prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2nc(CNC(=O)CC(C)(C)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)CC(C)(C)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2nc(CNC(=O)CCC(C)(C)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)CCC(C)(C)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2nc(CNc3c(C)n(C)n(N[C@@H]4C[C@](C)(OC)C4(C)C)c3=O)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNc3c(C)n(C)n(N[C@@H]4C[C@](C)(OC)C4(C)C)c3=O)n[nH]2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C45=O"
}
|
Can you make molecule COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2nc(CNc3nn(N[C@@H]4C[C@](C)(OC)C4(C)C)c(C)cc3=O)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNc3nn(N[C@@H]4C[C@](C)(OC)C4(C)C)c(C)cc3=O)n[nH]2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C45=O"
}
|
Can you make molecule COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2nc(CNC(=O)C[C@@H](Br)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
|
COc1ccc(-c2nc(CNC(=O)C[C@@H](Br)N[C@@H]3C[C@](C)(OC)C3(C)C)n[nH]2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
}
|
Can you make molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+](C[C@H]1[C@H](N)C(C)(C)OC1(C)C)OCOC
|
CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](C[C@H]1[C@H](N)C(C)(C)OC1(C)C)OCOC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCO&",
"old_substring": "C3CO"
}
|
Can you make molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CO[NH+](CCC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
C=CO[NH+](CCC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CO&",
"old_substring": "C3CO"
}
|
Can you make molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+](C[C@H]1[C@H](N)C(C)(C)OC1(C)C)C(=O)CC
|
CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](C[C@H]1[C@H](N)C(C)(C)OC1(C)C)C(=O)CC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "C3CO"
}
|
Can you make molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=C=CO[NH+](CCC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
C=C=CO[NH+](CCC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C=CO&",
"old_substring": "C3CO"
}
|
Can you make molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+](CC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
|
CCC[NH+](CC)C[C@H]1[C@H](N)C(C)(C)OC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&",
"old_substring": "C3CO"
}
|
Can you make molecule O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1ccc(-n2ccnc2)cc1I)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccc(-n2ccnc2)cc1I)C(=O)Nc1ccc2[nH]ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccccc18"
}
|
Can you make molecule O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1cc(-n2ccnc2)ccc1Br)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1cc(-n2ccnc2)ccc1Br)C(=O)Nc1ccc2[nH]ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccccc18"
}
|
Can you make molecule O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1ccc(-n2ccnc2)cc1Cl)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccc(-n2ccnc2)cc1Cl)C(=O)Nc1ccc2[nH]ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccccc18"
}
|
Can you make molecule O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1cccc(-n2ccnc2)c1Br)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1cccc(-n2ccnc2)c1Br)C(=O)Nc1ccc2[nH]ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccccc18"
}
|
Can you make molecule O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1cccc(-n2ccnc2)c1Cl)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1ccccc1-n1ccnc1)C(=O)Nc1ccc2[nH]ccc2c1
|
O=C(NCc1cccc(-n2ccnc2)c1Cl)C(=O)Nc1ccc2[nH]ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccccc18"
}
|
Can you make molecule CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c(C(=O)CCCC(=O)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CCCC(=O)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C6(=O)C7"
}
|
Can you make molecule CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c(C(=O)CC(C)(C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CC(C)(C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C6(=O)C7"
}
|
Can you make molecule CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c(C(=O)CCC(C)(C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CCC(C)(C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C6(=O)C7"
}
|
Can you make molecule CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c(C(=O)C[C@H](C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)C[C@H](C)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "C6(=O)C7"
}
|
Can you make molecule CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c(C(=O)C[C@@H](Br)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)CN3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
|
CCc1cccc2c(C(=O)C[C@@H](Br)N3C(=O)N[C@]4(CCCc5ccccc54)C3=O)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C6(=O)C7"
}
|
Can you make molecule CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC1=NN2C(=N)C(=C[C@@](C)(CCC)CC(C)C)C(=O)N=C2S1
|
CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1
|
CCCC1=NN2C(=N)C(=C[C@@](C)(CCC)CC(C)C)C(=O)N=C2S1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@](C)(C&)C&",
"old_substring": "C=4c1ccc5cc1"
}
|
Can you make molecule CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(C)(C)C=Cc1ccc(C(C)C)cc1
|
CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1
|
CCCCCC(C)(C)C=Cc1ccc(C(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC(C)(C)C&",
"old_substring": "CCCC1=NN2C(=N)C=4C(=O)N=C2S1"
}
|
Can you make molecule CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=Cc1ccc(C(C)C)cc1)CCC
|
CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1
|
CCCC(=Cc1ccc(C(C)C)cc1)CCC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&CCC",
"old_substring": "CCCC1=NN2C(=N)C=4C(=O)N=C2S1"
}
|
Can you make molecule CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1=C(C)C(=Cc2ccc(C(C)C)cc2)N=C1C
|
CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1
|
CCC1=C(C)C(=Cc2ccc(C(C)C)cc2)N=C1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC1=C(C)C=&N=C1C",
"old_substring": "CCCC1=NN2C(=N)C=4C(=O)N=C2S1"
}
|
Can you make molecule CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=Cc1ccc(C(C)C)cc1)(CC)CC
|
CCCC1=NN2C(=N)C(=Cc3ccc(C(C)C)cc3)C(=O)N=C2S1
|
CCC(C=Cc1ccc(C(C)C)cc1)(CC)CC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(C&)(CC)CC",
"old_substring": "CCCC1=NN2C(=N)C=4C(=O)N=C2S1"
}
|
Can you make molecule Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(O[C@H](C)CNSC(=O)C[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNSC(=O)C[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(O[C@H](C)CNCC(=C=O)C[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNCC(=C=O)C[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(O[C@H](C)CNC(=O)CCCC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)CCCC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(O[C@H](C)CNC(=O)CC(C)(C)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)CC(C)(C)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(O[C@H](C)CNC[S@+]([O-])CCC[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
|
Cc1ccc(O[C@H](C)CNC[S@+]([O-])CCC[C@H]2CS[C@@]3(C)CCC(=O)N23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
Cc1cc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&sc1&",
"old_substring": "Cc1nc4sc13"
}
|
Can you make molecule Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2ccc(F)cc2)cc1C(=O)NNC(=O)C(C)(C)C
|
Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
Cc1ccc(-c2ccc(F)cc2)cc1C(=O)NNC(=O)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1&",
"old_substring": "Cc1nc4sc13"
}
|
Can you make molecule Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)NNC(=O)c1cc2sc(-c3ccc(F)cc3)nc2s1
|
Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
CC(C)(C)C(=O)NNC(=O)c1cc2sc(-c3ccc(F)cc3)nc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2sc&cc2s1",
"old_substring": "Cc1nc4sc13"
}
|
Can you make molecule Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(-c2ccc(F)cc2)csc1C(=O)NNC(=O)C(C)(C)C
|
Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
Cc1c(-c2ccc(F)cc2)csc1C(=O)NNC(=O)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc&c1C",
"old_substring": "Cc1nc4sc13"
}
|
Can you make molecule Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)NNC(=O)c1ccc(C#CCc2ccc(F)cc2)s1
|
Cc1nc(-c2ccc(F)cc2)sc1C(=O)NNC(=O)C(C)(C)C
|
CC(C)(C)C(=O)NNC(=O)c1ccc(C#CCc2ccc(F)cc2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C#Cc1ccc&s1",
"old_substring": "Cc1nc4sc13"
}
|
Can you make molecule O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2I)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2I)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cc(C(F)(F)F)ccc2Br)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cc(C(F)(F)F)ccc2Br)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2Cl)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2Cl)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cccc(C(F)(F)F)c2Br)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cccc(C(F)(F)F)c2Br)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cccc(C(F)(F)F)c2Cl)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
|
O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2cccc(C(F)(F)F)c2Cl)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)C(=Cc3c(CCS(=O)(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(CCS(=O)(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C7(=O)[O-]"
}
|
Can you make molecule COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)CO)[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)CO)[nH]c4cc(OC)ccc34)SC2=S)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C7(=O)[O-]"
}
|
Can you make molecule COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)C(=Cc3c(C(O)O)[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(O)O)[nH]c4cc(OC)ccc34)SC2=S)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C7(=O)[O-]"
}
|
Can you make molecule COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)[O-])c1[nH]c2cc(OC)ccc2c1C=C1SC(=S)N(c2ccc(OC)cc2)C1=O
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
CCC(CC)(C(=O)[O-])c1[nH]c2cc(OC)ccc2c1C=C1SC(=S)N(c2ccc(OC)cc2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C7(=O)[O-]"
}
|
Can you make molecule COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N2C(=O)C(=Cc3c(CCCS(=O)(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(C(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
|
COc1ccc(N2C(=O)C(=Cc3c(CCCS(=O)(=O)[O-])[nH]c4cc(OC)ccc34)SC2=S)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C7(=O)[O-]"
}
|
Can you make molecule Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1I
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c15ccc6cc1"
}
|
Can you make molecule Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1oncc1C(=O)Nc1cc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)ccc1Br
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1
|
Cc1oncc1C(=O)Nc1cc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c15ccc6cc1"
}
|
Can you make molecule Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1Cl
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c15ccc6cc1"
}
|
Can you make molecule Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1oncc1C(=O)Nc1cccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)c1Br
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1
|
Cc1oncc1C(=O)Nc1cccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c15ccc6cc1"
}
|
Can you make molecule Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1oncc1C(=O)Nc1cccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)c1Cl
|
Cc1oncc1C(=O)Nc1ccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cc1
|
Cc1oncc1C(=O)Nc1cccc([N-]S(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c15ccc6cc1"
}
|
Can you make molecule CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](CC)Cc1nc2c(s1)CN(C(=O)Nc1ccc(C#N)cc1)C2
|
CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)Cc1nc2c(s1)CN(C(=O)Nc1ccc(C#N)cc1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N24"
}
|
Can you make molecule CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](CC)Cn1ncc2c1CN(C(=O)Nc1ccc(C#N)cc1)C2
|
CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)Cn1ncc2c1CN(C(=O)Nc1ccc(C#N)cc1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2cnn&c2C1",
"old_substring": "N24"
}
|
Can you make molecule CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](CC)Cc1onc2c1CN(C(=O)Nc1ccc(C#N)cc1)CC2
|
CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)Cc1onc2c1CN(C(=O)Nc1ccc(C#N)cc1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2noc&c2C1",
"old_substring": "N24"
}
|
Can you make molecule CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](CC)Cc1cc2n(n1)CCCN2C(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)Cc1cc2n(n1)CCCN2C(=O)Nc1ccc(C#N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N24"
}
|
Can you make molecule CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](CC)Cc1ccc2c(c1)CCN2C(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)CNC(=O)Nc1ccc(C#N)cc1
|
CCCC[C@H](CC)Cc1ccc2c(c1)CCN2C(=O)Nc1ccc(C#N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N24"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1ccc(C(=O)N(C)CCC(F)(F)F)cc1I
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1
|
CCOc1ccccc1-c1ccc(C(=O)N(C)CCC(F)(F)F)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cc(C(=O)N(C)CCC(F)(F)F)ccc1Br
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1
|
CCOc1ccccc1-c1cc(C(=O)N(C)CCC(F)(F)F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1ccc(C(=O)N(C)CCC(F)(F)F)cc1Cl
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1
|
CCOc1ccccc1-c1ccc(C(=O)N(C)CCC(F)(F)F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1Br
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1Cl
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1
|
CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17cccc6c1"
}
|
Can you make molecule Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)cc(C)c1NSC(=O)Cc1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NSC(=O)Cc1nnn[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)cc(C)c1NC(=O)CCCC(=O)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)CCCC(=O)c1nnn[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)cc(C)c1NC(=O)CC(C)(C)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)CC(C)(C)c1nnn[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)cc(C)c1NC(=O)CCC(C)(C)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1
|
Cc1cc(Br)cc(C)c1NC(=O)CCC(C)(C)c1nnn[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)cc(C)c1NSC(=O)[C@@H](C)c1nnn[n-]1
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Cc1cc(Br)cc(C)c1NC(=O)c1nnn[n-]1
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Cc1cc(Br)cc(C)c1NSC(=O)[C@@H](C)c1nnn[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(-c2ccccc2)oc2c(C(=O)N(CCC(C)C)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
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CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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Cc1c(-c2ccccc2)oc2c(C(=O)N(CCC(C)C)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(-c2ccccc2)oc2c(C(=O)N(CCCCBr)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
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CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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Cc1c(-c2ccccc2)oc2c(C(=O)N(CCCCBr)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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C=CCCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(-c2ccccc2)oc2c(C(=O)N(CCCCCl)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
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CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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Cc1c(-c2ccccc2)oc2c(C(=O)N(CCCCCl)[C@@H]3CCS(=O)(=O)C3)cccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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CCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
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C=CCCCCN(C(=O)c1cccc2c(=O)c(C)c(-c3ccccc3)oc12)[C@@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC5"
}
|
Can you make molecule Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nn(C)c(=O)c(CC(=O)SNCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(CC(=O)SNCC(C)(C)c2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nn(C)c(=O)c(C(=O)CCCC(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)CCCC(=O)NCC(C)(C)c2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nn(C)c(=O)c(C(C)(C)CC(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(C)(C)CC(=O)NCC(C)(C)c2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nn(C)c(=O)c(C(C)(C)CCC(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(C)(C)CCC(=O)NCC(C)(C)c2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nn(C)c(=O)c([C@H](C)C(=O)SNCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c(C(=O)NCC(C)(C)c2ccccc2)c1C
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Cc1nn(C)c(=O)c([C@H](C)C(=O)SNCC(C)(C)c2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1 less soluble in water? The output molecule should be similar to the input molecule.
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NC(=O)c1cccc(CNSC(=O)C[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNSC(=O)C[C@@H]2C[C@H]3CC[C@@H]2O3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1 less soluble in water? The output molecule should be similar to the input molecule.
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NC(=O)c1cccc(CNCC(=C=O)C[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNCC(=C=O)C[C@@H]2C[C@H]3CC[C@@H]2O3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNC(=O)CCCC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC(=O)CCCC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCc1cccc(C(N)=O)c1)[C@@H]1C[C@H]2CC[C@@H]1O2
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NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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CC(C)(CC(=O)NCc1cccc(C(N)=O)c1)[C@@H]1C[C@H]2CC[C@@H]1O2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNC[S@+]([O-])CCC[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1
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NC(=O)c1cccc(CNC[S@+]([O-])CCC[C@@H]2C[C@H]3CC[C@@H]2O3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])ccc1NC1=C2C=CC=C2C=C(C=Cc2ccccc2)CO1
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CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C
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Cc1cc([N+](=O)[O-])ccc1NC1=C2C=CC=C2C=C(C=Cc2ccccc2)CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=Cc2cccc&c2OC1",
"old_substring": "CC=4C2=O"
}
|
Can you make molecule CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])ccc1N=C1CCCC(=Cc2ccccc2)C1=O
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CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C
|
Cc1cc([N+](=O)[O-])ccc1N=C1CCCC(=Cc2ccccc2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC=&C1=O",
"old_substring": "CC=4C2=O"
}
|
Can you make molecule CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCC=Cc1ccccc1)=Nc1ccc([N+](=O)[O-])cc1C
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CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C
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CC(CCC=Cc1ccccc1)=Nc1ccc([N+](=O)[O-])cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCC=&C",
"old_substring": "CC=4C2=O"
}
|
Can you make molecule CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CC=C(C=Cc2ccccc2)O1
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CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C
|
Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CC=C(C=Cc2ccccc2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CC[C@@H]&O1",
"old_substring": "CC=4C2=O"
}
|
Can you make molecule CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([N+](=O)[O-])ccc1NCCCC=Cc1ccccc1
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CC(=Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C
|
Cc1cc([N+](=O)[O-])ccc1NCCCC=Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "CC=4C2=O"
}
|
Can you make molecule COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
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COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
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COCc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
|
COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
|
COCSc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1SC(C)=O
|
COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1SC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1C(=O)CS
|
COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1C(=O)CS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1C(=O)CI
|
COc1ccc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)cc1OC
|
COc1cc([C@@H]2c3c(-c4ccc(Cl)cc4)n[nH]c3C(=O)N2C2CCCC2)ccc1C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H]1c2ccccc2C[C@H]1CCCCC(F)(F)F
|
O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F
|
O[C@@H]1c2ccccc2C[C@H]1CCCCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C3CC(F)(F)F"
}
|
Can you make molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)CCC[C@@H]1Cc2ccccc2[C@H]1O
|
O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F
|
CC(C)(C)CCC[C@@H]1Cc2ccccc2[C@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C3CC(F)(F)F"
}
|
Can you make molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(CS)C[C@@H]1Cc2ccccc2[C@H]1O
|
O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F
|
CCC(CC)(CS)C[C@@H]1Cc2ccccc2[C@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(C&)(CC)CS",
"old_substring": "C3CC(F)(F)F"
}
|
Can you make molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(CC)C[C@@H]1Cc2ccccc2[C@H]1O
|
O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F
|
CCC(CC)(CC)C[C@@H]1Cc2ccccc2[C@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(C&)(CC)CC",
"old_substring": "C3CC(F)(F)F"
}
|
Can you make molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(Br)(CC)C[C@@H]1Cc2ccccc2[C@H]1O
|
O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F
|
CCC(Br)(CC)C[C@@H]1Cc2ccccc2[C@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(Br)(C&)CC",
"old_substring": "C3CC(F)(F)F"
}
|
Can you make molecule Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(CCNSC(=O)Cc3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNSC(=O)Cc3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(CCNC(=O)CCCC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)CCCC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(CCNC(=O)CC(C)(C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)CC(C)(C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(CCNC(=O)CCC(C)(C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)CCC(C)(C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2cc(CCNSC(=O)[C@@H](C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
|
Cc1cc2cc(CCNSC(=O)[C@@H](C)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
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