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CCC(=O)CCCc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CC6=O"
}
|
Can you make molecule CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Cc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CC(=O)c1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
|
CCCCC(=O)Cc1cc(CN2CCC3=NN=C(c4ccccc4F)[C@@H]3C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC(=O)C&",
"old_substring": "CC6=O"
}
|
Can you make molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCCCC2)cn1)[C@@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N14CCCCC1"
}
|
Can you make molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCCCCC2)cn1)[C@@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N14CCCCC1"
}
|
Can you make molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCC(C)(C)C2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCC(C)(C)C2)cn1)[C@@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)C1",
"old_substring": "N14CCCCC1"
}
|
Can you make molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCC(C)(C)CC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCC(C)(C)CC2)cn1)[C@@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)CC1",
"old_substring": "N14CCCCC1"
}
|
Can you make molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Nc1ccc(S(=O)(=O)N2CC3(CCCCC3)C2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CCCCC2)cn1)[C@@H](C)CO
|
C[C@H](Nc1ccc(S(=O)(=O)N2CC3(CCCCC3)C2)cn1)[C@@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC2(CCCCC2)C1",
"old_substring": "N14CCCCC1"
}
|
Can you make molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2c(Cl)cccc2Cl)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2c(Cl)cccc2Cl)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1&",
"old_substring": "c18cccc(C)c1"
}
|
Can you make molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cc(C)c(Cl)c(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cc(C)c(Cl)c(C)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(C)c1Cl",
"old_substring": "c18cccc(C)c1"
}
|
Can you make molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cc3cc(Cl)ccc3o2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cc3cc(Cl)ccc3o2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(Cl)ccc2o1",
"old_substring": "c18cccc(C)c1"
}
|
Can you make molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(/C=C/Br)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(/C=C/Br)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(/C=C/Br)c1",
"old_substring": "c18cccc(C)c1"
}
|
Can you make molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2ccc3sc(Cl)nc3c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C
|
COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2ccc3sc(Cl)nc3c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2sc(Cl)nc2c1",
"old_substring": "c18cccc(C)c1"
}
|
Can you make molecule CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCS(=O)(=O)[N-]c1ccc(NSC(=O)C[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NSC(=O)C[C@H]2CCC[NH+](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCS(=O)(=O)[N-]c1ccc(NCC(=C=O)C[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NCC(=C=O)C[C@H]2CCC[NH+](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)CCCC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)CCCC(=O)[C@H]2CCC[NH+](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)CC(C)(C)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)CC(C)(C)[C@H]2CCC[NH+](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCS(=O)(=O)[N-]c1ccc(NC[S@+]([O-])CCC[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC(=O)[C@H]2CCC[NH+](C)C2)cc1
|
CCCCS(=O)(=O)[N-]c1ccc(NC[S@+]([O-])CCC[C@H]2CCC[NH+](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C37=O"
}
|
Can you make molecule Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4ccc(Cl)s4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4ccc(Cl)s4)o3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c19cccs1"
}
|
Can you make molecule Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4ccc(Br)s4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4ccc(Br)s4)o3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c19cccs1"
}
|
Can you make molecule Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4sccc4Br)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4sccc4Br)o3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c19cccs1"
}
|
Can you make molecule Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4csc(I)c4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4csc(I)c4)o3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c19cccs1"
}
|
Can you make molecule Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cc5c(s4)CSC5)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
|
Fc1ccc(Oc2ccnc(Sc3nnc(-c4cc5c(s4)CSC5)o3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c19cccs1"
}
|
Can you make molecule N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccccc1.Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21
|
N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1
|
Clc1ccccc1.Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Ic1ccccc1
|
N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Ic1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Fc1ccc(F)cc1
|
N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Fc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1F",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C.Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21
|
N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1
|
Cc1ccccc1C.Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Fc1cccc(F)c1
|
N#Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)c2cn(Cc3ccccc3)c3ccccc23)cc1
|
Cn1cc(C(=O)N2CSC[C@H]2C(=O)Nc2ccc(C#N)cc2)c2ccccc21.Fc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1F",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCCl)Cn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](CCCl)Cn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&)CCCl",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CCCl)Cn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@H](CCCl)Cn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CCCl",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)CCCn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](Cl)CCCn1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)CCC&",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)C[C@H](CC)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)C[C@H](CC)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&C[C@H](C)CC",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
|
CC[C@@H](Cl)[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)[C@H]&C",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CN(C)C1CCOCC1)c1ncc(-c2ccc(C)cc2)o1
|
Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1
|
CCC(CC)(C(=O)CN(C)C1CCOCC1)c1ncc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCN(C)C1CCOCC1)c1ncc(-c2ccc(C)cc2)o1
|
Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1
|
CCC(CC)(C(=O)CCN(C)C1CCOCC1)c1ncc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1ncc(-c2ccc(C)cc2)o1)[S@+]([O-])CN(C)C1CCOCC1
|
Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1
|
CC[C@H](c1ncc(-c2ccc(C)cc2)o1)[S@+]([O-])CN(C)C1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&[S@](=O)C&",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](C(=O)c1ncc(-c2ccc(C)cc2)o1)C(=O)N(C)C1CCOCC1
|
Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1
|
CCCC[C@H](C(=O)c1ncc(-c2ccc(C)cc2)o1)C(=O)N(C)C1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H](C&=O)C&=O",
"old_substring": "C6CC4=O"
}
|
Can you make molecule Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cnc(CCC[S@+]([O-])[C@@H](C)N(C)C3CCOCC3)o2)cc1
|
Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1
|
Cc1ccc(-c2cnc(CCC[S@+]([O-])[C@@H](C)N(C)C3CCOCC3)o2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "C6CC4=O"
}
|
Can you make molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1Cl
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c15ccc(F)cc1"
}
|
Can you make molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1Br
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c15ccc(F)cc1"
}
|
Can you make molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)c(Cl)c1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c15ccc(F)cc1"
}
|
Can you make molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(I)cc1F
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(I)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c15ccc(F)cc1"
}
|
Can you make molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1cc2c(F)cccc2s1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1
|
C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1cc2c(F)cccc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c15ccc(F)cc1"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOSC(=O)Cc1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOSC(=O)Cc1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C39=O"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)CCCC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)CCCC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C39=O"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)CC(C)(C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)CC(C)(C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C39=O"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)CCC(C)(C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)CCC(C)(C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C39=O"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOSC(=O)[C@@H](C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOC(=O)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
|
CCOSC(=O)[C@@H](C)c1c(NC(=O)[C@H]2CCCN2S(C)(=O)=O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C39=O"
}
|
Can you make molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)Cc2ccc(C)c(C)c2O)cc1
|
Cc1ccc(C(=O)Cc2cccc(O)c2)cc1
|
Cc1ccc(C(=O)Cc2ccc(C)c(C)c2O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&c(O)c1C",
"old_substring": "c14cccc(O)c1"
}
|
Can you make molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)Cc2cccc(C)c2C)cc1
|
Cc1ccc(C(=O)Cc2cccc(O)c2)cc1
|
Cc1ccc(C(=O)Cc2cccc(C)c2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c14cccc(O)c1"
}
|
Can you make molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)Cc2cccc(F)c2F)cc1
|
Cc1ccc(C(=O)Cc2cccc(O)c2)cc1
|
Cc1ccc(C(=O)Cc2cccc(F)c2F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(F)c1F",
"old_substring": "c14cccc(O)c1"
}
|
Can you make molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)Cc2ccc(I)cc2)cc1
|
Cc1ccc(C(=O)Cc2cccc(O)c2)cc1
|
Cc1ccc(C(=O)Cc2ccc(I)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c14cccc(O)c1"
}
|
Can you make molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)Cc2ccc(C)cc2C=O)cc1
|
Cc1ccc(C(=O)Cc2cccc(O)c2)cc1
|
Cc1ccc(C(=O)Cc2ccc(C)cc2C=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&c(C=O)c1",
"old_substring": "c14cccc(O)c1"
}
|
Can you make molecule Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)cc1I
|
Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1ccc(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccccc15"
}
|
Can you make molecule Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)cc1Cl
|
Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1ccc(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccccc15"
}
|
Can you make molecule Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1cc(I)ccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1ccccc15"
}
|
Can you make molecule Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)c1
|
Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1ccc(I)c(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccccc15"
}
|
Can you make molecule Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)c1
|
Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
|
Cc1ccc(Br)c(-c2nn(CN3CCCc4ccc(S(C)(=O)=O)cc43)c(=S)o2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccccc15"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)cc1I
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1
|
CCOc1ccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c14cccc7c1"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)ccc1Br
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1
|
CCOc1cc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c14cccc7c1"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)cc1Cl
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1
|
CCOc1ccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c14cccc7c1"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1Br
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c14cccc7c1"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1Cl
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1
|
CCOc1cccc([C@H](C)NC[C@@](C)(O)c2ccc(F)cc2F)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c14cccc7c1"
}
|
Can you make molecule CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1CCCCCN1SC(=O)Cc1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1SC(=O)Cc1cnc2sc(C)cn2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C34=O"
}
|
Can you make molecule CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1CCCCCN1C(=O)CCCC(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)CCCC(=O)c1cnc2sc(C)cn2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C34=O"
}
|
Can you make molecule CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1CCCCCN1C(=O)CC(C)(C)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)CC(C)(C)c1cnc2sc(C)cn2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1CCCCCN1C(=O)CCC(C)(C)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)CCC(C)(C)c1cnc2sc(C)cn2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H]1CCCCCN1SC(=O)[C@@H](C)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1C(=O)c1cnc2sc(C)cn2c1=O
|
CC[C@@H]1CCCCCN1SC(=O)[C@@H](C)c1cnc2sc(C)cn2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C34=O"
}
|
Can you make molecule N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(OCC(=O)NCc2ccc(CO)cc2I)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1
|
N#Cc1ccc(OCC(=O)NCc2ccc(CO)cc2I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17cccc8c1"
}
|
Can you make molecule N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(OCC(=O)NCc2cc(CO)ccc2Br)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1
|
N#Cc1ccc(OCC(=O)NCc2cc(CO)ccc2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17cccc8c1"
}
|
Can you make molecule N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(OCC(=O)NCc2ccc(CO)cc2Cl)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1
|
N#Cc1ccc(OCC(=O)NCc2ccc(CO)cc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17cccc8c1"
}
|
Can you make molecule N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2Br)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17cccc8c1"
}
|
Can you make molecule N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2Cl)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2)cc1
|
N#Cc1ccc(OCC(=O)NCc2cccc(CO)c2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17cccc8c1"
}
|
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