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S0014483519307730 | Optic nerve head neuroretinal rim thickness quantified as minimum rim width is a sensitive measure for assessing early glaucomatous disease . The BMO MRW is sensitive to transient fluctuations in intraocular pressure but the time course over which BMO MRW decreases and recovers with changes in IOP remains unknown . The... | Changes in intraocular pressure result in rapid changes in the neuroretinal rim. The neuroretinal rim continues to change over a period of 2h with sustained IOP. Residual thinning of the neuroretinal rim persists after 2h of IOP reduction. There is individual variability in the rate and extent of rim tissue thinning. |
S0014483519307754 | IQ domain GTPase activating protein 1 is a multidomain scaffold protein that is involved in cytoskeleton dynamics and tumor metastasis . Although the role of IQGAP1 in various cancers had been reported the function of IQGAP1 in pterygium has not been studied . In this study surgically excised pterygium and control conj... | IQGAP1 is expressed in both the normal conjunctiva and pterygium. Greater clinical severity of pterygium is correlated with higher IQGAP1 expression. Greater mast cells and microvascular counts are associated with clinical severity of pterygium. |
S0014483519307821 | We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase inhibitor Nov3r after ischemia reperfusion injury in rats . IR injury was induced by applying 150mmHg of intraocular pressure for 50min . Nov3r was orally administered 3h before and 24h after IR injury . TUNEL positive cells increased and ... | Pyruvate Dehydrogenase Kinase PDK inhibitor Nov3r increased retinal Pyruvate Dehydrogenase PDH activity. Nov3r showed protective effects of RGCs in Ischemia Reperfusion IR induced injury. Nov3r reduced activation of Iba1 positive microglial cells in IR injury. Nov3r ameliorated metabolic dysfunction in rat retinas afte... |
S0014483519307869 | Bombina variegata 8 also known as prokineticin 2 is a potent pro angiogenic factor . However its role in retinal neovascularization remains unknown . In this study we explored the role of Bv8 in the pathogenesis of RNV . We found that the expression of Bv8 was significantly increased in two different models of retinal ... | The expression of Bombina variegate 8 Bv8 was significantly increased in the retinal neovascularization RNV mouse model. Bv8 neutralizing not only inhibited RNV but also decreased the mRNA and protein level of several pro angiogenic factors. Recombinant human Bv8 protein promoted human retinal microvascular endothelial... |
S0014483519307894 | Cytologic features such as the shape and size of tumor cells can predict metastatic death in uveal melanoma and other cancers but suffer from poor reproducibility . In this study we investigate the interobserver concordance of digital morphometry and correlate the results with BRCA associated protein 1 expression and | Twelve cell size and shape features were analyzed digitally in uveal melanoma. The average number of cells analyzed in each of 27 tumors was 1957 SD 349 . Interobserver concordance was 85 for all morphometric variables 0.700.93 . Tumor nuclei size correlated to BAP 1 protein expression BAP 1 mutation status monosomy 3 ... |
S0014483519307936 | Keratocytes synthesize stromal proteins and participate in wound healing through successive differentiation into corneal fibroblasts and myofibroblasts . Cultured keratocytes or corneal fibroblasts are also known as non professional phagocytes and innate immune cells . However whether the corneal fibroblasts phagocytiz... | Corneal fibroblast cells are macrophage like fibroblasts. Corneal fibroblasts can engulf dead bacteria processed cellular debris and entire dead cells. Dying and dead cells stimulate corneal fibroblasts to further induce inflammatory factors. |
S001448351930795X | To observe the morphologic and histopathologic changes of femtosecond laser assisted small incision allogenic intrastromal lenticule implantation in monkey corneas . 6 healthy adult monkeys were included . One eye of two monkeys and both eyes of one monkey received femtosecond lenticule extraction with a 4.0 diopter co... | Small incision allogenic intrastromal lenticule implantation is feasible and safe for reshaping the cornea. Corneal healing remained stable while refraction showed a moderate regression within postoperative 2 years. The mechanism of histopathologic change require further investigation. |
S0014483519308012 | Preclinical imaging especially of rodent models plays a major role in experimental ophthalmology . Our aim was to determine if ultrasound can be used to visualize and measure flow dynamics in the retrobulbar vessels supplying and draining the eye and the potential of contrast microbubbles to provide image and measureme... | Blood flow in the retrobulbar vessels of the rat eye was visualized using plane wave ultrasound. Spectrograms allowed determination of arterial and venous velocities over the cardiac cycle. Intravenous contrast microbubbles enhanced visualization of blood flow. After initial peak contrast enhancement declined exponenti... |
S0014483519308024 | Besides apoptosis necrosis can also occur in a highly regulated and genetically controlled manner defined as regulated necrosis which is characterized by a loss of cell membrane integrity and release of cytoplasmic content . Depending on the involvement of its signal pathway regulated necrosis can be further classified... | Regulated necrosis plays a key role in pathogenesis of blindness diseases. Necroptosis contributes to the death of RGC RPE and cone cells. Ferroptosis contributes to the death of RGC RPE and cone cells. |
S0014483519308036 | Homo sapiens MIR7 3 host gene a long non coding RNA has been reported to be connected with the progression of several tumors and could be served as a prognostic marker . Our study intends to explore the biological function and potential molecular mechanism of MIR7 3HG in Retinoblastoma progression . Two Rb cell lines Y... | High expression of MIR7 3HG was presented in Rb tissues and cells. MIR7 3HG executed promotion effect in Rb cell development. Associations among MIR7 3HG miR 27a 3p and PEG10 have been affirmed. Connections among PEG10 MIR7 3HG and miR 27a 3p were further identified. MIR7 3HG miR 27a 3p and PEG10 formed a network to pr... |
S0014483519308048 | How the absence of gravity affects the physiology of human beings is generating global research interest as space exploration including missions aboard the International Space Station continues to push boundaries . Here we examined changes in retinal microcirculation and visual electrophysiology in mice suspended by th... | The effects of simulated microgravity on retinal microcirculation remain unknown. The effect of simulated and real microgravity conditions on the optic nerve head is similar. The changes in the electroretinograms may be related to abnormal retinal microcirculation. However the changes are reversible with no permanent i... |
S0014483519308127 | The purpose of this study was to characterize and develop a primate model of chronic retinal neovascularization and vascular leakage that can be employed to assess efficacy of experimental therapeutics targeting retinal ischemic and neovascular diseases . African green monkeys received bilateral intravitreal injection ... | DL 2 aminoadipic acid DLAAA induces chronic retinal vascular leakage in primates. DLAAA induces retinal neovascularization and edema followed by atrophy. Vascular leakage responds to anti VEGF therapy before returning after drug washout. DLAAA model enables evaluation of retinal neovascular therapeutic candidates. |
S0014483519308164 | Endothelin 1 a potent vasoconstrictor plays a significant role in the pathophysiology of ocular conditions like glaucoma . Glaucoma is characterized by apoptotic loss of retinal ganglion cells and loss of visual fields and is a leading cause of irreversible blindness . In glaucomatous eyes retinal ischemia causes relea... | MgAT protects against endothelin 1 induced retinal ganglion cells in rats. MgAT suppresses endothelin 1 induced retinal expression of IL 1 IL 6 and TNF . MgAT suppresses endothelin 1 induced activation of NFKB and c Jun in rat retinas. MgAT protects against endothelin 1 induced changes in visual behaviour of rats. |
S0014483519308218 | Mesenchymal stem cells exhibit beneficial effects on autoimmune dacryoadenitis . However the underlying mechanisms are not fully understood . In this study we investigated the therapeutic effect of human umbilical cord mesenchymal stem cells on rabbit autoimmune dacryoadenitis an animal model of Sjgren s syndrome dry e... | HUC MSCs infused after disease onset efficiently attenuated rabbit autoimmune dacryoadenitis. HUC MSC treatment promoted the expression of M2 macrophage associated molecules in diseased LGs. HUC MSCs modulated M2 macrophage polarization via activating AKT pathway. |
S0014483519308383 | Vitreous liquefactive processes play an integral role in ocular health . Knowledge of the degree of liquefaction would allow better monitoring of ocular disease progression and enable more informed therapeutic dosing for an individual patient . Presently this process can not be monitored in a non invasive manner . | MRI protocol optimisation allows acquisition of homogenous T2 maps of artificial vitreous humour. Artificial vitreous humour T2 can be correlated with viscoelastic properties of the gel. An optimised MRI protocol can non invasively identify regional variations in T2 within porcine vitreous humour . |
S0014483519308462 | Diabetic retinopathy is considered as a diabetes related complication that can lead to severe visual impairments . By 2030 it is expected that 1 in 5 adults will suffer from the disease . Suitable animal models for chronic DR are essential for a better understanding of the pathophysiology and to further develop new tre... | Reliable DR animal models that reproduce the whole spectrum of the disease are crucial to the development of new therapies. Ins2. mouse model develops an inflammatory response in the retina predominantly in early stages of DR. Ins2. mouse model shows a dysregulation in pro and antiangiogenic factors in the retina. |
S0014483519308474 | Preeclampsia is a hypertensive complication of pregnancy . Its cause is still unknown and it could be a risk factor for future ophthalmic problems . Retinal vascular bed alterations have been described as a consequence of PE suggesting a retinopathy . Factors related to angiogenesis and vascular permeability such as va... | AT1 receptor and Pro renin renin receptor participates in preeclampsia retinopathy. VEGF and PEDF are augmented in preeclamptic retinopathy. L NAME induced hypertension develops faster in previously preeclamptic animals. AT1 receptor and Pro renin renin receptor participate in L NAME induced retinopathy. VEGF and PEDF ... |
S0014483519308619 | There is accumulating evidence that aging shifts the central nervous system milieu towards a proinflammatory state with increased reactivity of microglia in the aging eye and brain having been implicated in the development of age related neurodegenerative conditions . Indeed alterations to microglial morphology and fun... | Retinal macrophage reactivity was enhanced in older mice following IOP elevation. Retinal macrophage responses to injury were altered in chimeric mice. Gliosis was attenuated following IOP elevation in chimeric mice. Altered macrophage responses in chimeric mice was independent of bone marrow age. Irradiation may alter... |
S0014483519308668 | Sudden acquired retinal degeneration syndrome in dogs is proposed to have an immune mediated etiology . However there is conflicting evidence regarding the presence of antiretinal antibodies as assessed by western blotting in the serum of SARDS patients . Because of the possibility that antibodies recognize only confor... | The serum of dogs with SARDS contains anti photoreceptor IgG. Dogs with SARDS have elevated total circulating IgM and reduced total circulating IgG compared with matched controls. Canine SARDS and human AIR have similarities in terms of presence of antiretinal antibodies on indirect immunofluorescence. |
S001448351930870X | We report an analysis of the aqueous humor metabolome of primary open angle glaucoma in comparison to normal controls . The AH samples were obtained from human donors POAG . The AH samples were subjected to one dimensional | We report the metabolites of control versus primary open angle glaucoma POAG aqueous humor AH . We used. H nuclear magnetic resonance NMR and isotopic ratio outlier analysis IROA using a Q Exactive mass spectrometer. There were significant metabolite changes found in the POAG AH. |
S0014483519308735 | The intraepithelial corneal nerves that innervate the corneal epithelium are maintained through interactions with corneal epithelial cells and the extracellular matrix they produce . One to several axons bundle together within the basal cell layer and extend parallel to the ocular surface or branch and extend apically ... | FIB SEM shows the EBM thinning near sites where ICNs come in close contact. FIB SEM shows debris in lysosomes after trephine injury. Stromal nerves impacted by trephine only injury. Immune cells are reduced at the corneal periphery after trephine injury. |
S0014483519308826 | There is a need to find alternative treatments for MEe . Bromfenac has shown promise in inhibiting the COX 2 enzymatic pathway that partially causes the inflammatory cascade which contributes to the precipitation of ME . However like other NSAID s its intraocular half life is limited . We hypothesize that a delayed rel... | Diabetic macular edema is the main cause of impaired BCVA in developed countries. The pathogenesis of DME is multifactorial but one of the main routes is inflammation. Although Anti VEGF therapy is the gold standard of therapy it is not enough to perfectly handle DME. By attacking the COX 2 pathway of inflammation it i... |
S0014483519308863 | Gene therapy has been proposed as a feasible strategy for RGC survival and optic nerve regeneration . Some preclinical and clinical studies revealed intraocular inflammation after intravitreal injection of adeno associated virus by slit lamp or indirect ophthalmoscope . Here we evaluate the longitudinal profile of imme... | This study revealed the acute inflammatory responses and retinal edema after intravitreal injection of AAV2 mediated gene. Intravitreal injection of AAV2 mediated gene didn t influence RGC survival in normal rats. OCT can help to evaluate the time lapse. inflammatory response of gene therapy. |
S0014483519308930 | The central biological clock system of bird is formed by hypothalamus suprachiasmatic nucleus pineal gland and retina thereby interacting with each other in a neuroendocrine loop . Previous results have confirmed that monochromatic light can influence the clock genes in the pineal gland hypothalamus and retina of chick... | The cultured chick retinal tissue was established and the biological clock of retina was affected by the color of light. In constant dark the molecular clock and melatonin in isolated chick retina tissue maintained circadian oscillation. Green light increased melatonin and. by enhancing the circadian expression of mela... |
S0014483519308966 | Strong communication and interaction between the retinal pigment epithelium and the photoreceptor cells is essential for vision . RPE cells are essential for supporting and maintaining PR cells by transporting nutrients waste products and ions and phagocytosing photoreceptor outer segments . POS phagocytosis follows a ... | Cldn2 RNA and protein expression show clear differences over time in RPE cells. Paracellular water and sodium transport in RPE might be facilitated by Cldn2 during the day. Genes involved in intracellular trafficking show differential day night expression. Genes involved in cytoskeleton remodelling show high expression... |
S0014483519309005 | The complement system may be activated in the posterior segment of the eye with chorioretinal disease which may be reflected to the concentration of anaphylatoxins in the aqueous humor . Little is known about the distribution of anaphylatoxins in the aqueous and vitreous humor . The aim of the present study was to inve... | Anaphylatoxins were detected in the eyes with idiopathic epiretinal membrane and idiopathic macular hole. The concentration of C3a in the aquous humor was significantly correlated to that in the vitreous humor. Measuring anaphylatoxins in the aqueous humor may be useful to estimate the complement activation in the vitr... |
S0014483519309029 | Retinopathy of prematurity is a growing cause of lifelong blindness and visual defects as improved neonatal care worldwide increases survival in very low birthweight preterm newborns . Advancing ROP is managed by laser surgery or a single intravitreal injection of anti VEGF typically at 3336 weeks gestational age . Whi... | PEDF derived 9 mer peptide PEDF 336 previously shown to inhibit laser induced CNV in mice was tested in OIR. IVT injection of 1 L PEDF 336 1.257.5 g in neonatal mouse eyes at transition from 75 O2 to room air P12 reduced NV and VO at P17. While PEDF 336 displayed dose responsive efficacy anti mouse VEGFA164 was active ... |
S0014483519309066 | The presence of a phagocytic peak of photoreceptor outer segments by the retinal pigment epithelium one or 2h after the onset of light has been reported for several diurnal and nocturnal species . This peak in phagocytic activity also persists under constant lighting conditions thus demonstrating that the timing of thi... | Identified a new pathway mitochondrial oxidative phosphorylation associated with circadian control of phagocytic activity. About 20 of the whole RPE transcriptome may be under circadian clock regulation. Known RPE phagocytic pathways integrin protein phosphorylation cAMP signaling are possibly under circadian control. ... |
S0014483519309133 | Scleral fibroblast activation occurs in glaucomatous and myopic eyes . Here we perform an unbiased screen to identify kinase inhibitors that reduce fibroblast activation to diverse stimuli | Scleral biomechanics and collagen ultrastructure are altered in glaucoma. We performed a screen to identify kinase inhibitors that reduce scleral myofibroblast differentiation. The multikinase inhibitor dasatinib reduces scleral myofibroblasts at nanomolar dosages. |
S001448352030004X | Familial exudative vitreoretinopathy is a disease exhibits a wide range of clinical signs ranging mild peripheral retinal vascular anomalies to severe retinal detachments . Individuals with mild FEVR are frequently asymptomatic with good visual function and are often undiagnosed . However little is known about the gene... | First report on the spectrum of genetic mutations in patients with asymptomatic mild FEVR cohort. The clinical and genetic characteristics were analyzed. Ten novel variants were detected. |
S0014483520300130 | Restoration of corneal sensitivity is of utmost importance to maintain corneal homeostasis following any injury or insult for which both corneal nerve regeneration and re innervation are essential . Fibrosis poses a major impediment for re innervation . We have in this study evaluated the influence of various nerve gro... | Corneal innervation is imperative for corneal homeostasis. Fibrosis can impede the path of corneal nerve re innervation. Pirfenidone does not adversely affect trigeminal neuron cell growth. Topical therapy with pirfenidone and Nerve growth factor are complementary for corneal healing. |
S0014483520300476 | is a common bacterial isolate from cases of microbial keratitis . The virulence factors that contribute to its pathogenicity during this disease have not been fully resolved . The aim of the current study was to examine the effects of the extracellular protease Staphopain A on corneal virulence . Two strains were used ... | The staphylococcal protease staphopain contributes to fibronectin binding. The staphylococcal protease staphopain contributes to pathology during keratitis. Inhibition of staphopain by staphostatin A significantly reduces corneal pathology during keratitis. |
S001448352030049X | Basement membranes are highly specialized extracellular matrices . More than providing scaffolds basement membranes are recognized as dynamic and versatile structures that modulate cellular responses to regulate tissue development function and repair . Increasing evidence suggests that in addition to providing structur... | Major components of the EBM are collagens laminins perlecan and nidogens. Keratocytes and corneal fibroblasts contribute components during EBM regeneration. The EBM regulates the localization of TGF PDGF HGF and KGF. Defective regeneration of the EBM underlies stromal fibrosis. |
S0014483520300543 | We aim to determine whether lymphatic drainage from the eye changes with age . Using quantitative photoacoustic tomography groups of young and older mice were studied in the live state . 10 CD 1 mice of 23 months were studied in addition to 13 older mice of 1213 months . In each of 23 mice near infrared tracer was inje... | A novel non invasive photoacoustic imaging approach was used to quantify lymphatic drainage from the eye. Lymphatic drainage from the eye was found to be reduced in older compared to younger mice. Age related decline of ocular lymphatic function and impaired clearance of proteins from the eye may be relevant to the und... |
S0014483520300683 | This study aimed to assess the cytotoxic effect of low molecular weight components and conventional silicone oils 1000cSt with different degree of purification using in vitro cytotoxicity tests . Direct contact cytotoxicity tests were performed in BALB 3T3 and human retinal pigment epithelial cells using quantitative a... | Silicone oils with various purification degree were not cytotoxicity on BALB3T3 and ARPE 19cells. Low molecular weight components were not cytotoxicity on BALB3T3 and ARPE 19cells. Acute direct cytotoxicity is not likely to influence the biocompatibility of purified SO 1000cSt. |
S001448352030141X | Expression patterns of voltage gated ion channels determine the spatio temporal dynamics of ion currents that supply excitable neurons in developing tissue with proper electrophysiological properties . The purpose of the study was to identify fast cationic inward currents in mouse retinal horizontal cells and describe ... | Mouse retinal horizontal cells express T type calcium and sodium channels. Sodium and calcium currents are downregulated during development. Activation and inactivation kinetics of sodium and calcium channels remain similar during development. T type calcium channels contribute to the dark resting membrane potential. F... |
S001448352030292X | Bowman s layer lies immediately posterior to the epithelial basement membrane and anterior to the stroma proper in humans chickens quail zebra fish deer giraffe antelope California sea lions guinea pig and several other species . It is not found in dog wolf cat tiger lions rabbit pigs cows goats or horses . Development... | Bowman s layer is present in some species and absent in others. Bowman s layer is not a barrier to passage of large molecules. A Bowman s like layer may regenerate after corneal surgery. Bowman s layer likely maintained by ongoing epithelial stromal interactions. |
S0014483520302931 | To characterize microRNAs and their possible roles in high myopia by using next generation sequencing . Aqueous humor samples were obtained from 25 highly myopic eyes and 25 cataract eyes at the onset of surgery . miRNA next generation sequencing and bioinformatics analyses were performed using RNA extracted from 30 sa... | microRNA profiles in human eyes have not been reported. MiR 886 miR 369 miR 370 etc. were higher expressed in high myopia miR 10b miR 143 and miR 145 were suppressed. Aberrantly expressed miRNAs are crucial for precise diagnosis prognosis and response predictions of myopia. |
S0014483520302943 | Axonal transport blockade is an initial step in retinal ganglion cell degeneration in glaucoma and targeting maintenance of normal axonal transport could confer neuroprotection . We present an objective quantitative method for assessing axonal transport blockade in mouse glaucoma models . Intraocular pressure was eleva... | A method to quantify axonal transport blockade in mouse optic nerve is presented. Localized accumulation in four zones of the optic nerve was quantified. The method was applied to glaucoma pretreated with glyceraldehyde or losartan. Method can assess neuroprotection in glaucoma models at an early time point. |
S0014483520302955 | Our study aimed to investigate the differentially expressed circRNAs and their potential roles in orbital adipose connective tissue from patients with thyroid associated ophthalmopathy . The orbital adipose connective tissue samples from three TAO patients and three control individuals were collected for RNA sequencing... | 607 mRNAs and 163 circRNAs were identified as differentially expressed in orbital adipose connective tissue of TAO. CircRNA mRNA co expression and circRNA miRNA interaction networks were constructed to reveal the roles of circRNAs in TAO. Expressions of MMP2 TNXB PTGFR CCND1 TNFRSF19 circRNA 14936 circRNA 14940 and cir... |
S0014483520302967 | Artificial cornea is an effective treatment option for cases of severe corneal loss . In this study we prepared a core skirt designed artificial cornea with orthogonal microfiber grid scaffold . We fabricated PCL orthogonal microfiber grid scaffolds by a direct writing technique and then combined them with compressed c... | Preparation of orthogonal microfiber grid scaffold by direct writing technology. A new core skirt artificial cornea in which microfiber grid scaffolds act as a connection between the core and the skirt. Constructed a 3D co culture model of corneal stromal cells and neurons. |
S0014483520302980 | Evidence suggests that the relevant variable in the anti myopigenic effect of increased time spent outdoors is the increase in light intensity . Because light is the strongest Zeitgeber it is plausible that the effects of bright light exposure depend on time of day and may impact circadian rhythms . In these studies we... | Brief bright light inhibits myopic eye growth only when given in the evening. Concurrent brief bright light and hyperopic defocus inhibits growth in the morning. Bright light at transition times affect ocular rhythms. Effect of bright light on eye growth depend on whether defocus is continuous or brief. |
S0014483520302992 | Animal studies suggest that the retinal dysfunction in diabetic subjects that precedes overt clinical vasculopathy may be due to a retinal dopamine deficit . We analyzed levels of dopamine and its primary metabolite 3 4 dihydroxyphenylacetic acid in the vitreous of diabetic and non diabetic human subjects . Adult patie... | Animal models of diabetes mellitus DM indicate that deficits in retinal dopamine precede vascular dysfunction and contribute to compromised visual function. Levels of dopamine and 3 4 dihydroxyphenylacetic acid DOPAC in vitreous of human subjects were analyzed. No statistically significant differences in dopamine or DO... |
S0014483520303006 | The purpose of this study was to evaluate the optic nerve head lamina cribrosa retina and choroid in school age children using spectral domain optical coherence tomography and to assess these structural parameters in relation to age axial length and refractive error . Healthy children ages 11.152.62 years underwent cyc... | Bruch s membrane opening area is larger in myopic children compared to non myopic children. Minimum rim width and anterior lamina cribrosa surface depth are not associated with age axial length or refraction. Foveal retinal thickness is significantly associated with age. Once corrected for lateral magnification rNFL th... |
S001448352030302X | Selective pericyte loss the histological hallmark of early diabetic retinopathy enhances the breakdown of the blood retinal barrier in diabetes . However the role of pericytes on BRB alteration in diabetes and the signaling pathways involved in their effects are currently unknown . To understand the role of diabetes in... | Transcriptomic analysis of pericytes isolated from diabetic animals revealed a core set of DEGs. The top up and down regulated genes may play a role in inflammation apoptosis pericyte migration and barrier alteration. Notch3 downregulation in diabetic pericytes may lead to increased autophagy inflammation and permeabil... |
S0014483520303031 | Optic neuropathies such as glaucoma lead to retinal ganglion cell death . Transgenic mouse strains that express fluorescent proteins under the control of the Thy1 promoter have permitted single RGC imaging . Specifically in one strain of mice expressing yellow fluorescent protein fluorescence is expressed in only 0.2 o... | We identify 13 morphological clusters of retinal ganglion cells in Thy1 yellow fluorescent protein expressing mice. Among the 13 clusters there was a wide range in features with further variation within dendritic field size. Agreement with previous dye injection studies suggests Thy1 is expressed non discriminatingly i... |
S0014483520303043 | The purpose of this study was to investigate whether single nucleotide polymorphisms of the tumor necrosis factor receptor superfamily and their ligand gene are associated with susceptibility to Behcet s Disease in Chinese Han . A two phase case control study was performed in 1055 BD patients and 1829 healthy controls ... | We designed the population based two phase case control study. Identification of a novel SNP rs1800692 associated with BD in a Chinese Han population. The polymorphism of TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population. Our data provides a new insight into the role of TNF pathway in BD an... |
S0014483520303055 | Segmental flow in the human trabecular meshwork is a well documented phenomenon but in depth mechanistic investigations of high flow and low flow regions are restricted due to the small amount of tissue available from a single donor . To address this issue we have generated and characterized multiple paired HF and LF c... | Here we generate novel cell strains from segmental regions of human TM tissues. High flow and low flow cell strains have similar growth and proliferation rates. THBS2 VCAM1 and TIMP1 are potential low flow cell markers. Low flow cell markers may be useful for developing targeted therapeutics. |
S0014483520303067 | Epithelial to mesenchymal transition contributes to fibrosis associated pathologies including scarring of different ocular tissues . Recently targeting EMT is seen as an appropriate therapeutic approach for different fibrosis related eye diseases such as macular degeneration or glaucoma surgery related fibrosis . Never... | HCjE cells are prone to EMT triggered by prolonged TGF 1 but not TGF 2 treatment. The DNA demethylation agent 5 AzaC reverts EMT in TGF 1 treated HCjE cells. miRNAs are the main targets of 5 AzaC in TGF 1 treated HCjE cells. DNA methylation of the miR 200 family is the key step in EMT induction in HCjE cells. miR 200 l... |
S0014483520303080 | The purpose of this study is to evaluate outflow pathways from subconjunctival blebs and to identify their identity . Post mortem porcine human and bovine eyes were acquired and tracers were injected into the subconjunctival space to create raised blebs where outflow pathways were visualized qualitatively and quantitat... | Glaucoma bleb forming surgeries rely upon subconjunctival aqueous outflow. Subconjunctival drug delivery is limited by subconjunctival aqueous outflow. Subconjunctival outflow is hypothesized to be via lymphatics or blood vessels. Structural molecular imaging demonstrates use of the lymphatic route. Better understood e... |
S001448352030316X | Recently we discovered that the cosmetic preservatives benzalkonium chloride and formaldehyde are especially toxic to human meibomian gland epithelial cells . Exposure to these agents at concentrations approved for human use leads within hours to cellular atrophy and death . We hypothesize that these effects are not un... | At concentrations approved for human use we measured the effect of cosmetic preservatives methylparaben ethylparaben phenoxyethanol and chlorphenesin on the morphology signaling ability survival proliferation and differentiation of IHMGECs. Our findings support our hypothesis and show that the cosmetic preservatives me... |
S0014483520303171 | Dry eye syndrome is a common disease associated to eyes inflammation irritation and tear film instability . The enzymatic complex of xanthine oxidoreductase is involved in the generation of reactive oxygen species and uric acid that in the end can cause reperfusion injuries irritation and pathological conditions . Furt... | Arabinogalactan AG and hyaluronic acid HA artificial drops AD was studied. AG entails uric acid UA and ROS reduction of 27 and 38 . HA involves no statically significant reduction of uric acid or ROS. AG and HA combination involves the reduction of UA and ROS equal to 38 and 62 . |
S0014483520303183 | Structure and function of the retina mainly rely on its fatty acid composition . Evidence from epidemiological studies and from animal experiments indicates that FA composition of the retina is influenced by the diet . Mice under chronic high fat diet develop metabolic syndrome a risk factor for diabetes that is associ... | HFD modifies the relative proportion of retinal linoleic and alpha linolenic acids. Imbalance in retinal essential fatty acids had no impact on the DHA and AA content. HFD decreases retinal omega 7 MUFAs. HFD modulates retinal content in plasmalogens. |
S0014483520303195 | Leucine rich 2 glycoprotein 1 is involved in several pathophysiological processes including angiogenesis cutaneous wound repair and cancer metastasis . In this study we investigated the potential role and mechanism of LRG1 in corneal re epithelialisation and nerve regeneration in streptozotocin induced diabetic mice . ... | Hyperglycemia downregulated the expression of Leucine rich 2 glycoprotein 1 LRG1 in corneal epithelial cells. LRG1 accelerated corneal epithelial wound healing and nerve regeneration both in normal and diabetic mice. LRG1 accelerated corneal re epithelialisation and nerve regeneration via upregulation of matrix metallo... |
S0014483520303201 | The objective of this study is to characterize the retinal degeneration phenotype of CXCR5 NRF2 double knockout mice at the early adult age . CXCR5 KO mice and NRF2 KO mice were bred to create CXCR5 NRF2 DKO mice . The assessment of RD features included fundus and optical coherence tomography imaging periodic acid Schi... | CXCR5. and NRF2. mice are known to develop retinal degeneration with age. Both strains were cross bred to create CXCR5. .NRF2. double knockout DKO mice. DKO mice develop retinal degeneration at early adult age 46 months . DKO mice have increased microglia marker TMEM119 and accumulation of IgG in RPE and retina. DKO mi... |
S0014483520303213 | The study of corneal stromal keratocytes is motivated by its strong association with corneal health and visual function . They play a dominant role in the maintenance of corneal homeostasis and transparency through the production of collagens proteoglycans and corneal crystallins . Trauma induced apoptosis of keratocyt... | Corneal stromal keratocytes have strong link to corneal health and visual functions. Keratocyte changes alter stromal organization causing opacities and vision loss. Important to study their roles in ocular pathologies wound healing and treatments. Progress of cell and or scaffold based approach in stromal regeneration... |
S0014483520303225 | Limbal epithelial stem cells are required for the maintenance and repair of the corneal epithelial surface . The difficulty in obtaining human corneal tissue for research purposes means that animal models for studying the corneal and limbal epithelium are extremely useful . Porcine corneal tissue represents an attracti... | Stem cells are enriched in the porcine limbus and this represents a suitable model for studying the human limbus. Organ cultured porcine corneas with an intact limbus are capable of maintaining the corneal epitehlium. The proliferative response of limbal epitehlial progenitors to wounding can be visualised |
S0014483520303237 | This work sought to compare aqueous angiographic segmental patterns with bead based methods which directly visualize segmental trabecular meshwork tracer trapping . Additionally segmental protein expression differences between aqueous angiographic derived low and high outflow human TM regions were evaluated . Post mort... | Aqueous Angiography AA is capable of visualizing segmental aqueous humor outflow AHO in living human eyes. AA segmental AHO patterns matched that of bead based methods which trapper tracers in the trabecular meshwork TM . AA determined high and low flow TM regions showed segmental changes in pro fibrotic markers. |
S0014483520303249 | Diabetic retinopathy is a neurovascular complication of diabetes mellitus that leads to blindness in the working age population . Retinal Mller cells proliferate and produce pro angiogenic factors including vascular endothelial growth factor and hepatocyte growth factor via the reactive oxygen species thioredoxin inter... | Mller cells proliferate and produce pro angiogenic factors including vascular endothelial growth factor VEGF and hepatocyte growth factor HGF via the reactive oxygen species ROS thioredoxin interacting protein TXNIP NACHT LRR and PYD domains containing protein 3 NLRP3 inflammasome axis to promote proliferative DR. In a... |
S0014483520303250 | In this work we have analyzed the main clinical and corneal histological parameters that may be associated to the spherical equivalent age and gender of individuals with myopic refractive errors . For this purpose 108 cornea stroma lenticules were obtained from patients subjected to ReLEx SMILE myopia correction . Hist... | High myopia is associated to the expression of CRY 1 by the cornea stroma. The age of the patient is associated to CRY A CRY 1 and type V collagen. No correlation between high myopia and gender was found. |
S0014483520303274 | The mammalian cornea maintains its thickness and transparency primarily by the activity of a fluid pump located in the endothelial cell layer . The accepted concept the pump leak theory holds that the active transport of solute from the stroma to the aqueous humor leads to a steady state osmotic pressure gradient acros... | The pump leak theory for the corneal endothelial control of corneal hydration although decades old is still valid. This theory holds that the transport of solute creates an osmotic gradient to balance the stromal swelling pressure. The associated term fluid pump is a misnomer in that steady state fluid flow is a conseq... |
S0014483520303286 | Uveal melanoma is the most common primary intraocular malignancy in adults and has a high mortality rate . Tumor microenvironment is crucial in controlling and influencing the behavior of malignant tumors . Thus illustrating the prognostic values of adaptive immune resistance signatures and infiltrating immune cells in... | Primary UM and primary SKCM exhibit distinct TMEs. Higher levels of infiltrating stromal and immune cells in UM are related to more aggressive biology and poor prognosis. Increased levels of CD8. T cells and adaptive immune resistance markers are predictive factors for poor prognosis in UM. Some common mutations in UM ... |
S0014483520303298 | Vogt Koyanagi Harada disease is a common type of uveitis in China but the diagnosis criteria of VKH disease is controversial . The aim of this study was to investigate potential diagnostic plasma biomarkers for VKH disease . A case control study including 55 VKH patients and 30 healthy controls in a tertiary referral c... | A plasma metabolomics study of VKH disease is presented. A different plasma metabolic phenotype disease was found in VKH disease. D mannose L lysine and stearic acid can be potential diagnostic biomarkers. |
S0014483520303304 | Bone marrow mesenchymal stem cell derived small extracellular vesicles but not fibroblast sEV provide retinal ganglion cell neuroprotection both | Damage to the optic nerve leads to permanent loss of retinal ganglion cells RGC . Neuroprotective strategies are required to prevent loss of RGC and function. The ability of miRNA to down regulate mRNA makes them a candidate treatment. Here we deliver multiple miRNA to retinae of animals prior to optic nerve crush. Com... |
S001448352030333X | Limbal function is a key determinant of corneal epithelial integrity . Lineage tracing studies in mice have highlighted that the centripetal movement of epithelial progenitors from the limbus drives both the steady state maintenance of the corneal epithelium and its regeneration following injury . It is well establishe... | Corneal epithelial cells are primarily derived from cells originating in the limbal epithelium. Niche integrity is required for repopulation of the limbus with progenitors following selective removal of limbal epithelium. The canonical Wnt catenin signalling pathway is a key regulator of stem cell characteristics of th... |
S0014483520303353 | The aim of this study was to examine the expression of the cytokines and chemokines receptor 3 molecule in endothelial cells and vascular structures in a murine model of corneal neovascularization and in samples of neovascularized human corneas . An immunofluorescence assay using the murine model showed a greater propo... | CCR3 receptor is present in vascularized corneal tissue. There is a CCR3 CD31 colocalization in corneal neovessels. There is discrete expression of eotaxin3 in neovascularized corneas. |
S0014483520303365 | We reviewed the literature on the aqueous humor proteome of primary open angle glaucoma patients in order to obtain deeper insight into the pathophysiology of POAG . We searched Pubmed and Embase up to May 2019 for studies that compared AH protein composition between POAG and cataract . Untargeted studies were divided ... | Reanalyzed or combined outcome of untargeted proteomic studies LC MS MS on glaucoma aqueous humor. The immune system is activated in glaucoma aqueous humor. There is dysregulation of selenium and folate in glaucoma aqueous humor. Aqueous humor proteome differs between progressive filtration surgery and stable cataract ... |
S0014483520303377 | Scleritis is a sight threatening inflammation characterized by severe pain and redness of the eye . It can cause blindness by severe complications like scleral and corneal necrosis keratitis and uveitis . The pathogenesis of scleritis is largely unknown due to a combination of the rarity of the disease the little avail... | The pathogenesis of scleritis a sight threatening ocular inflammation characterized by intense pain is largely unknown. Autoimmunity has been hypothesized however defining autoantibodies and or T cell reactivity are not yet clarified. Matrix metalloproteinases may be responsible for scleral destruction their blockage m... |
S001448352030347X | The effect of various combinations of cervical arterial ligations on retinal blood flow levels is not known in rats . We hypothesized 1 No artery exists between the Circle of Willis and the eye 2 Selective Combinations enable varying RBF levels between normal and zero 3 In certain Combinations the capillary bed of the ... | Various combinations of cervical ligations can clarify blood supply to the eye. There is no direct communication between the Circle of Willis and the eye. The pterygopalatine artery is the input to the ophthalmic artery. The capillary bed of the head can be a link in the ocular blood supply. By choosing the ligations r... |
S0014483520303481 | The corneal wound healing response is typically initiated by injuries to the epithelium and or endothelium that may also involve the stroma . However it can also be triggered by immune or infectious processes that enter the stroma via the limbal blood vessels . For mild injuries or infections such as epithelial abrasio... | Keratocyte apoptosis is the first observable stromal event after anterior corneal injury. Normal or defective regeneration of the EBM controls regenerative vs. fibrotic healing. Descemet s membrane modulates regenerative vs. fibrotic healing for posterior injuries. Fibrosis is dynamic with ongoing mitosis development a... |
S0014483520303493 | Basement membranes are layers of extracellular matrix which anchor the epithelium or endothelium to connective tissues in most organs . Descemet s membrane which is the basement membrane for the corneal endothelium is a dense thick relatively transparent and cell free matrix that separates the posterior corneal stroma ... | Descemet s membrane is the basement membrane of the corneal endothelium. Descemet s membrane modulates aqueous humor TGF beta and stromal fibrosis. Descemet s membrane has poor potential to regenerate. |
S001448352030350X | Physico chemical properties of three cataract associated missense mutants of B crystallin were analyzed . The oligomers formed by the R11H mutant were smaller whereas the oligomers of the P20S and R56W mutants were larger than those of the wild type protein . The P20S mutant possessed lower thermal stability than the w... | Cataract associated R11H P20S R56W mutants of B crystallin HspB5 were analyzed. Mutation R11H decreases while P20S and R56W increase the size of HspB5 oligomers. All mutations affect the interaction of HspB5 with its genuine partner HspB4. P20S mutant has lower chaperone like activity in vitro than the wild type protei... |
S0014483520303535 | The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying tissues from injury . Central to this protection are the corneal limbal and conjunctival epithelia . The corneal epithelium is a self renewing stratified squamous epithelium that protects the underlyi... | Limbal corneal epithelial stem cell biology. Application of single cell RNAseq to limbal epithelial stem cells. The role of autophagy in stem cell maintenance. How microRNAs contribute to limbal epithelial stem cell homeostasis. Eph ephrins help to regulate the limbal corneal epithelial boundary. |
S0014483520303614 | Primary blast injury to the retina and optic nerve causes progressive visual loss and neurodegeneration . Military personnel are exposed to multiple low overpressure blast waves which may be in quick succession such as during breacher training or in combat . We investigated the necroptotic cell death pathway in the ret... | The retina and optic nerve can be injured after repeated primary blast injury rPBI . Retinal necroptosis protein RIPK3 increased after rPBI. Intravitreal injections and rPBI can cause additive injury with increased cell death and inflammation. Treatment with pharmacological necroptosis inhibitor Necrostatin 1s may prov... |
S0014483520303626 | The lamina cribrosa is the initial site of glaucomatous injury . Pathological changes to the lamina cribrosa include posterior displacement of the lamina cribrosa loss of trophic support and remodeling of the extracellular matrix . Optic nerve head astrocytes and lamina cribrosa cells synthesize extracellular matrix pr... | Dissection of human optic nerve head ONH . A technique to isolate human ONH astrocytes and lamina cribrosa cells from a single ONH explant. Characterization of ONH cells. |
S001448352030364X | Herein partially summarizes one scientist clinician s wanderings through the jungles of primate aqueous humor outflow over the past 45 years . Totally removing the iris has no effect on outflow facility or its response to pilocarpine whereas disinserting the ciliary muscle from the scleral spur trabecular meshwork comp... | Cholinomimetics increase outflow facility solely via CM contraction. Epinephrine RKIs and NO facility by inhibiting TM contractility relaxing TM and dilating SC. PGF. Fu by CM cell MMP synthesis release and remodeling CM ECM collagen. Viral vectors can transfer reporter genes expressing for 2yrs in live monkey TM genes... |
S0014483520303663 | Pathological ocular angiogenesis commonly results in visual impairment or even blindness . Unveiling the mechanisms of pathological angiogenesis is critical to identify the regulators and develop effective targeted therapies . Here we used corneal neovascularization model to investigate the mechanism of pathological oc... | We used cornea as a unique system for studying the mechanism of pathological ocular angiogenesis. FTO regulates the progression of corneal neovascularization. FTO regulates vascular endothelial function via m. A YTHDF2 mechanism. Targeting m. A modification is a potential therapy for pathological ocular angiogenesis. |
S0014483520303675 | Although anti VEGF therapies have radically changed clinical practice there is still an urgent demand for novel integrative approaches for sight threatening retinal vascular diseases . As we hypothesize that protein tyrosine kinases are key signaling mediators in retinal vascular disease we performed a comprehensive ac... | Retinal tyrosine kinome profiling reveals hyperactivity in diabetic Akimba mice. Functional network analysis identifies Src FAK family kinases as central node. Specific Src family kinase inhibition potently suppresses. angiogenesis. |
S0014483520303687 | In this study we established an experimental human corneal stroma model of simulated cornea tissue composed of thin anterior cornea strips layers obtained from small incision lenticular extraction surgery . We investigated the biomechanical effect of ultraviolet A riboflavin cross linking at different depths of corneal... | Biomechanical property changes are based on corresponding changes in morphology. The increase of corneal stiffness correlated with decrease in interfibrillar spacing. The stiffening effect was depth dependent after Collagen crosslinking. |
S0014483520303717 | The development of the eye requires the co ordinated integration of optical and neural elements to create a system with requisite optics for the given animal . The eye lens has a lamellar structure with gradually varying protein concentrations that increase towards the centre creating a gradient refractive index or GRI... | Refractive index gradient in chick lens is evident in the embryonic lens at day 10. The gradient is parabolic along the optic axis and biphasic in the equatorial plane. Tissue compaction does not appear to pay a role in formation of the gradient. |
S0014483520303729 | Hyperosmolarity is pro inflammatory stress to the ocular surface epithelium associated with dry eye disease . Astaxanthin is a kind of carotene which exists in seafood and plays important roles in the amelioration of inflammatory diseases like arteriosclerosis inflammatory bowel disease sepsis rheumatoid arthritis gast... | Hyperosmolarity induced the expression of HMGB1 and inflammatory cytokine in dry eye model. Astaxanthin decreased the expression of HMGB1 and inflammatory cytokines in dry eye model under hyperosmolarity. PI3K Akt signaling pathway may participate in the expression of HMGB1 and the protection of astaxanthin in dry eye.... |
S0014483520303730 | The corneal endothelium is the inner cell monolayer involved in the maintenance of corneal transparence by the generation of homeostatic dehydration . The glycosaminoglycans of the corneal stroma develop a continuous swelling pressure that should be counteracted by the corneal endothelial cells through active transport... | and. genes are expressed in human corneal endothelial cells at mRNA and protein levels. gene expression is upregulated in fetal samples. gene expression is upregulated in PPCD and FECD samples. gene expression is downregulated in fetal samples. gene expression is upregulated in FECD samples. |
S0014483520303742 | Tears have a vital function to protect and lubricate the ocular surface . Tear production distribution and clearance is tightly regulated by the lacrimal functional unit to meet ocular surface demands . The tear film consists of an aqueous mucin layer containing fluid and soluble factors produced by the lacrimal glands... | The complex structure and composition of the tear film protects the cornea promotes wound healing and maintains eye comfort and quality vision. The integrated lacrimal functional unit regulates tear production and maintains stability. Altered tear composition and stability in dry eye cause eye inflammation corneal dise... |
S0014483520303754 | Platelet derived growth factor is associated with clinical proliferative vitreoretinopathy which is characterized by formation of sub or epi retinal membranes that consist of cells including retinal pigment epithelial RPE cells and extracellular matrix . RPE cells play an important role in PVR pathogenesis . Previous f... | The predominant PDGFR isoform in RPE cells isolated from PVR membranes is PDGFR. Depletion of PDGFR. in RPEMs suppresses vitreous stimulated Akt activation and cell contraction. PDGFR. is a potential target for PVR therapy. |
S0014483520303766 | Large animal models of optic nerve injury are essential for translating novel findings into effective therapies due to their similarity to humans in many respects . However most current tests evaluating the integrity of retinal ganglion cells and optic nerve are based on rodent animal models . We aimed to evaluate and ... | We established a system to test optic nerve s integrity in Goats and rhesus macaques. Anesthesia with isoflurane resulted in more reproducible FVEP than xylazine in goats. Anesthesia with xylazine resulted in more reproducible PERG than xylazine in goats. Intra ocular crosstalk of PERG was undetectable in goats. Large ... |
S0014483520303778 | Primary angle closure glaucoma and retinitis pigmentosa can co occur but the mechanism of their association is not yet established . The purpose of this study was to investigate the differences in ocular biometry parameters and molecular genetics in patients with PACG with or without RP and to determine the association... | Ocular biometry parameters were similar between the patients with PACG alone and with PACG accompanied by RP. The c.1841G T in CRB1 was associated with the combination of RP and glaucoma. Variants in RetNet genes associated with patients with PACG with or without RP. |
S001448352030378X | Myofibroblast transformation of human Tenon s fibroblasts severely challenges the outcome of glaucoma filtration surgery . epigallocatechin 3 gallate is considered as a potential reagent to overcome this issue for its anti fibrosis effect on various human diseases but it is unclear on the fibrosis of Tenon s fibroblast... | EGCG markedly attenuates the proliferation and migration of Tenon s fibroblasts. EGCG inhibits TGF 1 induced myofibroblast transition in Tenon s fibroblasts. EGCG is a potential reagent against postoperative scarring in glaucoma surgery. |
S001448352030381X | Optical coherence tomography angiography is a rapidly developing technique which generates angiographic images non invasively . This study proposes a method to determine the vessel density in OCTA scans in general and especially the local peripapillary vessel density . The method produces vessel density heatmaps that c... | The developed vessel density heatmaps enables investigation of local vessel density. Large optic disc drusen volume results in low local peripapillary vessel density. Investigation of the impact on vessel density from local anatomic conditions. Multiplexed optical coherence tomography imaging. |
S0014483520303821 | Pterygium is a degenerative disease that characterized by excessive fibrovascular proliferation . To reduce the recurrence rate surgery is the main strategy in combination with adjacent procedures or adjunctive therapy . One of the most common adjunctive agents mitomycin C is known as an alkylating agent that inhibits ... | LDL is conjugated with mitomycin C loaded nanoparticles for targeted delivery. Activated pterygium fibroblasts uptake more targeted nanoparticles. LDL targeted MMC shows a good antiproliferative effect on pterygium fibroblasts. LDL targeted MMC shows a lower toxicity to normal fibroblasts. |
S0014483520303833 | To identify the feasibility of reconstructing corneal endothelial sheets by seeding non infected monoclonal human corneal endothelial cells onto porcine Descemet s membrane and verifying the function in vitro and in vivo . Denuded porcine DM was decellularized for haematoxylin and eosin staining and DNA was removed via... | Human corneal endothelial cells HCECs cultured on porcine Descemets membrane DM expressed functional proteins. Corneas received the reconstructed HCEC sheets became transparency after Descemets membrane endothelial keratoplasty DMEK . The corneal thickness and the density of corneal endothelial cells were similar to no... |
S0014483520303857 | The cornea is an avascular transparent ocular tissue that serves as a refractive and protective structure for the eye . Over 90 of the cornea is composed of a collagenous rich extracellular matrix within the stroma with the other 10 composed by the corneal epithelium and endothelium layers and their corresponding suppo... | 3 dimensional corneal tissue models more closely re capitulate the human cornea. Co culture approaches can be applied to develop a full thickness cornea. Advances in bioprinting have allowed the development of a printed human cornea. Vitamin C promotes significant collagen deposition by corneal fibroblasts. Self assemb... |
S0014483520303869 | Circular RNA Homeodomain Interacting Protein Kinase 3 was found to involve in the pathogenesis of age related cataract . Here we further disclosed the related target genes and molecular mechanism of circHIPK3 in the ARC progression . The expression of circHIPK3 microRNA 2213p was detected using the quantitative real ti... | CircHIPK3 is down regulated while miR 2213p is up regulated in human lens epithelium samples of ARC patients. CircHIPK3 protects HLECs from dysfunction. MiR 2213p aggravates the damage of HLECs. MiR 2213p is a target of circHIPK3 and regulates the activation of PI3K AKT pathway. CircHIPK3 miR 2213p PI3K AKT pathway inv... |
S0014483520303870 | Formation of the eye lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells . To attain their mature structure and transparent function nascent lens fiber cells must complete a precise cellular remodeling program hallmarked by the complete elimination of organelles to form the cor... | Hypoxia activates HIF1a in the eye lens. HIF1a regulates lens BNIP3L expression. Hypoxia and HIF1a regulate degradation of lens non nuclear organelles. |
S0014483520303882 | CLN2 neuronal ceroid lipofuscinosis is a hereditary neurodegenerative disorder characterized by progressive vision loss neurological decline and seizures . CLN2 disease results from mutations in | Progressive retinal degeneration occurs in CLN2 neuronal ceroid lipofuscinosis. Retinal degeneration results from deficiency in lysosomal enzyme TPP1. Periodic intravitreal injection of recombinant TPP1 preserves retinal structure and function. |
S0014483520303894 | The retina is one of the most metabolically active tissues yet the processes that control retinal metabolism remains poorly understood . The mTOR complex that drives protein and lipid biogenesis and autophagy has been studied extensively in regards to retinal development and responses to optic nerve injury but the proc... | mTORC1 and mTORC2 and component proteins are highly expressed in normal adult rat retina compared to brain and liver. mTORC1 and ribosomal protein S6 are localized primarily to retinal ganglion cells of human rat and mouse retinas. mTORC2 localizes primarily in retinal glial cells of post mortem human eyes and adult ra... |
S0014483520303900 | To quantify short term microvascular changes after pars plana vitrectomy with internal limiting membrane peeling in patients with idiopathic macular hole using optical coherence tomography angiography . Cohort Study . This study included patients with IMH . Affected eyes were compared with fellow eyes . 66mm OCTA image... | Microvascular changes do appear after macular hole closure. The deep vascular plexus showed improved microvasculature after surgery. Regression of intraretinal cystoid spaces could explain those changes. |
S0014483520303912 | Retinal ischemia leads to an early severe damage of the retina and thus plays an important role in eye diseases such as angle closure glaucoma or retinal vascular occlusion . In retinal diseases there is common sense about the affection of the optic nerve by ischemic injury . However the exact dynamic processes of this... | Structural alterations and demyelination are detectable in the optic nerve at the earliest 3 days after ischemic injury. The microglia activation in the optic nerve starts already days before the later onset of the structural damage. Results indicate that the optic nerve degenerates subsequently after retinal damage in... |
S0014483520303924 | Imaging mass spectrometry enables targeted and untargeted visualization of the spatial localization of molecules in tissues with great specificity . The lens is a unique tissue that contains fiber cells corresponding to various stages of differentiation that are packed in a highly spatial order . The application of IMS... | New tissue preparation allows imaging mass spectrometry of lens cytoskeletal proteins. Imaging mass spectrometry shows distinct molecular zones across lens. Location of intermediate filament switch in lens cortex revealed in images. |
S0014483520303948 | The outcomes of refractive surgical procedures to improve uncorrected vision in patientsincluding photorefractive keratectomy laser in situ keratomileusis Small Incision Lenticule Extraction and corneal inlay proceduresis in large part determined by the corneal wound healing response after surgery . The wound healing r... | Wound healing is a major determinate of outcomes for corneal refractive surgery. The corneal wound healing response varies with the type of corneal refractive surgery. The risk of scarring fibrosis haze increases with higher levels of correction after PRK. LASIK is rarely associated with haze because the central epithe... |
S001448352030395X | No other tissue in the body depends more on the composition and organization of the extracellular matrix for normal structure and function than the corneal stroma . The precise arrangement and orientation of collagen fibrils lamellae and keratocytes that occurs during development and is needed in adults to maintain str... | The unique corneal stromal structure and function is regulated by different extracellular matrix components. The stroma proper as well as Bowman and Descemetslayers have unique ECM compositions and functions. Regulated collagen fibril formation is critical for stromal structure and function. ECM molecules including SLR... |
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