prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C2[C@H](c3cccc(OC(C)(C)CCBr)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OC(C)(C)CCBr)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&(C)CCBr",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)Oc1cccc([C@@H]2CC(=O)N[C@H]3C2=C(C)NN3c2ccc([O-])nn2)c1
|
CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CCCC(C)(C)Oc1cccc([C@@H]2CC(=O)N[C@H]3C2=C(C)NN3c2ccc([O-])nn2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C2[C@H](c3cccc(OCC(C)(C)CBr)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OCC(C)(C)CBr)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(C)(C)CBr",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C2[C@H](c3cccc(OC(C(C)C)C(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OC(C(C)C)C(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&C(C)C",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C2[C@H](c3cccc(OC(=O)CCCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
|
CC1=C2[C@H](c3cccc(OC(=O)CCCC(C)C)c3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CCCC&=O",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(C)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)=O",
"old_substring": "C6(N)=O"
}
|
Can you make molecule CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CCCCC(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CCCCC(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C6(N)=O"
}
|
Can you make molecule CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC/C(N)=N/O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC/C(N)=N/O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C6(N)=O"
}
|
Can you make molecule CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC/C(N)=N\O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC/C(N)=N\O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C6(N)=O"
}
|
Can you make molecule CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC(N)=S
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O
|
CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1CC(N)=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "C6(N)=O"
}
|
Can you make molecule Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cl)c(NC(=O)COSC(=O)CC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COSC(=O)CC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C59=O"
}
|
Can you make molecule Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cl)c(NC(=O)COCC(=C=O)CC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COCC(=C=O)CC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C59=O"
}
|
Can you make molecule Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cl)c(NC(=O)COC(=O)CCCC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)CCCC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C59=O"
}
|
Can you make molecule Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cl)c(NC(=O)COC(=O)CC(C)(C)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)CC(C)(C)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C59=O"
}
|
Can you make molecule Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cl)c(NC(=O)COC[S@+]([O-])CCCC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC(=O)C23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
|
Cc1ccc(Cl)c(NC(=O)COC[S@+]([O-])CCCC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C59=O"
}
|
Can you make molecule C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN([C@@]2(C[NH+]3CCC([NH+](C)C)CC3)CCCS[C@H]2C)CC1
|
C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1
|
CC1CCN([C@@]2(C[NH+]3CCC([NH+](C)C)CC3)CCCS[C@H]2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C4[NH3+]"
}
|
Can you make molecule C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN([C@@]2(CC3=CCC[NH+]([NH+](C)C)C3)CCCS[C@H]2C)CC1
|
C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1
|
CC1CCN([C@@]2(CC3=CCC[NH+]([NH+](C)C)C3)CCCS[C@H]2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C4[NH3+]"
}
|
Can you make molecule C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN([C@@]2(C3(C)CC[NH+]([NH+](C)C)CC3)CCCS[C@H]2C)CC1
|
C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1
|
CC1CCN([C@@]2(C3(C)CC[NH+]([NH+](C)C)CC3)CCCS[C@H]2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C4[NH3+]"
}
|
Can you make molecule C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN([C@@]2(C[NH+]3CCC(C)([NH+](C)C)CC3)CCCS[C@H]2C)CC1
|
C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1
|
CC1CCN([C@@]2(C[NH+]3CCC(C)([NH+](C)C)CC3)CCCS[C@H]2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&(C)CC1",
"old_substring": "C4[NH3+]"
}
|
Can you make molecule C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCN([C@@]2([NH+]3CCC([NH+](C)C)CC3)CCCS[C@H]2C)CC1
|
C[C@@H]1SCCC[C@]1(C[NH3+])N1CCC(C[NH+](C)C)CC1
|
CC1CCN([C@@]2([NH+]3CCC([NH+](C)C)CC3)CCCS[C@H]2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "C4[NH3+]"
}
|
Can you make molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc(C)c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc(C)c2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17cccc([N+](=O)[O-])c1C"
}
|
Can you make molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc(Br)c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc(Br)c2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c17cccc([N+](=O)[O-])c1C"
}
|
Can you make molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cc(C=O)c(F)cc2Cl)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cc(C=O)c(F)cc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C=O)c(F)cc1Cl",
"old_substring": "c17cccc([N+](=O)[O-])c1C"
}
|
Can you make molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cc(C)c(C)cc2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cc(C)c(C)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)c(C)cc1C",
"old_substring": "c17cccc([N+](=O)[O-])c1C"
}
|
Can you make molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2ccc(I)c(C)c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1
|
COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2ccc(I)c(C)c2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)c(C)c1C",
"old_substring": "c17cccc([N+](=O)[O-])c1C"
}
|
Can you make molecule O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O=C(/C=C/Sc1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(N2CCC([C@@H](O)c3ccccc3)CC2)nc1-c1cc2cccc(Cl)c2o1
|
O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O=Cc1sc(N2CCC([C@@H](O)c3ccccc3)CC2)nc1-c1cc2cccc(Cl)c2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(N2CCC([C@@H](O)c3ccccc3)CC2)sc1-c1cc2cccc(Cl)c2o1
|
O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O=Cc1nc(N2CCC([C@@H](O)c3ccccc3)CC2)sc1-c1cc2cccc(Cl)c2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N1CCC([C@@H](O)c2ccccc2)CC1)n1nc(-c2cc3cccc(Cl)c3o2)oc1=S
|
O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O=C(N1CCC([C@@H](O)c2ccccc2)CC1)n1nc(-c2cc3cccc(Cl)c3o2)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](c1ccccc1)C1CCN(O/N=C/c2ccc(-c3cc4cccc(Cl)c4o3)o2)CC1
|
O=C(c1cc2cccc(Cl)c2o1)N1CCC([C@@H](O)c2ccccc2)CC1
|
O[C@@H](c1ccccc1)C1CCN(O/N=C/c2ccc(-c3cc4cccc(Cl)c4o3)o2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C34"
}
|
Can you make molecule Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(CC(=O)SN2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(CC(=O)SN2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)CCCC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)CCCC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(C)(C)CC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(C)(C)CC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(C)(C)CCC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(C)(C)CCC(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c([C@H](C)C(=O)SN2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c(C(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
|
Cc1c([C@H](C)C(=O)SN2CC[C@H](NC(=O)OC(C)(C)C)C[C@H]2C)cnn1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C48=O"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(N2CCN(CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CCN(CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN&CC1",
"old_substring": "N15CC[NH+]4CC1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(N2CCO[C@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CCO[C@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCO[C@H]&C1",
"old_substring": "N15CC[NH+]4CC1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C[C@@H](CCO)CN1c1ccc([N+](=O)[O-])cc1/C=N/c1ccc2c(c1)oc1ccccc12
|
O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=C1C[C@@H](CCO)CN1c1ccc([N+](=O)[O-])cc1/C=N/c1ccc2c(c1)oc1ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&C[C@H]&CC1=O",
"old_substring": "N15CC[NH+]4CC1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(N2CCO[C@@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CCO[C@@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCO[C@@H]&C1",
"old_substring": "N15CC[NH+]4CC1"
}
|
Can you make molecule O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(N2CCS[C@@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CC[NH+](CCO)CC2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
|
O=[N+]([O-])c1ccc(N2CCS[C@@H](CCO)C2)c(/C=N/c2ccc3c(c2)oc2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCS[C@@H]&C1",
"old_substring": "N15CC[NH+]4CC1"
}
|
Can you make molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC[C@@H]1CCN(CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CCN(CC(=O)Nc2nc3ccc(F)cc3s2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCN&C1",
"old_substring": "[C@@H]19CC[NH+]7C1"
}
|
Can you make molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC[C@@H]1CC[C@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
|
CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CC[C@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@H]&O1",
"old_substring": "[C@@H]19CC[NH+]7C1"
}
|
Can you make molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC[C@@H]1CC[C@@H](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CC[C@@H](CC(=O)Nc2nc3ccc(F)cc3s2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]19CC[NH+]7C1"
}
|
Can you make molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC[C@@H]1CC[C@@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
|
CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1CC[C@@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&O1",
"old_substring": "[C@@H]19CC[NH+]7C1"
}
|
Can you make molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC[C@@H]1N=C[C@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
|
CCOC[C@@H]1CC[NH+](CC(=O)Nc2nc3ccc(F)cc3s2)C1
|
CCOC[C@@H]1N=C[C@H](CC(=O)Nc2nc3ccc(F)cc3s2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=C[C@H]&O1",
"old_substring": "[C@@H]19CC[NH+]7C1"
}
|
Can you make molecule O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3Cl)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3Cl)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccc(I)cc3)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccc(I)cc3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-n2cc(CN3CC[NH+]([C@H]4CCCC[C@@H]4O)CC3)cn2)cc1I
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1
|
Cc1ccc(-n2cc(CN3CC[NH+]([C@H]4CCCC[C@@H]4O)CC3)cn2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3cccc(Br)c3)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3cccc(Br)c3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(-n2cc(CN3CC[NH+]([C@H]4CCCC[C@@H]4O)CC3)cn2)c1C
|
O[C@H]1CCCC[C@@H]1[NH+]1CCN(Cc2cnn(-c3ccccc3)c2)CC1
|
Cc1cccc(-n2cc(CN3CC[NH+]([C@H]4CCCC[C@@H]4O)CC3)cn2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1nc2ccccc2[nH]1)NC(=O)[C@@H](C)Sc1ccc(Cl)cc1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1
|
CC[C@@H](CCc1nc2ccccc2[nH]1)NC(=O)[C@@H](C)Sc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]46C"
}
|
Can you make molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@@H](CBr)CCc1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@@H](CBr)CCc1nc2ccccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]46C"
}
|
Can you make molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@@H](CBr)CCCc1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@@H](CBr)CCCc1nc2ccccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]46C"
}
|
Can you make molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](CCl)CCCc1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](CCl)CCCc1nc2ccccc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]46C"
}
|
Can you make molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H]1CCC[C@H](c2nc3ccccc3[nH]2)C1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1
|
C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H]1CCC[C@H](c2nc3ccccc3[nH]2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]46C"
}
|
Can you make molecule O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Cc1noc(Cc2ccccc2Cl)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccccc2Cl)n1)c1ccc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Cc1noc(Cc2ccc(I)cc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccc(I)cc2)n1)c1ccc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Cc1noc(C=Cc2ccccc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(C=Cc2ccccc2)n1)c1ccc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cc2nc(CS(=O)(=O)c3ccc4ccccc4c3)no2)cc1I
|
O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1
|
Cc1ccc(Cc2nc(CS(=O)(=O)c3ccc4ccccc4c3)no2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Cc1noc(Cc2cccc(Br)c2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2ccccc2)n1)c1ccc2ccccc2c1
|
O=S(=O)(Cc1noc(Cc2cccc(Br)c2)n1)c1ccc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)Cc1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COSC(=O)Cc1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCCC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)CCCC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)CC(C)(C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)CCC(C)(C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
|
COSC(=O)[C@@H](C)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C45=O"
}
|
Can you make molecule CC1CCC(C#N)([C@H](O)C=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(C#N)([C@H](C)N=O)CC1
|
CC1CCC(C#N)([C@H](O)C=O)CC1
|
CC1CCC(C#N)([C@H](C)N=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)N=O",
"old_substring": "[C@@H]2(O)C=O"
}
|
Can you make molecule CC1CCC(C#N)([C@H](O)C=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(C#N)([C@H](O)C2=CCCC2)CC1
|
CC1CCC(C#N)([C@H](O)C=O)CC1
|
CC1CCC(C#N)([C@H](O)C2=CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(O)C1=CCCC1",
"old_substring": "[C@@H]2(O)C=O"
}
|
Can you make molecule CC1CCC(C#N)([C@H](O)C=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(C#N)([C@]2(O)CCOC2)CC1
|
CC1CCC(C#N)([C@H](O)C=O)CC1
|
CC1CCC(C#N)([C@]2(O)CCOC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@]1&(O)CCOC1",
"old_substring": "[C@@H]2(O)C=O"
}
|
Can you make molecule CC1CCC(C#N)([C@H](O)C=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(C#N)([C@H](C)C(=O)Cl)CC1
|
CC1CCC(C#N)([C@H](O)C=O)CC1
|
CC1CCC(C#N)([C@H](C)C(=O)Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(=O)Cl",
"old_substring": "[C@@H]2(O)C=O"
}
|
Can you make molecule CC1CCC(C#N)([C@H](O)C=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(C#N)([C@]2(C)CCOC2=O)CC1
|
CC1CCC(C#N)([C@H](O)C=O)CC1
|
CC1CCC(C#N)([C@]2(C)CCOC2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@]1&(C)CCOC1=O",
"old_substring": "[C@@H]2(O)C=O"
}
|
Can you make molecule CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=S)Sc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOC(=S)Sc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O34"
}
|
Can you make molecule CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=N)Cc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOC(=N)Cc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O34"
}
|
Can you make molecule CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCC(=O)c1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCC(=O)CCC(=O)c1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O34"
}
|
Can you make molecule CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](O)CCc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CC[C@H](O)CCc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O34"
}
|
Can you make molecule CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)/C=C/Sc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCOc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
|
CCC(=O)/C=C/Sc1c(OC)cc(C[NH+]2CCNC(=O)[C@@H]2CC)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O34"
}
|
Can you make molecule CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
|
CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1
|
CC(C)[C@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "CC[C@@H]24"
}
|
Can you make molecule CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
|
CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1
|
CCC[C@@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "CC[C@@H]24"
}
|
Can you make molecule CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc([C@H]2CCC=C2CC[NH2+]CCCC(C)(C)C)cn1
|
CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1
|
Cn1cc([C@H]2CCC=C2CC[NH2+]CCCC(C)(C)C)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC1=CCC[C@@H]1&",
"old_substring": "CC[C@@H]24"
}
|
Can you make molecule CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
|
CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1
|
CCCC[C@@H](CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "CC[C@@H]24"
}
|
Can you make molecule CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@](C)(CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
|
CC[C@@H]([NH2+]CCCC(C)(C)C)c1cnn(C)c1
|
CC[C@](C)(CCc1cnn(C)c1)[NH2+]CCCC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@]&(C)CC&",
"old_substring": "CC[C@@H]24"
}
|
Can you make molecule Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccc(N(C)C)cc2I)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccc(N(C)C)cc2I)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccccc15"
}
|
Can you make molecule Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cc(N(C)C)ccc2Br)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cc(N(C)C)ccc2Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccccc15"
}
|
Can you make molecule Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccc(N(C)C)cc2Cl)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccc(N(C)C)cc2Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccccc15"
}
|
Can you make molecule Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cccc(N(C)C)c2Br)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cccc(N(C)C)c2Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccccc15"
}
|
Can you make molecule Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cccc(N(C)C)c2Cl)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2ccccc2N(C)C)cc1F
|
Cc1nccn1-c1ccc(C[NH2+][C@@H](C)c2cccc(N(C)C)c2Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccccc15"
}
|
Can you make molecule Cn1ncc(SCC(=O)[O-])c(Cl)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(SCCS(=O)(=O)[O-])c(Cl)c1=O
|
Cn1ncc(SCC(=O)[O-])c(Cl)c1=O
|
Cn1ncc(SCCS(=O)(=O)[O-])c(Cl)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C2C(=O)[O-]"
}
|
Can you make molecule Cn1ncc(SCC(=O)[O-])c(Cl)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NOSc1cnn(C)c(=O)c1Cl
|
Cn1ncc(SCC(=O)[O-])c(Cl)c1=O
|
CC(=O)NOSc1cnn(C)c(=O)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)NO&",
"old_substring": "C2C(=O)[O-]"
}
|
Can you make molecule Cn1ncc(SCC(=O)[O-])c(Cl)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(SCCC(=O)O)c(Cl)c1=O
|
Cn1ncc(SCC(=O)[O-])c(Cl)c1=O
|
Cn1ncc(SCCC(=O)O)c(Cl)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC(=O)O",
"old_substring": "C2C(=O)[O-]"
}
|
Can you make molecule Cn1ncc(SCC(=O)[O-])c(Cl)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(Sc1cnn(C)c(=O)c1Cl)C(=O)[O-]
|
Cn1ncc(SCC(=O)[O-])c(Cl)c1=O
|
CCC(CC)(Sc1cnn(C)c(=O)c1Cl)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C2C(=O)[O-]"
}
|
Can you make molecule Cn1ncc(SCC(=O)[O-])c(Cl)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncc(SCCCS(=O)(=O)[O-])c(Cl)c1=O
|
Cn1ncc(SCC(=O)[O-])c(Cl)c1=O
|
Cn1ncc(SCCCS(=O)(=O)[O-])c(Cl)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C2C(=O)[O-]"
}
|
Can you make molecule CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC1=NCCS1
|
CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC1=NCCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C1=NCCS1",
"old_substring": "CN3C"
}
|
Can you make molecule CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC1=NCCCS1
|
CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC1=NCCCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C1=NCCCS1",
"old_substring": "CN3C"
}
|
Can you make molecule CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)C(=S)SC(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
CN(C)C(=S)SC(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN(C)C(=S)S&",
"old_substring": "CN3C"
}
|
Can you make molecule CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCI)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
O=C(CCI)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CI",
"old_substring": "CN3C"
}
|
Can you make molecule CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC(=S)N1CCCC1
|
CN(C)C(=O)Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1
|
O=C(Nc1cccc(CN[C@H](Cc2ccccc2)C(F)(F)F)c1)SC(=S)N1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N1CCCC1",
"old_substring": "CN3C"
}
|
Can you make molecule CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
C=CSc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC6"
}
|
Can you make molecule CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(C(C)C)no3)CC2)c1
|
CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(C(C)C)no3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC6"
}
|
Can you make molecule CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
C=CCCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC6"
}
|
Can you make molecule CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(CCCCl)no3)CC2)c1
|
CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(CCCCl)no3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC6"
}
|
Can you make molecule CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(CCCCS)no3)CC2)c1
|
CCc1noc([C@@H](C)[NH+]2CC=C(c3cccc(OC)c3)CC2)n1
|
COc1cccc(C2=CC[NH+]([C@H](C)c3nc(CCCCS)no3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC6"
}
|
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