prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)NSC(=O)Cc1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NSC(=O)Cc1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)NC(=O)CCCC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)CCCC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)NC(=O)CC(C)(C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)CC(C)(C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)NC(=O)CCC(C)(C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)CCC(C)(C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)NSC(=O)[C@@H](C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NC(=O)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
|
CCC(C)(C)NSC(=O)[C@@H](C)c1ccc(S(=O)(=O)[N-]c2ccccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C37=O"
}
|
Can you make molecule CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NC1(C)Cc2ccccc2C1)NCCCN1CCCCCC1=O
|
CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
CC(C)(CC(=O)NC1(C)Cc2ccccc2C1)NCCCN1CCCCCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)NC1(C)Cc2ccccc2C1)NCCCN1CCCCCC1=O
|
CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
CC(C)(CCC(=O)NC1(C)Cc2ccccc2C1)NCCCN1CCCCCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(NC2(C)Cc3ccccc3C2)c(=O)n(NCCCN2CCCCCC2=O)n1C
|
CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
Cc1c(NC2(C)Cc3ccccc3C2)c(=O)n(NCCCN2CCCCCC2=O)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
}
|
Can you make molecule CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(=O)c(NC2(C)Cc3ccccc3C2)nn1NCCCN1CCCCCC1=O
|
CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
Cc1cc(=O)c(NC2(C)Cc3ccccc3C2)nn1NCCCN1CCCCCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
}
|
Can you make molecule CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(NC(=O)C[C@@H](Br)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
CC1(NC(=O)NCCCN2CCCCCC2=O)Cc2ccccc2C1
|
CC1(NC(=O)C[C@@H](Br)NCCCN2CCCCCC2=O)Cc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](CC(=O)SNCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](CC(=O)SNCc3nnc(C)n3C)CCC2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](CC(=C=O)CNCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](CC(=C=O)CNCc3nnc(C)n3C)CCC2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](C(=O)CCCC(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)CCCC(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](C(C)(C)CC(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(C)(C)CC(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](CCC[S@@+]([O-])CNCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](C(=O)NCc3nnc(C)n3C)CCC2=O)cc1C
|
Cc1ccc(N2C[C@@H](CCC[S@@+]([O-])CNCc3nnc(C)n3C)CCC2=O)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(NC(=O)CN[C@@H](CCc2ccccc2)C(C)(C)C)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](CCc2ccccc2)C(C)(C)C)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@H]58C(F)(F)F"
}
|
Can you make molecule CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(NC(=O)CN[C@@H](C)CC(C)(C)Cc2ccccc2)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](C)CC(C)(C)Cc2ccccc2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]58C(F)(F)F"
}
|
Can you make molecule CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@](C)(CNCC(=O)Nc1cc(CC)nn1C)Cc1ccccc1
|
CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1
|
CCC[C@](C)(CNCC(=O)Nc1cc(CC)nn1C)Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@](C)(C&)C&",
"old_substring": "[C@H]58C(F)(F)F"
}
|
Can you make molecule CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(NC(=O)CNc2c(F)cc(F)c(-c3ccccc3)c2F)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1
|
CCc1cc(NC(=O)CNc2c(F)cc(F)c(-c3ccccc3)c2F)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(F)cc(F)c&c1F",
"old_substring": "[C@H]58C(F)(F)F"
}
|
Can you make molecule CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(NC(=O)CN=CCC[C@H](C)Cc2ccccc2)n(C)n1
|
CCc1cc(NC(=O)CN[C@@H](c2ccccc2)C(F)(F)F)n(C)n1
|
CCc1cc(NC(=O)CN=CCC[C@H](C)Cc2ccccc2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@H](C)C&",
"old_substring": "[C@H]58C(F)(F)F"
}
|
Can you make molecule CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCc1ccc(Cl)s1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1ccc(Cl)s1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c15cccs1"
}
|
Can you make molecule CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCc1ccc(Br)s1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1ccc(Br)s1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c15cccs1"
}
|
Can you make molecule CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCc1sccc1Br)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1sccc1Br)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c15cccs1"
}
|
Can you make molecule CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCc1csc(I)c1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1csc(I)c1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c15cccs1"
}
|
Can you make molecule CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCc1cc2c(s1)CSC2)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cccs1)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
|
CN(CCc1cc2c(s1)CSC2)C(=O)[C@@H]1C[C@@H]1c1ccccc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c15cccs1"
}
|
Can you make molecule CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)n1cc(Cc2ccccc2)c(=O)[nH]c1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)n1cc(Cc2ccccc2)c(=O)[nH]c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&c(=O)[nH]c1=O",
"old_substring": "c15c(N)n6c(=O)[nH]c1=O"
}
|
Can you make molecule CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1cn(Cc2ccccc2)c(=S)[nH]1
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1cn(Cc2ccccc2)c(=S)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cn&c(=S)[nH]1",
"old_substring": "c15c(N)n6c(=O)[nH]c1=O"
}
|
Can you make molecule CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]c(Cc2ccccc2)nc(=O)c1N(CC(C)C)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
|
Cc1[nH]c(Cc2ccccc2)nc(=O)c1N(CC(C)C)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(C)[nH]c&nc1=O",
"old_substring": "c15c(N)n6c(=O)[nH]c1=O"
}
|
Can you make molecule CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1ncc(Cc2ccccc2)c(=O)[nH]1
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1ncc(Cc2ccccc2)c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc&c(=O)[nH]1",
"old_substring": "c15c(N)n6c(=O)[nH]c1=O"
}
|
Can you make molecule CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1cc(=O)[nH]c(Cc2ccccc2)n1
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
|
CC(C)CN(C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O)c1cc(=O)[nH]c(Cc2ccccc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(=O)[nH]c&n1",
"old_substring": "c15c(N)n6c(=O)[nH]c1=O"
}
|
Can you make molecule COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@@]1(c2ccccn2)CC[C@H](Nc2nccn(C)c2=O)C1
|
COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1
|
COc1ccccc1[C@@]1(c2ccccn2)CC[C@H](Nc2nccn(C)c2=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@]1(c2ccccn2)CC[C@H](Nc2nccn(C)c2=O)C1
|
COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1
|
COc1ccccc1[C@]1(c2ccccn2)CC[C@H](Nc2nccn(C)c2=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1C(C)(C)[C@H](CCCc1ccccn1)Nc1nccn(C)c1=O
|
COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1
|
COc1ccccc1C(C)(C)[C@H](CCCc1ccccn1)Nc1nccn(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@H]356"
}
|
Can you make molecule COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@@]1(c2ccccn2)CCC[C@@H](Nc2nccn(C)c2=O)C1
|
COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1
|
COc1ccccc1[C@@]1(c2ccccn2)CCC[C@@H](Nc2nccn(C)c2=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@@H]1CC(Nc2nccn(C)c2=O)C[C@H](c2ccccn2)C1
|
COc1ccccc1[C@@H](Nc1nccn(C)c1=O)c1ccccn1
|
COc1ccccc1[C@@H]1CC(Nc2nccn(C)c2=O)C[C@H](c2ccccn2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C[C@H]&C[C@H]&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](C=C2CCC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](C=C2CCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCC1",
"old_substring": "C15CC1"
}
|
Can you make molecule CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CCCCC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CCCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C15CC1"
}
|
Can you make molecule CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](C=C2CCCC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](C=C2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC1",
"old_substring": "C15CC1"
}
|
Can you make molecule CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2SCCCS2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2SCCCS2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C15CC1"
}
|
Can you make molecule CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2SCSCS2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1
|
CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2SCSCS2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C15CC1"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(CCC[C@@H](CCl)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc(CCC[C@@H](CCl)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]79C"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(CCC2=CN=N[C@H]2NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc(CCC2=CN=N[C@H]2NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]79C"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc([C@@H]2CC[C@@H](NC(=O)C(=O)Nc3ccc(Cl)c([N+](=O)[O-])c3)C2)c1
|
CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc([C@@H]2CC[C@@H](NC(=O)C(=O)Nc3ccc(Cl)c([N+](=O)[O-])c3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]79C"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(CC(C)(C)[C@@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc(CC(C)(C)[C@@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]79C"
}
|
Can you make molecule CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cccc(CC[C@H](CC)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc([C@H](C)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
|
CCOc1cccc(CC[C@H](CC)NC(=O)C(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]79C"
}
|
Can you make molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCCCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCCCN(c2c(F)cccc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1",
"old_substring": "[C@H]15CCN4C1"
}
|
Can you make molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCCN(Cc2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCCN(Cc2c(F)cccc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCN(C&)C1",
"old_substring": "[C@H]15CCN4C1"
}
|
Can you make molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CC12CCN(c1c(F)cccc1F)CC2
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CC12CCN(c1c(F)cccc1F)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCN&CC2",
"old_substring": "[C@H]15CCN4C1"
}
|
Can you make molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1C=C(Cc2c(F)cccc2F)N=N1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1C=C(Cc2c(F)cccc2F)N=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C(C&)N=N1",
"old_substring": "[C@H]15CCN4C1"
}
|
Can you make molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CC[C@H](c2c(F)cccc2F)O1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1
|
O=C(CCCN1C(=O)CNC1=O)N[C@H]1CC[C@H](c2c(F)cccc2F)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@H]&O1",
"old_substring": "[C@H]15CCN4C1"
}
|
Can you make molecule O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/S[C@@H]1CCCC[C@@H]1C(F)(F)F)Nc1ccc2ncccc2c1
|
O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=C(/C=C/S[C@@H]1CCCC[C@@H]1C(F)(F)F)Nc1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(Nc2ccc3ncccc3c2)nc1[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=Cc1sc(Nc2ccc3ncccc3c2)nc1[C@@H]1CCCC[C@@H]1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(Nc2ccc3ncccc3c2)sc1[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=Cc1nc(Nc2ccc3ncccc3c2)sc1[C@@H]1CCCC[C@@H]1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N/N=C/C[C@@H]1CCCC[C@@H]1C(F)(F)F)Nc1ccc2ncccc2c1
|
O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F
|
O=C(N/N=C/C[C@@H]1CCCC[C@@H]1C(F)(F)F)Nc1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&N/N=C/C&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
FC(F)(F)[C@H]1CCCC[C@H]1N1CCC(=NONc2ccc3ncccc3c2)CC1
|
O=C(Nc1ccc2ncccc2c1)[C@@H]1CCCC[C@@H]1C(F)(F)F
|
FC(F)(F)[C@H]1CCCC[C@H]1N1CCC(=NONc2ccc3ncccc3c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C35"
}
|
Can you make molecule CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=O)=NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(C=O)=NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&C=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCCCCCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCC4=O"
}
|
Can you make molecule CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCNCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)NCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
|
CCC(=O)CCCNCc1ccc(-c2noc([C@H]3CCCO3)n2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CCC4=O"
}
|
Can you make molecule C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCC(=O)N1CCOC1=O)CCC1CC[NH2+]CC1
|
C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1
|
C[NH+](CCC(=O)N1CCOC1=O)CCC1CC[NH2+]CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[NH+](C&)C&",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CC[NH+]1CCC(CC2CC[NH2+]CC2)CC1)N1CCOC1=O
|
C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1
|
O=C(CC[NH+]1CCC(CC2CC[NH2+]CC2)CC1)N1CCOC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCC1=CCC[NH+](CC2CC[NH2+]CC2)C1)N1CCOC1=O
|
C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1
|
O=C(CCC1=CCC[NH+](CC2CC[NH2+]CC2)C1)N1CCOC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(CC(=O)N2CCOC2=O)CC[NH+](CC2CC[NH2+]CC2)CC1
|
C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1
|
CC1(CC(=O)N2CCOC2=O)CC[NH+](CC2CC[NH2+]CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(CC2CC[NH2+]CC2)CC[NH+](CCC(=O)N2CCOC2=O)CC1
|
C[NH+](CC(=O)N1CCOC1=O)CC1CC[NH2+]CC1
|
CC1(CC2CC[NH2+]CC2)CC[NH+](CCC(=O)N2CCOC2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&(C)CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCCC4)CC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCCCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCCCC4)CC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCSCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCSCC4)CC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CC=CC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CC=CC4)CC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)SSN4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)N4CCOCC4)CC3)CC2)o1
|
Cc1ccc(C[NH+]2CCC(N3CCC(C(=O)SSN4CCOCC4)CC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3Cl)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3Cl)c(C)c2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccc(I)cc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccc(I)cc3)c(C)c2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1-n1[nH]c2cc(=O)n(C=Cc3ccccc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(C=Cc3ccccc3)c(C)c2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cn2c(C)c3c(=O)n(-c4ccccc4C)[nH]c3cc2=O)cc1I
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
|
Cc1ccc(Cn2c(C)c3c(=O)n(-c4ccccc4C)[nH]c3cc2=O)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3cccc(Br)c3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
|
Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3cccc(Br)c3)c(C)c2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(I)o4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(I)o4)C3=O)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)o1",
"old_substring": "c19ccco1"
}
|
Can you make molecule Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(Br)o4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(Br)o4)C3=O)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)o1",
"old_substring": "c19ccco1"
}
|
Can you make molecule Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(Cl)o4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccc(Cl)o4)C3=O)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)o1",
"old_substring": "c19ccco1"
}
|
Can you make molecule Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4occc4Br)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4occc4Br)C3=O)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&occc1Br",
"old_substring": "c19ccco1"
}
|
Can you make molecule Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4sccc4C)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4ccco4)C3=O)c(=O)n2c1
|
Cc1ccc2nc(NC3CCC(C)CC3)c(C=C3SC(=S)N(Cc4sccc4C)C3=O)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1C",
"old_substring": "c19ccco1"
}
|
Can you make molecule COc1cccc2c1CCCC2(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cccc2c1CCCC2(C)C
|
COc1cccc2c1CCCC2(C)C
|
COCc1cccc2c1CCCC2(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc2c1CCCC2(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cccc2c1CCCC2(C)C
|
COc1cccc2c1CCCC2(C)C
|
COCSc1cccc2c1CCCC2(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc2c1CCCC2(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1cccc2c1CCCC2(C)C
|
COc1cccc2c1CCCC2(C)C
|
CC(=O)Sc1cccc2c1CCCC2(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc2c1CCCC2(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCc2c(C(=O)CS)cccc21
|
COc1cccc2c1CCCC2(C)C
|
CC1(C)CCCc2c(C(=O)CS)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc2c1CCCC2(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCc2c(C(=O)CI)cccc21
|
COc1cccc2c1CCCC2(C)C
|
CC1(C)CCCc2c(C(=O)CI)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1cccc(CC(=O)SN[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(CC(=O)SN[C@H](C)c2oc3ccccc3c2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C49=O"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)CCCC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)CCCC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C49=O"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1cccc(C(C)(C)CC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(C)(C)CC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C49=O"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1cccc(C(C)(C)CCC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(C)(C)CCC(=O)N[C@H](C)c2oc3ccccc3c2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C49=O"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1cccc([C@H](C)C(=O)SN[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc(C(=O)N[C@H](C)c2oc3ccccc3c2C)c1
|
CCN(CC)S(=O)(=O)c1cccc([C@H](C)C(=O)SN[C@H](C)c2oc3ccccc3c2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C49=O"
}
|
Can you make molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COCc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COCSc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(SC(C)=O)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
|
COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COc1cc(SC(C)=O)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)CS)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
|
COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COc1cc(C(=O)CS)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)CI)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
|
COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N23)c(OC)c1
|
COc1cc(C(=O)CI)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@H]2C(=O)N(CCO)CC(=O)N12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1ccc(Cl)s1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1ccc(Cl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c18cccs1"
}
|
Can you make molecule CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1ccc(Br)s1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c18cccs1"
}
|
Can you make molecule CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1sccc1Br
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1sccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c18cccs1"
}
|
Can you make molecule CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1csc(I)c1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1csc(I)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c18cccs1"
}
|
Can you make molecule CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cc2c(s1)CSC2
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1
|
CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cc2c(s1)CSC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c18cccs1"
}
|
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