Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
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ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
0
DISCUSSION
1
5
[ "B5", "B9", "B10", "B12", "B13", "B14" ]
20,532,126
pmid-9067487|NA|pmid-8134923|pmid-17521147|pmid-12520400|pmid-9175843|NA|NA|pmid-12850100|NA
Deca-BDE has extremely poor water solubility, and so precipitates from the water column and accumulates in sediments.
[ "5", "9", "10", "12", "13", "14" ]
117
43,519
0
false
Deca-BDE has extremely poor water solubility, and so precipitates from the water column and accumulates in sediments.
[]
Deca-BDE has extremely poor water solubility, and so precipitates from the water column and accumulates in sediments.
true
true
true
true
true
7,530
0
DISCUSSION
1
14
[ "B5", "B9", "B10", "B12", "B13", "B14" ]
20,532,126
pmid-9067487|NA|pmid-8134923|pmid-17521147|pmid-12520400|pmid-9175843|NA|NA|pmid-12850100|NA
Several studies of PBDEs monitoring in mammal and humans are being reported, and human breast milk samples extracted from women near Austin, Texas, had summed PBDE concentrations higher than 400 ng/g-lipid (14).
[ "5", "9", "10", "12", "13", "14" ]
211
43,520
1
false
Several studies of PBDEs monitoring in mammal and humans are being reported, and human breast milk samples extracted from women near Austin, Texas, had summed PBDE concentrations higher than 400 ng/g-lipid.
[ "14" ]
Several studies of PBDEs monitoring in mammal and humans are being reported, and human breast milk samples extracted from women near Austin, Texas, had summed PBDE concentrations higher than 400 ng/g-lipid.
true
true
true
true
true
7,530
1
DISCUSSION
0
null
null
20,532,126
null
We evaluated the developmental immunotoxicity of penta-BDE and deca-DBDE in offspring mice indirectly exposed to PBDEs.
null
119
43,521
0
false
null
null
We evaluated the developmental immunotoxicity of penta-BDE and deca-DBDE in offspring mice indirectly exposed to PBDEs.
true
true
true
true
true
7,531
1
DISCUSSION
0
null
null
20,532,126
null
Pregnant female C57BL/6J mice were orally administered penta-BDE, deca-BDE or corn oil for 5 weeks, from gestational day 6 to lactational day 21 to evaluation the developmental immunotoxicity of the offsprings.
null
210
43,522
0
false
null
null
Pregnant female C57BL/6J mice were orally administered penta-BDE, deca-BDE or corn oil for 5 weeks, from gestational day 6 to lactational day 21 to evaluation the developmental immunotoxicity of the offsprings.
true
true
true
true
true
7,531
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
An in vivo study using in C57BL/6J found only a moderate immune suppression at the longest duration of sub-chronic exposure of DE-71, a commercial penta-BDE mixture (15).
[ "15", "16", "1", "2" ]
170
43,523
1
false
An in vivo study using in C57BL/6J found only a moderate immune suppression at the longest duration of sub-chronic exposure of DE-71, a commercial penta-BDE mixture.
[ "15" ]
An in vivo study using in C57BL/6J found only a moderate immune suppression at the longest duration of sub-chronic exposure of DE-71, a commercial penta-BDE mixture.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
In this study, dams and PND21 with penta-BDE had significantly smaller absolute and relative spleen and thymus masses than control mice.
[ "15", "16", "1", "2" ]
136
43,524
0
false
In this study, dams and PND21 with penta-BDE had significantly smaller absolute and relative spleen and thymus masses than control mice.
[]
In this study, dams and PND21 with penta-BDE had significantly smaller absolute and relative spleen and thymus masses than control mice.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
The relatively smaller spleens of mice exposed to penta-BDE may be due to compromised immune development.
[ "15", "16", "1", "2" ]
105
43,525
0
false
The relatively smaller spleens of mice exposed to penta-BDE may be due to compromised immune development.
[]
The relatively smaller spleens of mice exposed to penta-BDE may be due to compromised immune development.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
Yet no significant differences were found in dams and PND21 exposed to deca-BDE.
[ "15", "16", "1", "2" ]
80
43,526
0
false
Yet no significant differences were found in dams and PND21 exposed to deca-BDE.
[]
Yet no significant differences were found in dams and PND21 exposed to deca-BDE.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
The thymic atrophy and altered thymocyte cellularity are characteristic effects of halogenated aromatic hydrocarbons toxicity via the aryl hydrocarbon receptor.
[ "15", "16", "1", "2" ]
160
43,527
0
false
The thymic atrophy and altered thymocyte cellularity are characteristic effects of halogenated aromatic hydrocarbons toxicity via the aryl hydrocarbon receptor.
[]
The thymic atrophy and altered thymocyte cellularity are characteristic effects of halogenated aromatic hydrocarbons toxicity via the aryl hydrocarbon receptor.
true
true
true
true
true
7,532
2
DISCUSSION
1
16
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
AhR seemed to be probably only minimally bound by PBDEs (16).
[ "15", "16", "1", "2" ]
61
43,528
1
false
AhR seemed to be probably only minimally bound by PBDEs.
[ "16" ]
AhR seemed to be probably only minimally bound by PBDEs.
true
true
true
true
true
7,532
2
DISCUSSION
1
1
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
In another immunotoxicity study, dosing human lymphocytes in vitro with two PBDE congeners, a tetra-BDE (BDE-47) and a penta-BDE (BDE-85), no significant differences were found that mitogen-induced proliferation and IgG synthesis were not affected by the PBDE (1).
[ "15", "16", "1", "2" ]
264
43,529
1
false
In another immunotoxicity study, dosing human lymphocytes in vitro with two PBDE congeners, a tetra-BDE (BDE-47) and a penta-BDE (BDE-85), no significant differences were found that mitogen-induced proliferation and IgG synthesis were not affected by the PBDE.
[ "1" ]
In another immunotoxicity study, dosing human lymphocytes in vitro with two PBDE congeners, a tetra-BDE (BDE-47) and a penta-BDE (BDE-85), no significant differences were found that mitogen-induced proliferation and IgG synthesis were not affected by the PBDE.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
This study reveals that splenic T cell proliferation in dams and PND21 exposed to penta-BDE was increased, and there were no significant difference in splenic B cell proliferation in all treatment groups.
[ "15", "16", "1", "2" ]
204
43,530
0
false
This study reveals that splenic T cell proliferation in dams and PND21 exposed to penta-BDE was increased, and there were no significant difference in splenic B cell proliferation in all treatment groups.
[]
This study reveals that splenic T cell proliferation in dams and PND21 exposed to penta-BDE was increased, and there were no significant difference in splenic B cell proliferation in all treatment groups.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
The antibody (total IgG1 and IgM) production show no significant difference in all treatment groups relative to controls.
[ "15", "16", "1", "2" ]
121
43,531
0
false
The antibody production show no significant difference in all treatment groups relative to controls.
[ "total IgG1 and IgM" ]
The antibody production show no significant difference in all treatment groups relative to controls.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
In flow cytometric analyses of splenic lymphocytes, the PBDE exposure resulted in significant reductions in CD4+ and CD8+ T-cells.
[ "15", "16", "1", "2" ]
130
43,532
0
false
In flow cytometric analyses of splenic lymphocytes, the PBDE exposure resulted in significant reductions in CD4+ and CD8+ T-cells.
[]
In flow cytometric analyses of splenic lymphocytes, the PBDE exposure resulted in significant reductions in CD4+ and CD8+ T-cells.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
B-cells also showed similar reductions in the mouse tetra-BDE dose group only.
[ "15", "16", "1", "2" ]
78
43,533
0
false
B-cells also showed similar reductions in the mouse tetra-BDE dose group only.
[]
B-cells also showed similar reductions in the mouse tetra-BDE dose group only.
true
true
true
true
true
7,532
2
DISCUSSION
1
2
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
PBDE congener equally suppressed murine splenic T- and B-cells (2).
[ "15", "16", "1", "2" ]
67
43,534
1
false
PBDE congener equally suppressed murine splenic T- and B-cells.
[ "2" ]
PBDE congener equally suppressed murine splenic T- and B-cells.
true
true
true
true
true
7,532
2
DISCUSSION
1
15
[ "B15", "B16", "B1", "B2" ]
20,532,126
pmid-15951077|pmid-17964624|pmid-9067487|NA
In this study, total T cell, Th cell and Tc cell, only in PND21 exposed to penta-BDE, was slightly increased.
[ "15", "16", "1", "2" ]
109
43,535
0
false
In this study, total T cell, Th cell and Tc cell, only in PND21 exposed to penta-BDE, was slightly increased.
[]
In this study, total T cell, Th cell and Tc cell, only in PND21 exposed to penta-BDE, was slightly increased.
true
true
true
true
true
7,532
3
DISCUSSION
0
null
null
20,532,126
null
This study presented slightly the changes of immune systems in dams and F1 offsprings by PBDEs exposure, but significantly in PND21 exposed to penta-BDE.
null
153
43,536
0
false
null
null
This study presented slightly the changes of immune systems in dams and F1 offsprings by PBDEs exposure, but significantly in PND21 exposed to penta-BDE.
true
true
true
true
true
7,533
3
DISCUSSION
0
null
null
20,532,126
null
As the results, PBDE exposure at high enough levels may lead to immune impairment, especially in young age, but immune system of offsprings may be recovered as they grew.
null
170
43,537
0
false
null
null
As the results, PBDE exposure at high enough levels may lead to immune impairment, especially in young age, but immune system of offsprings may be recovered as they grew.
true
true
true
true
true
7,533
3
DISCUSSION
0
null
null
20,532,126
null
These results imply that PBDEs given to the dam were transferred to the offspring during gestation and lactation, and PBDEs transferred from the dam affect immune system of offspring.
null
183
43,538
0
false
null
null
These results imply that PBDEs given to the dam were transferred to the offspring during gestation and lactation, and PBDEs transferred from the dam affect immune system of offspring.
true
true
true
true
true
7,533
0
INTRODUCTION
1
1
[ "DDQ216C1" ]
20,508,037
pmid-18064051|pmid-18204446
The low-affinity receptors for the Fc region of IgG, FcγRII and FcγRIII, play a key role in regulation of the immune response to IgG.
[ "1" ]
133
43,539
0
false
The low-affinity receptors for the Fc region of IgG, FcγRII and FcγRIII, play a key role in regulation of the immune response to IgG.
[]
The low-affinity receptors for the Fc region of IgG, FcγRII and FcγRIII, play a key role in regulation of the immune response to IgG.
true
true
true
true
true
7,534
0
INTRODUCTION
1
1
[ "DDQ216C1" ]
20,508,037
pmid-18064051|pmid-18204446
Following cross linking of the receptors by immune-complexed antigen, they are important in phagocytosis and presentation of complexed antigen, as well as in responses such as cytokine production.
[ "1" ]
196
43,540
0
false
Following cross linking of the receptors by immune-complexed antigen, they are important in phagocytosis and presentation of complexed antigen, as well as in responses such as cytokine production.
[]
Following cross linking of the receptors by immune-complexed antigen, they are important in phagocytosis and presentation of complexed antigen, as well as in responses such as cytokine production.
true
true
true
true
true
7,534
0
INTRODUCTION
1
1
[ "DDQ216C1" ]
20,508,037
pmid-18064051|pmid-18204446
The FcγRs are predominantly activatory, with the exception of the FcγRIIB receptor which has an inhibitory effect on signalling through the activatory FcγRs as well as the B cell receptor (1).
[ "1" ]
192
43,541
1
false
The FcγRs are predominantly activatory, with the exception of the FcγRIIB receptor which has an inhibitory effect on signalling through the activatory FcγRs as well as the B cell receptor.
[ "1" ]
The FcγRs are predominantly activatory, with the exception of the FcγRIIB receptor which has an inhibitory effect on signalling through the activatory FcγRs as well as the B cell receptor.
true
true
true
true
true
7,534
1
INTRODUCTION
1
2
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
The human 1q23.3 locus contains five FCGR genes (FCGR2A, FCGR2B, FCGR2C, FCGR3A and FCGR3B)
[ "2", "3", "4", "5", "6", "8", "9" ]
91
43,542
0
false
The human 1q23.3 locus contains five FCGR genes
[ "FCGR2A, FCGR2B, FCGR2C, FCGR3A and FCGR3B" ]
The human 1q23.3 locus contains five FCGR genes
true
true
false
true
false
7,535
1
INTRODUCTION
1
2
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
encoding the FcγRII and FcγRIII receptor families.
[ "2", "3", "4", "5", "6", "8", "9" ]
50
43,543
0
false
encoding the FcγRII and FcγRIII receptor families.
[]
encoding the FcγRII and FcγRIII receptor families.
false
true
true
true
false
7,535
1
INTRODUCTION
1
2
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
There is high sequence similarity between the genes, in part due to an ancestral segmental duplication, which produced FCGR3B and formed the pseudogene FCGR2C from copies of the 5′ end of FCGR2B and the 3′ end of FCGR2A (2).
[ "2", "3", "4", "5", "6", "8", "9" ]
224
43,544
1
false
There is high sequence similarity between the genes, in part due to an ancestral segmental duplication, which produced FCGR3B and formed the pseudogene FCGR2C from copies of the 5′ end of FCGR2B and the 3′ end of FCGR2A.
[ "2" ]
There is high sequence similarity between the genes, in part due to an ancestral segmental duplication, which produced FCGR3B and formed the pseudogene FCGR2C from copies of the 5′ end of FCGR2B and the 3′ end of FCGR2A.
true
true
true
true
true
7,535
1
INTRODUCTION
1
3
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
The duplicated regions are 98% identical (3), and arose following the division of the great apes from the new world monkeys (4,5).
[ "2", "3", "4", "5", "6", "8", "9" ]
130
43,545
1
false
The duplicated regions are 98% identical, and arose following the division of the great apes from the new world monkeys.
[ "3", "4,5" ]
The duplicated regions are 98% identical, and arose following the division of the great apes from the new world monkeys.
true
true
true
true
true
7,535
1
INTRODUCTION
1
2
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
The locus is complicated by the presence of more recent, >99% identical, copy number variable (CNV) regions, the exact limits and number of which have not been conclusively defined (6–8).
[ "2", "3", "4", "5", "6", "8", "9" ]
187
43,546
0
false
The locus is complicated by the presence of more recent, >99% identical, copy number variable (CNV) regions, the exact limits and number of which have not been conclusively defined.
[ "6–8" ]
The locus is complicated by the presence of more recent, >99% identical, copy number variable (CNV) regions, the exact limits and number of which have not been conclusively defined.
true
true
true
true
true
7,535
1
INTRODUCTION
1
9
[ "DDQ216C2", "DDQ216C3", "DDQ216C4", "DDQ216C5", "DDQ216C6", "DDQ216C8", "DDQ216C9" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
The homology in the region of the ancestral duplication is likely to facilitate CNV formation (9).
[ "2", "3", "4", "5", "6", "8", "9" ]
98
43,547
1
false
The homology in the region of the ancestral duplication is likely to facilitate CNV formation.
[ "9" ]
The homology in the region of the ancestral duplication is likely to facilitate CNV formation.
true
true
true
true
true
7,535
2
INTRODUCTION
1
10
[ "DDQ216C10" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Polymorphisms in the low-affinity FcγRs have been associated with a variety of autoimmune diseases, foremost among them systemic lupus erythematosus (SLE).
[ "10" ]
155
43,548
0
false
Polymorphisms in the low-affinity FcγRs have been associated with a variety of autoimmune diseases, foremost among them systemic lupus erythematosus (SLE).
[]
Polymorphisms in the low-affinity FcγRs have been associated with a variety of autoimmune diseases, foremost among them systemic lupus erythematosus (SLE).
true
true
true
true
true
7,536
2
INTRODUCTION
1
10
[ "DDQ216C10" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
SLE is clinically diverse, but is unified by autoantibody production, deposition of immune complexes (ICs) in organs including the joints, skin and kidneys, and a subsequent inflammatory response to the deposited ICs.
[ "10" ]
217
43,549
0
false
SLE is clinically diverse, but is unified by autoantibody production, deposition of immune complexes (ICs) in organs including the joints, skin and kidneys, and a subsequent inflammatory response to the deposited ICs.
[]
SLE is clinically diverse, but is unified by autoantibody production, deposition of immune complexes (ICs) in organs including the joints, skin and kidneys, and a subsequent inflammatory response to the deposited ICs.
true
true
true
true
true
7,536
2
INTRODUCTION
1
10
[ "DDQ216C10" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
The inflammation in these organs results in tissue damage leading to a diverse range of clinical features, from skin rashes and cytopenias through to organ-threatening glomerulonephritis (10).
[ "10" ]
192
43,550
1
false
The inflammation in these organs results in tissue damage leading to a diverse range of clinical features, from skin rashes and cytopenias through to organ-threatening glomerulonephritis.
[ "10" ]
The inflammation in these organs results in tissue damage leading to a diverse range of clinical features, from skin rashes and cytopenias through to organ-threatening glomerulonephritis.
true
true
true
true
true
7,536
2
INTRODUCTION
1
10
[ "DDQ216C10" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Failure of FcγR-mediated clearance of ICs and control of inflammatory responses are thought to be a predisposing factor to SLE.
[ "10" ]
127
43,551
0
false
Failure of FcγR-mediated clearance of ICs and control of inflammatory responses are thought to be a predisposing factor to SLE.
[]
Failure of FcγR-mediated clearance of ICs and control of inflammatory responses are thought to be a predisposing factor to SLE.
true
true
true
true
true
7,536
3
INTRODUCTION
1
11
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
Alterations in the function of FcγRs have been associated with SLE.
[ "11", "12", "13", "14", "8", "15" ]
67
43,552
0
false
Alterations in the function of FcγRs have been associated with SLE.
[]
Alterations in the function of FcγRs have been associated with SLE.
true
true
true
true
true
7,537
3
INTRODUCTION
1
11
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
A substitution in FcγRIIA where histidine replaces arginine at position 131 (R131H, rs1801274) increases the affinity of binding to IgG2 (11), and increases phagocytosis of IgG2 opsonin.
[ "11", "12", "13", "14", "8", "15" ]
186
43,553
1
false
A substitution in FcγRIIA where histidine replaces arginine at position 131 increases the affinity of binding to IgG2, and increases phagocytosis of IgG2 opsonin.
[ "R131H, rs1801274", "11" ]
A substitution in FcγRIIA where histidine replaces arginine at position 131 increases the affinity of binding to IgG2, and increases phagocytosis of IgG2 opsonin.
true
true
true
true
true
7,537
3
INTRODUCTION
1
12
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
In FcγRIIIA, a valine for phenylalanine substitution (V176F, rs396991) lowers affinity for IgG1 and IgG3, and prevents binding to IgG4 (12).
[ "11", "12", "13", "14", "8", "15" ]
140
43,554
1
false
In FcγRIIIA, a valine for phenylalanine substitution (V176F, rs396991) lowers affinity for IgG1 and IgG3, and prevents binding to IgG4.
[ "12" ]
In FcγRIIIA, a valine for phenylalanine substitution lowers affinity for IgG1 and IgG3, and prevents binding to IgG4.
true
true
true
true
true
7,537
3
INTRODUCTION
1
13
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
Two isoforms of FcγRIIIB are encoded by haplotypes of four SNPs: the FcγRIIIB-HNA1a isoform has reduced N-linked glycosylation compared with the FcγRIIIB-HNA1b isoform, and has increased affinity for IgG3, mediating increased phagocytosis of IgG1 and IgG3 ICs (13).
[ "11", "12", "13", "14", "8", "15" ]
265
43,555
1
false
Two isoforms of FcγRIIIB are encoded by haplotypes of four SNPs: the FcγRIIIB-HNA1a isoform has reduced N-linked glycosylation compared with the FcγRIIIB-HNA1b isoform, and has increased affinity for IgG3, mediating increased phagocytosis of IgG1 and IgG3 ICs.
[ "13" ]
Two isoforms of FcγRIIIB are encoded by haplotypes of four SNPs: the FcγRIIIB-HNA1a isoform has reduced N-linked glycosylation compared with the FcγRIIIB-HNA1b isoform, and has increased affinity for IgG3, mediating increased phagocytosis of IgG1 and IgG3 ICs.
true
true
true
true
true
7,537
3
INTRODUCTION
1
14
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
The low-affinity alleles of all three receptors have been linked to risk of SLE in linkage and association studies (14).
[ "11", "12", "13", "14", "8", "15" ]
120
43,556
1
false
The low-affinity alleles of all three receptors have been linked to risk of SLE in linkage and association studies.
[ "14" ]
The low-affinity alleles of all three receptors have been linked to risk of SLE in linkage and association studies.
true
true
true
true
true
7,537
3
INTRODUCTION
1
8
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
The presence of CNV regions can lead to apparent violation of Hardy–Weinberg equilibrium, and can lead to exclusion of probes binding within these regions from genome-wide association studies (GWAS) (8).
[ "11", "12", "13", "14", "8", "15" ]
203
43,557
1
false
The presence of CNV regions can lead to apparent violation of Hardy–Weinberg equilibrium, and can lead to exclusion of probes binding within these regions from genome-wide association studies (GWAS).
[ "8" ]
The presence of CNV regions can lead to apparent violation of Hardy–Weinberg equilibrium, and can lead to exclusion of probes binding within these regions from genome-wide association studies (GWAS).
true
true
true
true
true
7,537
3
INTRODUCTION
1
15
[ "DDQ216C11", "DDQ216C12", "DDQ216C13", "DDQ216C14", "DDQ216C8", "DDQ216C15" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
This may be the reason that only FcγRIIA-131R, and not SNPs in FcγRIIIB and FcγRIIIA, was identified as associated with SLE by GWAS (15).
[ "11", "12", "13", "14", "8", "15" ]
137
43,558
1
false
This may be the reason that only FcγRIIA-131R, and not SNPs in FcγRIIIB and FcγRIIIA, was identified as associated with SLE by GWAS.
[ "15" ]
This may be the reason that only FcγRIIA-131R, and not SNPs in FcγRIIIB and FcγRIIIA, was identified as associated with SLE by GWAS.
true
true
true
true
true
7,537
4
INTRODUCTION
1
16
[ "DDQ216C16", "DDQ216C17", "DDQ216C18", "DDQ216C16", "DDQ216C19", "DDQ216C16" ]
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
The disruption of the inhibitory function of FcγRIIB due to the conversion of an isoleucine to a threonine in the transmembrane domain of the inhibitory receptor (I232T, rs1050501) (16) is also associated with SLE in Asians (17) and Caucasians (18).
[ "16", "17", "18", "16", "19", "16" ]
249
43,559
1
false
The disruption of the inhibitory function of FcγRIIB due to the conversion of an isoleucine to a threonine in the transmembrane domain of the inhibitory receptor (I232T, rs1050501) is also associated with SLE in Asians and Caucasians.
[ "16", "17", "18" ]
The disruption of the inhibitory function of FcγRIIB due to the conversion of an isoleucine to a threonine in the transmembrane domain of the inhibitory receptor is also associated with SLE in Asians and Caucasians.
true
true
true
true
true
7,538
4
INTRODUCTION
1
16
[ "DDQ216C16", "DDQ216C17", "DDQ216C18", "DDQ216C16", "DDQ216C19", "DDQ216C16" ]
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
This appears to be due to a failure of the threonine form of the receptor (FcγRIIB-232T) to partition to lipid rafts, perhaps due to the polar nature of the threonine, or disruption of a protein sequence necessary for raft entry (16,19).
[ "16", "17", "18", "16", "19", "16" ]
237
43,560
0
false
This appears to be due to a failure of the threonine form of the receptor (FcγRIIB-232T) to partition to lipid rafts, perhaps due to the polar nature of the threonine, or disruption of a protein sequence necessary for raft entry.
[ "16,19" ]
This appears to be due to a failure of the threonine form of the receptor (FcγRIIB-232T) to partition to lipid rafts, perhaps due to the polar nature of the threonine, or disruption of a protein sequence necessary for raft entry.
true
true
true
true
true
7,538
4
INTRODUCTION
1
16
[ "DDQ216C16", "DDQ216C17", "DDQ216C18", "DDQ216C16", "DDQ216C19", "DDQ216C16" ]
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
Exclusion from lipid rafts abolished the inhibition of activatory signalling initiated by crosslinking of FcγRIIIB and the activatory FcγR or B cell receptor by IC (16).
[ "16", "17", "18", "16", "19", "16" ]
169
43,561
1
false
Exclusion from lipid rafts abolished the inhibition of activatory signalling initiated by crosslinking of FcγRIIIB and the activatory FcγR or B cell receptor by IC.
[ "16" ]
Exclusion from lipid rafts abolished the inhibition of activatory signalling initiated by crosslinking of FcγRIIIB and the activatory FcγR or B cell receptor by IC.
true
true
true
true
true
7,538
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
Copy number (CN) variable areas may cover ∼5% of the genome, and contribute to the genetic variation between individuals (7).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
125
43,562
1
false
Copy number (CN) variable areas may cover ∼5% of the genome, and contribute to the genetic variation between individuals.
[ "7" ]
Copy number (CN) variable areas may cover ∼5% of the genome, and contribute to the genetic variation between individuals.
true
true
true
true
true
7,539
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
CN of the low-affinity FCGR genes and the association of CN with disease have recently been investigated.
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
105
43,563
0
false
CN of the low-affinity FCGR genes and the association of CN with disease have recently been investigated.
[]
CN of the low-affinity FCGR genes and the association of CN with disease have recently been investigated.
true
true
true
true
true
7,539
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
Studies using multiplex ligand probe amplification (MLPA) have investigated gene CN across the locus in Caucasians (6,20).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
122
43,564
0
false
Studies using multiplex ligand probe amplification (MLPA) have investigated gene CN across the locus in Caucasians.
[ "6,20" ]
Studies using multiplex ligand probe amplification (MLPA) have investigated gene CN across the locus in Caucasians.
true
true
true
true
true
7,539
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
qPCR methods have also been used to determine CN of FCGR3B alone in Caucasians (21–24) or in Chinese (23,25).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
109
43,565
0
false
qPCR methods have also been used to determine CN of FCGR3B alone in Caucasians or in Chinese.
[ "21–24", "23,25" ]
qPCR methods have also been used to determine CN of FCGR3B alone in Caucasians or in Chinese.
false
true
true
true
false
7,539
5
INTRODUCTION
1
21
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
In these studies, low CN of FCGR3B was associated with SLE (22,23) or SLE nephritis (21) in Caucasians, although both low and high CN was also recently associated with SLE (24) and no association with SLE was reported in Chinese (23,25).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
237
43,566
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false
In these studies, low CN of FCGR3B was associated with SLE or SLE nephritis in Caucasians, although both low and high CN was also recently associated with SLE and no association with SLE was reported in Chinese.
[ "22,23", "21", "24", "23,25" ]
In these studies, low CN of FCGR3B was associated with SLE or SLE nephritis in Caucasians, although both low and high CN was also recently associated with SLE and no association with SLE was reported in Chinese.
true
true
true
true
true
7,539
5
INTRODUCTION
1
23
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
These studies are limited, however, by the requirement to categorize the continuous distribution of data generated by qPCR assays into discrete CN ‘bins’ (21,22,24) or alternatively to compare the means (23).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
208
43,567
1
false
These studies are limited, however, by the requirement to categorize the continuous distribution of data generated by qPCR assays into discrete CN ‘bins’ or alternatively to compare the means.
[ "21,22,24", "23" ]
These studies are limited, however, by the requirement to categorize the continuous distribution of data generated by qPCR assays into discrete CN ‘bins’ or alternatively to compare the means.
true
true
true
true
true
7,539
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
The limitations of the qPCR method may also be responsible for the wide discrepancy between the percentage of Caucasian individuals with low FCGR3B CN determined by qPCR [approximately 10–25% (22), and 40% (21)] and MLPA methods (5–7%) (6,20).
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
243
43,568
0
false
The limitations of the qPCR method may also be responsible for the wide discrepancy between the percentage of Caucasian individuals with low FCGR3B CN determined by qPCR and MLPA methods.
[ "approximately 10–25% (22), and 40% (21)", "5–7%", "6,20" ]
The limitations of the qPCR method may also be responsible for the wide discrepancy between the percentage of Caucasian individuals with low FCGR3B CN determined by qPCR and MLPA methods.
true
true
true
true
true
7,539
5
INTRODUCTION
1
7
[ "DDQ216C7", "DDQ216C6", "DDQ216C20", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C22", "DDQ216C23", "DDQ216C21", "DDQ216C24", "DDQ216C23", "DDQ216C25", "DDQ216C21", "DDQ216C22", "DDQ216C24", "DDQ216C23", "DDQ216C22", "DDQ216C21", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
A more accurate method of CN designation is therefore needed to confirm the association with SLE.
[ "7", "6", "20", "21", "24", "23", "25", "22", "23", "21", "24", "23", "25", "21", "22", "24", "23", "22", "21", "6", "20" ]
97
43,569
0
false
A more accurate method of CN designation is therefore needed to confirm the association with SLE.
[]
A more accurate method of CN designation is therefore needed to confirm the association with SLE.
true
true
true
true
true
7,539
6
INTRODUCTION
0
null
null
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
It is important to clarify the effect of FCGR3B CN in disease, and determine if it is independent of the effect of other polymorphisms in the locus.
null
148
43,570
0
false
null
null
It is important to clarify the effect of FCGR3B CN in disease, and determine if it is independent of the effect of other polymorphisms in the locus.
true
true
true
true
true
7,540
6
INTRODUCTION
0
null
null
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
In this study, we used an assay combining three paralogue ratio tests (PRTs) to define three CNV regions within the FCGR locus, and determine the prevalence of variation of these regions in Caucasian, East Asian and Kenyan populations.
null
235
43,571
0
false
null
null
In this study, we used an assay combining three paralogue ratio tests (PRTs) to define three CNV regions within the FCGR locus, and determine the prevalence of variation of these regions in Caucasian, East Asian and Kenyan populations.
true
true
true
true
true
7,540
6
INTRODUCTION
0
null
null
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
Further, the previous association of low FCGR3B CNV in SLE in Caucasians was supported, and an association with SLE was identified in a second ethnic group, Hong Kong Chinese.
null
175
43,572
0
false
null
null
Further, the previous association of low FCGR3B CNV in SLE in Caucasians was supported, and an association with SLE was identified in a second ethnic group, Hong Kong Chinese.
true
true
true
true
true
7,540
6
INTRODUCTION
0
null
null
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
We describe differences in linkage disequilibrium (LD) in the FCGR region between ethnic groups for the SLE-associated SNPs and with FCGR3B CNV, while taking into account FCGR3A CNV.
null
182
43,573
0
false
null
null
We describe differences in linkage disequilibrium (LD) in the FCGR region between ethnic groups for the SLE-associated SNPs and with FCGR3B CNV, while taking into account FCGR3A CNV.
true
true
true
true
true
7,540
6
INTRODUCTION
0
null
null
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
We show that although there is LD between FCGR3B CN and FCGR2B-I232T, both show an independent effect on SLE risk.
null
114
43,574
0
false
null
null
We show that although there is LD between FCGR3B CN and FCGR2B-I232T, both show an independent effect on SLE risk.
true
true
true
true
true
7,540
0
DISCUSSION
1
15
[ "DDQ216C15" ]
20,508,037
pmid-18064051|pmid-18204446
Using a triple PRT assay, we have confirmed association of low CN of FCGR3B with SLE.
[ "15" ]
85
43,575
0
false
Using a triple PRT assay, we have confirmed association of low CN of FCGR3B with SLE.
[]
Using a triple PRT assay, we have confirmed association of low CN of FCGR3B with SLE.
true
true
true
true
true
7,541
0
DISCUSSION
1
15
[ "DDQ216C15" ]
20,508,037
pmid-18064051|pmid-18204446
Although the association in Caucasians was previously reported, this triple PRT assay allows clearer designation of integer values for CN.
[ "15" ]
138
43,576
0
false
Although the association in Caucasians was previously reported, this triple PRT assay allows clearer designation of integer values for CN.
[]
Although the association in Caucasians was previously reported, this triple PRT assay allows clearer designation of integer values for CN.
true
true
true
true
true
7,541
0
DISCUSSION
1
15
[ "DDQ216C15" ]
20,508,037
pmid-18064051|pmid-18204446
The association found in Hong Kong Chinese is novel, and is important as it validates the effect of FCGR3B CN in a different genetic background.
[ "15" ]
144
43,577
0
false
The association found in Hong Kong Chinese is novel, and is important as it validates the effect of FCGR3B CN in a different genetic background.
[]
The association found in Hong Kong Chinese is novel, and is important as it validates the effect of FCGR3B CN in a different genetic background.
true
true
true
true
true
7,541
0
DISCUSSION
1
15
[ "DDQ216C15" ]
20,508,037
pmid-18064051|pmid-18204446
The highest ORs for risk of SLE of the common polymorphisms strongly associated by GWAS are the major histocompatibility complex region (OR = 2.0), interferon regulatory factor 5 (IRF5, OR = 1.8) and complement receptor 3 subunit integrin alpha M (ITGAM OR = 1.6) (15).
[ "15" ]
269
43,578
1
false
The highest ORs for risk of SLE of the common polymorphisms strongly associated by GWAS are the major histocompatibility complex region (OR = 2.0), interferon regulatory factor 5 (IRF5, OR = 1.8) and complement receptor 3 subunit integrin alpha M (ITGAM OR = 1.6).
[ "15" ]
The highest ORs for risk of SLE of the common polymorphisms strongly associated by GWAS are the major histocompatibility complex region (OR = 2.0), interferon regulatory factor 5 and complement receptor 3 subunit integrin alpha M.
true
true
true
true
true
7,541
0
DISCUSSION
1
15
[ "DDQ216C15" ]
20,508,037
pmid-18064051|pmid-18204446
This places the OR for FCGR3B low CN, at 1.6, among the strongest genetic risk factors yet identified for SLE.
[ "15" ]
110
43,579
0
false
This places the OR for FCGR3B low CN, at 1.6, among the strongest genetic risk factors yet identified for SLE.
[]
This places the OR for FCGR3B low CN, at 1.6, among the strongest genetic risk factors yet identified for SLE.
true
true
true
true
true
7,541
1
DISCUSSION
1
38
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
FcγRIIIB is expressed primarily on neutrophils, where it is the most common FcγR (38,39).
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
89
43,580
0
false
FcγRIIIB is expressed primarily on neutrophils, where it is the most common FcγR.
[ "38,39" ]
FcγRIIIB is expressed primarily on neutrophils, where it is the most common FcγR.
true
true
true
true
true
7,542
1
DISCUSSION
1
38
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
The strong association of low CN of FCGR3B with SLE suggests a hitherto un-emphasized role of neutrophils in protection from SLE.
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
129
43,581
0
false
The strong association of low CN of FCGR3B with SLE suggests a hitherto un-emphasized role of neutrophils in protection from SLE.
[]
The strong association of low CN of FCGR3B with SLE suggests a hitherto un-emphasized role of neutrophils in protection from SLE.
true
true
true
true
true
7,542
1
DISCUSSION
1
38
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
Defects in IC clearance have been implicated in SLE, and macrophages from SLE patients show reduced soluble IC uptake (40,41).
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
126
43,582
0
false
Defects in IC clearance have been implicated in SLE, and macrophages from SLE patients show reduced soluble IC uptake.
[ "40,41" ]
Defects in IC clearance have been implicated in SLE, and macrophages from SLE patients show reduced soluble IC uptake.
true
true
true
true
true
7,542
1
DISCUSSION
1
23
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
Neutrophils lacking FcγRIIIB had profoundly reduced soluble IC uptake, and increasing FCGR3B CN correlated with FcγRIIIB surface expression and increasing IC uptake (23).
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
170
43,583
1
false
Neutrophils lacking FcγRIIIB had profoundly reduced soluble IC uptake, and increasing FCGR3B CN correlated with FcγRIIIB surface expression and increasing IC uptake.
[ "23" ]
Neutrophils lacking FcγRIIIB had profoundly reduced soluble IC uptake, and increasing FCGR3B CN correlated with FcγRIIIB surface expression and increasing IC uptake.
true
true
true
true
true
7,542
1
DISCUSSION
1
23
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
FcγRIIIB is also important in tethering neutrophils under flow conditions, which is required to allow extravasation into the tissues (42,43); such adhesion correlated with FCGR3B CN (23).
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
187
43,584
1
false
FcγRIIIB is also important in tethering neutrophils under flow conditions, which is required to allow extravasation into the tissues ; such adhesion correlated with FCGR3B CN.
[ "42,43", "23" ]
FcγRIIIB is also important in tethering neutrophils under flow conditions, which is required to allow extravasation into the tissues ; such adhesion correlated with FCGR3B CN.
true
true
true
true
true
7,542
1
DISCUSSION
1
23
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
FcγRIIIB appears less important in initiating superoxide release, since increased FCGR3B CN in individuals within a family did not cause significantly increased release upon stimulation (23).
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
191
43,585
1
false
FcγRIIIB appears less important in initiating superoxide release, since increased FCGR3B CN in individuals within a family did not cause significantly increased release upon stimulation.
[ "23" ]
FcγRIIIB appears less important in initiating superoxide release, since increased FCGR3B CN in individuals within a family did not cause significantly increased release upon stimulation.
true
true
true
true
true
7,542
1
DISCUSSION
1
38
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
A contribution to IC clearance may be made by neutrophils trafficking to sites of IC deposition and clearing complexes once there.
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
130
43,586
0
false
A contribution to IC clearance may be made by neutrophils trafficking to sites of IC deposition and clearing complexes once there.
[]
A contribution to IC clearance may be made by neutrophils trafficking to sites of IC deposition and clearing complexes once there.
true
true
true
true
true
7,542
1
DISCUSSION
1
38
[ "DDQ216C38", "DDQ216C39", "DDQ216C40", "DDQ216C41", "DDQ216C23", "DDQ216C42", "DDQ216C43", "DDQ216C23", "DDQ216C23" ]
20,508,037
pmid-8463268|pmid-12169732|pmid-16951347|pmid-17981207|pmid-17827395|pmid-17122850|pmid-19597530|pmid-2538508|pmid-19201911|pmid-1430231|pmid-11953981|pmid-18559452|pmid-11420040|pmid-16934243|pmid-18559452|pmid-18559452
Reduced FcγRIIIB expression could thus lead to increased IC deposition and resulting inflammatory damage and disease.
[ "38", "39", "40", "41", "23", "42", "43", "23", "23" ]
117
43,587
0
false
Reduced FcγRIIIB expression could thus lead to increased IC deposition and resulting inflammatory damage and disease.
[]
Reduced FcγRIIIB expression could thus lead to increased IC deposition and resulting inflammatory damage and disease.
true
true
true
true
true
7,542
2
DISCUSSION
1
44
[ "DDQ216C44", "DDQ216C48", "DDQ216C15", "DDQ216C31", "DDQ216C46" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
FcγRIIIB is attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and does not contain intrinsic cytoplasmic signalling domains or associate with signalling adaptor proteins used by other FcγRs.
[ "44", "48", "15", "31", "46" ]
218
43,588
0
false
FcγRIIIB is attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and does not contain intrinsic cytoplasmic signalling domains or associate with signalling adaptor proteins used by other FcγRs.
[]
FcγRIIIB is attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and does not contain intrinsic cytoplasmic signalling domains or associate with signalling adaptor proteins used by other FcγRs.
true
true
true
true
true
7,543
2
DISCUSSION
1
44
[ "DDQ216C44", "DDQ216C48", "DDQ216C15", "DDQ216C31", "DDQ216C46" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Instead, it is thought to colocalize with and signal through other receptors, such as complement receptor 3 (CR3) and FcγRIIA, to facilitate neutrophil functions such as phagocytosis and the oxidative burst (44–48).
[ "44", "48", "15", "31", "46" ]
215
43,589
0
false
Instead, it is thought to colocalize with and signal through other receptors, such as complement receptor 3 (CR3) and FcγRIIA, to facilitate neutrophil functions such as phagocytosis and the oxidative burst.
[ "44–48" ]
Instead, it is thought to colocalize with and signal through other receptors, such as complement receptor 3 (CR3) and FcγRIIA, to facilitate neutrophil functions such as phagocytosis and the oxidative burst.
true
true
true
true
true
7,543
2
DISCUSSION
1
44
[ "DDQ216C44", "DDQ216C48", "DDQ216C15", "DDQ216C31", "DDQ216C46" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Therefore, it is interesting to note that polymorphisms in ITGAM (part of the CR3 receptor) and FCGR2A are strongly associated with SLE in GWA studies (15,31).
[ "44", "48", "15", "31", "46" ]
159
43,590
0
false
Therefore, it is interesting to note that polymorphisms in ITGAM (part of the CR3 receptor) and FCGR2A are strongly associated with SLE in GWA studies.
[ "15,31" ]
Therefore, it is interesting to note that polymorphisms in ITGAM (part of the CR3 receptor) and FCGR2A are strongly associated with SLE in GWA studies.
true
true
true
true
true
7,543
2
DISCUSSION
1
44
[ "DDQ216C44", "DDQ216C48", "DDQ216C15", "DDQ216C31", "DDQ216C46" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Although in this study no interaction was found by logistic regression between the FCGR2A SLE-associated SNP and FCGR3B CN, an interaction with ITGAM was not tested.
[ "44", "48", "15", "31", "46" ]
165
43,591
0
false
Although in this study no interaction was found by logistic regression between the FCGR2A SLE-associated SNP and FCGR3B CN, an interaction with ITGAM was not tested.
[]
Although in this study no interaction was found by logistic regression between the FCGR2A SLE-associated SNP and FCGR3B CN, an interaction with ITGAM was not tested.
true
true
true
true
true
7,543
2
DISCUSSION
1
46
[ "DDQ216C44", "DDQ216C48", "DDQ216C15", "DDQ216C31", "DDQ216C46" ]
20,508,037
pmid-8616885|pmid-7681086|pmid-1328206|pmid-18204446|pmid-18204098|pmid-8046243
Since CR3 is important in FcγRIIIB-mediated phagocytosis in neutrophils (46), it is possible that polymorphisms which inhibit CR3 binding to complement or interaction with FcγRIIIB may exacerbate the effect of low FCGR3B CN.
[ "44", "48", "15", "31", "46" ]
224
43,592
1
false
Since CR3 is important in FcγRIIIB-mediated phagocytosis in neutrophils, it is possible that polymorphisms which inhibit CR3 binding to complement or interaction with FcγRIIIB may exacerbate the effect of low FCGR3B CN.
[ "46" ]
Since CR3 is important in FcγRIIIB-mediated phagocytosis in neutrophils, it is possible that polymorphisms which inhibit CR3 binding to complement or interaction with FcγRIIIB may exacerbate the effect of low FCGR3B CN.
true
true
true
true
true
7,543
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
CN of FCGR2C alters in parallel with both FCGR3A and FCGR3B in the CNV regions.
[ "6", "6", "6" ]
79
43,593
0
false
CN of FCGR2C alters in parallel with both FCGR3A and FCGR3B in the CNV regions.
[]
CN of FCGR2C alters in parallel with both FCGR3A and FCGR3B in the CNV regions.
true
true
true
true
true
7,544
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
FCGR2C is a pseudogene in the majority of individuals.
[ "6", "6", "6" ]
54
43,594
0
false
FCGR2C is a pseudogene in the majority of individuals.
[]
FCGR2C is a pseudogene in the majority of individuals.
true
true
true
true
true
7,544
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
In a Caucasian population, however, 18% of individuals had at least one FCGR2C allele with an open reading frame, due to a variant which changes the common stop codon in exon 3 to a glutamine (6).
[ "6", "6", "6" ]
196
43,595
1
false
In a Caucasian population, however, 18% of individuals had at least one FCGR2C allele with an open reading frame, due to a variant which changes the common stop codon in exon 3 to a glutamine.
[ "6" ]
In a Caucasian population, however, 18% of individuals had at least one FCGR2C allele with an open reading frame, due to a variant which changes the common stop codon in exon 3 to a glutamine.
true
true
true
true
true
7,544
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
The expression level of FCGR2C on NK cells correlates to presence of this open reading frame allele, rather than total gene CN (6).
[ "6", "6", "6" ]
131
43,596
1
false
The expression level of FCGR2C on NK cells correlates to presence of this open reading frame allele, rather than total gene CN.
[ "6" ]
The expression level of FCGR2C on NK cells correlates to presence of this open reading frame allele, rather than total gene CN.
true
true
true
true
true
7,544
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
Although there was an association of FCGR2C-ORF frequency with risk of idiopathic thrombocytopenic purpura, there was no association with total CN of FCGR2C (6).
[ "6", "6", "6" ]
161
43,597
1
false
Although there was an association of FCGR2C-ORF frequency with risk of idiopathic thrombocytopenic purpura, there was no association with total CN of FCGR2C.
[ "6" ]
Although there was an association of FCGR2C-ORF frequency with risk of idiopathic thrombocytopenic purpura, there was no association with total CN of FCGR2C.
true
true
true
true
true
7,544
3
DISCUSSION
1
6
[ "DDQ216C6", "DDQ216C6", "DDQ216C6" ]
20,508,037
pmid-1831223|pmid-9276722|pmid-1532589|pmid-19674504|pmid-17122850|pmid-18204446|pmid-17827395|pmid-17827395|pmid-17827395
The increase in FCGR2C concomitant with FCGR3B in the SLE population in our study is therefore unlikely to correlate to increased FCGR2C expression.
[ "6", "6", "6" ]
148
43,598
0
false
The increase in FCGR2C concomitant with FCGR3B in the SLE population in our study is therefore unlikely to correlate to increased FCGR2C expression.
[]
The increase in FCGR2C concomitant with FCGR3B in the SLE population in our study is therefore unlikely to correlate to increased FCGR2C expression.
true
true
true
true
true
7,544
4
DISCUSSION
0
null
null
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
This study also highlights the complexity of the low-affinity FCGR locus.
null
73
43,599
0
false
null
null
This study also highlights the complexity of the low-affinity FCGR locus.
true
true
true
true
true
7,545
4
DISCUSSION
0
null
null
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
In large cohorts from multiple ethnic groups, we were able to identify multiple individuals with variation in two different CNV regions.
null
136
43,600
0
false
null
null
In large cohorts from multiple ethnic groups, we were able to identify multiple individuals with variation in two different CNV regions.
true
true
true
true
true
7,545
4
DISCUSSION
0
null
null
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
A third CNV region (CNR3) primarily found in East Asian populations was also identified which, although it included FCGR3A and FCGR2C, had altered breakpoints compared to the more common CNR2 region.
null
199
43,601
0
false
null
null
A third CNV region (CNR3) primarily found in East Asian populations was also identified which, although it included FCGR3A and FCGR2C, had altered breakpoints compared to the more common CNR2 region.
true
true
true
true
true
7,545
4
DISCUSSION
0
null
null
20,508,037
pmid-16170323|pmid-12115230|pmid-20385827|pmid-16170323|pmid-16115811|pmid-16170323
It is likely that there are multiple breakpoints of CNV regions within the areas of homology in this locus.
null
107
43,602
0
false
null
null
It is likely that there are multiple breakpoints of CNV regions within the areas of homology in this locus.
true
true
true
true
true
7,545
5
DISCUSSION
1
27
[ "DDQ216C27", "DDQ216C7" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
A previous study has examined LD of FCGR3B CNV or FcγRIIIB-HNA1 polymorphisms with proximal SNPs in HapMap individuals, and found no SNPs with sufficiently high LD (assessed by r2) to be predictive, although the study was limited by the SNP data available and did not include any SNPs within the ancestral duplication of...
[ "27", "7" ]
337
43,603
1
false
A previous study has examined LD of FCGR3B CNV or FcγRIIIB-HNA1 polymorphisms with proximal SNPs in HapMap individuals, and found no SNPs with sufficiently high LD (assessed by r2) to be predictive, although the study was limited by the SNP data available and did not include any SNPs within the ancestral duplication of...
[ "27" ]
A previous study has examined LD of FCGR3B CNV or FcγRIIIB-HNA1 polymorphisms with proximal SNPs in HapMap individuals, and found no SNPs with sufficiently high LD to be predictive, although the study was limited by the SNP data available and did not include any SNPs within the ancestral duplication of FCGR genes.
true
true
true
true
true
7,546
5
DISCUSSION
1
7
[ "DDQ216C27", "DDQ216C7" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
Others have assessed LD between SNPs and di-allelic CNVs (7).
[ "27", "7" ]
61
43,604
1
false
Others have assessed LD between SNPs and di-allelic CNVs.
[ "7" ]
Others have assessed LD between SNPs and di-allelic CNVs.
true
true
true
true
true
7,546
5
DISCUSSION
1
27
[ "DDQ216C27", "DDQ216C7" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
We examined linkage between the multi-allelic FCGR3B CNV and SLE-associated SNPs in East Asian, Caucasian and Kenyan control cohorts, and demonstrated weak-to-moderate LD in the FCGR locus.
[ "27", "7" ]
189
43,605
0
false
We examined linkage between the multi-allelic FCGR3B CNV and SLE-associated SNPs in East Asian, Caucasian and Kenyan control cohorts, and demonstrated weak-to-moderate LD in the FCGR locus.
[]
We examined linkage between the multi-allelic FCGR3B CNV and SLE-associated SNPs in East Asian, Caucasian and Kenyan control cohorts, and demonstrated weak-to-moderate LD in the FCGR locus.
true
true
true
true
true
7,546
5
DISCUSSION
1
27
[ "DDQ216C27", "DDQ216C7" ]
20,508,037
pmid-18776908|pmid-17827395|pmid-19309690|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-17529978|pmid-18559452|pmid-16482158|pmid-19741716|pmid-18559452|pmid-19946035|pmid-16482158|pmid-17529978|pmid-19741716|pmid-18559452|pmid-17529978|pmid-16482158|pmid-17827395|pmid-19309690|pmid-19143032|pmid-1877690...
The differing degree of LD between FCGR2B and FCGR3B found when comparing the FCGR3B deletion haplotype or the duplication haplotype may indicate that these events formed independently, and may have subtly different breakpoints.
[ "27", "7" ]
228
43,606
0
false
The differing degree of LD between FCGR2B and FCGR3B found when comparing the FCGR3B deletion haplotype or the duplication haplotype may indicate that these events formed independently, and may have subtly different breakpoints.
[]
The differing degree of LD between FCGR2B and FCGR3B found when comparing the FCGR3B deletion haplotype or the duplication haplotype may indicate that these events formed independently, and may have subtly different breakpoints.
true
true
true
true
true
7,546
6
DISCUSSION
1
17
[ "DDQ216C17", "DDQ216C18", "DDQ216C49", "DDQ216C18" ]
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
The FCGR2B-I232T polymorphism was found to be in LD with FCGR3B CNV in Chinese and Caucasians.
[ "17", "18", "49", "18" ]
94
43,607
0
false
The FCGR2B-I232T polymorphism was found to be in LD with FCGR3B CNV in Chinese and Caucasians.
[]
The FCGR2B-I232T polymorphism was found to be in LD with FCGR3B CNV in Chinese and Caucasians.
true
true
true
true
true
7,547
6
DISCUSSION
1
18
[ "DDQ216C17", "DDQ216C18", "DDQ216C49", "DDQ216C18" ]
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
The association of homozygosity of the FcγRIIB-232T allele with SLE has been well established in East Asian populations (17,18,49), and in this study we confirm our previously reported association in Caucasians (18) with an effect size (OR = 2.6) among the highest for SLE.
[ "17", "18", "49", "18" ]
273
43,608
1
false
The association of homozygosity of the FcγRIIB-232T allele with SLE has been well established in East Asian populations, and in this study we confirm our previously reported association in Caucasians with an effect size (OR = 2.6) among the highest for SLE.
[ "17,18,49", "18" ]
The association of homozygosity of the FcγRIIB-232T allele with SLE has been well established in East Asian populations, and in this study we confirm our previously reported association in Caucasians with an effect size (OR = 2.6) among the highest for SLE.
true
true
true
true
true
7,547
6
DISCUSSION
1
17
[ "DDQ216C17", "DDQ216C18", "DDQ216C49", "DDQ216C18" ]
20,508,037
pmid-12115230|pmid-20385827|pmid-14651519|pmid-20385827
Critically, FCGR3B CNV was demonstrated to independently contribute to SLE risk despite the LD with FCGR2B-I232T.
[ "17", "18", "49", "18" ]
113
43,609
0
false
Critically, FCGR3B CNV was demonstrated to independently contribute to SLE risk despite the LD with FCGR2B-I232T.
[]
Critically, FCGR3B CNV was demonstrated to independently contribute to SLE risk despite the LD with FCGR2B-I232T.
true
true
true
true
true
7,547
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
There were two intriguing negative findings in this study.
[ "22", "23", "50", "6", "20" ]
58
43,610
0
false
There were two intriguing negative findings in this study.
[]
There were two intriguing negative findings in this study.
true
true
true
true
true
7,548
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
The first was that there was no association with AAV.
[ "22", "23", "50", "6", "20" ]
53
43,611
0
false
The first was that there was no association with AAV.
[]
The first was that there was no association with AAV.
true
true
true
true
true
7,548
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
The evidence for association of FCGR3B CN with vasculitis has been contradictory—low CN was initially associated with disease (22), but this finding was not replicated in a second study using a similar qPCR assay (23).
[ "22", "23", "50", "6", "20" ]
218
43,612
1
false
The evidence for association of FCGR3B CN with vasculitis has been contradictory—low CN was initially associated with disease, but this finding was not replicated in a second study using a similar qPCR assay.
[ "22", "23" ]
The evidence for association of FCGR3B CN with vasculitis has been contradictory—low CN was initially associated with disease, but this finding was not replicated in a second study using a similar qPCR assay.
true
true
true
true
true
7,548
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
In the current study, we found no association or distinct trend in either direction.
[ "22", "23", "50", "6", "20" ]
84
43,613
0
false
In the current study, we found no association or distinct trend in either direction.
[]
In the current study, we found no association or distinct trend in either direction.
true
true
true
true
true
7,548
7
DISCUSSION
1
50
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
It is plausible that FCGR3B low CN does not have a significant effect on AAV, since ICs are not thought to play a major role in AAV pathogenesis (50).
[ "22", "23", "50", "6", "20" ]
150
43,614
1
false
It is plausible that FCGR3B low CN does not have a significant effect on AAV, since ICs are not thought to play a major role in AAV pathogenesis.
[ "50" ]
It is plausible that FCGR3B low CN does not have a significant effect on AAV, since ICs are not thought to play a major role in AAV pathogenesis.
true
true
true
true
true
7,548
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
The previous association with low AAV depended upon integer CN designation from a qPCR assay, and the number of low CN individuals in Caucasian controls was high (10–25%) compared to what has been identified here with the triple PRT (7%) and previously with MLPA (5–7%) (6,20).
[ "22", "23", "50", "6", "20" ]
277
43,615
0
false
The previous association with low AAV depended upon integer CN designation from a qPCR assay, and the number of low CN individuals in Caucasian controls was high (10–25%) compared to what has been identified here with the triple PRT (7%) and previously with MLPA (5–7%).
[ "6,20" ]
The previous association with low AAV depended upon integer CN designation from a qPCR assay, and the number of low CN individuals in Caucasian controls was high compared to what has been identified here with the triple PRT (7%) and previously with MLPA (5–7%).
true
true
true
true
true
7,548
7
DISCUSSION
1
22
[ "DDQ216C22", "DDQ216C23", "DDQ216C50", "DDQ216C6", "DDQ216C20" ]
20,508,037
pmid-17529978|pmid-18559452|pmid-16624931|pmid-17827395|pmid-19309690
Thus findings based solely on qPCR assays must be treated with caution, and confirmed using other methods.
[ "22", "23", "50", "6", "20" ]
106
43,616
0
false
Thus findings based solely on qPCR assays must be treated with caution, and confirmed using other methods.
[]
Thus findings based solely on qPCR assays must be treated with caution, and confirmed using other methods.
true
true
true
true
true
7,548
8
DISCUSSION
1
14
[ "DDQ216C14" ]
20,508,037
pmid-19674504
There was no association of FCGR3B CN with severe bacterial infection or malaria in Kenyan and Vietnamese cohorts.
[ "14" ]
114
43,617
0
false
There was no association of FCGR3B CN with severe bacterial infection or malaria in Kenyan and Vietnamese cohorts.
[]
There was no association of FCGR3B CN with severe bacterial infection or malaria in Kenyan and Vietnamese cohorts.
true
true
true
true
true
7,549
8
DISCUSSION
1
14
[ "DDQ216C14" ]
20,508,037
pmid-19674504
Neutrophils are known to play a critical role in the clearance of bacteria.
[ "14" ]
75
43,618
0
false
Neutrophils are known to play a critical role in the clearance of bacteria.
[]
Neutrophils are known to play a critical role in the clearance of bacteria.
true
true
true
true
true
7,549