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S0009279720310334 | Thromboembolism is a major cause of morbidity and mortality worldwide . Most therapeutic drugs for treating thrombosis can cause hemorrhage and have short half lives within human blood circulation resulting in a need to discover and develop novel anticoagulants antithrombotics . EuRP 61 has been isolated from a plant l... | A novel antithrombolytic protease derived from Euphorbia. latex. The enzyme exhibited fibrinolytic anticoagulant and antiplatelet activities. Its fibrinogenolytic activity was not abolished by blood circulating inhibitors. The enzyme appears safe for cell viability especially in human blood cells. |
S000927972031036X | Developing brain is very sensitive to the influence of environmental factors during gestation and the neonatal period . The aim of the study is to assess cobalt and iron accumulation in the brain as well as changes in the expression of iron regulatory proteins transferrin receptor 1 hepcidin and ferroportin in suckling... | Late prenatal and early postnatal exposure to cobalt chloride increases significantly brain Co content in suckling mice. CoCl. provokes changes in the expression of iron regulatory proteins transferrin receptor 1 hepcidin and ferroportin. Cobalt toxicity affects iron homeostasis in the developing brain with further pos... |
S000927972031053X | The novel human coronavirus 2 called SARS CoV 2 is the causative agent of Coronavirus Induced Disease and has spread causing a global pandemic . Currently there is no vaccine to prevent infection nor any approved drug for the treatment . The development of a new drug is time consuming and can not be relied on as a solu... | Rapamycin an mTOR inhibitor can be repurposed for treatment of COVID 19. Rapamycin inhibits protein synthesis pro inflammatory cytokines and delays aging. Rapamycin action targeted on host factors and not viral machinery. Rapamycin act on cell proliferation may aid in reducing viral replication. |
S0009279720311108 | To investigate the effect of gamabufotalin on metastasis and modulation of stemness features in osteosarcoma and the molecular mechanisms underlying such effects . Human osteosarcoma U2OS MG 63cell lines were used in this study . Cell proliferation migration and invasion were determined by MTT assay wound healing assay... | Higher levels of TGF periostin p AKT PI3K were observed in osteosarcoma spheroids. The TGF periostin PI3K AKT pathway promotes osteosarcoma procession. GBT exerts an anti tumor effect by blocking osteosarcoma CSCs and invasion capacity. |
S0009279720311121 | Cisplatin is an antineoplastic drug well recognized for its success in the battle against several types of cancer in adult juvenile and child populations . Meanwhile this drug is also famous due to its serious side effects such as hepatotoxicity . This study evaluated the hepatoprotective effectiveness of Diphenyl Dise... | Cisplatin induced metabolic disorders and oxidative damage in liver of rats. PhSe. and Ebselen preserved redox balance after cisplatin exposure. PhSe. and Ebselen PhSe. showed hepatoprotective effects against cisplatin. |
S0009279720311182 | Dextromethorphan is a cough suppressant available in many prescribed and over the counter medications . Adverse reactions induced by DM have been regularly reported including allergic skin reactions in some cases . However the underlying mechanisms of local anaphylaxis induced by DM have not been elucidated . In this s... | Dextromethorphan DM was firstly found to induce anaphylaxis. and. MRGPRX2 was confirmed to be critical to anaphylaxis induced by DM. Close monitoring should be drawn on patients with drugs containing DM. |
S0009279720311285 | Artesunate is a kind of derivative of artemisinin which possesses potent anti cancer effect in addition to its anti malarial property . And autophagy was a highly conserved process exerting a double edged effect in cancer cell survival . Besides apoptosis is a programmed cell death program crucial to cell homeostasis .... | Artesunate induce caspase dependent apoptosis in human bladder cancer cells. Artesunate time and dose dependently activated autophagy in human bladder cancer cells. Apoptosis in human bladder cancer cells were induced by artesunate activated autophagy. AMPK mTOR ULK1 pathway mediated artesunate induced autophagy depend... |
S000927972031139X | Due to drug resistance and side effects the development of novel therapeutics for the treatment of lung cancer is still in an urgent need . Morusin a naturally occurring prenylated flavonoid isolated from the root bark of | Morusin induced apoptosis in A549 and NCIH292cells. Morusin induced autophagy in A549 and NCIH292cells. Modulation of MAPK ERK MAPK JNK and PI3K AKT NF B involved in morusin induced cell death. |
S0009279720311558 | The unfolded protein response is an emerging target pathway for cancer treatment owing to its ability to induce cell death . In our previous analysis of UPR modulating small molecules we had reported that piperazine oxalate derivative compounds are able to promote increased phosphorylation of eukaryotic translation ini... | A new piperazine oxalate derivate AMC 04 induces apoptosis in human cancer cells. AMC 04 induces apoptosis. the activation of the ATF4 CHOP DR5 pathway. Induction of DR5 by AMC 04 is regulated by ROS mediated p38 activation. AMC 04 can bind to the histone methyltransferases revealed by molecular docking analysis. AMC 0... |
S0009279720311960 | Two types of cholinesterases are present in mammalian blood and tissues acetylcholinesterase and butyrylcholinesterase . While AChE regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions BChE in plasma has been suggested to be involved in detoxifying toxic com... | Acetylcholinesterase is the predominant esterase in bovine ovine and caprine plasma. Porcine and equine plasma contain predominantly butyrylcholinesterase. Monoclonal antibodies MAbs against fetal bovine serum AChE inhibit AChEs from ruminants. MAbs against fetal bovine serum AChE do not cross react with BChE. Residues... |
S0009279720311984 | The calcineurin inhibitor cyclosporin A is one of the most common immunosuppressive agents used in organ transplantation . However its clinical use is often limited by several unwanted effects including nephrotoxicity and hepatotoxicity . By using immunohistochemical and ELISA techniques it was found that CsA administr... | Cyclosporin A activates ADAM 17 in the liver and kidney of albino mice. Cyclosporin A activates EGFR in the liver and kidney of albino mice. Cyclosporin A activates ERK1 2 signaling cascade in the liver and kidney of albino mice. PEG SOD attenuates ADAM 17 EGFR ERK1 2 signaling induced by cyclosporine A. |
S0009279720312011 | Cell cycle dysregulation is the mainstay of aberrant cell proliferation which leads to tumor progression . Mutations in tumor cells initiate various dysregulated pathways and spontaneous over proliferation with genomic chromosomal instability . Despite advances in cancer therapy it has remained a medicinal challenge to... | carboline alkaloids are natural based promising agents with potential therapeutic applications. carbolines derivatives greatly ameliorate cell cycle dysregulations in cancer. carbolines suppress CDK PLK 1 IKK to exert their anti cancer effects. carboline alkaloids block Kinesin Eg5 DNA integration in combating cancer. ... |
S000927972031276X | Ulcerative colitis is a chronic disease driven primarily by uncontrolled pervasive inflammatory responses affecting the colon and rectum . Currently available medications carry multiple detrimental adverse effects which have emphasized the mandatory need for safer and more efficient novel therapeutic alternatives . Mel... | Melittin exerted potent antiulcerogenic effect in acetic acid induced colitis model. Melittin amended the elevated levels of inflammatory cytokines. Melittin inhibited the upstream inflammatory molecules TLR4 TRAF6 p38 MAPK and NF B. Melittin reversed alterations in PGE2 and enzymes involved in its synthesis. Melittin ... |
S0009279720313363 | Cisplatin based chemotherapy is a common first line regimen for treating nonsmall cell lung cancer . However drug resistance is still a major problem . The purposes of this study were to evaluate whether sclareol can reverse cisplatin resistance and to investigate its possible mechanisms . A549 cells the human NSCLC ce... | Drug resistance is still a critical issue in clinical chemotherapy. Platinum based compounds such as cisplatin are first line drugs for treating non small cell lung cancer NSCLC . Excision repair cross complementation group 1 ERCC1 a DNA repair enzyme involved in cisplatin resistance. Sclareol is a natural aromatic com... |
S0009279720313375 | acetic acids exhibit a wide range of pharmacological activities . Among them the only derivative used in clinical practice is the aldose reductase inhibitor epalrestat . Structurally related compounds 5 | Six rhodanine acetic acid derivatives were tested for aldose reductase inhibition. Four compounds inhibited aldose reductase more potently than epalrestat. Inhibition selectivity relative to aldehyde reductase exceeded that of epalrestat. Negligible cytotoxicity to the HepG2 cell line was recorded for all compounds. SA... |
S0009279720313922 | The on going pandemic of COVID 19 wreaked by a viral infection of SARS CoV 2 has generated a catastrophic plight across the globe . Interestingly one of the hallmarks of COVID 19 is the so called cytokine storm due to attack of SARS Cov 2 in the lungs . Considering mesenchymal stem cells therapy could contribute agains... | Coronavirus disease COVID 19 emerged out as a potential global biological disaster caused by SARS CoV 2. Early detection of the SARS CoV 2 had a better prognosis for treatment strategies. Clinical trials among repurposed molecules had progressed with several methodological limitations. Systemic overview of various aspe... |
S0009279720314216 | Ginsenoside Rb1 is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic antioxidative and antirheumatic agent its oral bioavailability is poor due to its limited solubility . In this study the solubility of GsRb1 was improved by encapsulating it in polymeric nanocapsules therefor... | GsRb1 is the best constituent of ginseng. GsRb1 oral bioavailability is poor due to its limited solubility. The solubility of GsRb1 was improved by encapsulating it in polymeric nanoparticles. Nano GsRb1 is a novel approach to deliver GsRb1. |
S0009279720314460 | A cellular model of cardiomyocytes and mitochondria isolated from mouse liver were used to understand the drug action of BPDZ490 and BPDZ711 two benzopyran analogues of the reference potassium channel opener cromakalim on mitochondrial respiratory parameters and swelling by comparing their effects with those of the par... | New cromakalim analogues inhibit mitochondrial respiration rate with low toxicity. Benzopyran derivatives inhibit the Calcium induced swelling of mitochondria. Cromakalim. does not act on respiration rate and swelling of mitochondria. Benzopyran derivatives decrease the ATP synthesis. BPDZ490 behaves as a mild uncoupli... |
S0009279720314617 | Irinotecan is widely prescribed for treatment of various intractable cancers such as advanced and metastatic colon cancer cells but its continuous treatment promotes the resistance development . In this study we established CPT11 resistant variants of three human colon cancer cell lines and found that gain of the resis... | Gain of CPT11 resistance up regulates AKR1C3 expression in colon cancer cells. AKR1C3 accelerates the resistance through metabolizing cytotoxic HNE. The CPT11 resistance is also ascribed to the ABCB1 up regulation via PXR activation. Treatment with inhibitors of AKR1C3 and ABCB1 overcomes the CPT11 resistance. Author s... |
S0009279720314885 | Polo like kinase 1 is a prominent mediatory player during the cell cycle mitosis and cytokinesis in eukaryotic cells . Besides its physiological roles PLK1 expression is upregulated in a wide range of human malignant tumors and its overexpression worsens prognosis therefore specific inhibition of PLK1 in tumor cells is... | GSK461364A evaluated for antiproliferative activity against Raji K562 PC3 MCF 7 and MDA MB 231cell lines. GSK461364A exhibited the best cytotoxic activity against Raji cells. GSK461364A arrested the cells at G2 M phase of the cell cycle and caused DNA damage. GSK461364A also induced apoptosis and altered total oxidant ... |
S0009279720315325 | Leishmaniasis is a parasitic neglected tropical disease and result in a broad spectrum of clinical manifestations ranging from a single ulceration to a progressive and fatal visceral disease . Comprising a limited and highly toxic therapeutic arsenal new treatments are urgently needed . Targeting delivery of drugs has ... | Nanoliposomal nitazoxanide NTZ LP eliminates amastigotes of. The uptake of NTZ LP by infected macrophages is similar to uninfected cells. NTZ LP localizes in a closer proximity to the amastigotes inside the macrophages. NTZ LP reduces the parasite burden by 82 liver and 50 spleen of hamsters. |
S0009279720315593 | The present study aims to explore the effects of astaxanthin on the semen quality of diabetes mellitus KKAy mice . A total of 60 DM KKAy mice with similar body weights and initial blood glucose and serum lipid levels were assigned to four groups namely one control and three astaxanthin treatments . Results show that or... | Astaxanthin decreased fasting blood glucose of diabetes mellitus KKAy mice. Astaxanthin decreased serum lipid levels of diabetes mellitus KKAy mice. Astaxanthin improved sperm quality of diabetes mellitus KKAy mice. |
S0009279720315726 | 1 Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen . Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase enzymes . Previously we have observed induction of micronuclei and mitotic arrest by 1 MP in a Chinese hamster derived cell line expressing both huma... | 1 Methylpyrene is potently aneugenic in metabolism proficient mammalian cells. 1 Methylpyrene may disrupt mitotic apparatus by interfering with tubulin. 1 Methylpyrene may retard mitotic progression. |
S0009279720315799 | COVID 2019 pandemic is affecting people worldwide in the absence of an effective treatment strategy . Several suggestive therapeutic options through drug repurposing are recommended but a complete consensus is not reached . A combination of Hydroxychloroquine and Azithromycin has been widely tried and discussed but its... | Hydroxychloroquine and azithromycin is widely tried for recent pandemic. It is discussed to prolong QT interval causing severe adverse events. Potential drug targets involved in this process were screened using system biology. Pathways were also screened for drug combination mediated adverse events. |
S0009279720316367 | DNA is the store house of all necessary hereditary information for growth of cells and tissues . Physiological functionality of DNA depends on its 3D helical structure and any distortion in a structure may lead to mutation and genomic instability that may translate into disease like cancer . In order to prevent DNA dam... | CD and UVVis spectra of ctDNA indicated conformational change after EP binding. Docking showed EP binds reversibly as an intercalator and in a minor groove of DNA. EP is an effective antioxidant. EP significantly protects DNA against radiation induced damage. |
S0009279720316896 | Erythrocytes represent the main cell component in circulation and recently have become a topic of intensive scientific interest . The relevance of erythrocytes as a model for cytotoxicity screening of xenobiotics is under the spotlight of this review . Erythrocytes constitute a fundamental cellular model to study poten... | Erythrocytes are a valuable. model for cytotoxicity screening of xenobiotics. Erythrocytes can be used as a cellular model in examination of oxidative stress. Red blood cells can be successfully applied as drug delivery systems. Xenobiotics can interact with erythrocytes membrane and induce eryptosis. |
S0014483518303907 | Diabetic retinopathy is a microvascular complication of diabetes and one of the most common causes of blindness in active stage . This study is performed to explore the effects of microRNA 21 on retinal vascular endothelial cell viability and angiogenesis in rats with DR via the phosphatidylinositiol 3 kinase protein k... | Roles of miR 21 in EC viability and angiogenesis of DR were studied. MiR 21 targeted. and repressed its expression. Increased miR 21 and reduced. expression were observed in rats with DR. Increased angiogenesis was observed in retina of rats with DR. Activated PI3K Akt VEGF axis induced VEGF mRNA transcription and expr... |
S0014483519300193 | Although acute hyperoxia hypoxia alternation can shift sharply physiological processes of vessel development e.g . oxygen induced retinopathy very little is known of metabolic products resulted from the neovascularization disorder . In this study the influence of abnormal oxygen exposures on the plasma metabolomic prof... | Plasma metabolomics study of rats with oxygen induced retinopathy OIR . Distinct differences of plasma metabolome were found in vaso obeliteration and neovasculization phases of rat OIR. Proline and arginine and proline metabolism pathway might be important in occurrence and development of rat OIR . |
S0014483519302039 | Retinal ganglion cell degeneration leading to irreversible blindness in chronic optic neuropathies commonly begins with dendritic shrinkage followed by axon degeneration . Although limited axon regeneration in the optic nerve is possible with a genetic deletion of PTEN SOCS3 after optic nerve injury the roles of PTEN S... | PTEN but not SOCS3 deletion ameliorates RGC dendritic shrinkage after ON crush. Rate of dendritic shrinkage in SOCS3 deleted RGCs are no different from control. SOCS3 deletion enhances axon regeneration in the optic nerve but not the retina. Intrinsic RGC axon and dendritic preservation mechanisms are molecularly disti... |
S0014483519302441 | Congenital cataracts the most common cause of visual impairment and blindness in children worldwide have diverse etiologies . According to statistics analysis about one quarter of congenital cataracts caused by genetic defects . Various mutations of more than one hundred genes have been identified in hereditary catarac... | Congenital cataracts represent the leading cause of visual disability in childhood. Genetic researches identified various mutations of associated genes acting through varied mechanisms in inherited cataract. Future studies in lens regeneration and anti aggregation drugs may provide new insights into treatment of congen... |
S0014483519302489 | We studied the early protein profile in the ocular tissue extracted after LASIK and SMILE surgery . SMILE and LASIK was performed in contralateral eyes and stromal tissue samples were collected from 10 eyes of 5 donors . The stromal tissue samples were analyzed using label free quantification approach and ITRAQ labelli... | Collagens proteoglycans corneal crystallins expressed differentially in SMILE and LASIK as compared to control. Reduced expression of proinflammatory factors and lesser reduction in neurotrophic markers in SMILE compared to LASIK. Novel factors 14 3 3 class of proteins PEDF associated with the immediate post surgical r... |
S0014483519302738 | Astigmatism is a refractive error due to meridional differences in refractive powers of lens or cornea . The resulting failure to focus image points in a single plane causes blurred vision at all distances . In this study using an animal model of lens induced astigmatism we tested the hypothesis that induced astigmatis... | Crossed cylinder lenses induced compensatory refractive astigmatism in chicks. This effect was prevented by excitotoxins which disrupt retinal image processing. This effect was not prevented by tetrodotoxin block of nerve conduction in the eye. Lens induced astigmatism in chicks is mediated by local signaling within th... |
S0014483519302945 | The bird retina offers an excellent model to investigate the mechanisms that coordinate the morphogenesis histogenesis and differentiation of neuron and glial cells . Although these developmental features have been intensively studied in the chicken | Altricial and precocial bird species differ in the timing of visual system maturation. Visual system development occurs faster in precocial bird species than in altricial bird species. Retinal neurogenesis is intense at perinatal stages in altricial bird species. |
S0014483519303185 | Limbal stem cells a subpopulation of limbal epithelial basal cells are crucial to the homeostasis and wound healing of corneal epithelium . The identification and isolation of LSCs remains a challenge due to lack of specific LSCs biomarkers . In this study Haematoxylin eosin 4 6 diamidino 2 phenylindole and immunohisto... | The differentiation of CECs is related to eye opening in mice. Dynamic spatial expression pattern reveals a temporal restriction of LSCs putative biomarkers. The order of Vim p63 CK15 CK14 might represent the stemness degree in ocular surface during mouse development. |
S0014483519303586 | Glaucoma is a major cause of blindness and IOP reduction remains the only clinically validated therapy . In this study we analyze a novel IOP lowering strategy that uses a modest negative pressure applied locally to the periorbital region by a pair of goggles with each lens individually connected to a programmable pump... | A novel strategy for IOP management has been recently proposed patients wear goggles to deliver a modest negative pressure to the anterior globe and orbit. We used a lumped parameter mathematical model to investigate possible mechanisms of IOP lowering in this treatment. Model predictions are consistent with clinical d... |
S0014483519303768 | Rhegmatogenous retinal detachment is the most common type of RD the separation of neurosensory retina from the underlying retinal pigment epithelium . The RRD patients can be benefited from appropriate treatment if detected early especially for the people predicted at high risk . In this study we aimed to investigate t... | rs1793958 variant is significantly associated with reduced risk of RRD in southern Chinese population. RRD patients carrying rs1793958G allele have milder RD severity compared to those carrying the wildtype AA genotype. RRD patients have poorer visual acuity and lower intraocular pressure in their surgical eyes compare... |
S0014483519303793 | Age related macular degeneration is a predominant cause of visual deficit in aged population . Abnormal accumulation of cholesterol including oxidized low density lipoprotein underneath the retinal pigment epithelium cells contributes to the development of AMD . Gypenosides are glycosides extracted from | Gypenosides enhance cholesterol efflux in retinal pigment epithelium cells. Gypenosides reduce uptake and accumulation of oxidized LDL in retinal pigment epithelium cells. Gypenosides suppress oxidized LDL induced ROS production in retinal pigment epithelium cells. Gypenosides inhibit oxidized LDL induced inflammation ... |
S0014483519303975 | Uveitis is usually considered as a vision threatening multiple system intraocular inflammatory disease . Among uveitis VogtKoyanagiHarada disease and Behcet s disease are common non infectious uveitis entities . Although the exact pathogenesis of uveitis is not yet clear it is acknowledged that the combination of a cer... | Summary SNPs genes associated with VKH disease and BD were enumerated. Summary CNVs genes associated with VKH disease and BD were generalized. Epigenetic factors especially DNA methylation and ncRNAs were closely related to VKH disease and BD. |
S0014483519304014 | In this study we evaluated the effect of placenta derived Mesenchymal Stem Cells versus placebo in improving corneal transparency following experimental injury in an ex vivo organ culture model of post mortem human corneas . We also compared the influence of MSCs on the basic histopathology of the cornea and the immuno... | Mesenchymal Stem Cells show reduced corneal scarring. Corneal transparency increases significantly with Mesenchymal Stem Cells. Histopathological staining shows marked difference between cases and controls. |
S0014483519304075 | Pre harvest burning of sugarcane fields produces large amounts of air pollutants which are known to cause health problems including ocular surface abnormalities . In this study we evaluated the effect of biomass burning on mucus quality and mucin gene expression in the conjunctiva of sugarcane workers and residents of ... | Sugarcane burning is known to produce large amounts of air pollutants at the harvest season. Impression cytology of bulbar and tarsal conjunctiva of sugarcane workers and residents nearby town were collected. The samples were processed to analysis the mucus profile neutral acid and the MUC1 MUC5AC and MUC16 mRNA levels... |
S0014483519304099 | The objectives of the present work were to assess by spectral domain optical coherence tomography the changes in thickness of the outer nuclear layer the ONL photoreceptor inner segment and the retinal thickness as a function of age in the normal canine retina . OCT retinal scans extending from the edge of the optic ne... | Changes by OCT of the ONL ONL IS and retinal thickness of the canine retina. Thinning of retinal thickness occurs early in life. The superior retina is thicker than the inferior. The decline was modeled fitting a one phase decay model. |
S0014483519304117 | Elevated intraocular pressure is the primary risk factor for glaucoma and is the only treatable feature of the disease . There is a correlation between elevated pressure and homeostatic reductions in the aqueous humor outflow resistance via changes in the extracellular matrix of the trabecular meshwork . It is unclear ... | Segmental flow regions of the TM are relatively stable after 7 days of perfusion. Intermediate flow regions are increased after perfusion at elevated pressure. These dynamic changes are part of the normal homeostatic response to pressure. Contralateral eyes show small differences in amounts of flow regions. |
S0014483519304154 | Microglial cells are important contributors to the neuroinflammation and blood vessel damage that occurs in ischemic retinopathies . We hypothesized that key effectors of the renin angiotensin aldosterone system angiotensin II and aldosterone increase the density of microglia in the retina and stimulate their productio... | Angiotensin II and aldosterone increased the density of microglia in the retina. Blockade of the angiotensin type 1 receptor and aldosterone reduced reactive oxygen species and the expression of NADPH oxidase NOX isoforms in retinal microglia exposed to hypoxia. Blockade of the angiotensin type 1 receptor and aldostero... |
S0014483519304208 | Ocular rigidity is thought to play a role in the pathogenesis of glaucoma but the lack of reliable non invasive measurements has been a major technical challenge . We recently developed a clinical method using optical coherence tomography time lapse imaging and automated choroidal segmentation to measure the pulsatile ... | Clinical validation of a non invasive method for measuring ocular rigidity. Strong correlation between OR coefficients obtained non invasively and invasively. Integrated choroidal anatomy to improve our mathematical model and OR measurements. The method is reproducible and can be used to measure OR accurately. |
S001448351930435X | Porcine models of ophthalmological diseases are often used in pre clinical translational studies due to pigs similarities to humans . In particular the iodoacetic acid model of photoreceptor degeneration seems to mimic well the endstage phenotype of human pathologies as retinitis pigmentosa and age related macular dege... | Iodoacetic acid 12mg kg does not alter the morphology of the inner retina and optic pathways. Functionality of the optic pathway seems to be impaired as confirmed by weak residual flash visually evoked potentials. This photoreceptor degeneration model seems to be suitable for retinal prosthesis preclinical testing. |
S0014483519304415 | Childhood glaucoma is an important cause of blindness world wide . Eleven genes are currently known to cause inherited forms of glaucoma with onset before age 20 . While all the early onset glaucoma genes cause severe disease considerable phenotypic variability is observed among mutations carriers . In particular | Eleven genes responsible for childhood forms of glaucoma are currently known. Variable clinical features can be observed in patients with mutations in childhood glaucoma genes. mutations can cause ocular and systemic disease. mutations causing ocular disease and hearing loss are primarily located in the forkhead domain... |
S0014483519304427 | Death of retinal photoreceptors is the basis of prevalent blinding diseases . Since steroids might have a therapeutic role in retinal degenerations we compared the protective effects of dexamethasone and progesterone on photoreceptor death induced by mifepristone and light exposure . | Dexamethasone progesterone protect 89 photoreceptors in mifepristone light injured retinas. Photoreceptor protection correlated with steroid specific changes in cell death regulators. Steroid dependent protection might also be associated to changes in rhodopsin and GR. |
S0014483519304580 | Neuronal excitotoxicity caused by over activation of N Methyl D Aspartate receptors is an important risk factor for the retinal ganglion cells death in glaucoma . D serine played a role as a key co agonist for NMDA receptor activity and neurotoxicity . Our previous studies have demonstrated that increased D serine and ... | Phosphorylation of ERK 1 2 and p38 increased in the COH model but not JNK. DAAO treatment induced the phosphorylation of ERK 1 2 in the COH model. ERK inhibitor PD98059 attenuated DAAO mediated reduction in RGC apoptosis. Inhibition of p ERK induced elevated GFAP expression in Mller cells in the COH model. |
S0014483519304609 | Elevated inflammatory cytokines contribute to the pathogenesis of various retinal diseases such as diabetic retinopathy retinal vasculitis and retinitis . However the underlying mechanism of retinal inflammation remains largely unknown . Recent studies demonstrated that acetylcholinesterase is an inflammatory indicator... | A novel function of ACHE in regulating retinal inflammation via NF B signaling. ACHE inhibition attenuating TNF induced retinal inflammation and vascular leakage likely through suppression of NF B signaling activation. Donepezil as a promising therapeutic agent for retinal inflammatory diseases. |
S0014483519304610 | Retinal detachment induces ischemia and oxygen deficiency in the retina and results in multiple pathological events photoreceptor cell degeneration and death is the eventual cause of vision decline . In this study we investigated the therapeutic effects of mesenchymal stem cell derived exosomes in a rat retinal detachm... | In this study we investigated the therapeutic effects of mesenchymal stem cell derived exosomes MSC Exos in a RD model. MSC Exos reduced retinal inflammation enhanced autophagy suppressed apoptosis and maintained retinal structure. Proteomic analysis revealed MSC Exos contained proteins that have therapeutic effects. |
S0014483519304683 | Neuropathic dry eye is one of the most frequently seen complications after corneal refractive surgery however its incidence decreases in a significant manner along the first six months postoperative reaching between 10 and 45 incidence . However little is known on the inflammatory status of the ocular surface during th... | Clinical variables completely restore after 6 months of ASA refractive surgery. Some tear pro inflammatory cytokines chemokines do not recover their basal values. Ocular surface homeostasis is not completely restored after 6 months of ASA surgery. |
S0014483519304701 | The eye is a very important organ in the human body which is affected by various external factors . One of these factors is the sunlight which can cause the visual impairment and as well as the increase in the oxidative stress . The heme oxygenase I plays a very important role in the fight against the oxidative stress ... | HO enzyme is a protective protein against oxidative stress and main producer of CO recognized as anti depression factor. Seasonal variation in HO expression in retina tissue was investigated. Changes in the gene expression and protein synthesis of HO 1 and HO 2 isoforms were characterized. The impact of some factors su... |
S0014483519304725 | Adaptation to changes in ambient light intensity in retinal cells and circuits optimizes visual functions . In the retina light adaptation results in changes in light sensitivity and spatiotemporal tuning of ganglion cells . Under light adapted conditions contrast sensitivity of ganglion cells is a bandpass function of... | The optokinetic response is useful for assessing retinal function s in chicks. Dopamine and nitric oxide modulate high photopic adaptation in retinal circuits. Dopamine does this by stimulating nitric oxide release. Blocking connexin35 mediated cell cell coupling simulates high photopic adaptation. The chick has untapp... |
S0014483519304798 | Our previous work reported that minocycline induced inhibition of microglial activation aggravated visual injury in an oxygen induced retinopathy animal model . We hypothesized that minocycline might have aggravated injury to the photoreceptor . Some patients who use minocycline to treat acne complain of visual impairm... | Minocycline inhibits photoreceptor cell proliferation and promotes apoptosis. Minocycline treatment promotes ER stress mediated apoptosis. and. Minocycline regulates Nrf2 levels to mediate ER stress levels. |
S0014483519304816 | Age related macular degeneration is a complex disease with multiple genetic and environmental risk factors . In the age of molecular genetics many investigators have established a link between genes and development or progression of the disease . This later evolved to determine whether phenotypic features of AMD have d... | We continue to explore the genetic architecture that underlies the development of age related macular degeneration AMD . Genetics based risk models for the onset of AMD differ from those that predict the risk of AMD progression. Genetic profiling of individuals who may benefit from nutritional supplements has been show... |
S0014483519304828 | Acylated lysine residues represent major chemical modifications in proteins . We investigated the malonylation and propionylation of lysine residues in the proteins of aging human lenses . Western blot results showed that the two modifications are present in human lens proteins . Liquid chromatography mass spectrometry... | SIRT3 and SIRT5 are present in human lenses and they are catalytically active in epithelial cells but not in fiber cells. Malonylation and propionylation of lysine residues occurs in human lens proteins and the levels of MalK and PropK do not change significantly during aging. The absence of SIRT3 and SIRT5 leads to in... |
S0014483519304920 | Administration of RC28 E a VEGF bFGF dual decoy receptor have shown relative therapeutic value in ocular in vivo models including laser induced choroidal neovascularization in monkeys and streptozotocin induced diabetic retinopathy in rats . In the present study we have elucidated the pharmacokinetics profiles of RC28 ... | Drug could rapidly distribute into focus of eye after intravitreal administration. Exposure in choroid and retina could reach efficacy dose. Approximately one quarter drug enters blood circulation system through the blood ocular barrier. |
S0014483519304981 | Proliferative vitreoretinopathy is a blinding fibrotic eye disease that develops in 810 of patients who undergo primary retinal detachment reparative surgery and in 4060 of patients with open globe injury . At present there is no pharmacological treatment for this devastating disease . Vitreal growth factors activate t... | p110d is highly expressed in epiretinal membranes from patients with PVR. p110 is highly expressed in cultured cells from epiretinal membranes from patients with PVR. Idelalisib specifically inhibits vitreous induced Akt activation. Idelalisib effectively prevents vitreous induced proliferation migration and contractio... |
S0014483519305135 | The purpose of the current work was to utilize a three dimensional corneal epithelial tissue model to study dry eye disease and oxidative stress related corneal epithelial injuries for the advancement of ocular therapeutics . Air liquid interface cultures of normal human corneal epithelial cells were used to produce 3D... | Physiologically relevant organotypic normal human corneal epithelial tissue model. Realistic exposures to environmental factors low humidity UV harmful agents. 3D tissues reproduce key features of oxidative stressinduced ocular damage. Specific cellular and molecular responses to different types of oxidative stress. Re... |
S0014483519305160 | The avascular cornea trabecular meshwork and lens obtain iron an essential biometal from the aqueous humor . The mechanism by which this exchange is regulated however is unclear . Recently we reported that non pigmented ciliary epithelial cells express ferroportin an iron export protein modulated by hepcidin the master... | Hepcidin is synthesized locally by cells of the anterior eye segment AS . Co expression of ferroportin suggests autonomous regulation of iron in the AS. Hepcidin is upregulated by IL6 implicating iron in inflammation of the AS. |
S0014483519305214 | Diabetic retinopathy is triggered by retinal cell damage stimulated by the diabetic milieu including increased levels of intraocular free fatty acids . Free fatty acids may serve as an initiator of inflammatory cytokine release from Mller cells and the resulting cytokines are potent stimulators of retinal endothelial p... | The PPAR inhibitor GSK0660 inhibits palmitic acid stimulated inflammatory mediator production by Mller cells. GSK0660 inhibits TNF induced leukocyte adhesion in both HRMEC and mouse retina. GSK0660 blocks TNF induced leukostasis by modulating the levels of CCL8 and CXCL10. GSK0660 s effects on retinal cells are mediate... |
S001448351930541X | Previous metabolomics studies from our lab found altered plasma levels of bile acids in patients with age related macular degeneration compared to controls . In this study we investigated the ability of the bile acid taurocholic acid to inhibit features of AMD modeled | TCA protects RPE monolayer tight junctions. TCA inhibits VEGF induced cell migration in choroidal endothelial cells. TCA inhibits VEGF induced tube formation in choroidal endothelial cells |
S0014483519305469 | The accumulation of chondroitin sulfate proteoglycans in the glial scar following acute damage to the central nervous system limits the regeneration of injured axons . Given the rich diversity of CSPG core proteins and patterns of GAG sulfation identifying the composition of these CSPGs is essential for understanding t... | Chondroitin sulfate proteoglycans in the optic nerve are upregulated following a crush injury. Proteoglycan expression is associated with astrogliosis. Different proteoglycan core proteins are localized differentially in the optic nerve. There is a major increase in 4 sulfated glycosaminoglycans. Optic nerve crush stim... |
S0014483519305470 | The interaction of keratocytes with extracellular matrix components plays an important role in the maintenance of corneal transparency and shape as well as in the healing of corneal wounds . In particular the interaction of these cells with collagen and cell mediated collagen contraction contribute to wound closure . E... | Endo180 is required for collagen gel contraction mediated by corneal fibroblasts. Endo180 is up regulated in migrating keratocytes during corneal wound healing. Interaction of Endo180 with collagen influences corneal fibroblast morphology. |
S0014483519305664 | Vision loss is a devastating consequence of systemic hypoxia but the cellular mechanisms are unclear . We investigated the impact of acute hypoxia in the retina and optic nerve . We induced systemic hypoxia 10 O | Acute systemic hypoxia led to glial response in the visual system. Hypoxia induced astrocyte stress and reactivity in the unmyelinated optic nerve. Hypoxia led to loss of oligodendrocytes in the myelinated optic nerve. |
S0014483519305676 | The eye lens is mainly composed of crystallins which undergo modifications such as oxidation deamidation and isomerization with aging . Asp58 Asp76 Asp84 and Asp151 residues of A crystallin are site specifically isomerized to L iso D and D iso isomers in aged related cataract lenses . In addition an A6680 peptide corre... | A substation to the L iso form at Asp76 in A6680 peptides changed its properties. The A6680 peptide containing L iso Asp76 gains chaperone activity. The A6680 peptide containing L iso Asp76 has sheet structure. |
S0014483519305779 | Our study aimed to reveal the underlying pathologic mechanisms of thyroid associated ophthalmopathy by integrative transcriptomics and proteomic analysis of extraocular muscles . The study involved 11 TAO patients and 11 control donors . Total RNA was extracted from EOM samples of 5 TAO patients and 5 control individua... | Proteomic analysis revealed differentially expressed proteins mainly related to component and contraction of EOM from TAO. Gene microarray analysis identified differentially expressed genes mainly involved in cell adhesion and ECM metabolism. Western blotting verified the up regulation and down regulation of versican a... |
S0014483519305846 | In order to study the pathophysiological alterations of the ciliary body during persistent hypotony it is necessary to develop an animal model without CB injury . In this study we successfully established a modified model of persistent hypotony without CB injury in New Zealand rabbits . A 23 gauge pars plana vitrectomy... | A model of hypotony without ciliary body injury is essential. We established a model of persistent hypotony without ciliary body injury. This is the only animal model that simulates secondary changes of hypotony. This model represents a valuable tool for studying hypotony. |
S0014483519305871 | Glaucoma is an age related neurodegenerative disease that is commonly associated with sensitivity to intraocular pressure . The disease selectively targets retinal ganglion cells and constituent axons . RGC axons are rich in voltage gated sodium channels which are essential for action potential initiation and regenerat... | Voltage gated sodium NaV channel 1.2 is localized predominately in ganglion cell intraretinal axons. Retinal ganglion cell light responses are modulated by the NaV1.2 channel specific blocker Phrixotoxin 3. Elevating intraocular pressure for four weeks decreases NaV1.2 protein expression in the retina. |
S0014483519305913 | The reactive oxygen species producing enzyme NADPH oxidase 4 is upregulated in response to TGF in lens epithelial cells | Nox4 is not essential but involved in TGF induced lens EMT. Nox4 deficiency delays the onset of TGF induced cataract. In situ Nox2 upregulation may compensate for a loss of Nox4 expression. ERK1 2 signaling is required for TGF Smad2 3 signaling. |
S0014483519306001 | Optic fissure closure defects result in uveal coloboma a potentially blinding condition affecting between 0.5 and 2.6 per 10 000 births that may cause up to 10 of childhood blindness . Uveal coloboma is on a phenotypic continuum with microphthalmia and anophthalmia the so called MAC spectrum . This review gives a brief... | Uveal coloboma a rare potentially blinding condition affecting between 0.5 and 2.6 per 10 000 births. Isolated and syndromic cases of uveal coloboma. Current knowledge on the genetics of human uveal coloboma with a specific focus on CHARGE and COACH syndromes. Approaches to identify genes involved in optic fissure clos... |
S0014483519306177 | This study was conducted to evaluate the impact of varying scleral material properties on the biomechanical response of the cornea under air puff induced deformation . Twenty pairs of human donor eyes were obtained for this study . One eye from each pair had its sclera stiffened using 4 glutaraldehyde while the fellow ... | Highlight 1 Altering scleral stiffness significantly impacted corneal deformation response. Highlight 2 Corneal deformation response is due to coupling of corneal and scleral properties. Highlight 3 Highest Concavity response parameters may be sensitive to scleral changes. |
S0014483519306207 | Myopic children have larger ciliary muscles than non myopic children suggesting that the ciliary muscle may have an impact on or be affected by refractive error development . The guinea pig represents an attractive model organism for myopia development research . The purpose of the study was to investigate whether form... | Induced axial myopia in guinea pigs results inciliary muscle morphological changes that differ from human myopia. Induced ciliary muscle changes suggest atrophy or inhibited muscle growth. New guinea pig strains were described for myopia development research. |
S0014483519306232 | Corneal neovascularization is a common sight threatening pathology that can be induced by a variety of inflammatory and angiogenic stimuli . Current CNV treatments include anti inflammatory drugs and antibody based inhibitors of vascular endothelial growth factor . However these are not always effective and novel thera... | Treatment with topical nucleolin binding aptamer AS1411 decreased corneal neovascularization. AS1411 is able to reduce migration proliferation and tube formation of VEGF stimulated human limbal stromal cells HLSC . miRNA 21 and 221 reduction by AS1411 on VEGF HLSC explains in part the effect of AS1411 on corneal neovas... |
S0014483519306281 | Multiple retinal cells harbor a circadian oscillator including retinal pigment epithelial cells . However little is known about the functions that are regulated by the RPE clock . The aim of this study was to investigate whether the circadian clock in the RPE regulates the transport of glucose and its glycolytic metabo... | The. and. transporter genes are highly expressed in ARPE 19cells. RPE monolayer organization is necessary for rhythmic transporter expression. POS incubation affects transporter expression in a time dependent manner. RPE mediated transport is rhythmic for lactate but not for glucose. |
S0014483519306542 | The lamina cribrosa in glaucoma is with augmented production of extracellular matrix proteins and connective tissue fibrosis . Fundamental pathological mechanisms for this fibrosis comprise fibrotic growth factors and oxidative stress . Transient receptor potential canonical channels channels play a key role in ECM fib... | The lamina cribrosa in glaucoma is associated with increased extracellular matrix production and connective tissue fibrosis. Underlying pathological mechanisms of fibrosis include oxidative stress. TRPC channels play a key role in ECM fibrosis. TRPC1 C6 expression is enhanced in glaucoma LC cells. TRPC1 C6 contribute t... |
S0014483519306608 | A recently described subtype of foveal hypoplasia with congenital nystagmus and optic nerve decussation defects was found to be associated with mutations in the Five Israeli families with congenital foveal hypoplasia were studied two of Karait Jewish origins and three of Indian Jewish origins . Subjects underwent a com... | Foveal hypoplasia is a congenital disorder characterized by a lack of foveal depression in the foveal area. This study describes five unrelated families with foveal hypoplasia and nystagmus associated with SLC38A8 gene mutations. Expression in both Indian and Karaite Jewish ethnicities could be suggestive for common an... |
S0014483519306633 | The gut microbiota and its influence on host metabolism are considered to be an environmental factor that contributes to the progression of many immune and neurodegenerative diseases . However the features of the GM and serum metabolites in Primary open angle glaucoma patients have not been clearly elucidated . The pur... | POAG patients have different gut microbiota and serum metabolites with healthy subjects. Gut microbiota and host metabolism might be linked with glaucoma. Gut microbiota and metabolites targeted interventions of glaucoma should be considered in future. |
S0014483519306700 | Keratoconus is a controversial ophthalmological disease often considered both multifactorial and multigenic with poor or not entirely understood etiopathogenesis . Corneal collagen crosslinking procedure is the most common surgical therapy for KC which both slows corneal thinning and halts disease progression . While e... | Oxidative stress is an important component of keratoconus pathological development. Corneal collagen crosslinking procedure is the most efficient treatment for keratoconus. Oxidative status changes can be observed in the tears of patients with keratoconus in a direct correlation to Amsler Krumeich stages. Oxidative sta... |
S0014483519306724 | Quantitative analysis of aqueous humor was performed to investigate glucose metabolism in patients with central retinal vein occlusion and to explore metabolic changes after anti vascular endothelial growth factor treatment . AH samples were collected from 35 patients . Participants diagnosed with CRVO were compared to... | Succinate glutamate and glutamine were significantly low in patients with CRVO. The ketoglutarate citrate ratio was positively correlation with glutamine levels. Lactate levels increased significantly after intravitreal anti VEGF administration. The change in CMT was negatively correlated with lactate increase. RGC thi... |
S0014483519306785 | Glaucoma is a progressive neurodegenerative process affecting the retinal ganglion cells and the optic nerve . Oxidative stress has been implicated in glaucoma pathogenesis and iron is a potent generator of oxidative stress . The oral iron chelator deferiprone is protective against retinal degenerations associated with... | Oral DFP improved RGC survival in a microbead induced mouse model of glaucoma. DFP administration preserved retinal ganglion cells and optic nerve axons in hypertensive glaucomatous eyes. Iron chelation may be neuroprotective in glaucoma. |
S0014483519306797 | Experimental evidence suggests that dopamine modulates refractive eye growth . We evaluated whether increasing endogenous DA activity using pharmacological or genetic approaches decreased myopia susceptibility in mice . First we assessed the effects of systemic L 3 4 dihydroxyphenylalanine injections on form deprivatio... | Systemic L DOPA administration prevents form deprivation myopia in mice. The dopamine packaging protein VMAT2 may affect early form deprivation myopia. Endogenously increased dopamine activity prevents form deprivation myopia in mice. |
S0014483519306839 | Retinal ischemia is a common condition that may lead into vision impairment and blindness . In this study we evaluated changes separately in On and Off visual responses induced by retinal ischemia . To do this reversible retinal ischemia was induced in anaesthetized rats by increasing the intraocular pressure until the... | Collicular Off responses were more sensitive than ON responses to ischemia. Duration of ischemia differentially affected both responses On and Off . Recovery of ischemia was not complete in the SC whereas the ERG remained unaltered. |
S0014483519306967 | Orbital venous malformations are the most common benign orbital vascular disorders in adults and are characterized as enlarging encapsulated vascular neoplasms . These painless lesions grow slowly and become symptomatic with proptosis or visual disturbance . However the pathogenic mechanism and diagnostic markers of OV... | Transcriptome screening revealed 2 upregulated and 4 downregulated signaling pathways in OVM samples. E2F1 was identified as the key transcriptional factor in regulating aberrant expression of lncRNAs. The plasma EGF and Leptin levels were significantly elevated in OVM patients. |
S0014483519306979 | Multiple aspects of cornea development including the innervation of the cornea by trigeminal axons are sensitive to embryonic levels of thyroid hormone . Although previous work showed that increased TH levels could enhance the rate of axonal extension within the cornea in a thyroxine dependent manner details underlying... | Pericorneal nerve ring formation was accelerated and corneas became precociously innerved in T3 treated embryos. T3 acts as a trophic factor to directly stimulate trigeminal nerve growth. Robo Slit pathway expression is reduced in eyefronts following T3 exposure. Growth rate and defasciculation of nerves increased with... |
S0014483519307031 | Piezo channel is one of the mechanosensitive channels that senses pressure and shearing stress . Previous reports show that Piezo channel is expressed in many tissues such as skin and lung and they have many important roles . In addition the mRNA of | Piezo 1 2 were expressed in the cornea trabecular meshwork lens epithelial cells and on the retinal ganglion cell layer. Yoda 1 suppressed neurite outgrowth in retinal ganglion cells. GsMTx4 promoted neurite outgrowth in retinal ganglion cells. |
S0014483519307110 | The purpose of this study was to investigate the role of exosomes derived from platelet rich plasma in the regulation of the fibrogenic activity of Mller cells and the underlying mechanism . We studied the effects of PRP Exos on the fibrogenic activity of human retinal Mller cells in vitro . PRP Exos were isolated from... | We firstly studied the role of PRP Exos in the regulation of fibrogenic activity of Mller cells and its mechanism. PRP Exos from diabetic rats could effectively increase proliferative and migratory activities of Mller cells. PRP Exos may contribute to the activation of YAP and promote the fibrogenic activity via the PI... |
S001448351930716X | As the peroxisome proliferator activated receptor alpha agonist fenofibrate has been widely used to be a good lipid regulating drug in the clinical application . In this study we investigated the mechanism by which keratocytes inhibit the corneal neovascularization through PPAR activation . To do this the CNV model was... | PPAR gene knockout promoted the CNV induced by VEGFr3 and MMP13. PPAR activation inhibited the CNV via downregulating VEGFr3 and MMP13 expression. PPAR gene knockout could promote the VEGFr3 and MMP13 expression in keratocytes. Fenofibrate decreased VEGFr3 and MMP13 expression levels in keratocytes. |
S0014483519307171 | The transparent and refractive properties of the ocular lens are dependent on its precise cellular structure supported by the regulation of lens cellular processes of proliferation and differentiation that are essential throughout life . The ERK MAPK signalling pathway plays a crucial role in regulating lens cell proli... | The loss of Spreds results in a small lens eye phenotype. Spreds negatively regulate ERK1 2 signalling. Spreds negatively regulate lens epithelial cell proliferation. Spreds 1 and 2 complement each other in lens development. |
S0014483519307213 | Autophagy plays critical roles in various ocular diseases including age related macular degeneration . Tie2 expressing macrophages play crucial roles in angiogenesis . To investigate the role of TEMs and autophagy in the development of AMD we employed macrophage specific Tie2 knockout mice and used a laser induced chor... | Knockdown of Tie2 expressing macrophagesin the laser induced CNVmicesuppress angiogenesisby reducing VEGF and autophagy. Supernatant from Tie2 knockoutmacrophagesinhibited migration tube formation VEGF and autophagyof bEnd.3 cells. Peritoneal macrophages from Tie2 knockout mice inhibitVEGFand autophagyby AMPK signaling... |
S0014483519307298 | Elastic fibres provide tissues with elasticity and flexibility . In the healthy human cornea elastic fibres are limited to the posterior region of the peripheral stroma but their specific functional role remains elusive . | mg. mice showed abnormalities in corneal thickness from embryonic development through to adulthood. Elastic fibres were evident from E16.5 in both the WT and mg. mouse corneas. Adult mg. mouse corneas exhibited a disorganised elastic fibre network with unusually high levels of branching. The disrupted collagen arrangem... |
S001448351930733X | Various severe ocular diseases are associated with an elevated intravitreal expression of VEGF A which increases the permeability of retinal endothelial cells or retinal pigment epithelial cells | Blocking VEGFR2 efficiently reverts VEGF induced dysfunction of cells of the BRB. Additional blocking of other non tyrosine kinase receptors is not superior. Inhibiting VEGFR2 does not alter vitality of REC or RPE cells. Long term cultivated ARPE 19cells respond differently to VEGF A than short term cultivated ones. |
S0014483519307353 | Persistent non infectious uveitis has a significant morbidity but the extent to which this is accompanied by inflammation driven remodelling of the tissue is unclear . To address this question we studied a series of samples selected from two ocular tissue repositories and identified 15 samples with focal infiltration .... | Active inflammation continues in cases of persistent uveitis. Some patients develop ectopic lymphoid like structure. In these cases targeting B cells may be beneficial. |
S0014483519307377 | Imaging techniques have revolutionised the assessment of retinal disease in humans and animal models . Here we describe a novel technique for the | Mouse models of RP that express GFP within rods allow spatiotemporal assessment of retinal degeneration. using cSLO. Mean grey values derived from the resulting images represent global indices of overall photoreceptor survival. This allows simple and objective mapping of focal photoreceptor loss or preservation followi... |
S0014483519307432 | Methamphetamine an addictive stimulant of neurotransmitters is associated with cardiovascular and neurological diseases . METH induced ophthalmic complications are also present but have been insufficiently investigated . The purpose of this study is to investigate the retinal effects of METH . C57BL 6 mice were adminis... | Methamphetamine induces retinal neurodegeneration in mice. PECAM 1 and glycocalyx are lost from retinal vessels and central retinal artery following methamphetamine administration. Methamphetamine increases MMP 14 levels in the retina and MMP 2 and MMP 9 levels in plasma. |
S0014483519307444 | The present study was designed to investigate the effect of topical erythropoietin on the healing process of induced necrotizing scleritis and to evaluate the ocular side effects of this treatment modality in a rabbit model . Necrotizing scleritis was induced in 8 New Zealand albino rabbits . The animals were then rand... | Topical erythropoietin increased the rate of healing in induced necrotizing scleritis in rabbit eyes. The effect of erythropoietin was mediated by the inhibition of inflammation and apoptosis and stimulation of angiogenesis. Neovascularization of the cornea iris or retina was not observed in the treated eyes. |
S0014483519307511 | Loss of choriocapillaris in advanced age related macular degeneration is well documented but changes in early AMD have not been quantified . Postmortem eyes from donors with clinically documented early AMD were examined in choroidal whole mounts to determine the area pattern and severity of CC loss . Choroids from post... | There is significant loss of submacular choriocapillaris in subjects with early AMD compared to control subjects. On the contrary there was no vascular pathology in paramacular choriocapillaris of the AMD subjects. Attenuation of choriocapillaris was associated with arteriosclerotic and hypertensive changes in Sattler ... |
S0014483519307535 | Corneal neovascularization can cause abnormal blood vessels to grow in the normally transparent and translucent cornea leading to various sight threatening eye diseases . microRNAs and circular RNAs are known to play essential roles in the regulation of numerous biological functions . It is urgently needed to understan... | CZNF609 acted as a miR 184 sponge to block miR 184 activity. Overexpression of miR 184 suppressed HCEKs cell proliferation migration in vitro and angiogenesis in vivo. The miR 184 mediated inhibition effect can be rescued through the re introduction of cZNF609. |
S0014483519307687 | To investigate the protective effect of inhibiting miR 181a on diabetic corneal nerve in mice we chose male C57BL 6 mice with streptozotocin induced diabetes as animal models . The expression of miR 181a in trigeminal ganglion tissue of diabetic mice was detected by real time PCR . In vitro we cultured mouse trigeminal... | We evaluated the expression of miR 181a which is significantly different between normal and diabetic mice in trigeminal ganglion tissue. The target genes of miR 181a were predicted by bioinformatics software Atg5 and Bcl 2 were identified as potential targets. This study demonstrated that inhibiting the expression of m... |
S0014483519307729 | Retinal detachment results in disruption of retinal physiology and visual function . Although surgical intervention has been well developed to restore the retinal anatomic structure post op progression of visual function decline is prominent in a large proportion of patients . Therefore the establishment of a disease m... | A modified model of retinal detachment in mice was established to better mimic pathogenesis. Vitreous humor extraction followed by visible hyaluronic acid injection increased the stability of model. Retinal vasculature after retinal detachment was evaluated by 3D imaging and reconstruction. |
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