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S0009279719318502 | Adriamycin nephropathy model a rodent model of nephrotic syndrome disease that was caused by the nephrotoxicity of adriamycin has been widely used for pharmacodynamic evaluation of traditional Chinese medicine in the treatment of kidney injury . Although some studies have clearly shown the pathological process of AN th... | Adriamycin nephrotic rat model can imitate human nephrotic syndrome. A value based on topological parameters is to evaluate the importance of target. The key target genes of adriamycin induced renal injury are Mapk10 and Ptgs2. Regulation of biosynthesis of unsaturated fatty acids is involved in kidney injury. |
S0009279719318587 | Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease asthma pulmonary fibrosis and lung cancer . Currently there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics . Berbe... | Inflammatory responses play a crucial role in chronic respiratory diseases. Berberine functions through the NF kB ERK1 2 and p38 MAPK pathways. Berberine causes a decrease in pro inflammatory cytokine levels. Berberine improves the histological changes in the lung tissue of rat models. Berberine suppresses tumours by i... |
S0009279719318952 | Polycystic Ovary Syndrome as a common endocrine disorder is accompanied by hyperandrogenism insulin resistance ovulation problems and infertility . Various types of off label drugs like metformin have been used for the management of targeted problems caused by PCOS such as insulin resistance and hyperandrogenism . Nico... | NAM and MNAM reversed the abnormal estrous cycles of letrozole induced PCOS rats. . NAM and MNAM showed the anti androgenic and insulin sensitizing effects. NAM and MNAM activate AMPK in adipose and ovarian tissues of PCOS rats. |
S0009279719319283 | Ginsenoside Rg1 is an active ingredient extracted from the roots of ginsenoside and an naphthylisothiocyanate induced rat model of intrahepatic cholestasis was used to investigate the protective effect of Rg1 on cholestasis . 48 SD male rats were randomly divided into 6 groups control group model group UDCA group low d... | Ginsenoside Rg1 can alleviate ANIT induced intrahepatic cholestasis in rats. Ginsenoside Rg1 can activate farnesoid X receptor. Ginsenoside Rg1 can regulate transporters and metabolic enzymes. |
S0009279719319532 | Oxidative stress in cardiac myocytes is an important pathogenesis of cardiac lipotoxicity . Autophagy is a cellular self digestion process that can selectively remove damaged organelles under oxidative stress and thus presents a potential therapeutic target against cardiac lipotoxicity . Globular CTRP9 is a newly ident... | Impaired autophagic flux induced by palmitic acid contribute to cytotoxicity in NRCMs. CTRP9 upregulates autophagy in NRCMs in the absence or presence of palmitic acid. CTRP9 alleviated PA induced lipotoxicity in NRCMs. ATG5 knockdown eliminated the protective effect of CTRP9 on the cardiac lipotoxicity. |
S0009279719319581 | Runx2 is a key transcription factor which is associated with osteoblast differentiation and expressed in ER human breast cancer cell lines . Runx2 also participates in mammary gland development . Deregulation of RNA Pol III genes is tightly linked to tumor development while Brf1 specifically regulates these gene transc... | Runx2 was overexpressed in human cases of breast cancer. High Runx2 expression of breast cancer cases display worse prognosis. Alcohol increased Runx2 to elevate Brf1 and Pol III gene transcription. Inhibiting Runx2 repressed Brf1 expression and Pol III gene transcription. Runx2 and Brf1 colocalize in nucleus of tumor ... |
S0009279719319647 | Epithelial mesenchymal transformation plays a crucial role in the metastasis of bladder cancer which makes bladder cancer difficult to cure . Bladder cancer is the most common malignancy of the urinary system and distant metastasis is the leading cause of death . Therefore finding a bioactive drug that can specifically... | Thymoquinone inhibits migration and invasion in bladder cancer cells. Thymoquinone suppresses EMT in bladder cancer cells. Thymoquinone inhibits the activation of Wnt catenin signaling pathway. catenin plays a key role in EMT inhibition induced by TQ. Thymoquinone exerts an anti metastasis effect of bladder cancer in v... |
S0009279719319854 | Epigenetic variations can play remarkable roles in different normal and abnormal situations . Such variations have been shown to have a direct role in the pathogenesis of various diseases either through inhibition of tumor suppressor genes or increasing the expression of oncogenes . Enzymes involving in epigenetic mach... | In normal and pathogenic cases epigenetics may play an important role. Epigenetic machinery mutations can have preventive therapeutic potential. This outlines a basis for epigenetic therapies in AML. |
S0009279719319970 | Pyroptosis a form of programmed cell death has garnered increasing attention as it relates to innate immunity and diseases . The discovery of caspase 1 3 4 5 8 11 function in sensing various challenges expands the spectrum of pyroptosis mediators and also reveals that pyroptosis is not cell type specific . Recent studi... | Pyroptosis is a pro inflammatory form of programmed cell death. Pyroptosis can be mainly induced via the activation of caspase 3 4 5 8 11. Pyroptosis plays crucial roles in the pathogenesis of cancer diseases. Pyroptosis pathway is a potential therapeutic target in cancer diseases. |
S0009279719320046 | Early initiated decontamination is demonstrated to be crucial to avoid systemic effects of highly toxic and low volatile agents exposed on the skin . Skin decontamination can be performed by simple procedures such as washing with soap and water or by using advanced decontamination products containing absorption and age... | Repeated swabbing and time for RSDL to act on skin is important for VX decontamination. For decontamination of nerve agents water content should be kept low to avoid a wash in effect. Soapy water decontamination significantly increased skin penetration of VX. |
S0009279719320101 | Geraniol like other plant derived natural bioactive compounds has been found to possess antiproliferative properties that are essential to cope with malignant tumors . However the mechanisms of molecular action of GOH are not fully elucidated . The aim of this study was to evaluate the effect of GOH on some oxidative p... | GOH effects on some oxidative parameters in HepG2 and A549 were studied. Lipids were damage but not DNA in both tumor cells. SOD and CAT were more sensitive in HepG2 than in A549 while GST was not affected. ROS and lactate increased but not nitric oxide in HepG2. Oxidative stress could mediate the anti proliferative ef... |
S0009279719320149 | The review summarizes literature data on the DNA binding DNA protecting and DNA damaging activities of a range of natural human endogenous and exogenous compounds . Small natural organic molecules bind DNA in a site specific mode by arranging tight touch with the structure of the major and minor grooves as well as indi... | Numerous polyphenols and other natural compounds bind DNA. Small organic molecules that bind to DNA can both exogenous and endogenous. The DNA binding compound can damage and protect DNA against other genotoxic agents. Conditions when a compound damages or protects DNA are difficult to elucidate. |
S0009279719320393 | In this study we assessed the efficacy of the Reactive Skin Decontamination Lotion Kit against parathion and aldicarb pesticide dermal exposure in a guinea pig model . The pesticides inhibit acetylcholinesterase leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholine . The RSDL Kit... | Guinea pigs dermally exposed to parathion and aldicarb were decontaminated with RSDL. RSDL Kit is an effective decontaminant against parathion and aldicarb pesticide. Base on the in vivo study the Kit can help mitigate acute exposure from pesticides. |
S0009279719320526 | Phytoestrogens are plant derived substances with a similar structure to 17 beta estradiol which have protective roles in estrogen dependent diseases . Isoflavones the most well known subgroup of phytoestrogens play protective roles against chemicals induced liver injuries through several molecular mechanisms . Hepatopr... | Isoflavones protect the liver against injury induced by hepatotoxic drugs. Isoflavones exert a protective role against alcoholic liver disease. Isoflavones play a protective role in toxicant induced liver injury. Mechanisms of hepatoprotective roles of isoflavones have been summarized. |
S0009279719320769 | Human scalp hair is a biological matrix that can trap chemical vapours from explosives drugs and chemical weapons . The external contamination of human s hair following exposure to organophosphorus nerve agent was simulated by model compounds triethyl phosphate and diisopropyl fluorophosphate . In this work were expose... | Scalp hair can be used as a passive sensor able to trap organophosphorous agents. Sorption kinetics are best fitted by a bimodal firstorder model. Sorption isotherms follow Freundlich model. Qualitative and quantitative informations can be expected in the field. |
S0009279719321003 | The inhibition of the enzyme acetylcholinesterase is a frequently used therapeutic option to treat Alzheimer s disease . By decreasing the levels of acetylcholine degradation in the synaptic space some cognitive functions of patients suffering from this disease are significantly improved . Rivastigmine is one of the mo... | XRD and DSC indicated that rivastigmine interacted with DMPC and DMPE bilayers. Rivastigmine induces morphological alterations in human erythrocytes. Rivastigmine molecules locate in both monolayers of the human erythrocyte membrane. |
S0009279719321143 | Acetylcholinesterase terminates cholinergic neurotransmission by hydrolyzing acetylcholine . The collagen tailed AChE tetramer is a product of 2 genes ACHE and ColQ . The AChE tetramer consists of 4 identical AChE subunits and one polyproline rich peptide whose function is to hold the 4 AChE subunits together . Our goa... | Trypsin digestion converted collagen tailed AChE to soluble AChE tetramers. Trypsin shortened the collagen tail leaving only polyproline rich peptides. AChE assembles into tetramers by interaction with a polyproline rich peptide. Mass spectrometry identified the polyproline rich peptides in TcAChE tetramers. |
S0009279719321295 | An imbalance between oxidants and antioxidants in favour of oxidants potentially leading to damage is termed oxidative stress . Antioxidants either enzymatic or non enzymatic are the ones that can reduce diverse effects of pro oxidants such as DNA proteins and lipids damage . Chalcones are open chain flavonoids that ar... | biological model system. The best antioxidative properties showed methyl phenol and nitro chalcones. Further investigation should lead to chalcones use in human medicine. |
S0009279719321301 | Rheumatoid Arthritis affects approximately 1 of the total world population . Despite incessant research and development of new therapeutic agents management of RA is still a troublesome affair . Histone Deacetylase 1 is an epigenetic regulator which play important role in pathogenesis of RA . In present study we hypoth... | Histone Deacetylase 1 HDAC1 is an epigenetic regulator in pathogenesis of RA. Phenethyl isothiocyanate PEITC is a potent inhibitor of HDAC1. In this study efficacy of PEITC was evaluated against RA in rats. Primary and secondary lesions TNF HDAC1 levels and histology were evaluated. Results suggest potent anti RA activ... |
S0009279719321386 | Triple negative breast cancer is the most aggressive form of breast cancer with limited intervention options . Moreover a number of belligerent therapeutic strategies adopted to treat such aggressive forms of cancer have demonstrated detrimental side effects . This necessitates exploration of targeted chemotherapeutics... | A novel indenone derivative nID demonstrated anticancer potential in triple negative breast cancer TNBC cells. The nID caused G1 arrest in breast cancer MDA MB 231 cells. It modulated the p53 NF B survivin axis to upregulate p21. in MDA MB 231. The nID induced p53 dependent senescence in TNBC MDA MB 231 and MDA MB 468 ... |
S0009279720300041 | In patients with acute kidney injury progressively converting into chronic kidney disease proteinuria and high blood pressure predict progression to end stage renal disease . Although Renin angiotensin aldosterone system regulates blood pressure and kidney disease through both direct and indirect mechanisms . RAAS bloc... | The RAAS is a critical regulator of blood volume and systemic vascular resistance. RAAS inhibitors prevent proteinuria kidney fibrosis and the slow decline of renal function. RAAS inhibitors play a protective role in both the early and end stages of kidney disease. |
S0009279720300168 | A growing body of evidence indicates that exposure to nonylphenol a typical persistent organic pollutant in early life results in the impairment of the central nervous system but the underlying mechanism still remains to be elucidated . High levels of pro inflammatory cytokines in the brain have been implicated in the ... | NP exposure in early life increased pro inflammatory cytokines in prefrontal cortex. NP exposure in early life also increased these cytokines in intestine and serum. Gut brain communication may contribute to increased cytokines in prefrontal cortex. |
S0009279720300326 | Montelukast is a cysteinyl leukotriene receptor antagonist with efficacy against a variety of diseases including asthma and inflammation related conditions . However various neuropsychiatric events suspected to be related to montelukast have been reported recently with limited understanding on their association and und... | This study provides the first. evidence on Montelukast toxicity to microglial and neuronal cells. Provides evidence that this toxicity may be mediated by inflammatory response. Suggests that the inflammatory response and toxicity may contribute to neuropsychiatric events seen with montelukast use. |
S0009279720300478 | Reactive oxygen species is mainly produced as a by product from electron transport chain of mitochondria and effectively eliminated by cellular antioxidants . However 2 chloroethyl ethyl sulfide exposure to keratinocytes declined antioxidant capacity and increased accumulation of ROS triggered alteration of mitochondri... | CEES exposure enhance electron leakage from mitochondria leading to ROS accumulation and decline the antioxidants activity. Accumulated ROD due to CEES exposure augments decrease in m and increased in mitochondrial mass. CEES exposure provoked mitochondrial dysfunctions in keratinocytes. Fragmented mtDNA due to CEES ex... |
S0009279720300545 | Non small cell lung cancer is one of the common malignant tumors and multidrug resistance and tumor metastasis limit the anticancer effect of NSCLC . Therefore it is necessary to develop new anticancer drug that can inhibit MDR and metastasis of NSCLC . In the present study we found that 5 4 piperazine 1 carbonyl 2 | MAY inhibits microtubule polymerization in A549 and A549 Taxol cells. MAY induces apoptosis in A549cells and A549 Taxol cells. MAY inhibits P gp expression and function in A549 Taxol cells. MAY inhibits EMT by targeting Twist1 in A549 Taxol cells. |
S0009279720300636 | UDP glucuronosyltransferases are a family of phase II drug metabolizing enzymes that catalyze glucuronidation of numerous endogenous and exogenous substrates . Carbon tetrachloride CCl | Dysregulation of UGTs in CCl. induced liver injury rats is isoform specific. CCl. dysregulated UGTs in rats depending on the exposure time. CCl. induced liver injuries could inhibited the enzyme activities of rat UGTs. UGTs dysregulation was accompanied by the diversity of nuclear receptors expression. |
S0009279720300661 | The mortality rates for acute myeloid leukemia are very high necessitating the search for novel chemotherapeutic candidates . Herein we investigated the anticancer potential of a new synthetic compound 2 ethyl 3 methyliden 1 tosyl 2 3 dihydroquinolin 4 1 | Anticancer potential of a new quinolinone analog was assessed. AJ 374 was highly cytotoxic for HL 60cells but not for healthy HUVEC cells. AJ 374 induced apoptosis by intrinsic and extrinsic pathway without ROS generation. The compound promoted the cell cycle arrest in the subG0 G1 phase. |
S0009279720300703 | Ketamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs that influence monoamine neurotransmitters including noradrenaline dopamine or serotonin . Ketamine is thought to act by blocking N methyl | Ketamine is thought to act by blocking N methyl. aspartate NMDA receptors in the brain. Ketamine is an arylcycloalkylamine that is structurally related to phencyclidine PCP . This review exploring the molecular targets for the treatment and psychomimetic phenomena of the ketamine. |
S0009279720300788 | Oxidative stress induced apoptosis of retinal ganglion cells contributes to the development and progression of glaucoma . Sestrin2 a stress inducible protein has a potent antioxidant capacity that can provide cytoprotection against various noxious stimuli . However whether Sesn2 is involved in protecting RGCs from oxid... | Sesn2 expression is induced by in H. exposure in RGCs. Sesn2 overexpression alleviated H. induced injury in RGCs. Sesn2 enhances Nrf2 activation by inhibiting Keap1. Sesn2 exerts cytoprotective effect by enhancing Nrf2 activation. |
S0009279720301216 | Ulcerative colitis is a chronic idiopathic and inflammatory disease of the rectal and colonic mucosa . Studies have shown that Toll like receptors 4 and Signal Transducer and Activator of Transcription 3 mediated the decline in immune function and inflammatory infiltration are potential pathomechanism of UC occurrence ... | Mice model with UC are established via dextran sodium sulphate administration. Erianin has anti ulcerative colitis UC activity in mice with UC. Erianin shows anti inflammatory and antioxidant function in mice with UC. Erianin s anti UC activity is collaboratively mediated by TLR4 and STAT3. |
S0009279720301228 | Increasing studies have well documented the involvement of numerous lncRNAs in regulating the malignant phenotypes of various tumors including non small cell lung cancer cells . However up to date the effects and mechanism of lncRNA amine oxidase copper containing 4 pseudogene in NSCLC progression remain undefined . AO... | AOC4P was lowly expressed in NSCLC cells. AOC4P overexpression inhibited the proliferation and the Wnt catenin pathway in NSCLC cells. AOC4P overexpression suppressed the invasion and induced apoptosis of NSCLC cells. AOC4P overexpression suppressed tumor growth in a xenograft mouse model. |
S000927972030137X | Apple polyphenols have attracted much attention due to their various bioactivities . In this study the protective effect of AP against chronic ethanol exposure induced neural injury as well as the possible mechanisms were investigated . Body weight daily average food intake and daily average fluid intake were measured ... | Apple polyphenols improved chronic ethanol exposure induced inhibition of body weight and daily average food intake. Motor activity and motor coordination were not influenced after chronic ethanol exposure under our experimental protocol. Apple polyphenols improved chronic ethanol induced memory impairments in the Y ma... |
S0009279720301381 | Herbal medicines and their bioactive compounds are increasingly being recognized as useful drugs for cancer treatments . The parasitic fungus Cordyceps militaris is an attractive anticancer herbal since it shows very powerful anticancer activity due to its phytocompound cordycepin . We previously discovered and reporte... | Xylitol induces selective cancer death through oxidative stress caused by the induced CHAC1. Xylitol mediated CHAC1 induction is required for the ER stress. Xylitol efficiently sensitized cancer cells to chemotherapeutic drugs. as well as |
S0009279720301496 | In the present study eighteen inhibitors of the hydrolytic enzymes of the endocannabinoid system were investigated for antioxidant activity using lipid peroxidation method . Among the assayed compounds ten belong to carbamates with phenyl 3 ylcarbamate | antioxidant activity was evaluated using lipid peroxidation LP method. activity of the most potent compound. was comparable with standard antioxidants. Theoretical calculations were involved in order to clarify a possible mechanism of action. Appropriate models for HAT SET and SPLET mechanisms of the antioxidant activi... |
S0009279720301629 | The debilitating nature of cognitive impairment in epilepsy and the potential of some traditional antiepileptics to further deteriorate cognitive function are areas of growing concern . Glucagon like peptide 1 deficiency has been linked to reduced seizure threshold as well as cognitive dysfunction . Here we tested whet... | PTZ kindling is associated with diminished hippocampal GLP 1. SITA protected against PTZ induced seizures and cognitive deficits in rats. SITA improves cognitive function in kindled rats evidenced by lowered A and p tau as well as increased Ach levels. SITA corrects glutamate GABA imbalance in kindled rats possibly via... |
S0009279720301800 | Till now monocrotophos has been addressed as a neurotoxic stressor . Limited studies investigate its aftermath on bone pathologies . Given the fact that MCP is a propensely used insecticide in developing countries this study investigates its potential to mirror osteoporotic features and bone loss incurred in a rodent m... | Oral gavaging of MCP to Swiss albino mice mimic human trabecular bone loss. MCP induced loss of bone mass is due to increased osteoclastogenesis. This model can be used for osteoporotic preclinical therapeutic investigations. |
S0009279720302398 | Human butyrylcholinesterase is a stoichiometric bioscavenger that protects from the toxicity of nerve agents . Non human primates are suitable models for toxicity studies that can not be performed in humans . We evaluated the biochemical properties of native macaque tetramers compared to recombinant MaBChE monomers PEG... | Macaque and human butyrylcholinesterase have similar catalytic properties. Biochemical properties of monomeric and tetrameric BChE forms are identical. 2 PAM reactivates DFP inhibited HuBChE 300 fold faster than DFP Macaque BChE. Proline 285 in HuBChE has a major role in fast reactivation by 2 PAM. |
S0009279720302489 | Oncogenic alterations in the BRAF gene are identified in an estimate of 50 of melanomas and cause melanoma development . BRAF kinase inhibitors including vemurafenib and dabrafenib were discovered and used in the clinical treatment of BRAF mutant metastatic melanoma . Though BRAFi s therapeutic advantages are short ter... | BRAFi were used in the clinical treatment of BRAF mutant metastatic melanoma. BRAFi s therapeutic advantages are short term associated with drug resistance. Rho regulated gene transcription is a promising therapeutic approach to restore sensitivity to BRAFi resistant tumors. |
S0009279720302556 | The prenylated flavonoid icaritin is currently undergoing phase 3 clinical trial for the treatment of advanced hepatocellular carcinoma based on a solid array of preclinical and clinical data . The antitumor activity originates from the capacity of the drug to modulate several signaling effectors in cancer cells mainly... | The prenyl flavonoid icaritin is in clinical trial for the treatment of hepatocellular carcinoma. The estrogen receptor ER36 and sphingosine kinase 1 are icaritin targets. The drug modulates multiple cellular pathways contributing to the anticancer activity. The drug displays immune modulatory effects that reinforce th... |
S0009279720302878 | Despite advances in cancer treatment modalities DNA still stands as one of the targets for anticancer agents . DNA minor groove binders represent an important investigational chemotherapeutic class with promising cytotoxic capacity . Herein this study reports the potent cytotoxic effect of a series of repurposed flexib... | In vitro cytotoxicity of flexible triaryl guanidines and imidamides against breast cancer. Flow cytometric cell cycle and apoptosis analysis of MCF 7cells treated with imidamide. Imidamide. induces significant increase of p53 PUMA and Bax gene expression and reduction of Bcl 2. In vivo anticancer effect on treated EAC ... |
S000927972030301X | Osteoarthritis is a common degenerative joint disease that is closely associated with inflammation . Stachydrine is a bioactive alkaloid with anti inflammatory activity . However the role of STA in OA remains unknown . This study aimed to explore the effects of STA on OA chondrocytes in the presence of IL 1 . Primary h... | STA inhibits IL 1 induced production of NO and PGE2 in chondrocytes. STA decreases IL 1 induced expression of iNOS and COX 2 in chondrocytes. STA suppresses IL 1 induced production of TNF and IL 6 in chondrocytes. STA inhibits IL 1 induced production of ECM degrading enzymes in chondrocytes. STA prevents IL 1 induced N... |
S0009279720303264 | A previous study demonstrated that glutathione produces specific antidepressant like effect in the forced swimming test a predictive test of antidepressant activity . The present study investigated the involvement of multiple cellular targets implicated in the antidepressant like effect of GSH in the FST . The antidepr... | GSH produces synergistic antidepressant effect when combined with antidepressants. NMDAR NOS pathway inhibition is implicated in the antidepressant effect of GSH. GABA receptors are involved in the antidepressant like effect of GSH. 1 adrenoceptor activation is associated to GSH antidepressant effect. Redox mediated si... |
S000927972030346X | The sepsis is considered as serious clinic pathological condition related with high rate of morbidity and mortality in critical care settings . In the proposed study the hydrazides derivatives | The NCHDH and NTHDH treatment markedly improved the survival rate and biochemical parameters. The NCHDH and NTHDH treatment markedly improved the histological parameters compared to LPS control. The NCHDH and NTHDH treated group showed significant reduction in the oxidative stress and enhanced the anti oxidants enzymes... |
S0009279720303768 | Cardiac inflammation plays a critical role in the development of heart failure . Inflammation induced oxidative stress contributes to aberrant cardiac metabolism and mitochondrial function . GLP 1 receptor agonists are a type of blood glucose lowering agent typically used in the treatment of type 2 diabetes . Recent st... | Cardiac inflammation plays a significant role in heart failure. Liraglutide ameliorates IL 1 induced mitochondrial dysfunction and metabolic disturbance. AMPK activation is required for the action of Liraglutide. |
S000927972030404X | Inhibition of mouse double minute 2 homolog p53 interaction and reactivation of p53 signaling have been explored as effective anticancer therapeutic strategy . The potent and specific antitumor activity shown by Nutlins first class of MDM2 p53 inhibitors discovered has made these compounds potential antitumor candidate... | A new piperazine compound was obtained through molecular simplification of Nutlins. LQFM126 prototype promoted cell cycle arrest and apoptosis in melanoma cells. LQFM126 has shown low estimated toxicity and. antiangiogenic activity. |
S000927972030418X | Doxorubicin administration decreases cardiac soluble guanylate cyclase activity . We hypothesized that bypassing impaired NO sGC cGMP pathway resulting from the activation of oxidized and heme free soluble guanylate cyclase could be a therapeutic target for DOX mediated cardiomyopathy . The present study investigated t... | Doxorubicin directly induces oxidative stress in the mitochondria. Doxorubicin reduces cardiac soluble guanylate cyclase and reduces sGC activity. sGC pathway activation could be a therapeutic target for DOX mediated cardiotoxicity. BAY60 2770 a sGC activator may relieve cardiotoxicity caused by doxorubicin. |
S0009279720304361 | Embryonic studies have demonstrated the neurotoxic teratogenic and neurobehavioral toxicity of ethanol . Although multiple mechanisms may contribute to these effects oxidative stress has been described as the major damage pathway . In this regard natural antioxidants have the potential to counteract oxidative stress in... | Zebrafish embryos were co exposed to 1 EtOH and 24 EPI at 2 hpf for 24 h. Embryonic exposure to EtOH resulted in malformations which were ameliorated by 24 EPI. EtOH exposure resulted in an increased accumulation of GSSG that was overturned by 24 EPI. Exposure to EtOH resulted in aversive behaviour disruption of 5 dpf ... |
S0009279720304415 | Acacetin is a natural flavonoid that is widely distributed in plants and possesses numerous pharmacological activities . The aim of the present study was to investigate the effects of acacetin on the activities of the cytochrome P450 family members CYP1A2 CYP2B1 CYP2C11 CYP2D1 CYP2E1 and CYP3A2 in rat liver microsomes | We investigated effects of acacetin on activities of cytochrome P450 family members. UPLC MS MS method developed for simultaneous detection of substrates and metabolites. CYP2B1 CYP2C11 CYP2E1 CYP1A2 and CYP3A2 were inhibited by acacetin. AUC CL and C. of drug substrates differed significantly with acacetin. Acacetin c... |
S0009279720304749 | Alzheimer s disease is a common neurodegenerative disease and its pathogenesis is closely related to amyloid peptide . The deposition of A in the brain due to impaired A clearance is considered as an important cause of AD . The decrease in A clearance is closely related to the autophagy dysfunction in brains of AD pati... | Graphene oxide GO protected neurons in pathological conditions. Microglia and neurons were co cultured to simulate pathological environment. GO promoted the clearance of A in pathological conditions. GO induced autophagy of microglia and neurons through the AMPK mTOR pathway. |
S0009279720304750 | Hydroxychloroquine is frequently used medications for many auto immunity diseases . However HCQ induced retinal toxicity which might result in irreversible retinopathy is one of the most important complications of HCQ . However the molecular mechanism underlying the HCQ retinal toxicity is still not well known . Retina... | Explore the biomarker of Hydroxychloroquine induced retinal toxicity. Investigate the disturbed metabolic pathways in retinal pigment epithelial cells by HCQ exposure. Provide new clues to the pathogenesis of HCQ induced retinopathy. |
S0009279720304841 | Lung cancer is one of the leading causes of cancer related death worldwide . It has aggressive manifestation high ability to promote metastasis and late diagnosis . In the present study we investigated the cytotoxic effect of 3 3 5 5 tetramethoxybiphenyl 4 4diol against the A549 human non small cell lung carcinoma line... | predictions showed good drug likeness potential for TMBP. TMBP promotes cytotoxic action and changes in cell size in A549cells. TMBP increases the production of ROS and disrupts the cell cycle in G2 M. TMBP alters the m and. promotes formation of droplets lipid in A549. Treatment with TMBP induces apoptosis in tumor ce... |
S0009279720304865 | The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease . Multiple complex regulatory pathways manifest chronic pulmonary di... | Plant derived therapeutics for managing chronic respiratory disorders. Activity of natural product based molecules on key regulatory pathways of COPD. Preclinical evidence for the efficacy of natural product moieties. Clinical significance of plant derived molecules in pulmonary distress. |
S0009279720304889 | The present study analyzed whether melatonin could mediate the expression of VEGF IL 6 and TNF as well as the apoptotic index in rats with diabetic retinopathy . Fifty Wistar albino rats were divided into the following groups GC rats without induction of diabetes by streptozotocin GD rats induced to diabetes by strepto... | Melatonin mitigates the adverse effects of diabetic retinopathy. Melatonin reduced inflammatory cytokines in the retina of rats with diabetes. Melatonin is a good alternative in the treatment of diabetic retinopathy. |
S0009279720304890 | Altered intracellular distribution of weak base anticancer drugs owing to lysosomal sequestration is one purported mechanism contributing to chemotherapy resistance . This has often been demonstrated with the example of daunorubicin chemotherapy with its characteristic red fluorescence used to trace it in cellular comp... | Image analysis cannot provide a real picture of DNR distribution in cells. There is a complex relationship between DNR fluorescence and its concentration in different compartments. LC MS MS analysis of cell extracts can provide reliable picture about lysosomal accumulation of DNR. Lysosomal sequestration of DNR is not ... |
S0009279720304920 | The renin angiotensin aldosterone system is a hormonal system that has a critical role in maintaining the normotensive state and electrolyte balance of the organism . The RAAS also has an important influence in the development of various pathophysiological conditions especially those concerning the renal system cardiov... | RAAS may contribute to disease development through generation of oxidative stress. Blocking RAAS can prevent such RAAS generated ROS. Aliskiren is an antihypertensive agent that blocks RAAS. RAAS blockage by aliskiren prevents ROS generation so reducing severity of disease. Aliskiren may be used as antioxidant independ... |
S0009279720304956 | Glutathione S transferases are a key enzyme superfamily involved in the detoxification and cytoprotection of a wide variety of xenobiotics such as carcinogens anticancer drugs environmental toxicants and endogenously produced free radicals . In the liver the hGSTA1 isoenzyme is the most abundant and catalyzes the gluta... | NF treatment resulted in increased hGSTA1 activity in HepG2 cells. NFmediated induction of hGSTA1 expression is at transcriptional level. NFmediated induction of hGSTA1 is AHR dependent. AHR activation promotes its recruitment to the. gene promoter. |
S000927972030507X | To avoid being preyed organisms must be able to identify predatory threats by sensing molecules released by predators and to employ effective strategies to prevent detection by predators . Furthermore in the wild organisms are also exposed to chemicals that may alter their behavioral traits such as neuroactive pharmace... | Chlorpromazine CPZ and Fish kairomone FK caused functional alteration in. Feeding rate was decreased in all treatment conditions. Oxygen consumption was only affected in the mixture treatment CPZ FK . For life history traits and phototactic behavior the effects of FK dominated those of CPZ. |
S0009279720305159 | Activation of Notch signaling is associated with tumor aggressiveness poor clinical outcome and drug resistance in breast cancer patients . Targeting Notch signaling with small molecule inhibitors may be a better strategy for anticancer drug development . We identified 3 O p Coumaroylbetulinic acid as a lead compound a... | 3 O E p Coumaroyl betulinic acid induces apoptosis in breast cancer cells. 3 O E p Coumaroyl betulinic acid arrest cell cycle in breast cancer cells. 3 O E p Coumaroyl betulinic acid down regulate Notch signaling pathway. 3 O E p Coumaroyl betulinic acid suppress stemness markers in mammosphere. |
S0009279720305391 | Hetero mononuclear rhenium metal complexes using different substituted indole pyrazoline based ligands were synthesized and characterized by spectroscopic and analytical methods . The binding of the rhenium complexes to Herring sperm DNA was monitored by UV spectroscopy viscosity measurements and molecular docking stud... | Synthesis and characterization of pyrazoline indole based Re I carbonyls. Cell anti proliferation activity on MCF 7 HCT116 and A549cell lines. Complexes have potent anticancer activity than standard drugs carboplatin and oxaliplatin. DNA interaction antibacterial. and. cytotoxicity studies. |
S0009279720305494 | Currently whether nod like receptor family pyrin domain containing 3 inflammasome activation contributes to neuropathy induced by 2 5 Hexanedione the toxic metabolite of | HD induces NLRP3 inflammasome activation in sciatic nerve of rats. NLRP3 inflammasome inhibitor glybenclamide protects against HD induced toxicity. Glybenclamide inhibits HD induced macrophage infiltration and M1 activation. |
S0009279720305676 | Although physiological levels of iron are essential for numerous biological processes excess iron causes critical tissue injury . Under iron overload conditions non chelated iron generates reactive oxygen species that mediate iron induced tissue injury with subsequent induction of apoptosis necrosis and inflammatory re... | Taxifolin ameliorates iron overload induced hepatocellular apoptosis. Taxifolin enhances hepatocellular survival under iron overload conditions. Taxifolin improves hepatocellular regeneration under iron overload conditions. Taxifolin down regulates iron overload induced inflammatory responses. Taxifolin modulates iron ... |
S000927972030569X | Hundreds of millions of people worldwide are exposed to unacceptable levels of carcinogenic inorganic arsenic . Animal models have shown that selenium and arsenic are mutually protective through the formation and elimination of the seleno bis | Selenide but not selenite efficiently protected human HepG2 cells against arsenite. Selenide accumulated to a greater extent than selenite in HepG2 cells. Intracellular selenium availability is important for protection against arsenite. Selenite is likely converted to selenide. for antagonism of arsenic toxicity. Selen... |
S0009279720305755 | Oxidative stress provides a major contribution to the pathogenesis of glaucoma and may induce retinal ganglion cell damage . Transforming growth factor has appeared as a neuroprotective protein in various indignities . However the TGF mechanism of protective effects against oxidative stress damage in RGCs still undeter... | TGF 1 protected RGCs from H2O2 induced oxidative stress. ALDH3A1 upregulation may defend RGCs against oxidative injury. TGF 1 enhanced the activation of Nrf2 HO 1 HIF 1 signal transduction. Pathway characterization of hydrogen peroxide induced oxidative stress on RGCs. |
S0009279720305937 | This study was aimed to investigate the cytotoxic potential of a natural compound progenin III on a broad range of cancer cell lines including various sensitive and drug resistant phenotypes . The cytotoxicity progenin III induced autophagic ferroptotic and necroptotic cell death were evaluated by the resazurin reducti... | The cytotoxicity of a naturally occuring spirostanol saponin progenin III was evaluated. Progenin III exerted cytotoxic effects towards the 18 cancer cell lines tested including animal and human cell lines. Progenin III induced apoptosis autophagy and necroptosis in CCRF CEM cells. |
S0009279720306244 | The capsaicin receptor TRPV1 is a heat activated cation channel modulated by inflammatory mediators and contributes to acute and chronic pain . TRPV1 channel is one of the most researched and targeted mechanisms for the development of novel analgesics . Over the years natural products have contributed enormously to the... | Searching the literature resulted in listing at least 136 natural modulators of TRPV1 channel. Natural TRPV1 modulators were of plant animal fungal or bacterial origin. Some natural products were small agonists or antagonists of TRPV1. Others were protein venoms. Many gaps in natural product research are present in dis... |
S0009279720306372 | A series of novel pyrrolopyrimidine urea derivatives were synthesized and evaluated for their anticancer activity against colon cancer cell lines . Compounds showed the remarkable cytotoxic activity on HCT 116 wt cell line . The most potent compound | Novel pyrrolopyrimidines were designed and synthesized. is the most potent compound against HCT 116wt cell with IC. value of 0.14M. induced apoptosis in HCT 116wt and HCT 116 p53 cells. increase the levels of casp 3 and casp 9 in HCT 116wt and HCT 116 p53 cells. induced p53 independent apoptosis via the mitochondrial p... |
S0009279720306402 | The aim of the study was to synthesize a new series of benzimidazole derivatives and to investigate the underlying molecular mechanisms of the potential cell cycle inhibition and apoptotic effects against a panel of selected human cancer cell lines along with HEK 293 human embryonic kidney cells . MTT assay was used to... | New benzimidazole derivatives 15 were cytotoxic to a panel of human cancer cells. HEK 293 embriyonic kidney cells were much less susceptible to compound 5. Bromo derivatived compound 5 induced apoptosis in all tested cancer cells. Compound 5 induced G. M arrest which was modulated by a p53 independent mechanism. |
S0009279720306451 | Testicular damage contributes to cyclosporine A induced male infertility . However the exact underlying molecular mediators involved in CsA induced testis disorder remains unclear . The present study aimed to characterize the role of mir 34a sirt 1 in CsA induced testicular injury alone or in combination with curcumin ... | Cyclosporine A increased oxidative stress manifestations in testis of rats. Cyclosporine A increased apoptotic cells by mitochondrial apoptotic pathway in testis of rats. Cyclosporine A increased the expression of mir 34a and decreased sirt 1 sirtuin 1 protein level in the testis tissue. Curcumin alleviated genes and p... |
S0009279720306505 | The development of fast acting antidepressants is crucial considering that conventional antidepressants require a long period to elicit therapeutic effects . Creatine an ergogenic guanidine like compound stands out as a candidate to exert fast antidepressant like responses . The present study investigated whether a sin... | Conventional antidepressants did not show fast behavioral effect in the NSF test. Creatine and ketamine presented rapid behavioral effect in the NSF test via mTORC1. The increase on BDNF levels evoked by creatine and ketamine is dependent on mTORC1. Ketamine promoted mTORC1 dependent hippocampal synaptic protein transl... |
S0009279720306530 | Excessive osteoclast leads to the imbalance in bone reconstruction and results in osteolytic diseases such as osteoporosis and rheumatic arthritis . Integrin | Tablysin 15 inhibits the formation and bone resorption of osteoclast. Tablysin 15 inhibits the. None. FAK NF B MAPK and Akt NFATc1 signaling pathways. In vivo Tablysin 15 inhibits LPS induced bone loss. |
S0009279720306566 | Triple negative breast cancer is highly metastatic and lacks effective therapeutic targets among several subtypes of breast cancer . Cancer metastasis promotes the malignancy of TNBC and is closely related to the poor prognosis of the TNBC patients . We aim to explore novel agents that effectively inhibit cancer metast... | SQ a CA 4 analogue inhibits triple negative breast cancer cell metastasis. SQ suppresses EMT process and MMP 9 expression. SQ decreases VEGF expression and secretion. SQ inhibits endothelial cell metastasis by down regulating VEGF secretion. SQ attenuates vasculogenic mimicry formation. |
S0009279720306608 | This study investigated the enantioselective metabolism of benoxacor an ingredient of herbicide formulations in microsomes or cytosol prepared from female or male rat livers . Benoxacor was incubated for 30min with microsomes or cytosol and its enantioselective depletion was measured using gas chromatographic methods .... | Benoxacor is metabolized by rat the hepatic cytochrome P450 system and carboxylesterases. Benoxacor is metabolized by hepatic glutathione S transferases. The. metabolism of benoxacor is sex dependent in rats. Benoxacor is enantioselectively metabolized by different drug metabolizing enzymes. |
S0009279720306633 | Since several decades oximes have been used as part of treatment of nerve agent intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase after its covalent inhibition by organophosphorus compounds such as pesticides and nerve agents . Recent findings have illustrated that besides ... | Synthesis of new Mannich phenol non oxime derivatives. New 4 N alkylamine derivatives of PADOC show reactivation potential. Mannich phenol dimers show surprising reactivation potential. The results point at potential new avenues for design of non oximes. |
S0009279720306682 | The caseinate and glycated caseinate generated from the transglutaminase catalyzed reaction of caseinate and oligochitosan were digested using pepsin and trypsin and the activity of the resultant digests was measured in rat intestinal epithelial cell line using several biological responses as indicators . Compared with... | IEC 6cells show responses to both glycated caseinate digest and caseinate digest. They promote cell growth and accumulate cell cycle progression at the S phase. They also possess apoptosis prevention and differentiation activity to the cells. Glycated caseinate digest has enhanced activity due to the TGase type glycati... |
S0009279720306724 | Since its inception in 1969 Chemico Biological Interactions has persistently published high quality research articles . As part of the journal s golden anniversary we performed an electronic search on Scopus to get all publications details . Based on citescore ranking percentile CBI holds 21st position in the top 113 r... | The 1st bibliometric study of chemico biological interactions. The data about top authors universities and countries are provided. The top 200 articles reviews and conference papers were analyzed by Vosviewer. |
S0009279720307286 | The present study was undertaken to assess the effect of imatinib mesylate a tyrosine kinase inhibitor and a well known anticancer with numerous medical benefits on blood sugar levels insulin and glucagon secretion in an experimental model of STZ induced diabetes mellitus . Type 1 diabetes mellitus was induced by a sin... | Imatinib improved DM indices in an experimental model of STZ induced T1DM. Imatinib showed preservation of morphological characteristics of pancreatic cells. Imatinib alleviated oxidative stress associating T1DM. Imatinib exerted anti inflammatory and anti apoptotic properties. |
S000927972030747X | Cigarette smoke is a complex mixture capable of triggering inflammation and oxidative damage in animals at pulmonary and systemic levels . Tempol reduces tissue injury associated with inflammation | Cigarette smoke exposure promotes inflammation and injury in lung parenchyma. Leukocytes release inflammatory mediators under acutely cigarette smoke exposure. Tempol attenuates inflammation and oxidative damage caused by cigarette smoke. Tempol activates Nrf2 pathway and reduces chemotaxis into inflammatory site. |
S0009279720307493 | A liquid chromatograpy nanoelectrospray ionization high resolution tandem mass spectrometry method was developed for quantitation of the DNA adducts 7 guanine and | We developed a LCNSIHRMS MS method for carboxyethylguanines in leukocyte DNA. Levels of. 1 CEG were 10 times higher than those of 7 2 CEG in human DNA. There was no difference in DNA adduct levels between smokers and non smokers. |
S0009279720307560 | Extensive application of methylene blue for therapeutic and diagnostic purposes and reports for unwanted side effects demand better understanding of the mechanisms of biological action of this thiazine dye . Because MB is redox active its biological activities have been attributed to transfer of electrons generation of... | SOD deficient mutants are hypersensitive to methylene blue. Methylene blue induces enzymes controlled by the. regulon. Induction of enzymes depended on. protein synthesis. Methylene blue activates the. regulon by intracellular redox cycling. |
S0009279720307572 | Alcoholic liver disease is a progressively aggravated liver disease with high incidence in alcoholics . Ethanol induced fat accumulation and the subsequent lipopolysaccharide driven inflammation bring liver from reversible steatosis to irreversible hepatitis fibrosis cirrhosis and even hepatocellular carcinoma . Peroxi... | PPAR plays pivotal roles in regulation of fatty acid homeostasis in liver. PPAR activity and or expression in liver is downregulated after ethanol exposure. The expression of PPAR in human liver may be similar to that in mice liver. PPAR expression is decreased in the liver of patients with NAFLD. |
S0009279720307663 | Many natural products are prodrugs which are biotransformed and activated after oral administration . The investigation of gastrointestinal and hepatic biotransformation can be facilitated by | Comparison of S9 and microsomal cytosolic fractions for. liver biotransformation. Aim Identifying differences in biotransformation of medicagenic acid. 13 biotransformation products were identified 4 are reported for the first time. Similar qualitative metabolic profile with minor quantitative differences. Both protoco... |
S0009279720307742 | General anaesthetics are some of the most widely used and essential therapeutic agents . However despite over a century of research the molecular mechanisms of general anaesthesia in the central nervous system remain elusive . Ketamine has been approved for use in general anaesthesia either alone or in combination with... | General anaesthetics are some of the most widely used and essential therapeutic agents. However despite over a century of research the molecular mechanisms of general anaesthesia in the CNS remain elusive. Ketamine has been approved for use in general anaesthesia either alone or in combination with other medications. |
S0009279720307791 | Cancer metastasis and resistance for chemotherapeutic agent correlate with epithelial mesenchymal transition while ROS production also involves in the EMT process However how autophagy mediated ROS production affects EMT remains unclear . Previous study showed that DpdtC could induce ferritinophagy in HepG2 cell . To i... | Iron chelator DpdtC induced EMT inhibition. DpdtC induced occurrence of ferritinophagy. Creating vicious cycle between ferritinophagy and ROS production contributed to EMT inhibition. DpdtbA induced p53 response resulted in downregulation of targeted genes and the EMT inhibition. |
S0009279720307948 | In terms of public health the 21st century has been characterized by coronavirus pandemics in 2002 03 the virus SARS CoV caused SARS in 2012 MERS CoV emerged and in 2019 a new human betacoronavirus strain called SARS CoV 2 caused the unprecedented COVID 19 outbreak . During the course of the current epidemic medical ch... | Flavonoids can inhibit key proteins involved in coronavirus infective cycle. SARS CoV proteases PL. and 3CL. can be inhibited by flavonoids. NTPase helicase and N protein of SARS CoV can be inhibited by flavonoids. |
S0009279720308103 | Presence of Simple Sequence Repeats both in genic and intergenic regions have been widely studied in eukaryotes prokaryotes and viruses . In the current study we undertook a survey to analyze the frequency and distribution of microsatellites or SSRs in multiple genomes of | 919 SSRs were found across 55 members of the Coronaviridae family. Genomes exhibit under representation of SSRs. Commonly 1213nt long hexanucleotide repeats occupying the genic region. Identified genic SSRs in SARS CoV 2 are under selection pressure against mutations. 29 of the total bases covered by SSRs in SARS CoV 2... |
S0009279720308231 | Ischemia reperfusion injury causes oxidative stress leading to severe cardiac dysfunction . Thus biologically active compounds with antioxidant properties may be viewed as a promising therapeutic strategy against oxidative related cardiac disorders . Usnic acid a natural antioxidant was complexed with cyclodextrin to i... | UA CD inclusion complex enhances the aqueous solubility of UA. Uncomplexed UA has no cardioprotective properties. UA CD inclusion complex protects hearts against myocardial IR injury. UA CD is a structurally engineered compound with active cardioprotective properties. |
S0009279720308553 | Cisplatin induces acute renal failure in humans and mice.Tubular apoptosis necrosis and inflammation are the primary pathogenesis of cisplatin induced acute kidney injury . We previously reported that the depletion of Numb from proximal tubules exacerbates tubular cells apoptosis in cisplatin induced AKI however the ro... | Cisplatin induces Acute kidney injury. Necrosis and Inflammation are involved in Acute kidney injury. Numb ameliorates Necrosis and Inflammation. |
S0009279720308723 | Hepatic ischemia reperfusion injury is not only one of the pathophysiological process involving the liver but also a complex systemic process affecting multiple tissues and organs . IRI after liver transplant occurs due to in major resections and occlusion of vessels or during the perioperative period leads to acute li... | The ischemia reperfusion damage represents a severe problem in the clinical practice due to several reasons. RAAS is activated locally in the injured cells by the occurrence of I R. ROS generation causes cell damage and leads to cell death via autophagy necrosis necroptosis and apoptosis. |
S0009279720308747 | Ellagic acid is a naturally occurring polyphenolic compound that has been shown to exhibit diverse beneficial pharmacological activities including anti osteoclastogenesis effect . However the molecular mechanism by which EA inhibits osteoclastogenesis remains to be elucidated . The protein protein interaction between r... | Ellagic acid EA inhibited RANKL induced osteoclast differentiation and F actin ring formation. EA directly bound to RANK and RANKL with strong affinities and blocked RANKLRANK interaction. EA suppressed canonical RANK signaling pathways in osteoclast precursors. EA downregulated master transcriptional factors and osteo... |
S000927972030884X | The lack of tissue selectivity of anticancer drugs generates intense collateral and adverse effects of cancer patients making the incorporation of vitamins or micronutrients into the diet of individuals to reduce side or adverse effects of antineoplastics . The study aimed to evaluate the effects of retinol palmitate o... | Toxicogenetic modulation by retinol palmitate. Reduced antineoplactic action in non tumour cells. Modulatory cytotoxic mutagenic and cell death in neoplastic cells. |
S0009279720309030 | Obesity is characterized by the deposition of excessive body fat and is caused by energy imbalance especially when consuming fat rich diets . High fat diet associated obesity is greatly common in patients with non alcoholic fatty liver disease that is emerging as one of the most universal causes of liver disease worldw... | High fat diet HFD is a crucial contributory factor affecting NAFLD progression. HFD triggered possible mechanisms are posited to explain NAFLD pathogenesis. Currently effective therapeutic options for NAFLD remain lifestyle interventions. |
S0009279720309157 | Hyperuricosuria is associated with kidney stone disease especially uric acid and calcium oxalate types . Nevertheless detailed mechanisms of hyperuricosuria induced kidney stone formation remained unclear . This study examined changes in cellular proteome and function of renal tubular cells after treatment with high do... | Proteomics revealed altered levels of 22 proteins in UA treated renal tubular cells. Intracellular ATP level was increased in UA treated renal tubular cells. Tissue repairing capability was enhanced in UA treated renal tubular cells. HSP70 HSP90 known CaOx crystal receptors were increased in apical membranes. CaOx bind... |
S0009279720309625 | Colorectal cancer represents one of the commonest malignancies around the world . PP9 a natural steroidal saponin was firstly isolated from the rhizomes of | PP9 a natural steroidal saponin suppresses proliferation and induces cell cycle arrest and apoptosis in CRC. PP9 exerts antitumor effects in xenografted mouse models. PP9 inhibits PI3K Akt GSK3 signaling in CRC cells. |
S0009279720309704 | Flavonoids are natural products widely recognized for their plurality of applications such as antiviral antiproliferative antitumor activities and antioxidant properties . The flavanone naringenin is presented in citrus fruits and has been studied to combat recurrent diseases that still lack effective treatment . Resea... | Synthesis and characterization of both lipophilic ethers and esters of the citrus naringenin a natural product. Regioselective preparation of 7. alkyl ethers. Inhibitory activities against Zika virus and proliferative cells of Melanoma and breast cancer cells. The lipophilic ethers present the ability to inhibit select... |
S0009279720309820 | Kinetic modeling of the behavior of complex chemical and biochemical systems is an effective approach to study of the mechanisms of the process . A kinetic model of coronaviral infection development with a description of the dynamic behavior of the main variables including the concentration of viral particles affected ... | The proposed kinetic model describes the dynamics of coronaviral infection development. Acidification and pH dependence of key enzymes is discussed as a basis of viral toxicity. An acute bifurcation transition of the system to collapse is demonstrated. The theory and experimental facts of thermoheliox therapy are discu... |
S0009279720309844 | The use of 3D models in various scientific applications is becoming more popular to replace traditional monolayers models . In this work we used a three dimensional in house model of epidermis using HaCaT immortalized cells to evaluate the dermal toxicity induced by Basic Blue 99 and Basic Red 51 both present in commer... | The hair dyes can cause some toxic effects in the body. The 3R s principle encourages the development and use of alternative methods to use of animals. The 3D model is an alternative method capable of mimicking dermal exposure. |
S000927972030987X | The 2 aminothiazole functionality has long been established as a privileged structural feature and therefore frequently exploited in the process of drug discovery and development . It has been introduced into numerous compounds due to its capacity for targeting a wide range of therapeutic target proteins . On the other... | The advantages of the 2 aminothiazole group in medicinal chemistry were detailed. 2 aminothiazoles were studied as toxicophores that form reactive metabolites. Chemical strategies that reduce the intrinsic hepatotoxicity were highlighted. |
S0009279720309911 | Only in the last decade the long term consequences of sepsis started to be studied and even less attention has been given to the treatment of psychological symptoms of sepsis survivors . It is estimated that 60 of sepsis survivors have psychological disturbances including depression anxiety and cognitive impairment . A... | CMI ameliorated long lasting behavioral alterations in sepsis survivor mice. CMI modulated peripheral cell count and oxidative stress in sepsis survivor mice. CMI reduced plasma markers of liver and kidney dysfunction induced by sepsis. CMI ameliorated BBB dysfunction induced by sepsis. CMI reduced inflammation and oxi... |
S0009279720310231 | Cancer continues to be one of the most challenging diseases to be treated and is one of the leading causes of deaths around the globe . Cancers account for 13 of all deaths each year with cancer related mortality expected to rise to 13.1 million by the year 2030 . Although we now have a large library of chemotherapeuti... | Cancer is one of the leading cause of death around the globe. Theranostics is a customised approach to cancer diagnosis. These nanomaterials can address cancer treatment issues and diagnostic challenges. |
S0009279720310322 | Caffeic acid is a phenolic compound widely found in commonly consumed foods such as pears apples and coffee and is pharmacologically known for its antioxidant anti inflammatory and anti asthmatic properties . However its relaxant activity in the aorta uterus and ileum smooth muscle has not been investigated . This stud... | Caffeic acid has a muscle relaxant effect on vascular smooth muscle myometrial and intestinal. Caffeic acid had an antispasmogenic effect on different organs aorta uterus and ileum of rats in the presence of K . The relaxing effect of caffeic acid is partially dependent on the calcium channels operated by type L voltag... |
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