prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH2+][C@@H]1CCC[C@@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
|
C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1
|
C[NH2+][C@@H]1CCC[C@@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@@H]345"
}
|
Can you make molecule C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH2+][C@H]1CC[C@@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
|
C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1
|
C[NH2+][C@H]1CC[C@@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@@H]345"
}
|
Can you make molecule C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH2+][C@H]1CC[C@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
|
C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1
|
C[NH2+][C@H]1CC[C@](c2ccc(F)cc2F)([C@@H]2CCOC3(CCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@@H]345"
}
|
Can you make molecule C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH2+][C@@H](CCC[C@@H]1CCOC2(CCC2)C1)C(C)(C)c1ccc(F)cc1F
|
C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1
|
C[NH2+][C@@H](CCC[C@@H]1CCOC2(CCC2)C1)C(C)(C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@@H]345"
}
|
Can you make molecule C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH2+]CC[C@H](C[C@@H]1CCOC2(CCC2)C1)C(=O)c1ccc(F)cc1F
|
C[NH2+][C@@H](c1ccc(F)cc1F)[C@@H]1CCOC2(CCC2)C1
|
C[NH2+]CC[C@H](C[C@@H]1CCOC2(CCC2)C1)C(=O)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@H](C&)C&=O",
"old_substring": "[C@@H]345"
}
|
Can you make molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2I)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2I)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2Br)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2Br)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)c(I)c2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)c(I)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cccc(NC[C@H](O)c2cc(Cl)ccc2Cl)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2cc(Cl)ccc2Cl)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)c(Cl)c2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)cc2)n1
|
CCOC(=O)c1cccc(NC[C@H](O)c2ccc(Cl)c(Cl)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCCOc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1CCCCOc1ccc(CN2CCOC(C)(C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C36"
}
|
Can you make molecule Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCCCOc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1CCCCCOc1ccc(CN2CCOC(C)(C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C36"
}
|
Can you make molecule Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1C1CC(Oc2ccc(CN3CCOC(C)(C)C3)cc2)C1
|
Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1C1CC(Oc2ccc(CN3CCOC(C)(C)C3)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C36"
}
|
Can you make molecule Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1SC(=S)OOc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1SC(=S)OOc1ccc(CN2CCOC(C)(C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C36"
}
|
Can you make molecule Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1NC(=S)SOc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1COc1ccc(CN2CCOC(C)(C)C2)cc1
|
Cc1noc(C)c1NC(=S)SOc1ccc(CN2CCOC(C)(C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C36"
}
|
Can you make molecule CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CO)=N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CCC(CO)=N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&CO",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CCCC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SN[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)SN[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CCCCC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=O)=N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CC(=O)N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
|
CCC(C=O)=N[C@@H]1C(=O)N(Cc2ccccc2OCCC(C)C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&C=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)c(-c3nccs3)cc1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)c(-c3nccs3)cc1C)c(=O)n2Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)c&cc1C",
"old_substring": "c14cc(C)n9c1C"
}
|
Can you make molecule CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(Cl)c(-c3nccs3)cc1Cl)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(Cl)c(-c3nccs3)cc1Cl)c(=O)n2Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)c&cc1Cl",
"old_substring": "c14cc(C)n9c1C"
}
|
Can you make molecule CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)nc3ccc(-c4nccs4)cc13)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)nc3ccc(-c4nccs4)cc13)c(=O)n2Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)nc2ccc&cc12",
"old_substring": "c14cc(C)n9c1C"
}
|
Can you make molecule CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)c(-c3nccs3)c(C)c1)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)c(-c3nccs3)c(C)c1)c(=O)n2Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)c&c(C)c1",
"old_substring": "c14cc(C)n9c1C"
}
|
Can you make molecule CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(Br)c(-c3nccs3)cc1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(C)n(-c3nccs3)c1C)c(=O)n2Cc1ccccc1
|
CCn1cnc2c1c(=O)n(CC(=O)c1cc(Br)c(-c3nccs3)cc1C)c(=O)n2Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1C",
"old_substring": "c14cc(C)n9c1C"
}
|
Can you make molecule CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCCCC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C16CCCC1"
}
|
Can you make molecule CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCCCCC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C16CCCC1"
}
|
Can you make molecule CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCC[NH2+][C@H](SC1=CCCCCC1)c1ccccc1F
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1
|
CC(=O)NCCC[NH2+][C@H](SC1=CCCCCC1)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C16CCCC1"
}
|
Can you make molecule CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCC(Cl)CC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCC(Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "ClC1CCC&CC1",
"old_substring": "C16CCCC1"
}
|
Can you make molecule CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCC[NH2+][C@H](CCC1=CCCC1)c1ccccc1F
|
CC(=O)NCCC[NH2+][C@@H](c1ccccc1F)C1CCCC1
|
CC(=O)NCCC[NH2+][C@H](CCC1=CCCC1)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC1=CCCC1",
"old_substring": "C16CCCC1"
}
|
Can you make molecule CC[C@H](S[C@H](C)c1cccs1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1cccs1)S[C@@H](CC)C(N)=O
|
CC[C@H](S[C@H](C)c1cccs1)C(N)=O
|
CC[C@@H](CCc1cccs1)S[C@@H](CC)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]34C"
}
|
Can you make molecule CC[C@H](S[C@H](C)c1cccs1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](S[C@@H](CBr)CCc1cccs1)C(N)=O
|
CC[C@H](S[C@H](C)c1cccs1)C(N)=O
|
CC[C@H](S[C@@H](CBr)CCc1cccs1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]34C"
}
|
Can you make molecule CC[C@H](S[C@H](C)c1cccs1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](S[C@@H](CBr)CCCc1cccs1)C(N)=O
|
CC[C@H](S[C@H](C)c1cccs1)C(N)=O
|
CC[C@H](S[C@@H](CBr)CCCc1cccs1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]34C"
}
|
Can you make molecule CC[C@H](S[C@H](C)c1cccs1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](S[C@H](CCl)CCCc1cccs1)C(N)=O
|
CC[C@H](S[C@H](C)c1cccs1)C(N)=O
|
CC[C@H](S[C@H](CCl)CCCc1cccs1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]34C"
}
|
Can you make molecule CC[C@H](S[C@H](C)c1cccs1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](S[C@H]1CCC[C@H](c2cccs2)C1)C(N)=O
|
CC[C@H](S[C@H](C)c1cccs1)C(N)=O
|
CC[C@H](S[C@H]1CCC[C@H](c2cccs2)C1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]34C"
}
|
Can you make molecule O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(SC(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(SC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C5(F)(F)F"
}
|
Can you make molecule O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CCCC(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CCCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C5(F)(F)F"
}
|
Can you make molecule O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CCCCC(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CCCCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C5(F)(F)F"
}
|
Can you make molecule O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CC(F)(F)C(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(CC(F)(F)C(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)F",
"old_substring": "C5(F)(F)F"
}
|
Can you make molecule O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)F)C1
|
O=C(CCCOc1ccccc1)N1CC[C@](O)(C(F)(F)C(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C5(F)(F)F"
}
|
Can you make molecule O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCC[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])CCC[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCC&",
"old_substring": "O=C4[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCCCC[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])CCCCC[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCCCC&",
"old_substring": "O=C4[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCCC(=O)[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])CCCC(=O)[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCCC&=O",
"old_substring": "O=C4[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=CO[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=CO[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=CO&",
"old_substring": "O=C4[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NO)[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C([O-])[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
|
O=C(NO)[C@H]1CCCC[NH+]1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NO",
"old_substring": "O=C4[O-]"
}
|
Can you make molecule COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COCCCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C5C6"
}
|
Can you make molecule COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COCCCCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5C6"
}
|
Can you make molecule COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CC(OC(=O)C2=C(C)NC3=C(C(=O)C[C@@H](c4ccccc4)C3)[C@H]2c2cccnc2)C1
|
COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COC1CC(OC(=O)C2=C(C)NC3=C(C(=O)C[C@@H](c4ccccc4)C3)[C@H]2c2cccnc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C5C6"
}
|
Can you make molecule COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
CO[C@@H](C)CCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5C6"
}
|
Can you make molecule COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CCC(OC(=O)C2=C(C)NC3=C(C(=O)C[C@@H](c4ccccc4)C3)[C@H]2c2cccnc2)CC1
|
COCCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3ccccc3)C2)[C@H]1c1cccnc1
|
COC1CCC(OC(=O)C2=C(C)NC3=C(C(=O)C[C@@H](c4ccccc4)C3)[C@H]2c2cccnc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C5C6"
}
|
Can you make molecule Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C16CCCCC1"
}
|
Can you make molecule Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CSC1=CCCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CSC1=CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C16CCCCC1"
}
|
Can you make molecule Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2C=CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2C=CC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1CCCCC1",
"old_substring": "C16CCCCC1"
}
|
Can you make molecule Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCCCCCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCCCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C16CCCCC1"
}
|
Can you make molecule Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1(C#N)CCCCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1CCCCC1
|
Cc1ncsc1C(=O)N1CCC[C@H]1c1nc2c(c(C)[nH+]1)CCCN2CC1(C#N)CCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCCCCCC1",
"old_substring": "C16CCCCC1"
}
|
Can you make molecule CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1Cc2nc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)sc2C1
|
CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1
|
CC(=O)N1Cc2nc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)sc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N24"
}
|
Can you make molecule CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1Cc2cnn([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)c2C1
|
CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1
|
CC(=O)N1Cc2cnn([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2cnn&c2C1",
"old_substring": "N24"
}
|
Can you make molecule CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1CCc2noc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)c2C1
|
CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1
|
CC(=O)N1CCc2noc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2noc&c2C1",
"old_substring": "N24"
}
|
Can you make molecule CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1CCCn2nc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)cc21
|
CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1
|
CC(=O)N1CCCn2nc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N24"
}
|
Can you make molecule CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1CCc2cc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)ccc21
|
CC(=O)N[C@@H](C)C(=O)Nc1ccc(F)c(Cl)c1
|
CC(=O)N1CCc2cc([C@@H](C)C(=O)Nc3ccc(F)c(Cl)c3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N24"
}
|
Can you make molecule C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](C)CN(SC(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(SC(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C5(=O)[C@H]6C"
}
|
Can you make molecule C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@H](C)CC&",
"old_substring": "C5(=O)[C@H]6C"
}
|
Can you make molecule C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@@H](C)CC&",
"old_substring": "C5(=O)[C@H]6C"
}
|
Can you make molecule C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](C)CN(C(=O)C[C@@H](Br)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)C[C@@H](Br)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C5(=O)[C@H]6C"
}
|
Can you make molecule C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](C)CN([C@@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN(C(=O)[C@@H](C)Sc2nnc(-c3c[nH]c4ccccc34)o2)C1
|
C[C@@H]1C[C@@H](C)CN([C@@H](C)CCSc2nnc(-c3c[nH]c4ccccc34)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5(=O)[C@H]6C"
}
|
Can you make molecule C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[S@@+]([O-])c1ccc(CCCC[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
|
C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
|
C[S@@+]([O-])c1ccc(CCCC[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C68"
}
|
Can you make molecule C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[S@@+]([O-])c1ccc(CCCCC[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(CCCCC[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C68"
}
|
Can you make molecule C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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C[S@@+]([O-])c1ccc(C2CC([NH+]3CCC(OC[C@H]4CCCO4)CC3)C2)cc1
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C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(C2CC([NH+]3CCC(OC[C@H]4CCCO4)CC3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C68"
}
|
Can you make molecule C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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C[S@@+]([O-])c1ccc(SC(=S)O[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(SC(=S)O[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C68"
}
|
Can you make molecule C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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C[S@@+]([O-])c1ccc(NC(=S)S[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
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C[S@@+]([O-])c1ccc(NC(=S)S[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C68"
}
|
Can you make molecule COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
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COSC(=O)Cc1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COSC(=O)Cc1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
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COC(=O)CCCC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)CCCC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)CC(C)(C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
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COC(=O)CCC(C)(C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)CCC(C)(C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COC(=O)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
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COSC(=O)[C@@H](C)c1ccccc1NC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(O)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C25=O"
}
|
Can you make molecule COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)(OC)C(=O)CN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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CCC(CC)(OC)C(=O)CN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5CC3=O"
}
|
Can you make molecule COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC)C(=O)CCN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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CCC(CC)(OC)C(=O)CCN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5CC3=O"
}
|
Can you make molecule COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](OC)[S@+]([O-])CN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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CC[C@H](OC)[S@+]([O-])CN1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&[S@](=O)C&",
"old_substring": "C5CC3=O"
}
|
Can you make molecule COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
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CCCC[C@H](C(=O)OC)C(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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CCCC[C@H](C(=O)OC)C(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H](C&=O)C&=O",
"old_substring": "C5CC3=O"
}
|
Can you make molecule COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
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COCCC[S@+]([O-])[C@@H](C)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC(=O)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
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COCCC[S@+]([O-])[C@@H](C)N1CC[C@](Cc2ccccc2-c2ccccc2F)(C(=O)N(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "C5CC3=O"
}
|
Can you make molecule O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(/C=C/SN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
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O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
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O=C(/C=C/SN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CCCCCN1N1CCC(=NONc2cc3c(cc2Br)OCCO3)CC1
|
O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
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O=C1CCCCCN1N1CCC(=NONc2cc3c(cc2Br)OCCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(N2CCCCCC2=O)CC1)Nc1cc2c(cc1Br)OCCO2
|
O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
|
O=C(NN=C1CCN(N2CCCCCC2=O)CC1)Nc1cc2c(cc1Br)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(N2CCCCCC2=O)CC1)Nc1cc2c(cc1Br)OCCO2
|
O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
|
O=C(NN=C1CCC(N2CCCCCC2=O)CC1)Nc1cc2c(cc1Br)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1cc2c(cc1Br)OCCO2)C(=O)SN1CCCCCC1=O
|
O=C(CN1CCCCCC1=O)Nc1cc2c(cc1Br)OCCO2
|
C/C(=N\ONc1cc2c(cc1Br)OCCO2)C(=O)SN1CCCCCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@@H]1CC[C@@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@@H]1CC[C@@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]17CCCN6C1"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@H](CCl)CCCS(=O)(=O)c1c(C)nn(CC(=O)NC(C)(C)C)c1C
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@H](CCl)CCCS(=O)(=O)c1c(C)nn(CC(=O)NC(C)(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]17CCCN6C1"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@H]1CCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@H]1CCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@@H]17CCCN6C1"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@H]1CCCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@H]1CCCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]17CCCN6C1"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@H]1CCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)CC1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1
|
CNC(=O)[C@H]1CCC[C@H](S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@@H]17CCCN6C1"
}
|
Can you make molecule O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1c(Cl)cc(Cl)cc1Br)C(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)C(=O)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)C&=O",
"old_substring": "O=C(C2)NNC4=O"
}
|
Can you make molecule O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1c(Cl)cc(Cl)cc1Br)N/N=C/Cc1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)N/N=C/Cc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/C&",
"old_substring": "O=C(C2)NNC4=O"
}
|
Can you make molecule O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOc1c(Cl)cc(Cl)cc1Br)NOc1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(CCCOc1c(Cl)cc(Cl)cc1Br)NOc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(CCC&)NO&",
"old_substring": "O=C(C2)NNC4=O"
}
|
Can you make molecule O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1c(Cl)cc(Cl)cc1Br)N/N=C/CCc1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(COc1c(Cl)cc(Cl)cc1Br)N/N=C/CCc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/CC&",
"old_substring": "O=C(C2)NNC4=O"
}
|
Can you make molecule O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCC(=O)c1ccc([N+](=O)[O-])cc1)Oc1c(Cl)cc(Cl)cc1Br
|
O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
|
O=C(CCC(=O)c1ccc([N+](=O)[O-])cc1)Oc1c(Cl)cc(Cl)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O=C(C2)NNC4=O"
}
|
Can you make molecule CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCBr
|
CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCn1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
C=CCCCCn1nccc1NC(=O)[C@H](C)Sc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCBr
|
CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCBr",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCS
|
CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCS
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCCS
|
CC(C)n1nccc1NC(=O)[C@H](C)Sc1ccccc1
|
C[C@H](Sc1ccccc1)C(=O)Nc1ccnn1CCCCCCS
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCCC&",
"old_substring": "CC5C"
}
|
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