prompt stringlengths 120 209 | completion stringlengths 15 103 | input_smiles stringlengths 14 103 | output_smiles stringlengths 15 103 | task_id int64 102 102 | winner_action dict |
|---|---|---|---|---|---|
Can you make molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2CCS(=O)(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2CCS(=O)(=O)[O-])c[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C6(=O)[O-]"
} |
Can you make molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)CO)c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)CO)c[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C6(=O)[O-]"
} |
Can you make molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(O)O)c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(O)O)c[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C6(=O)[O-]"
} |
Can you make molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(CC)(C(=O)[O-])c1cc(F)ccc1[N-]S(=O)(=O)c1c[nH]c(C(=O)[O-])c1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 | CCC(CC)(C(=O)[O-])c1cc(F)ccc1[N-]S(=O)(=O)c1c[nH]c(C(=O)[O-])c1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C6(=O)[O-]"
} |
Can you make molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2CCCS(=O)(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2C(=O)[O-])c[nH]1 | O=C([O-])c1cc(S(=O)(=O)[N-]c2ccc(F)cc2CCCS(=O)(=O)[O-])c[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C6(=O)[O-]"
} |
Can you make molecule CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCCCC1)n(C)c(=O)n2C | 102 | {
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C15CCCC1"
} |
Can you make molecule CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCCCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCCCCC1)n(C)c(=O)n2C | 102 | {
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C15CCCC1"
} |
Can you make molecule CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCSC1=CCCCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCSC1=CCCCCC1)n(C)c(=O)n2C | 102 | {
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C15CCCC1"
} |
Can you make molecule CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCC(Cl)CC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCC(Cl)CC1)n(C)c(=O)n2C | 102 | {
"fragment_index": 0,
"new_substring": "ClC1CCC&CC1",
"old_substring": "C15CCCC1"
} |
Can you make molecule CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCCCC1=CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCC1CCCC1)n(C)c(=O)n2C | CC(C)S(=O)(=O)c1cc2c(cc1NC(=O)CCCCC1=CCCC1)n(C)c(=O)n2C | 102 | {
"fragment_index": 0,
"new_substring": "C&CC1=CCCC1",
"old_substring": "C15CCCC1"
} |
Can you make molecule CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C(C(C)C)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)C(C(C)C)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)C&C(C)C",
"old_substring": "CC(C)C3"
} |
Can you make molecule CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)(CCC#N)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)(CCC#N)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)(C&)CCC#N",
"old_substring": "CC(C)C3"
} |
Can you make molecule CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](CI)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)[C@H](CI)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CI",
"old_substring": "CC(C)C3"
} |
Can you make molecule CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)(CCBr)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)(CCBr)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC&(C)CCBr",
"old_substring": "CC(C)C3"
} |
Can you make molecule CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CC[C@H](C)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | CC(C)CC[C@H](C)C1([C@@H]([NH3+])Cc2c(F)cccc2F)CCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)CC[C@@H]&C",
"old_substring": "CC(C)C3"
} |
Can you make molecule CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule. | CC(C)n1nc(-c2ccccc2Cl)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2ccccc2Cl)cc1NC(=O)N1CCC[C@@H]1C(N)=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c18ccccc1"
} |
Can you make molecule CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule. | CC(C)n1nc(-c2ccc(I)cc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2ccc(I)cc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c18ccccc1"
} |
Can you make molecule CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(-c2cc(NC(=O)N3CCC[C@@H]3C(N)=O)n(C(C)C)n2)cc1I | CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | Cc1ccc(-c2cc(NC(=O)N3CCC[C@@H]3C(N)=O)n(C(C)C)n2)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c18ccccc1"
} |
Can you make molecule CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule. | CC(C)n1nc(-c2cccc(Br)c2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | CC(C)n1nc(-c2cccc(Br)c2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | 102 | {
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c18ccccc1"
} |
Can you make molecule CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(-c2cc(NC(=O)N3CCC[C@@H]3C(N)=O)n(C(C)C)n2)c1C | CC(C)n1nc(-c2ccccc2)cc1NC(=O)N1CCC[C@@H]1C(N)=O | Cc1cccc(-c2cc(NC(=O)N3CCC[C@@H]3C(N)=O)n(C(C)C)n2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c18ccccc1"
} |
Can you make molecule CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)OC(=O)[C@H](C)CNC(=O)CC(C)(C)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)CC(C)(C)N[C@H]1CC[C@H]([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)OC(=O)[C@H](C)CNC(=O)CCC(C)(C)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)CCC(C)(C)N[C@H]1CC[C@H]([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(NC[C@@H](C)C(=O)OC(C)C)c(=O)n(N[C@H]2CC[C@H]([NH+](C)C)C2)n1C | CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 | Cc1c(NC[C@@H](C)C(=O)OC(C)C)c(=O)n(N[C@H]2CC[C@H]([NH+](C)C)C2)n1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
} |
Can you make molecule CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)c(NC[C@@H](C)C(=O)OC(C)C)nn1N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 | Cc1cc(=O)c(NC[C@@H](C)C(=O)OC(C)C)nn1N[C@H]1CC[C@H]([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
} |
Can you make molecule CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)OC(=O)[C@H](C)CNC(=O)C[C@@H](Br)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 | CC(C)OC(=O)[C@H](C)CNC(=O)C[C@@H](Br)N[C@H]1CC[C@H]([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
} |
Can you make molecule CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](CCc1ccc2[nH]c(=O)[nH]c2c1)[NH2+][C@@H]1CCN(C(C)=O)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 | CC[C@@H](CCc1ccc2[nH]c(=O)[nH]c2c1)[NH2+][C@@H]1CCN(C(C)=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]57C"
} |
Can you make molecule CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)N1CC[C@@H]([NH2+][C@@H](CBr)CCc2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@@H](CBr)CCc2ccc3[nH]c(=O)[nH]c3c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]57C"
} |
Can you make molecule CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)N1CC[C@@H]([NH2+][C@@H](CBr)CCCc2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@@H](CBr)CCCc2ccc3[nH]c(=O)[nH]c3c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]57C"
} |
Can you make molecule CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)N1CC[C@@H]([NH2+][C@H](CCl)CCCc2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](CCl)CCCc2ccc3[nH]c(=O)[nH]c3c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]57C"
} |
Can you make molecule CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)N1CC[C@@H]([NH2+][C@H]2CCC[C@H](c3ccc4[nH]c(=O)[nH]c4c3)C2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)C1 | CC(=O)N1CC[C@@H]([NH2+][C@H]2CCC[C@H](c3ccc4[nH]c(=O)[nH]c4c3)C2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]57C"
} |
Can you make molecule CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)OC(=S)S[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)OC(=S)S[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O57"
} |
Can you make molecule CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)OC(=N)C[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)OC(=N)C[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O57"
} |
Can you make molecule CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)C(=O)/C=C/S[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)C(=O)/C=C/S[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O57"
} |
Can you make molecule CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)[C@H](O)CCC[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)[C@H](O)CCC[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "O[C@@H]&CCC&",
"old_substring": "O57"
} |
Can you make molecule CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)c1cnn([C@H]2CC[C@@]3(C)C(=CC[C@@H]4[C@H]3CC[C@@]3(C)[C@H]4C[C@@H](C)[C@]3(OO)C(C)=O)C2)c(=O)c1 | CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@H]2CC[C@@]2(C)[C@H]3C[C@@H](C)[C@]2(OO)C(C)=O)C1 | CC(=O)c1cnn([C@H]2CC[C@@]3(C)C(=CC[C@@H]4[C@H]3CC[C@@]3(C)[C@H]4C[C@@H](C)[C@]3(OO)C(C)=O)C2)c(=O)c1 | 102 | {
"fragment_index": 0,
"new_substring": "O=c1cc&cnn1&",
"old_substring": "O57"
} |
Can you make molecule O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(COC(=S)Sc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(COC(=S)Sc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O45"
} |
Can you make molecule O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 less soluble in water? The output molecule should be similar to the input molecule. | N=C(Cc1ccc(I)cc1)OCC(=O)NC[C@@H]1COc2ccccc2O1 | O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | N=C(Cc1ccc(I)cc1)OCC(=O)NC[C@@H]1COc2ccccc2O1 | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O45"
} |
Can you make molecule O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(CCC(=O)c1ccc(I)cc1)CC(=O)NC[C@@H]1COc2ccccc2O1 | O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(CCC(=O)c1ccc(I)cc1)CC(=O)NC[C@@H]1COc2ccccc2O1 | 102 | {
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O45"
} |
Can you make molecule O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(C[C@H](O)CCc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(C[C@H](O)CCc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | 102 | {
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O45"
} |
Can you make molecule O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(/C=C/Sc1ccc(I)cc1)CC(=O)NC[C@@H]1COc2ccccc2O1 | O=C(COc1ccc(I)cc1)NC[C@@H]1COc2ccccc2O1 | O=C(/C=C/Sc1ccc(I)cc1)CC(=O)NC[C@@H]1COc2ccccc2O1 | 102 | {
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O45"
} |
Can you make molecule CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC less soluble in water? The output molecule should be similar to the input molecule. | CCc1c(-c2ccc3c(c2)OCCO3)nsc1S[C@H](C)C(=O)N[C@H](C)CC | CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC | CCc1c(-c2ccc3c(c2)OCCO3)nsc1S[C@H](C)C(=O)N[C@H](C)CC | 102 | {
"fragment_index": 0,
"new_substring": "c1&snc&c1&",
"old_substring": "c18ncc9n17"
} |
Can you make molecule CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC less soluble in water? The output molecule should be similar to the input molecule. | CCc1sc(S[C@H](C)C(=O)N[C@H](C)CC)nc1-c1ccc2c(c1)OCCO2 | CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC | CCc1sc(S[C@H](C)C(=O)N[C@H](C)CC)nc1-c1ccc2c(c1)OCCO2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&nc&c&s1",
"old_substring": "c18ncc9n17"
} |
Can you make molecule CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc3c(c2)OCCO3)nc1S[C@H](C)C(=O)N[C@H](C)CC | CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC | CCc1ccc(-c2ccc3c(c2)OCCO3)nc1S[C@H](C)C(=O)N[C@H](C)CC | 102 | {
"fragment_index": 0,
"new_substring": "c1&nc&ccc1&",
"old_substring": "c18ncc9n17"
} |
Can you make molecule CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc2c(S[C@H](C)C(=O)N[C@H](C)CC)ncc(-c3ccc4c(c3)OCCO4)c2n1 | CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC | CCc1ccc2c(S[C@H](C)C(=O)N[C@H](C)CC)ncc(-c3ccc4c(c3)OCCO4)c2n1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ncc&c2nc&ccc12",
"old_substring": "c18ncc9n17"
} |
Can you make molecule CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC less soluble in water? The output molecule should be similar to the input molecule. | CCc1nc2cc(-c3ccc4c(c3)OCCO4)ccc2nc1S[C@H](C)C(=O)N[C@H](C)CC | CC[C@@H](C)NC(=O)[C@@H](C)Sc1ncc(-c2ccc3c(c2)OCCO3)n1CC | CCc1nc2cc(-c3ccc4c(c3)OCCO4)ccc2nc1S[C@H](C)C(=O)N[C@H](C)CC | 102 | {
"fragment_index": 0,
"new_substring": "c1&nc2ccc&cc2nc1&",
"old_substring": "c18ncc9n17"
} |
Can you make molecule Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cc[nH]c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cc[nH]c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc[nH]c1",
"old_substring": "c15cn[nH]c1"
} |
Can you make molecule Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2nc(I)c(I)[nH]2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2nc(I)c(I)[nH]2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "Ic1nc&[nH]c1I",
"old_substring": "c15cn[nH]c1"
} |
Can you make molecule Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | O=c1[nH]ncc([C@H]2CCC[NH+](Cc3cc(-c4ccccc4)ccc3O)C2)c1Cl | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 | O=c1[nH]ncc([C@H]2CCC[NH+](Cc3cc(-c4ccccc4)ccc3O)C2)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cn[nH]c(=O)c1Cl",
"old_substring": "c15cn[nH]c1"
} |
Can you make molecule Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2ccc3[nH]ncc3c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2ccc3[nH]ncc3c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc2[nH]ncc2c1",
"old_substring": "c15cn[nH]c1"
} |
Can you make molecule Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 less soluble in water? The output molecule should be similar to the input molecule. | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2nc3ccccc3[nH]2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2cn[nH]c2)C1 | Oc1ccc(-c2ccccc2)cc1C[NH+]1CCC[C@H](c2nc3ccccc3[nH]2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "c1ccc2[nH]c&nc2c1",
"old_substring": "c15cn[nH]c1"
} |
Can you make molecule Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](CCc1nc(C)cs1)NC(=O)CCOc1ccccc1 | Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 | CC[C@@H](CCc1nc(C)cs1)NC(=O)CCOc1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]67C"
} |
Can you make molecule Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1csc(CC[C@H](CBr)NC(=O)CCOc2ccccc2)n1 | Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 | Cc1csc(CC[C@H](CBr)NC(=O)CCOc2ccccc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]67C"
} |
Can you make molecule Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1csc(CCC[C@H](CBr)NC(=O)CCOc2ccccc2)n1 | Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 | Cc1csc(CCC[C@H](CBr)NC(=O)CCOc2ccccc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]67C"
} |
Can you make molecule Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1csc(CCC[C@@H](CCl)NC(=O)CCOc2ccccc2)n1 | Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 | Cc1csc(CCC[C@@H](CCl)NC(=O)CCOc2ccccc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]67C"
} |
Can you make molecule Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1csc([C@H]2CCC[C@H](NC(=O)CCOc3ccccc3)C2)n1 | Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 | Cc1csc([C@H]2CCC[C@H](NC(=O)CCOc3ccccc3)C2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]67C"
} |
Can you make molecule COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)c[nH]2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)c[nH]2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&c[nH]1",
"old_substring": "c19cc8[nH]n1"
} |
Can you make molecule COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(-c2ccc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 | COc1cccc(-c2ccc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&[nH]1",
"old_substring": "c19cc8[nH]n1"
} |
Can you make molecule COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(-c2ccc3[nH]c(C(=O)N(CC(F)(F)F)C4CCOCC4)nc3c2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 | COc1cccc(-c2ccc3[nH]c(C(=O)N(CC(F)(F)F)C4CCOCC4)nc3c2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc2[nH]c&nc2c1",
"old_substring": "c19cc8[nH]n1"
} |
Can you make molecule COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(-c2ccc3[nH]cc(C(=O)N(CC(F)(F)F)C4CCOCC4)c3n2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 | COc1cccc(-c2ccc3[nH]cc(C(=O)N(CC(F)(F)F)C4CCOCC4)c3n2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc2[nH]cc&c2n1",
"old_substring": "c19cc8[nH]n1"
} |
Can you make molecule COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)c3cc[nH]c3n2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)[nH]n2)c1 | COc1cccc(-c2cc(C(=O)N(CC(F)(F)F)C3CCOCC3)c3cc[nH]c3n2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&c2cc[nH]c2n1",
"old_substring": "c19cc8[nH]n1"
} |
Can you make molecule CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCn1ccnc(NCCCC2=NCCN2C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCCC2=NCCN2C(=O)OC(C)(C)C)c1=O | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCN=C1C&",
"old_substring": "N36C"
} |
Can you make molecule CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCn1ccnc(NCCc2sc(C(=O)OC(C)(C)C)cc2C#N)c1=O | CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCc2sc(C(=O)OC(C)(C)C)cc2C#N)c1=O | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N36C"
} |
Can you make molecule CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCn1ccnc(NCCc2ccc(C(=O)OC(C)(C)C)cc2C#N)c1=O | CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCc2ccc(C(=O)OC(C)(C)C)cc2C#N)c1=O | 102 | {
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N36C"
} |
Can you make molecule CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCn1ccnc(NCCN2CCC(=NOC(=O)OC(C)(C)C)CC2)c1=O | CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCN2CCC(=NOC(=O)OC(C)(C)C)CC2)c1=O | 102 | {
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N36C"
} |
Can you make molecule CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCn1ccnc(NCCCC2=CCCN(C(=O)OC(C)(C)C)C2)c1=O | CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O | CCn1ccnc(NCCCC2=CCCN(C(=O)OC(C)(C)C)C2)c1=O | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N36C"
} |
Can you make molecule COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COCc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COCc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COCSc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COCSc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc2c(cc1SC(C)=O)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COc1cc2c(cc1SC(C)=O)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc2c(cc1C(=O)CS)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COc1cc2c(cc1C(=O)CS)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO6"
} |
Can you make molecule COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc2c(cc1C(=O)CI)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | COc1cc2c3cnn(CN4CCN(c5ccccc5OC)CC4)c(=O)c3n(C)c2cc1OC | COc1cc2c(cc1C(=O)CI)c1cnn(CN3CCN(c4ccccc4OC)CC3)c(=O)c1n2C | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO6"
} |
Can you make molecule COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C less soluble in water? The output molecule should be similar to the input molecule. | COc1c(C)cnc(CCCC[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(CCCC[NH2+][C@H]2CCC[C@@H](C)C2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C46"
} |
Can you make molecule COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C less soluble in water? The output molecule should be similar to the input molecule. | COc1c(C)cnc(CCCCC[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(CCCCC[NH2+][C@H]2CCC[C@@H](C)C2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C46"
} |
Can you make molecule COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C less soluble in water? The output molecule should be similar to the input molecule. | COc1c(C)cnc(C2CC([NH2+][C@H]3CCC[C@@H](C)C3)C2)c1C | COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(C2CC([NH2+][C@H]3CCC[C@@H](C)C3)C2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C46"
} |
Can you make molecule COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C less soluble in water? The output molecule should be similar to the input molecule. | COc1c(C)cnc(SC(=S)O[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(SC(=S)O[NH2+][C@H]2CCC[C@@H](C)C2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C46"
} |
Can you make molecule COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C less soluble in water? The output molecule should be similar to the input molecule. | COc1c(C)cnc(NC(=S)S[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(C[NH2+][C@H]2CCC[C@@H](C)C2)c1C | COc1c(C)cnc(NC(=S)S[NH2+][C@H]2CCC[C@@H](C)C2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C46"
} |
Can you make molecule Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(I)c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(I)c2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c18ccc(C)c([N+](=O)[O-])c1"
} |
Can you make molecule Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Br)c(C=O)c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Br)c(C=O)c2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(C=O)c1",
"old_substring": "c18ccc(C)c([N+](=O)[O-])c1"
} |
Can you make molecule Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(Cl)c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(Cl)c2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c18ccc(C)c([N+](=O)[O-])c1"
} |
Can you make molecule Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(Br)c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(Br)c2)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Br)c1",
"old_substring": "c18ccc(C)c([N+](=O)[O-])c1"
} |
Can you make molecule Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(F)c2F)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-] | Cc1ccc(C(=O)NCCNC(=O)c2ccc(Cl)c(F)c2F)cc1[N+](=O)[O-] | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(F)c1F",
"old_substring": "c18ccc(C)c([N+](=O)[O-])c1"
} |
Can you make molecule COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | COC(=O)CC(C)(C)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)CC(C)(C)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
} |
Can you make molecule COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | COC(=O)CCC(C)(C)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)CCC(C)(C)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
} |
Can you make molecule COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | COC(=O)C[C@@H](Br)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)C[C@@H](Br)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
} |
Can you make molecule COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(OOC)c1ccc(N2CCN(Cc3cccc(-c4ccccn4)c3)CC2)cc1 | COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | C=C(OOC)c1ccc(N2CCN(Cc3cccc(-c4ccccn4)c3)CC2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C=C(O&)c1ccc&cc1",
"old_substring": "C45=O"
} |
Can you make molecule COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(CC)(OC)C(=O)CCN1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | COC(=O)N1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | CCC(CC)(OC)C(=O)CCN1CCN(Cc2cccc(-c3ccccn3)c2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C45=O"
} |
Can you make molecule Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)[C@@H]1CCC[NH+]1Cc1cc2cccc(C)c2nc1-c1cccc(Cl)c1 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 | CC(=O)[C@@H]1CCC[NH+]1Cc1cc2cccc(C)c2nc1-c1cccc(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(C)=O",
"old_substring": "C5(N)=O"
} |
Can you make molecule Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc2cc(C[NH+]3CCC[C@H]3CCCCC(N)=O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3CCCCC(N)=O)c(-c3cccc(Cl)c3)nc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C5(N)=O"
} |
Can you make molecule Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc2cc(C[NH+]3CCC[C@H]3C/C(N)=N\O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C/C(N)=N\O)c(-c3cccc(Cl)c3)nc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&/C(N)=N\\O",
"old_substring": "C5(N)=O"
} |
Can you make molecule Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc2cc(C[NH+]3CCC[C@H]3CC/C(N)=N/O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3CC/C(N)=N/O)c(-c3cccc(Cl)c3)nc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C5(N)=O"
} |
Can you make molecule Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc2cc(C[NH+]3CCC[C@H]3CC/C(N)=N\O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3C(N)=O)c(-c3cccc(Cl)c3)nc12 | Cc1cccc2cc(C[NH+]3CCC[C@H]3CC/C(N)=N\O)c(-c3cccc(Cl)c3)nc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C5(N)=O"
} |
Can you make molecule CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule. | CO[C@H](CN[C@@H](c1ccc(Cl)s1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1ccc(Cl)s1)C1CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c15cccs1"
} |
Can you make molecule CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule. | CO[C@H](CN[C@@H](c1ccc(Br)s1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1ccc(Br)s1)C1CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c15cccs1"
} |
Can you make molecule CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule. | CO[C@H](CN[C@@H](c1sccc1Br)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1sccc1Br)C1CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c15cccs1"
} |
Can you make molecule CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule. | CO[C@H](CN[C@@H](c1csc(I)c1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1csc(I)c1)C1CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c15cccs1"
} |
Can you make molecule CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule. | CO[C@H](CN[C@@H](c1cc2c(s1)CSC2)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cccs1)C1CC1)c1ccccc1 | CO[C@H](CN[C@@H](c1cc2c(s1)CSC2)C1CC1)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c15cccs1"
} |
Can you make molecule CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C[C@H](NSC(=O)Cc1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NSC(=O)Cc1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
} |
Can you make molecule CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C[C@H](NC(=O)CCCC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)CCCC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
} |
Can you make molecule CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C[C@H](NC(=O)CC(C)(C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)CC(C)(C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
} |
Can you make molecule CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C[C@H](NC(=O)CCC(C)(C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)CCC(C)(C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
} |
Can you make molecule CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)C[C@H](NSC(=O)[C@@H](C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NC(=O)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | CC(C)C[C@H](NSC(=O)[C@@H](C)c1csc2ncccc2c1=O)C(=O)N1CCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
} |
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